Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E-box-binding homeobox 1: a case report.

Abstract:

BACKGROUND:The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E-box-binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial-mesenchymal transition, is involved in tumor transformation. CASE PRESENTATION:The patient had a left nephrectomy with the clinical diagnosis of left pelvic renal cancer. The resected specimen showed that the tumor surface comprised a noninvasive papillary urothelial carcinoma with the carcinoma in situ, and the invasive area comprised a plasmacytoid urothelial carcinoma characterized by the presence of single dyscohesive malignant cells that resembled plasma cells in a loose myxoid stroma. The noninvasive urothelial carcinoma was positive for cytokeratin and E-cadherin, and negative for vimentin and ZEB1. In contrast, the invasive plasmacytoid urothelial carcinoma was positive for cytokeratin and also vimentin and ZEB1, and negative for E-cadherin. Additionally, this component was immunoreactive for CD138 and CD38 that are immunohistochemical markers for plasma cells. CONCLUSION:We suggest that ZEB1 is involved in the plasmacytoid transformation by repressing the E-cadherin in a plasmacytoid urothelial carcinoma.

journal_name

Diagn Pathol

journal_title

Diagnostic pathology

authors

Takada-Owada A,Nozawa Y,Onozaki M,Noda S,Jamiyan T,Tokura Y,Nakazato Y,Kamai T,Ishida K

doi

10.1186/s13000-020-01043-6

subject

Has Abstract

pub_date

2020-10-08 00:00:00

pages

124

issue

1

issn

1746-1596

pii

10.1186/s13000-020-01043-6

journal_volume

15

pub_type

杂志文章
  • Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladder.

    abstract::Endocervicosis in the urinary bladder is a rare benign condition. We present a case in a 37-year-old woman with classical clinical and pathological features of endocervicosis. The unusual observation of endocervical-like mucinous epithelium in continuity with the urothelium in addition to fully developed endocervicosi...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-6-56

    authors: Cheah PL,Looi LM,Lee GE,Teoh KH,Mun KS,Nazarina AR

    更新日期:2011-06-23 00:00:00

  • Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review.

    abstract:BACKGROUND:Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicop...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1186/s13000-017-0604-9

    authors: Yamada S,Kirishima M,Hiraki T,Higashi M,Hatanaka K,Tanimoto A

    更新日期:2017-01-19 00:00:00

  • Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum.

    abstract:BACKGROUND:IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, IL4Rα and IL13Rα1 were reported to have roles in cancer progression and suggested as potential prognostic markers. However, studies on IL4Rα and IL13Rα1 in soft-tissue sarcomas have been limited. METHODS:This study investigated the im...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-020-01066-z

    authors: Kim KM,Hussein UK,Park SH,Moon YJ,Zhang Z,Ahmed AG,Ahn AR,Park HS,Kim JR,Jang KY

    更新日期:2021-01-09 00:00:00

  • Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.

    abstract:BACKGROUND:A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer. METHODS:Literature databases incl...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,meta分析

    doi:10.1186/1746-1596-9-134

    authors: Wang W,Chen J,Zhao F,Zhang B,Yu H

    更新日期:2014-07-01 00:00:00

  • Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples.

    abstract:BACKGROUND:A recently published transcript set is suitable for gene expression-based discrimination of normal colonic and colorectal cancer (CRC) biopsy samples. Our aim was to test the discriminatory power of the CRC-specific transcript set on independent biopsies and on formalin-fixed, paraffin-embedded (FFPE) tissue...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-015-0363-4

    authors: Kalmár A,Wichmann B,Galamb O,Spisák S,Tóth K,Leiszter K,Nielsen BS,Barták BK,Tulassay Z,Molnár B

    更新日期:2015-07-25 00:00:00

  • Factors associated with the survival of prostate cancer patients with rectal involvement.

    abstract:BACKGROUND:Prostate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated. PATIENTS AND METHODS:We collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in t...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-9-35

    authors: Wang H,Yao Y,Li B

    更新日期:2014-02-20 00:00:00

  • Use of virtual slide system for quick frozen intra-operative telepathology diagnosis in Kyoto, Japan.

    abstract::We started to use virtual slide (VS) and virtual microscopy (VM) systems for quick frozen intra-operative telepathology diagnosis in Kyoto, Japan. In the system we used a digital slide scanner, VASSALO by CLARO Inc., and a broadband optic fibre provided by NTT West Japan Inc. with the best effort capacity of 100 Mbps....

