Abstract:
BACKGROUND:Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polymorphisms and glioma risk. METHODS:We enrolled 300 glioma patients and 300 age- and gender-matched healthy controls. A prospective hospital-based case-control design and logistic regression analysis were utilized. The IL-8 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS:Glioma patients had a significantly higher frequency of IL-8 -251 AA genotype [odds ratio (OR) =1.91, 95% confidence interval (CI) = 1.22, 3.00; P = 0.005] and IL-8 -251 A allele (OR =1.36, 95% CI = 1.08, 1.70; P = 0.009) than controls. When stratified by the grade of glioma, patients with WHO IV glioma had a significantly higher frequency of IL-8 -251 AA genotype (OR =1.56, 95% CI = 1.01, 2.39; P = 0.04). CONCLUSIONS:To the best of our knowledge, this is the first report in the literature that the IL-8 -251 AA genotype and A allele were at a higher risk for glioma.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Liu H,Mao P,Xie C,Xie W,Wang M,Jiang Hdoi
10.1186/s13000-015-0378-xsubject
Has Abstractpub_date
2015-08-07 00:00:00pages
138issn
1746-1596pii
10.1186/s13000-015-0378-xjournal_volume
10pub_type
杂志文章abstract:BACKGROUND:PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition of the tumor-directed T-cell immune response. There are few reports in the literature evaluating PD...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0414-x
更新日期:2015-10-15 00:00:00
abstract:BACKGROUND:The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia. It was suggested that mismatched F8 replacement therapy may be a risk factor for the development of anti-factor F8 alloantibodies. Recently four single nucle...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-54
更新日期:2011-06-17 00:00:00
abstract::A 42-year-old male presented right upper abdomen pain for more than 6 days, which misdiagnose calculus of intrahepatic duct and acute cholecystitis. An approximately 1.5 cm x 1.0 cm x 1.0 cm nodule was found and resected in left lateral lobe of hepatic. Pathological examination showed spindle cell and fibroblast -like...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/1746-1596-8-195
更新日期:2013-12-02 00:00:00
abstract:BACKGROUND:Maspin is a unique member of the serine protease inhibitor superfamily and its expression is found in myoepithelial cells of normal mammary glands; therefore, it has been considered to be a myoepithelial marker. We previously reported that maspin was frequently expressed in biologically aggressive breast can...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-36
更新日期:2011-04-16 00:00:00
abstract:UNLABELLED:The differential diagnosis between idiopathic nonspecific interstitial pneumonia(INSIP) and idiopathic pulmonary fibrosis(IPF)/usual interstitial pneumonia(UIP)is tough in both clinicians and pathologists. In this study, we analyzed the lesions of right lung removed from a 58-year-old patient by gross and mi...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-167
更新日期:2012-12-03 00:00:00
abstract::Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, includ...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-019-0802-8
更新日期:2019-04-09 00:00:00
abstract::A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-year-old woman without a previous history of gravida or para, presented with intermittent abdominal pain at 26 we...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-015-0385-y
更新日期:2015-09-04 00:00:00
abstract:BACKGROUND:We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-00988-y
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after delivery have been reported, there are no report of autopsy cases of PTCL in the puerperal period. CASE PR...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-018-0707-y
更新日期:2018-05-22 00:00:00
abstract:BACKGROUND:Special AT-rich sequence binding protein 1 (SATB1) is found acting as a "genome organizer" that functions as a landing platform to regulate tissue-specific gene ex-pression. In breast cancer cell lines it has been proven that SATB1 could upregulate the expression of the HER2. In this paper, the relevance of ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0282-4
更新日期:2015-05-09 00:00:00
abstract:BACKGROUND:Sinonasal renal cell-like carcinoma (SRCLC) is an extremely rare low malignant tumor arising in the sinonasal tract, with histological mimicry of renal cell carcinoma. CASE PRESENTATION:We present a case of sinonasal renal cell-like carcinoma in a 63-year-old male patient. Computer tomography(CT) scanning r...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0660-1
更新日期:2017-10-17 00:00:00
abstract:BACKGROUND:The aim of this report is related to adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of the spermatic cord leiomyosarcoma. Primary paratesticular tumors are rare, only accounting for 7% to 10% of all intrascrotal tumors. In adults, more than 75% of these le...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-90
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0395-9
更新日期:2015-09-05 00:00:00
abstract:BACKGROUND:ABCG2 is an ABC transporter. It has been demonstrated that endogenous ABCG2 expression in certain cancers is a possible reflection of the differentiated phenotype of the cell of origin and likely contributes to intrinsic drug resistance. But little is known about the contribution of ABCG2 to the drug resista...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-90
更新日期:2011-09-27 00:00:00
abstract:BACKGROUND:Advancing knowledge in molecular pathogenesis of hepatocellular carcinoma (HCC) opens up new horizons in the diagnostic, prognostic and therapeutic perspectives. Assessing the expression of molecular targets prior to definitive treatment is gaining importance in clinical practice. In this study, we investiga...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-017-0649-9
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopa...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0613-8
更新日期:2017-03-04 00:00:00
abstract:BACKGROUND:Extra-adrenal paraganglioma of the retroperitoneum with metastasis to the vertebra is very rare. To our knowledge this is the first report of this kind of disease in the literature. CASE PRESENTATION:Here, we present an oroginal case of paraganglioma of the retroperitoneum with metastasis to the abdominal v...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-52
更新日期:2013-03-28 00:00:00
abstract:BACKGROUND:The association between the Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene and lung cancer risk remains controversial and inconclusive. Therefore, the meta-analysis was performed to provide a quality reevaluation of the association between the COMT Val158Met polymorphism and the risk ...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
doi:10.1186/s13000-014-0192-x
更新日期:2014-10-04 00:00:00
abstract:BACKGROUND:Osteosarcoma is the most common primary bone malignancy with high local aggressiveness and rapid metastasizing potential, resulting in poor survival. Increasing reports suggest that deregulated microRNAs (miRNAs) might provide novel therapeutic targets for cancers. However, the expression of miR-26a and miR-...
