Abstract:
BACKGROUND:Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare entity that was first described by Zambrano et al. in 2003 as "Clear cell sarcoma-like tumor of the gastrointestinal tract". It shares some of the histological features of clear cell sarcoma (CCS) but lacks the immunohistochemical reactivity for melanocytic markers. We report a case of GNET that was initially misdiagnosed as gastrointestinal stromal tumor (GIST). Recognizing this entity is important to avoid misdiagnosis. CASE PRESENTATION:A case of an 18-year-old male presented with a small intestinal tumor. Histologically it was characterized by polygonal cells arranged in pseudoalveolar pattern and situated in the muscularis propria. Scattered osteoclast-like multinucleated giant cells were also noted. The neoplastic cells were positive for S-100 protein and negative for HMB-45, Melan A, smooth muscle actin, desmin and CD117. EWSR1 gene rearrangement was detected by fluorescence in situ hybridization (FISH) analysis. The patient returned with recurrence after 36 months' management by surgical resection and died one year later. CONCLUSIONS:GNET can be mistaken histologically for other non-epithelial gastrointestinal tumors. Awareness of its existence and diagnostic criteria by the pathologist is necessary to avoid misdiagnosis, particularly as GIST, CCS or malignant peripheral nerve sheath tumor (MPNST).
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Alyousef MJ,Alratroot JA,ElSharkawy T,Shawarby MA,Al Hamad MA,Hashem TM,Alsayyah Adoi
10.1186/s13000-017-0620-9subject
Has Abstractpub_date
2017-03-20 00:00:00pages
29issue
1issn
1746-1596pii
10.1186/s13000-017-0620-9journal_volume
12pub_type
杂志文章,评审abstract::Primary involvement of skeletal muscle is a very rare event in ALK-1 positive anaplastic large cell lymphoma (ALCL). We describe a case of a 10-year old boy presenting with a three week history of pain and a palpable firm swelling at the dorsal aspect of the left thigh. Histological examination of the lesion revealed ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-38
更新日期:2012-04-12 00:00:00
abstract:UNLABELLED:A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary lining, that expressed cytokeratins 7, 5/6 and calretinin as well as nuclear WT-1 and apical membra...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-162
更新日期:2013-09-25 00:00:00
abstract:OBJECTIVES:RAD51 gene plays an important role in the pathogenesis of squamous cell carcinoma of the head and neck (SCCHN), colorectal cancer, ovarian cancer and acute leukaemia. A number of studies assessed the association between RAD51 135G/C polymorphism and the risk of these cancers in different population. However,...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
doi:10.1186/1746-1596-9-18
更新日期:2014-01-23 00:00:00
abstract::Sclerosing rhabdomyosarcoma (SRMS) is an infrequent variant of rhabdomyosarcoma characterized by extensive intercellular hyaline fibrosis. We report the case of a 37 year-old male with a 9 x 6 cm SRMS on the right elbow. Histologically, the tumor showed an abundant extracellular hyaline matrix with extratumoral vascul...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-5-52
更新日期:2010-08-11 00:00:00
abstract:BACKGROUND:The transcriptional co-activator, TAZ, is an important effector of the Hippo pathway and is critical for the development of human cancers. However, the expression and prognostic significance of TAZ in retinoblastoma is currently unclear. METHODS:TAZ expression was examined in 43 retinoblastoma samples by im...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0415-9
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) is one of the most powerful genetic analysis tools for pathological diagnoses. FISH can detect various genetic abnormalities including gene translocation that was specifically found in translocation-related sarcomas (TRSs). Here, we report the use of FISH in expert r...
journal_title:Diagnostic pathology
pub_type: 杂志文章,多中心研究
doi:10.1186/s13000-016-0486-2
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recurrence/progression for individual patients. We attempted to find an objective and reproducible histol...
journal_title:Diagnostic pathology
pub_type: 杂志文章,多中心研究
doi:10.1186/s13000-017-0639-y
更新日期:2017-07-24 00:00:00
abstract:UNLABELLED:Seven percent of renal cell carcinoma (RCC) cases are diagnosed as "unclassified" RCC by morphology. Genetic profiling of RCCs helps define renal tumor subtypes, especially in cases where morphologic diagnosis is inconclusive. This report describes a patient with synchronous clear cell RCC (ccRCC) and a tubu...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-21
更新日期:2012-02-27 00:00:00
abstract:UNLABELLED:Perivascular epithelioid cell tumor (PEComa) is a rare but distinct mesenchymal neoplasm composed of histologically and immunohistochemically unique perivascular epithelioid cells. Due to its relative rarity, little is known about the histogenesis and prognostic factors of this tumor. We describe a case of u...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/1746-1596-8-60
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:c-MET is an oncogene protein that plays important role in gastric carcinogenesis and has been introduced as a prognostic marker and potential therapeutic target. The aim of this study was to evaluate the frequency of c-MET overexpression and its relationship with clinicopathological variables in gastric canc...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-57
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Crowdsourcing, i.e., the outsourcing of tasks typically performed by a few experts to a large crowd as an open call, has been shown to be reasonably effective in many cases, like Wikipedia, the Chess match of Kasparov against the world in 1999, and several others. The aim of the present paper is to describe ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-S1-S6
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Previous studies suggested that apolipoprotein A5 (ApoA5) genetic polymorphisms (SNPs) may result in lipid metabolism disorders. Therefore, genetic polymorphisms in ApoA5 may be associated with the occurrence of osteonecrosis of femoral head (ONFH). METHODS:We designed a case-control study including 223 pat...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-014-0229-1
更新日期:2014-12-17 00:00:00
abstract::Telepathology, the practice of pathology at a long distance, has advanced continuously since 1986. Today, fourth-generation telepathology systems, so-called virtual slide telepathology systems, are being used for education applications. Both conventional and innovative surgical pathology diagnostic services are being ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-S1-S1
更新日期:2011-03-30 00:00:00
abstract:BACKGROUND:To identify critical genes and biological pathways in acute lung injury (ALI), a comparative analysis of gene expression profiles of patients with ALI + sepsis compared with patients with sepsis alone were performed with bioinformatic tools. METHODS:GSE10474 was downloaded from Gene Expression Omnibus, incl...