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-3-S1-S6

    authors: Tsuchihashi Y,Takamatsu T,Hashimoto Y,Takashima T,Nakano K,Fujita S

    更新日期:2008-07-15 00:00:00

  • NUT expression in primary lung tumours.

    abstract:BACKGROUND:Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-015-0395-9

    authors: Lund-Iversen M,Grøholt KK,Helland Å,Borgen E,Brustugun OT

    更新日期:2015-09-05 00:00:00

  • Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer.

    abstract:BACKGROUND:Carbonic anhydrase IX is a member of α-carbonic anhydrases that is preferentially expressed in solid tumors. It enables bicarbonate transport across the plasma membrane, neutralizing intracellular pH and conferring to cancer cells a survival advantage in hypoxic/acidic microenvironments. Overexpression of ca...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-016-0495-1

    authors: Ambrosio MR,Di Serio C,Danza G,Rocca BJ,Ginori A,Prudovsky I,Marchionni N,Del Vecchio MT,Tarantini F

    更新日期:2016-05-25 00:00:00

  • Renal cell -like carcinoma of the nasal cavity: a case report and review of the literature.

    abstract:BACKGROUND:Sinonasal renal cell-like carcinoma (SRCLC) is an extremely rare low malignant tumor arising in the sinonasal tract, with histological mimicry of renal cell carcinoma. CASE PRESENTATION:We present a case of sinonasal renal cell-like carcinoma in a 63-year-old male patient. Computer tomography(CT) scanning r...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1186/s13000-017-0660-1

    authors: Zhenwei-Chen,Zhaoming-Wang,Hongqi-Shi,Qinwei-Liu

    更新日期:2017-10-17 00:00:00

  • Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis.

    abstract:BACKGROUND:Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirr...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-019-0891-4

    authors: Lan YT,Wang ZL,Tian P,Gong XN,Fan YC,Wang K

    更新日期:2019-10-21 00:00:00

  • Quantitative analytical technique applied to histopathology of birds infected experimentally by the virus of chicken anemia virus.

    abstract::This research was conducted on ten glass slides selected from the histopathology evaluation chickens. Five slides of control's chickens healthy and five slides of chickens infected experimentally with chicken anemia virus (CAV slide) between one and twenty-one days post infection (PI), they were analyzed in magnificat...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-3-S1-S21

    authors: García L,Bermudez V,Brett M,Peroza L,Landa J,Borregales F

    更新日期:2008-07-15 00:00:00

  • Dry eye management in a Sjögren's syndrome mouse model by inhibition of p38-MAPK pathway.

    abstract:BACKGROUND:To investigate the therapeutic effect of p38-MAPK inhibitor, SB203580, on dry eye in a mouse model of Sjögren's syndrome (MRL/lpr mice). METHODS:18 female BALB/c mice and 44 female MRL/lpr mice were included. Mice were randomly assigned to the control or treatment group. The expression of phospho-p38 MAPK i...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-9-5

    authors: Ma X,Zou J,He L,Zhang Y

    更新日期:2014-01-20 00:00:00

  • Evaluation of diagnostic criteria for IgG4-related tubulointerstitial nephritis.

    abstract:BACKGROUND:IgG4-TIN is the most common pattern of renal involvement in IgG4-related disease. There are several proposed diagnostic criteria of IgG4-TIN recently. Two of them proposed by the Mayo Clinic and JSN are predominant. However, histopathological criteria of the number of IgG4+ plasma cells and several histologi...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-015-0311-3

    authors: Tang X,Zhu B,Chen R,Hu Y,Zhang Y,Zhu X,Chen H,Wang Y

    更新日期:2015-07-01 00:00:00

  • Concurrent acute myeloid leukemia and T lymphoblastic lymphoma in a patient with rearranged PDGFRB genes.

