Operative versus conservative treatment for patellar dislocation: a meta-analysis of 7 randomized controlled trials.


PURPOSE:Patellofemoral pathology is common, and patellofemoral dislocation mainly affects adolescents and young adults. We conducted a meta-analysis exclusively of RCTs to compare the clinical outcomes of patellar dislocation patients managed operatively versus non-operatively. METHODS:After systematic review of electronic databases and websites, a total of 7 RCTs reporting data on 402 subjects were included. The methodological quality of the literature was assessed using the PEDro critical appraisal tool. Mean differences (MDs) and risk ratio (RR) were calculated for the pooled effects. Heterogeneity was assessed using the I2 test. RESULTS:Data synthesis showed a lower rate of recurrent patellar dislocation post-treatment in patients managed operatively compared to non-operatively (P=0.01). CONCLUSION:The results suggest a difference in outcomes between the treatment strategies. However the limited number of studies and high risk of inherent bias indicate that future studies involving more patients in better-designed randomized controlled trials will be required. VIRTUAL SLIDES:The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8011948721221355.


Diagn Pathol


Diagnostic pathology


Cheng B,Wu X,Ge H,Qing Sun Y,Zhang Q




Has Abstract


2014-03-18 00:00:00










  • Association between Catechol-O-methyltransferase rs4680 (G>A) polymorphism and lung cancer risk.

    abstract:BACKGROUND:The association between the Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene and lung cancer risk remains controversial and inconclusive. Therefore, the meta-analysis was performed to provide a quality reevaluation of the association between the COMT Val158Met polymorphism and the risk ...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,meta分析


    authors: Tan X,Chen M

    更新日期:2014-10-04 00:00:00

  • NF-κB signaling and vesicle transport are correlated with the reactivation of the memory trace of morphine dependence.

    abstract:BACKGROUND:Morphine has been widely used as a clinical anesthetic and analgesic. However, abuse of morphine might result in psychological and physiological dependence. Previous studies have indicated that memory mechanisms play critical roles in morphine dependence. METHODS:Morphine dependence was established in mice ...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Ye J,Yang Z,Li C,Cai M,Zhou D,Zhang Q,Wei Y,Wang T,Liu Y

    更新日期:2014-07-10 00:00:00

  • Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target. PIK3CA, KRAS, and BRAF mutations, microsatell...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Lee HK,Kwon MJ,Ra YJ,Lee HS,Kim HS,Nam ES,Cho SJ,Park HR,Min SK,Seo J,Choe JY,Min KW,Kang SY

    更新日期:2020-10-14 00:00:00

  • Molecular modeling and description of a newly characterized activating mutation of the EGFR gene in non-small cell lung cancer.

    abstract:UNLABELLED:Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promising approach to prolong the otherwise very poor prognosis of patients with advanced UICC stages. Ep...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Otto C,Csanadi A,Fisch P,Werner M,Kayser G

    更新日期:2012-10-22 00:00:00

  • Diagnostic use of fluorescence in situ hybridization in expert review in a phase 2 study of trabectedin monotherapy in patients with advanced, translocation-related sarcoma.

    abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) is one of the most powerful genetic analysis tools for pathological diagnoses. FISH can detect various genetic abnormalities including gene translocation that was specifically found in translocation-related sarcomas (TRSs). Here, we report the use of FISH in expert r...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,多中心研究


    authors: Sugita S,Asanuma H,Hasegawa T

    更新日期:2016-04-12 00:00:00

  • Schizophrenia proteomics: biomarkers on the path to laboratory medicine?

    abstract::Over two million Americans are afflicted with schizophrenia, a debilitating mental health disorder with a unique symptomatic and epidemiological profile. Genomics studies have hinted towards candidate schizophrenia susceptibility chromosomal loci and genes. Modern proteomic tools, particularly mass spectrometry and ex...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Lakhan SE

    更新日期:2006-07-17 00:00:00

  • Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors.

    abstract:BACKGROUND:We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Akishima-Fukasawa Y,Honma N,Ogata H,Akasaka Y,Mikami T

    更新日期:2020-06-11 00:00:00

  • PD-L1 diagnostic tests: a systematic literature review of scoring algorithms and test-validation metrics.

    abstract:BACKGROUND:The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies t...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Udall M,Rizzo M,Kenny J,Doherty J,Dahm S,Robbins P,Faulkner E

    更新日期:2018-02-09 00:00:00

  • Focused scores enable reliable discrimination of small differences in steatosis.

