Abstract:
BACKGROUND:We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) were examined. METHODS:We calculated the average CD34-positive BVD and podoplanin (D2-40)-positive lymphatic vessel density (LVD) and the proportion of proliferating of endothelial cells in 14 Paget disease, 3 dermatitis biopsy, and 14 age-matched control cases. As a parameter related to blood flow in the nipple, the total CD34-positive blood vessel lumen area relative to the entire nipple area was measured in each Paget disease and control case using an automated image analysis system. Immunohistochemical expression of bFGF and VEGFA in Paget cells was also examined. RESULTS:The average BVD and LVD were significantly higher in the Paget disease cases than in the dermatitis (p = 0.003) and control (p < 0.001) cases. The proportion of proliferating endothelial cells was also increased in the Paget disease cases. The ratio of the CD34-positive blood vessel lumen area to nipple area was also significantly higher in the Paget disease than control cases (p = 0.003). The average BVD was correlated with the average LVD (r = 0.734, p < 0.001) and ratio of the blood vessel lumen area to nipple area (r = 0.692, p < 0.001). Immunohistochemical expression of bFGF was strong in all Paget disease cases, with a significantly higher expression score in the Paget disease than dermatitis (p = 0.003) and control (p < 0.001) cases. The bFGF, but not VEGFA, expression score, was strongly correlated with the average BVD (r = 0.818, p < 0.001) and ratio of the blood vessel lumen area to nipple area (r = 0.503, p = 0.006). CONCLUSION:These results provide direct histopathological evidence of a marked increase in nipple blood flow in Paget disease detected by clinical imaging. bFGF is considered to play a pivotal role in angiogenesis in mammary Paget disease.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Akishima-Fukasawa Y,Honma N,Ogata H,Akasaka Y,Mikami Tdoi
10.1186/s13000-020-00988-ysubject
Has Abstractpub_date
2020-06-11 00:00:00pages
75issue
1issn
1746-1596pii
10.1186/s13000-020-00988-yjournal_volume
15pub_type
杂志文章abstract:BACKGROUND:Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicop...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0604-9
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abstract:BACKGROUND:This study is an analysis of the prevalence of polymorphous low grade adenocarcinoma (PLGA) in epidemiological surveys of salivary tumors published in the English language from 1992 to 2012. METHODS:These surveys included studies from different researchers, countries and continents. The 57 surveys for which...
journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-2-16
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-62
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-018-0689-9
更新日期:2018-02-09 00:00:00
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journal_title:Diagnostic pathology
pub_type: 社论
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-014-0229-1
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2015-04-02 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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更新日期:2017-03-04 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0406-x
更新日期:2015-09-17 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-5-62
更新日期:2010-09-22 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-3-29
更新日期:2008-07-09 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/1746-1596-9-149
更新日期:2014-07-17 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-3-14
更新日期:2008-04-16 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-5-52
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-3-30
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2019-10-23 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-54
更新日期:2011-06-17 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-00994-0
更新日期:2020-06-29 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-90
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recurrence/progression for individual patients. We attempted to find an objective and reproducible histol...
journal_title:Diagnostic pathology
pub_type: 杂志文章,多中心研究
doi:10.1186/s13000-017-0639-y
更新日期:2017-07-24 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01042-7
更新日期:2020-10-06 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-142
更新日期:2014-07-10 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-3-S1-S12
更新日期:2008-07-15 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-191
更新日期:2013-11-21 00:00:00