    abstract::Concurrent hematologic malignancies are relatively rare. We encountered a case of concurrent acute myeloid leukemia (AML) and T lymphoblastic lymphoma. The bone marrow chromosome analysis showed the karyotype 46, XY, t(5;12)(q33;p13), which indicated presence of PDGFRB gene translocations. Therefore, this disease belo...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-7-19

    authors: Chang H,Chuang WY,Sun CF,Barnard MR

    更新日期:2012-02-22 00:00:00

  • PD-L1 expression in renal cell carcinoma clear cell type is related to unfavorable prognosis.

    abstract:BACKGROUND:PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition of the tumor-directed T-cell immune response. There are few reports in the literature evaluating PD...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-015-0414-x

    authors: Leite KR,Reis ST,Junior JP,Zerati M,Gomes Dde O,Camara-Lopes LH,Srougi M

    更新日期:2015-10-15 00:00:00

  • Localization of eosinophilic esophagitis from H&E stained images using multispectral imaging.

    abstract::This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin stained tissue components, especially the RBCs. In the method, a principal component analysis (PCA) w...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-6-S1-S2

    authors: Bautista PA,Yagi Y

    更新日期:2011-03-30 00:00:00

  • A relationship between slide quality and image quality in whole slide imaging (WSI).

    abstract::This study examined the effect of tissue section thickness and consistency--parameters outside the direct control of the imaging devices themselves--on WSI capture speed and image quality. Preliminary data indicates that thinner, more consistent tissue sectioning (such as those produced by automated tissue sectioning ...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-3-S1-S12

    authors: Yagi Y,Gilbertson JR

    更新日期:2008-07-15 00:00:00

  • Current evidences on XPC polymorphisms and gastric cancer susceptibility: a meta-analysis.

    abstract:BACKGROUND:Reduced DNA repair capacities due to inherited polymorphisms may increase the susceptibility to cancers including gastric cancer. Previous studies investigating the association between Xeroderma Pigmentosum group C (XPC) gene polymorphisms and gastric cancer risk reported inconsistent results. We performed a...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/1746-1596-9-96

    authors: Peng Q,Chen Z,Lu Y,Lao X,Mo C,Li R,Qin X,Li S

    更新日期:2014-05-23 00:00:00

  • Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus.

    abstract:BACKGROUND:Primary diffuse large B cell lymphoma (DLBCL) of the uterus is rare, and primary DLBCL arising from a uterine leiomyoma (collision tumor) has not been reported in the literature. CASE PRESENTATION:We describe the clinical, histological, immunohistochemical, and molecular features of primary DLBCL arising fr...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-016-0464-8

    authors: Zhao L,Ma Q,Wang Q,Zeng Y,Luo Q,Xiao H

    更新日期:2016-01-20 00:00:00

  • A novel model for Ki67 assessment in breast cancer.

    abstract:BACKGROUND:Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS:One hundred breast cancer s...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-9-118

    authors: Romero Q,Bendahl PO,Fernö M,Grabau D,Borgquist S

    更新日期:2014-06-16 00:00:00

  • Spontaneous isolated dissection of the superior mesenteric artery and aneurysm formation resulting from segmental arterial mediolysis: a case report.

    abstract:BACKGROUND:Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular wall of the SMA may be a contributor, but its pathogenesis is unclear. CASE PRESENTATION:A 57-year...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-017-0664-x

    authors: Akuzawa N,Kurabayashi M,Suzuki T,Yoshinari D,Kobayashi M,Tanahashi Y,Makita F,Saito R

    更新日期:2017-10-16 00:00:00

  • Microscopic endometrial perivascular epithelioid cell nodules: a case report with the earliest presentation of a uterine perivascular epithelioid cell tumor.