    abstract:BACKGROUND:Automated image analysis enables quantitative measurement of steatosis in histological images. However, spatial heterogeneity of steatosis can make quantitative steatosis scores unreliable. To improve the reliability, we have developed novel scores that are "focused" on steatotic tissue areas. METHODS:Focus...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Homeyer A,Hammad S,Schwen LO,Dahmen U,Höfener H,Gao Y,Dooley S,Schenk A

    更新日期:2018-09-20 00:00:00

  • Gene expression profiles analysis identifies key genes for acute lung injury in patients with sepsis.

    abstract:BACKGROUND:To identify critical genes and biological pathways in acute lung injury (ALI), a comparative analysis of gene expression profiles of patients with ALI + sepsis compared with patients with sepsis alone were performed with bioinformatic tools. METHODS:GSE10474 was downloaded from Gene Expression Omnibus, incl...

    journal_title:Diagnostic pathology

    pub_type: 撤回出版物,收录出版


    authors: Guo Z,Zhao C,Wang Z

    更新日期:2014-09-26 00:00:00

  • Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis.

    abstract:OBJECTIVES:This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC) in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. M...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Zhou Q,Chang H,Zhang H,Han Y,Liu H

    更新日期:2012-09-10 00:00:00

  • Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus.

    abstract:BACKGROUND:Primary diffuse large B cell lymphoma (DLBCL) of the uterus is rare, and primary DLBCL arising from a uterine leiomyoma (collision tumor) has not been reported in the literature. CASE PRESENTATION:We describe the clinical, histological, immunohistochemical, and molecular features of primary DLBCL arising fr...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Zhao L,Ma Q,Wang Q,Zeng Y,Luo Q,Xiao H

    更新日期:2016-01-20 00:00:00

  • Right-sided rhabdoid colorectal tumors might be related to the serrated pathway.

    abstract:BACKGROUND:Rhabdoid colorectal tumor (RCT) is a rare, highly aggressive neoplasm recurrent in elderly patients, commonly at the caecum. The molecular mechanisms underlying RCT pathogenesis remain poorly elucidated. The differential diagnosis is with the malignant rhabdoid tumors of infancy characterized by genetic inac...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Pancione M,Remo A,Sabatino L,Zanella C,Votino C,Fucci A,Di Blasi A,Lepore G,Daniele B,Fenizia F,Molinari E,Normanno N,Manfrin E,Vendraminelli R,Colantuoni V

    更新日期:2013-02-20 00:00:00

  • Adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of spermatic cord leiomyosarcoma.

    abstract:BACKGROUND:The aim of this report is related to adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of the spermatic cord leiomyosarcoma. Primary paratesticular tumors are rare, only accounting for 7% to 10% of all intrascrotal tumors. In adults, more than 75% of these le...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Galosi AB,Scarpelli M,Mazzucchelli R,Lopez-Beltran A,Giustini L,Cheng L,Montironi R

    更新日期:2014-05-06 00:00:00

  • Down-regulation of microRNA-26a and up-regulation of microRNA-27a contributes to aggressive progression of human osteosarcoma.

    abstract:BACKGROUND:Osteosarcoma is the most common primary bone malignancy with high local aggressiveness and rapid metastasizing potential, resulting in poor survival. Increasing reports suggest that deregulated microRNAs (miRNAs) might provide novel therapeutic targets for cancers. However, the expression of miR-26a and miR-...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,收录出版


    authors: Taheriazam A,Bahador R,Karbasy SH,Jamshidi SM,Torkaman A,Yahaghi E,Shakeri M

    更新日期:2015-09-17 00:00:00

  • DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.

    abstract::Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade d...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Kannuna H,Rubio CA,Silverio PC,Girardin M,Goossens N,Rubbia-Brandt L,Puppa G

    更新日期:2015-07-09 00:00:00

  • PEComa of the mesentery coexisting with colon cancer: a case report.

    abstract::Perivascular epithelioid cell tumor (PEComa) is a rare entity originating from mesenchymal tissue, which stains for both melanocytic and smooth muscle markers. We would like to present an unusual case of the PEComa of the mesentery which was unexpected discovery in a female patient with colonic adenocarcinoma. The tum...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Wejman J,Nowak K,Gielniewska L,Komorowska M,Dąbrowski W

    更新日期:2015-04-18 00:00:00

  • Quantitative analytical technique applied to histopathology of birds infected experimentally by the virus of chicken anemia virus.

