Abstract:
BACKGROUND:Ischemia/reperfusion (I/R) injury of heart is one of the major causes of acute cardiac injury, which may result in worsening or even loss of heart function. With novel microRNAs being evolutionarily discovered, numbers of them remained functionally unknown. We aimed to discover novel microRNAs with therapeutic or diagnostic potential in the setting of early cardiac I/R injury. METHODS:Cardiac electrical activity, biochemical detection and histopathology analysis were performed to reveal early changes of cardiac I/R injury. A microRNA array was performed to screen differential microRNAs in the mouse model of cardiac I/R injury. The differentially expressed microRNAs were validated in cardiac tissues and in serum samples. RESULTS:The abnormality in electrocardiogram and increases in serum cTnI levels suggested the successful establishment of cardiac I/R injury in mice. A total of 1882 microRNAs were identified, of which 11 were significantly down-regulated and 41 were significantly up-regulated at 3 h post reperfusion. microRNA 223-3p and microRNA 3113-5p were among the mostly altered microRNAs and were validated to be up-regulated within the early hours of I/R injury in heart tissues. In the circulating system, cTnI, a sensitive marker of cardiac injury, or microRNA 223-3p only increased within the first 6 h post I/R injury. However, microRNA 3113-5p stably increased in the serum, keeping an increase of 2.5-fold throughout the 24 h. In the human serum samples, microRNA 3113-5p was detected to be significantly upregulated as soon as 3 h after I/R stimuli and kept significantly higher levels within the 48 h. CONCLUSION:This is the first study that reported the functional roles of microRNA 3113-5p in cardiovascular system. Our data suggested that cardiac microRNA 3113-5p might be a useful target for therapeutic purposes and circulating microRNA 3113-5p might serve as a stable marker for early diagnosis of cardiac I/R injury.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Chen Y,Ye X,Yan Fdoi
10.1186/s13000-019-0894-1subject
Has Abstractpub_date
2019-10-31 00:00:00pages
121issue
1issn
1746-1596pii
10.1186/s13000-019-0894-1journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual incidence of 5 cases per million. The primary CNS anaplastic variant of DLBCL (A-DLBCL) is even less com...
journal_title:Diagnostic pathology
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doi:10.1186/s13000-019-0826-0
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章,多中心研究
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journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
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journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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journal_title:Diagnostic pathology
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doi:10.1186/1746-1596-6-S1-S5
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-4-13
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2013-02-20 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-77
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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journal_title:Diagnostic pathology
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doi:10.1186/1746-1596-5-21
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 社论
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2015-10-13 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2016-10-19 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-128
更新日期:2014-06-27 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-30
更新日期:2012-03-21 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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更新日期:2015-07-16 00:00:00
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journal_title:Diagnostic pathology
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doi:10.1186/1746-1596-7-19
更新日期:2012-02-22 00:00:00
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journal_title:Diagnostic pathology
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