Abstract:
BACKGROUND:Choriocarcinoma is a highly aggressive, malignant trophoblastic neoplasm that can be gestational or non-gestational in origin. Accurate discrimination between these two subtypes, the causative pregnancy type, and the pregnancy-to-treatment interval for gestational choriocarcinoma are vital for clinical management. METHODS:Fifteen choriocarcinomas were genotyped using multiplex fluorescent polymerase chain reaction amplification of 15 short tandem repeat (STR) loci and the amelogenin locus (XY determination). Genotype patterns at each locus from tumoral and maternal tissues were compared, and any prior or concurrent mole/placenta was also compared when available. According to STR results showing the presence or absence of the paternal chromosomal complement, the gestational or non-gestational origin of the tumor and the nature of the causative pregnancy was identified. RESULTS:Fourteen tumors were gestational. Of these, seven were androgenetic/homozygous XX, and two were androgenetic/heterozygous XX, indicating that the causative pregnancies were molar pregnancies. Among the nine molar pregnancies, five were of the occult type. A menopausal patient developed a tumor from a mole that occurred seven years ago, identified by the genetically identical allele from the tumor and prior mole. One tumor originating from a previous mole was interrupted by term delivery. Two tumors found eight weeks postpartum were identified as originating from a prior occult mole. A pelvic choriocarcinoma was separated from a genetically distinct third trimester intrauterine placenta. Five gestational tumors were biparental: 2 XX, 3 XY. Of three ovarian tumors, two were confirmed gestational (1 androgenetic/homozygous XX; 1 biparental XY), and one was an ovarian tumor (XX) with a complete match of the genotype for all 15 loci, therefore ascertaining its non-gestational origin. CONCLUSION:Gestational choriocarcinoma can originate in an androgenetic or biparental manner. The majority are androgenetic/homozygous XX, while a large number of them might be occult molar pregnancies. The origin of ectopic androgenetic choriocarcinoma with concurrent intrauterine placenta might be from either dispermic twin gestation (mole and coexistent nonmolar fetus) or an antecedent molar pregnancy. Choriocarcinoma shortly postpartum might not be associated with the last placenta. STR analysis can be useful in distinguishing gestational choriocarcinoma from non-gestational, as well as the causative pregnancy, and serve as a helpful examination tool for guiding clinical management.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Zhang X,Yan K,Chen J,Xie Xdoi
10.1186/s13000-019-0866-5subject
Has Abstractpub_date
2019-08-17 00:00:00pages
93issue
1issn
1746-1596pii
10.1186/s13000-019-0866-5journal_volume
14pub_type
杂志文章abstract:INTRODUCTION:Necrobiosis lipoidica diabeticorum is a rare disease of unclear etiology, that occurs in about 1% of diabetic patients. CASE REPORT:We present case of granulomatosis disciformis chronica et progressiva Miescher with good response to systemic corticosteroids therapy.Patient 45 years old woman, with primary...
journal_title:Diagnostic pathology
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abstract::This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin stained tissue components, especially the RBCs. In the method, a principal component analysis (PCA) w...
journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-3-S1-S21
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journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
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更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-05-23 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2012-09-10 00:00:00
abstract:BACKGROUND:A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer. METHODS:Literature databases incl...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
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更新日期:2014-07-01 00:00:00
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doi:10.1186/1746-1596-9-S1-S6
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pub_type: 杂志文章
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更新日期:2019-10-23 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-S1-S1
更新日期:2014-01-01 00:00:00
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journal_title:Diagnostic pathology
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更新日期:2019-05-10 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-57
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common mesonephric adenocarcinoma (MAC), which mostly arises the uterine cervix. Despite the similarities b...
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更新日期:2020-07-21 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2014-02-20 00:00:00
abstract:BACKGROUND:Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual incidence of 5 cases per million. The primary CNS anaplastic variant of DLBCL (A-DLBCL) is even less com...
journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2019-05-20 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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更新日期:2019-04-09 00:00:00