    abstract::This research was conducted on ten glass slides selected from the histopathology evaluation chickens. Five slides of control's chickens healthy and five slides of chickens infected experimentally with chicken anemia virus (CAV slide) between one and twenty-one days post infection (PI), they were analyzed in magnificat...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: García L,Bermudez V,Brett M,Peroza L,Landa J,Borregales F

    更新日期:2008-07-15 00:00:00

  • Spontaneous isolated dissection of the superior mesenteric artery and aneurysm formation resulting from segmental arterial mediolysis: a case report.

    abstract:BACKGROUND:Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular wall of the SMA may be a contributor, but its pathogenesis is unclear. CASE PRESENTATION:A 57-year...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Akuzawa N,Kurabayashi M,Suzuki T,Yoshinari D,Kobayashi M,Tanahashi Y,Makita F,Saito R

    更新日期:2017-10-16 00:00:00

  • Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review.

    abstract:OBJECTIVE:FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed in our institution, assess the cytomorphologic features that contribute to diagnostic errors and prop...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Zhu Y,Song Y,Xu G,Fan Z,Ren W

    更新日期:2020-01-03 00:00:00

  • Comparative analysis of confocal microscopy on fresh breast core needle biopsies and conventional histology.

    abstract:BACKGROUND:Evaluation of core needle biopsies (CNB) is a standard procedure for the diagnosis of breast cancer. However, tissue processing and image preparation is a time- consuming procedure and instant on-site availability of high-quality images could substantially improve the efficacy of the diagnostic procedure. Co...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Elfgen C,Papassotiropoulos B,Varga Z,Moskovszky L,Nap M,Güth U,Baege A,Amann E,Chiesa F,Tausch C

    更新日期:2019-06-15 00:00:00

  • Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.

    abstract:BACKGROUND:A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer. METHODS:Literature databases incl...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,meta分析


    authors: Wang W,Chen J,Zhao F,Zhang B,Yu H

    更新日期:2014-07-01 00:00:00

  • CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung.

    abstract:UNLABELLED:CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray photography, computed t...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Terada T

    更新日期:2012-02-14 00:00:00

  • A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature.

    abstract:UNLABELLED:Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case of gallbladder polypoid tumor revealing metastatic clear cell renal cell carcinoma, which demonstra...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Ghaouti M,Znati K,Jahid A,Zouaidia F,Bernoussi Z,El Fakir Y,Mahassini N

    更新日期:2013-01-10 00:00:00

  • Histological variants of cutaneous Kaposi sarcoma.

    abstract::This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anapla...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Grayson W,Pantanowitz L

    更新日期:2008-07-25 00:00:00

  • Current evidences on XPC polymorphisms and gastric cancer susceptibility: a meta-analysis.

    abstract:BACKGROUND:Reduced DNA repair capacities due to inherited polymorphisms may increase the susceptibility to cancers including gastric cancer. Previous studies investigating the association between Xeroderma Pigmentosum group C (XPC) gene polymorphisms and gastric cancer risk reported inconsistent results. We performed a...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章,meta分析,评审


    authors: Peng Q,Chen Z,Lu Y,Lao X,Mo C,Li R,Qin X,Li S

    更新日期:2014-05-23 00:00:00

  • Postauricular congenital alveolar rhabdomyosarcoma- a case report of an unusual entity.

    abstract:BACKGROUND:Congenital alveolar rhabdomyosarcoma is an extremely uncommon and invariably fatal tumor with the current therapy. Less than 25% of patients present with evidence of cutaneous metastasis. CASE PRESENTATION:We report a case of congenital alveolar rhabdomyosarcoma in an 18-month-old male who presented with a ...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Vankalakunti M,Das A,Rao NK

    更新日期:2006-10-17 00:00:00

  • High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma.

    abstract:BACKGROUND:Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA b...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Nodin B,Fridberg M,Jonsson L,Bergman J,Uhlén M,Jirström K

    更新日期:2012-07-17 00:00:00

  • NUT expression in primary lung tumours.

    abstract:BACKGROUND:Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Lund-Iversen M,Grøholt KK,Helland Å,Borgen E,Brustugun OT

    更新日期:2015-09-05 00:00:00

  • EGFR T790M detection and osimertinib treatment response evaluation by liquid biopsy in lung adenocarcinoma patients with acquired resistance to first generation EGFR tyrosine kinase inhibitors.

    abstract:BACKGROUND:Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical r...

    journal_title:Diagnostic pathology

    pub_type: 杂志文章


    authors: Li C,Jia R,Liu H,Zhang B,Wang C

    更新日期:2018-08-13 00:00:00