Abstract：
BACKGROUND:PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition of the tumor-directed T-cell immune response. There are few reports in the literature evaluating PD-L1 expression in association to prognosis specifically in renal cell cancer clear cell type (RCC-CC). METHODS:Immunohistochemistry using a PD-L1 polyclonal antibody was performed on a tissue microarray (TMA) that contained 115 surgical specimens of RCC-CC. Cases were classified based on the absence or presence of staining intensity in the cytoplasm and membranes of the tumor cells. Statistical analysis was used to determine the association of PD-L1 expression with classic prognostic factors and tumor recurrence. RESULTS:PD-L1 expression was positive in 56.5 % of tumors. The univariate analysis showed a correlation between PD-L1 expression and nuclear Fuhrman grade (p = 0.021) and microvascular tumor embolization (p = 0.039). One hundred and four patients were monitored for a mean time of 115.7 months. Seventeen patients (16.3 %) suffered tumor recurrence. Negative outcomes were associated with higher nuclear grade tumors, PD-L1 expression, and the presence of microvascular invasion. CONCLUSION:Our findings confirm that PD-L1 expression is an important prognostic factor in RCC-CC.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Leite KR,Reis ST,Junior JP,Zerati M,Gomes Dde O,Camara-Lopes LH,Srougi Mdoi
10.1186/s13000-015-0414-xsubject
Has Abstractpub_date
2015-10-15 00:00:00pages
189issn
1746-1596pii
10.1186/s13000-015-0414-xjournal_volume
10pub_type
杂志文章abstract：:Bronchoalveolar lavage (BAL) is a useful diagnostic tool in interstitial lung diseases (ILD). However, differential cell counts are often non specific and immunocytochemistry is time consuming. Staining of glycoproteins by periodic acid Schiff (PAS) reaction may help in discriminating different forms of ILD. In additi...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-4-13
更新日期：2009-04-23 00:00:00
abstract：BACKGROUND:The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC). PATIENTS AND METHODS:Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-8-25
更新日期：2013-02-15 00:00:00
abstract：:Cellular Angiofibroma (CA) represents a quite recently described mesenchymal tumour that occurs in both genders, in particular in the vulvo-vaginal region in women and in the inguino-scrotal area in men. The first description of this tumour dates from Nucci et al. article in 1997; since then, the literature reports di...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/s13000-015-0361-6
更新日期：2015-07-19 00:00:00
abstract：BACKGROUND:In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and efficiently. A multicenter randomized clinical trial was designed for adult patients to determine if the p...
journal_title：Diagnostic pathology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1746-1596-6-23
更新日期：2011-03-23 00:00:00
abstract：BACKGROUND:Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicop...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/s13000-017-0604-9
更新日期：2017-01-19 00:00:00
abstract：BACKGROUND:70-80% of sporadic endometrial carcinomas are defined as endometrioid carcinoma (EC). Early-stage, well differentiated endometrial carcinomas usually retain expression of estrogen and progesterone receptors (ER and PR, respectively), as advanced stage, poorly differentiated tumors often lack one or both of t...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-77
更新日期：2014-03-31 00:00:00
abstract：BACKGROUND:Prostate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated. PATIENTS AND METHODS:We collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in t...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-35
更新日期：2014-02-20 00:00:00
abstract：BACKGROUND:ALCAM (activated leukocyte cell adhesion molecule, CD166, MEMD) is a transmembrane protein of immunoglobulin superfamily (Ig-SF) and plays an important role in human malignant melanoma progression and formation of locoregional and distant metastases. The study using melanoma cell lines showed that overexpres...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-015-0331-z
更新日期：2015-07-02 00:00:00
abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target. PIK3CA, KRAS, and BRAF mutations, microsatell...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-01045-4
更新日期：2020-10-14 00:00:00
abstract：BACKGROUND:To investigate the therapeutic effect of p38-MAPK inhibitor, SB203580, on dry eye in a mouse model of Sjögren's syndrome (MRL/lpr mice). METHODS:18 female BALB/c mice and 44 female MRL/lpr mice were included. Mice were randomly assigned to the control or treatment group. The expression of phospho-p38 MAPK i...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-5
更新日期：2014-01-20 00:00:00
abstract：BACKGROUND:Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare entity that was first described by Zambrano et al. in 2003 as "Clear cell sarcoma-like tumor of the gastrointestinal tract". It shares some of the histological features of clear cell sarcoma (CCS) but lacks the immunohistochemical r...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/s13000-017-0620-9
更新日期：2017-03-20 00:00:00
abstract：BACKGROUND:Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAFV600E mutations and treatments of isolated HPLCH. METHODS:We identified seven patients with isolated HPLCH by reviewing the clinical an...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-016-0548-5
更新日期：2016-10-19 00:00:00
abstract：BACKGROUND/OBJECTIVE:Metastatic adenocarcinoma from an unknown primary site is a common clinical problem. Determining the cytokeratin (CK) 7/CK20 pattern of tumors is one of the most helpful procedures for this purpose since the CK7-/CK20+ pattern is typical of colorectal adenocarcinomas. CDX2, a critical nuclear trans...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-9
更新日期：2012-01-23 00:00:00
abstract：UNLABELLED:As rare condition, mucoepidermoid carcinoma may occur in liver although its etiology and pathogenesis is still unclear. We report here a case of intrahepatic mucoepidermoid carcinoma misdiagnosed as cholangiocarcinoma and squamous cell carcinoma by preoperative radiologic and intraoperative histological exam...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-24
更新日期：2014-01-29 00:00:00
abstract：BACKGROUND:Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS:One hundred breast cancer s...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-118
更新日期：2014-06-16 00:00:00
abstract：UNLABELLED:Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease i...