journal_title:Diagnostic pathology
pub_type: 杂志文章,收录出版
doi:10.1186/s13000-015-0400-3
更新日期:2015-09-17 00:00:00
abstract::Sclerosing rhabdomyosarcoma (SRMS) is an infrequent variant of rhabdomyosarcoma characterized by extensive intercellular hyaline fibrosis. We report the case of a 37 year-old male with a 9 x 6 cm SRMS on the right elbow. Histologically, the tumor showed an abundant extracellular hyaline matrix with extratumoral vascul...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-5-52
更新日期:2010-08-11 00:00:00
abstract:BACKGROUND:Choriocarcinoma is a highly aggressive, malignant trophoblastic neoplasm that can be gestational or non-gestational in origin. Accurate discrimination between these two subtypes, the causative pregnancy type, and the pregnancy-to-treatment interval for gestational choriocarcinoma are vital for clinical manag...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0866-5
更新日期:2019-08-17 00:00:00
abstract:BACKGROUND:To distinguish between malignant and benign lesions of the thyroid gland histological demonstration is often required since the fine-needle aspiration biopsy method applied pre-operatively has some limitations. In an attempt to improve diagnostic accuracy, markers using immunocytochemistry and immunohistoche...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1746-1596-7-97
更新日期:2012-08-13 00:00:00
abstract:BACKGROUND:Prostate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated. PATIENTS AND METHODS:We collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in t...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-35
更新日期:2014-02-20 00:00:00
abstract:BACKGROUND:Mixed adeno-neuroendocrine carcinoma (MANEC) of the biliary tract is rare with only a few reported cases. Consequently, knowledge about their pathogenesis, histopathological characteristics and outcomes is sparce. CASE PRESENTATION:A 53-year old man presented with epigastric pain on a background of excessiv...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-015-0439-1
更新日期:2015-11-20 00:00:00
abstract::Complement C4d component deposition in kidney allograft biopsies is an established marker of antibody-mediated rejection. In the Banff 07 classification of renal allograft pathology, semi-quantitative evaluation of the proportion of C4d-positive peritubular capilaries (PTC) is used. We aimed to explore the potential o...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-S1-S5
更新日期:2011-03-30 00:00:00
abstract::Non-necrotizing epithelioid granulomas have been described in association with many primary tumors. In such cases, they are designated as sarcoid-like reaction. Although it is more seen in carcinomas than in sarcomas, it is very rarely reported in renal carcinoma. Here, we describe a rare association of prominent peri...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-28
更新日期:2012-03-18 00:00:00
abstract:BACKGROUND:Esophageal cancer is one of the leading causes of cancer related deaths among the Iranians. There is still a high ratio of mortality and low 5 years survival which are related to the late onset and diagnosis. Majority of patients refer for the treatment in advanced stages of tumor progression. MAIN BODY:It ...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-019-0875-4
更新日期:2019-08-31 00:00:00
abstract:BACKGROUND:Congenital alveolar rhabdomyosarcoma is an extremely uncommon and invariably fatal tumor with the current therapy. Less than 25% of patients present with evidence of cutaneous metastasis. CASE PRESENTATION:We report a case of congenital alveolar rhabdomyosarcoma in an 18-month-old male who presented with a ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-1-37
更新日期:2006-10-17 00:00:00
abstract:BACKGROUND:To investigate the therapeutic effect of p38-MAPK inhibitor, SB203580, on dry eye in a mouse model of Sjögren's syndrome (MRL/lpr mice). METHODS:18 female BALB/c mice and 44 female MRL/lpr mice were included. Mice were randomly assigned to the control or treatment group. The expression of phospho-p38 MAPK i...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-5
更新日期:2014-01-20 00:00:00
abstract:BACKGROUND:The optimal course of clinical follow-up after a diagnosis of breast papillary lesion on a core needle biopsy (CNB) remains elusive. In particular, no reports in literature have addressed this question in African-American population. We describe our experience with breast papillary lesions in a primarily Afr...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-86
更新日期:2014-04-24 00:00:00