    abstract::Perivascular epithelioid cell (PEC) tumors (PEComas) are a family of related mesenchymal tumors composed of PECs which co-express melanocytic and smooth muscle markers. Although their distinctive histologic, immunohistochemical, ultrastructural, and genetic features have been clearly demonstrated, their histogenesis a...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-7-117

    authors: Fang CL,Lin YH,Chen WY

    更新日期:2012-09-03 00:00:00

  • Localized early mesenteric Castleman's disease presenting as recurrent intestinal obstruction: a case report.

    abstract::Primary neoplasms of the mesentery are very rare. They are usually of mesenchymal origin and include desmoid tumor, lipoma, liposarcoma, and fibrosarcoma. Metastatic carcinomas and lymphoma are more common. We report a rare case of localized mesenteric Castleman's disease, presenting as intestinal obstruction. Clinica...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/1746-1596-4-42

    authors: El Demellawy D,Herath C,Truong F,Nasr A,Alowami S

    更新日期:2009-12-04 00:00:00

  • A giant cord hemangioma with extramedullary hematopoiesis and elevated maternal serum human chorionic gonadotropin: a case report and review of the literature.

    abstract::A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-year-old woman without a previous history of gravida or para, presented with intermittent abdominal pain at 26 we...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1186/s13000-015-0385-y

    authors: Hara K,Fukumura Y,Saito T,Arakawa A,Okabe H,Takeda S,Yao T

    更新日期:2015-09-04 00:00:00

  • An autopsy case of peripheral T cell lymphoma occurring in a postpartum woman: a unique case suggesting changes in the immunocharacteristics of lymphoma cells before and after delivery.

    abstract:BACKGROUND:The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after delivery have been reported, there are no report of autopsy cases of PTCL in the puerperal period. CASE PR...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-018-0707-y

    authors: Mizutani K,Yamada S,Guo X,Futatsuya C,Kumagai M,Shioya A,Aikawa A,Nakada S,Kurose N,Minato H,Nojima T

    更新日期:2018-05-22 00:00:00

  • MicroRNA 3113-5p is a novel marker for early cardiac ischemia/reperfusion injury.

    abstract:BACKGROUND:Ischemia/reperfusion (I/R) injury of heart is one of the major causes of acute cardiac injury, which may result in worsening or even loss of heart function. With novel microRNAs being evolutionarily discovered, numbers of them remained functionally unknown. We aimed to discover novel microRNAs with therapeut...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-019-0894-1

    authors: Chen Y,Ye X,Yan F

    更新日期:2019-10-31 00:00:00

  • Unilateral synchronous papillary renal neoplasm with reverse polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations.

    abstract:BACKGROUND:The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with reverse polarity (PRNRP) with comprehensive immunohistochemical and molecular charact...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-020-01042-7

    authors: Lee HJ,Shin DH,Park JY,Kim SY,Hwang CS,Lee JH,Kim JY,Sol MY,Nam JK

    更新日期:2020-10-06 00:00:00

  • SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males.

    abstract:BACKGROUND:Somatostatin receptor 2 (SSTR2) encodes somatostatin receptor that can inhibit the cell proliferation of solid tumors. Promoter hypermethylation is likely to silence the expression of SSTR2. The goal of our study was to investigate the association between SSTR2 promoter methylation and the risk and progressi...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章

    doi:10.1186/s13000-016-0461-y

    authors: Shen Z,Chen X,Li Q,Zhou C,Li J,Ye H,Duan S

    更新日期:2016-01-22 00:00:00

  • Using a powered bone marrow biopsy system results in shorter procedures, causes less residual pain to adult patients, and yields larger specimens.

    abstract:BACKGROUND:In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and efficiently. A multicenter randomized clinical trial was designed for adult patients to determine if the p...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1746-1596-6-23

    authors: Berenson JR,Yellin O,Blumenstein B,Bojanower D,Croopnick J,Aboulafia D,Upadhyaya G,Spadaccini C

    更新日期:2011-03-23 00:00:00