journal_title：Diagnostic pathology
pub_type： 信件
doi：10.1186/1746-1596-9-62
更新日期：2014-03-19 00:00:00
abstract：:A 42-year-old male presented right upper abdomen pain for more than 6 days, which misdiagnose calculus of intrahepatic duct and acute cholecystitis. An approximately 1.5 cm x 1.0 cm x 1.0 cm nodule was found and resected in left lateral lobe of hepatic. Pathological examination showed spindle cell and fibroblast -like...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/1746-1596-8-195
更新日期：2013-12-02 00:00:00
abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) is one of the most powerful genetic analysis tools for pathological diagnoses. FISH can detect various genetic abnormalities including gene translocation that was specifically found in translocation-related sarcomas (TRSs). Here, we report the use of FISH in expert r...
journal_title：Diagnostic pathology
pub_type： 杂志文章,多中心研究
doi：10.1186/s13000-016-0486-2
更新日期：2016-04-12 00:00:00
abstract：:A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-year-old woman without a previous history of gravida or para, presented with intermittent abdominal pain at 26 we...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/s13000-015-0385-y
更新日期：2015-09-04 00:00:00
abstract：UNLABELLED:Perivascular epithelioid cell tumor (PEComa) is a rare but distinct mesenchymal neoplasm composed of histologically and immunohistochemically unique perivascular epithelioid cells. Due to its relative rarity, little is known about the histogenesis and prognostic factors of this tumor. We describe a case of u...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/1746-1596-8-60
更新日期：2013-04-15 00:00:00
abstract：BACKGROUND:Patients with pathologic stage (p-Stage) IA non-small cell lung cancer (NSCLC) have a good survival rate because of possible curative resection. However, up to 10% of these patients relapse postoperatively. To identify unfavorable prognostic factors, we retrospectively analyzed the clinicopathological featur...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-015-0249-5
更新日期：2015-04-02 00:00:00
abstract：BACKGROUND:Pleomorphic xanthoastrocytoma is rare, accounting for <1 % of all central nervous system (CNS) neoplasms. Angiomatous pleomorphic xanthoastrocytoma is an extremely rare variant of pleomorphic xanthoastrocytoma, with only six cases reported thus far. CASE PRESENTATION:A 24-year-old Chinese female patient who...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/s13000-016-0524-0
更新日期：2016-08-09 00:00:00
abstract：OBJECTIVES:RAD51 gene plays an important role in the pathogenesis of squamous cell carcinoma of the head and neck (SCCHN), colorectal cancer, ovarian cancer and acute leukaemia. A number of studies assessed the association between RAD51 135G/C polymorphism and the risk of these cancers in different population. However,...
journal_title：Diagnostic pathology
pub_type： 杂志文章,meta分析
doi：10.1186/1746-1596-9-18
更新日期：2014-01-23 00:00:00
abstract：PURPOSE:Patellofemoral pathology is common, and patellofemoral dislocation mainly affects adolescents and young adults. We conducted a meta-analysis exclusively of RCTs to compare the clinical outcomes of patellar dislocation patients managed operatively versus non-operatively. METHODS:After systematic review of elect...
journal_title：Diagnostic pathology
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1746-1596-9-60
更新日期：2014-03-18 00:00:00
abstract：:Perivascular epithelioid cell (PEC) tumors (PEComas) are a family of related mesenchymal tumors composed of PECs which co-express melanocytic and smooth muscle markers. Although their distinctive histologic, immunohistochemical, ultrastructural, and genetic features have been clearly demonstrated, their histogenesis a...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-117
更新日期：2012-09-03 00:00:00
abstract：BACKGROUND:To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). METHODS:LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. RE...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-019-0876-3
更新日期：2019-09-04 00:00:00
abstract：BACKGROUND:Ischemia/reperfusion (I/R) injury of heart is one of the major causes of acute cardiac injury, which may result in worsening or even loss of heart function. With novel microRNAs being evolutionarily discovered, numbers of them remained functionally unknown. We aimed to discover novel microRNAs with therapeut...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-019-0894-1
更新日期：2019-10-31 00:00:00
abstract：BACKGROUND:Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polym...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-015-0378-x
更新日期：2015-08-07 00:00:00
abstract：UNLABELLED:Cutaneous mast cell tumours (MCTs) are the most common skin tumours in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology are critical for the treatment of this disease. A cytologic diagnosis of m...
journal_title：Diagnostic pathology
pub_type： 杂志文章,收录出版
doi：10.1186/1746-1596-9-9
更新日期：2014-01-20 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the frequency of Thyroid Transcription Factor (TTF)-1 expression in small cell lung cancer (SCLC) and its value for the diagnosis of SCLC, the response to first line treatment as well as the prognostic impact on overall survival (OS). METHODS:We analyzed a total of 294 p...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-015-0250-z
更新日期：2015-04-02 00:00:00