journal_title:Diagnostic pathology
pub_type: 撤回出版物,收录出版
doi:10.1186/s13000-014-0176-x
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Primary non-Hodgkin lymphoma (NHL) of the breast represents 0.04-0.5% of malignant lesions of the breast and accounts for 1.7-2.2% of extra-nodal NHL. Most primary cases are of B-cell phenotype and only rare cases are of T-cell phenotype. Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma typica...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-4-11
更新日期:2009-04-02 00:00:00
abstract::This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin stained tissue components, especially the RBCs. In the method, a principal component analysis (PCA) w...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-S1-S2
更新日期:2011-03-30 00:00:00
abstract::A 42-year-old male presented right upper abdomen pain for more than 6 days, which misdiagnose calculus of intrahepatic duct and acute cholecystitis. An approximately 1.5 cm x 1.0 cm x 1.0 cm nodule was found and resected in left lateral lobe of hepatic. Pathological examination showed spindle cell and fibroblast -like...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/1746-1596-8-195
更新日期:2013-12-02 00:00:00
abstract:BACKGROUND:Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAFV600E mutations and treatments of isolated HPLCH. METHODS:We identified seven patients with isolated HPLCH by reviewing the clinical an...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-016-0548-5
更新日期:2016-10-19 00:00:00
abstract:BACKGROUND:Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients. METHODS:In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-75
更新日期:2012-06-28 00:00:00
abstract:BACKGROUND:In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and efficiently. A multicenter randomized clinical trial was designed for adult patients to determine if the p...
journal_title:Diagnostic pathology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1746-1596-6-23
更新日期:2011-03-23 00:00:00
abstract:BACKGROUND:Although synovial sarcoma is the 3rd most commonly occurring mesenchymal tumor in young adults, usually with a highly aggressive clinical course; remarkable differences can be seen regarding the clinical outcome. According to comparative genomic hybridization (CGH) data published in the literature, the simpl...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-107
更新日期:2011-11-03 00:00:00
abstract:BACKGROUND:Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common mesonephric adenocarcinoma (MAC), which mostly arises the uterine cervix. Despite the similarities b...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01012-z
更新日期:2020-07-21 00:00:00
abstract:BACKGROUND:Intestinal metaplasia (IM) of the gastric mucosa is classified as complete (Type I) and incomplete IM (Type II and III) subtypes, which showed significantly different risk for developing to gastric adenocarcinoma (GAC). GCRG213, a variant of L1-endonuclease (L1-EN), first identified in our lab, was upregulat...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0838-9
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:Kombucha, a fermented tea (KT) is claimed to possess many beneficial properties. The aim of this study was to evaluate clinical and histopathological alterations of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rat. METHODS:In present study 24 Wister -albino rats weighing 150-...
journal_title:Diagnostic pathology
pub_type: 杂志文章,收录出版
doi:10.1186/1746-1596-8-120
更新日期:2013-07-17 00:00:00
abstract::Primary liver tumors in children are rare with malignant hepatoblastoma being the most common neoplasm. In this report, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma. Pathological as...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-4-37
更新日期:2009-11-12 00:00:00
abstract:BACKGROUND:A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer. METHODS:Literature databases incl...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
doi:10.1186/1746-1596-9-134
更新日期:2014-07-01 00:00:00
abstract:UNLABELLED:Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promising approach to prolong the otherwise very poor prognosis of patients with advanced UICC stages. Ep...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-146
更新日期:2012-10-22 00:00:00
abstract:BACKGROUND:Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polym...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0378-x
更新日期:2015-08-07 00:00:00
abstract:BACKGROUND:PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition of the tumor-directed T-cell immune response. There are few reports in the literature evaluating PD...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0414-x
更新日期:2015-10-15 00:00:00
abstract:BACKGROUND:Tubular adenoma of the breast is a rare benign epithelial tumor and only a few literatures have been reported; so far, no cases of tubular adenoma occurred in the accessory breast have been reported in the English literature. Clinical presentation and management of our patient are discussed along with a revi...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0286-0
更新日期:2015-06-04 00:00:00