Abstract：
BACKGROUND:The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC). PATIENTS AND METHODS:Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76 years (av. 62), were cytologically reviewed in comparison with histological findings. RESULTS:The endometrial cytological findings were summarized as follows: mucous and watery diathesis as a background lacking or with little necrotic inflammatory changes; micropapillary cluster formation; abrupt transition between carcinoma cells and normal cells; nuclear enlargement; high N/C ratio; and single or a few prominent nucleoli. Histologically, one case had EIC alone in the EMP; three cases had EIC with stromal invasion confined to the EMP; and four cases had EIC in the atrophic endometrium in addition to EIC in the EMP. Seven patients have taken a disease-free course after surgical resection, but one patient died 44 months following the initial diagnosis because of the massive tumor extending over her peritoneal cavity. CONCLUSIONS:Endometrial cytology may be helpful for the detection of early endometrial adenocarcinomas with serous features including EIC. Some early stage endometrial adenocarcinomas represented by EIC exceptionally take an aggressive clinical course irrespective of a lack of extrauterine lesions. VIRTUAL SLIDES:The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1651876760876449.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Yasuda M,Katoh T,Hori S,Suzuki K,Ohno K,Maruyama M,Matsui N,Miyazaki S,Ogane N,Kameda Ydoi
10.1186/1746-1596-8-25subject
Has Abstractpub_date
2013-02-15 00:00:00pages
25issn
1746-1596pii
1746-1596-8-25journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Appendiceal parasites can cause symptoms of appendiceal pain, independent of microscopic evidence of acute inflammation. The diagnosis of a parasitic infestation is generally achieved only after the pathologic examination of the resected appendices. PATIENTS/METHODS:Pathology department records were reviewe...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-2-16
更新日期：2007-05-24 00:00:00
abstract：BACKGROUND:ABCG2 is an ABC transporter. It has been demonstrated that endogenous ABCG2 expression in certain cancers is a possible reflection of the differentiated phenotype of the cell of origin and likely contributes to intrinsic drug resistance. But little is known about the contribution of ABCG2 to the drug resista...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-6-90
更新日期：2011-09-27 00:00:00
abstract：BACKGROUND:Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAFV600E mutations and treatments of isolated HPLCH. METHODS:We identified seven patients with isolated HPLCH by reviewing the clinical an...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-016-0548-5
更新日期：2016-10-19 00:00:00
abstract：UNLABELLED:Cutaneous mast cell tumours (MCTs) are the most common skin tumours in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology are critical for the treatment of this disease. A cytologic diagnosis of m...
journal_title：Diagnostic pathology
pub_type： 杂志文章,收录出版
doi：10.1186/1746-1596-9-9
更新日期：2014-01-20 00:00:00
abstract：BACKGROUND:The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after delivery have been reported, there are no report of autopsy cases of PTCL in the puerperal period. CASE PR...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-018-0707-y
更新日期：2018-05-22 00:00:00
abstract：BACKGROUND:High altitude pulmonary edema (HAPE) affects individuals and is characterized by alveolar flooding with protein-rich edema as a consequence of blood-gas barrier disruption. In this study, we hypothesized that aquaporin 5 (AQP5) which is one kind of water channels may play a role in preservation of alveolar e...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-8-193
更新日期：2013-11-25 00:00:00
abstract：BACKGROUND:Although often associated with holoprosencephaly, little detail of the histopathology of cyclopia is available. Here, we describe the ocular findings in a case of trisomy 13 to better understand the histogenesis of the rosettes, or tubules, characteristic of the retinal dysplasia associated with this conditi...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-2-48
更新日期：2007-12-18 00:00:00
abstract：BACKGROUND:Several studies reported the dysregulation of miR-541 in the progression of some human malignancies. Osteosarcoma (OS) is one of the most common primary malignant bone tumors. This study aimed to assess the expression and clinical significance of miR-541 in OS patients and explore the biological function of ...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-01008-9
更新日期：2020-07-24 00:00:00
abstract：BACKGROUND:Patients with pathologic stage (p-Stage) IA non-small cell lung cancer (NSCLC) have a good survival rate because of possible curative resection. However, up to 10% of these patients relapse postoperatively. To identify unfavorable prognostic factors, we retrospectively analyzed the clinicopathological featur...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-015-0249-5
更新日期：2015-04-02 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) remains a major worldwide cause of cancer-related morbidity and mortality largely due to the insidious onset of the disease. The current clinical procedures utilized for disease diagnosis are invasive, unpleasant, and inconvenient. Hence, the need for simple blood tests that could be ...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-53
更新日期：2014-03-12 00:00:00
abstract：BACKGROUND:The feasibility of evaluating an objective grading of cervical intraneoplasia lesions (CIN) is attempted using an automatic computerized system able to measure several valuable parameters with special reference to epithelium differentiation. METHODS:4 groups of 10 images each were selected at random from 68...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-5-7
更新日期：2010-01-22 00:00:00
abstract：:Complement C4d component deposition in kidney allograft biopsies is an established marker of antibody-mediated rejection. In the Banff 07 classification of renal allograft pathology, semi-quantitative evaluation of the proportion of C4d-positive peritubular capilaries (PTC) is used. We aimed to explore the potential o...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-6-S1-S5
更新日期：2011-03-30 00:00:00
abstract：BACKGROUND:Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recurrence/progression for individual patients. We attempted to find an objective and reproducible histol...
journal_title：Diagnostic pathology
pub_type： 杂志文章,多中心研究
doi：10.1186/s13000-017-0639-y
更新日期：2017-07-24 00:00:00
abstract：BACKGROUND:Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirr...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-019-0891-4
更新日期：2019-10-21 00:00:00
abstract：BACKGROUND:The novel pandemic A (H1N1) pdm09 virus was first identified in Mexico in April 2009 and since then it spread worldwide over a short period of time. Although the virus infection is generally associated with mild disease and a relatively low mortality, it is projected that mutations in specific regions of the...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-8-124
更新日期：2013-07-31 00:00:00
abstract：BACKGROUND:To investigate the therapeutic effect of p38-MAPK inhibitor, SB203580, on dry eye in a mouse model of Sjögren's syndrome (MRL/lpr mice). METHODS:18 female BALB/c mice and 44 female MRL/lpr mice were included. Mice were randomly assigned to the control or treatment group. The expression of phospho-p38 MAPK i...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-5
更新日期：2014-01-20 00:00:00
abstract：BACKGROUND:Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA b...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-82
更新日期：2012-07-17 00:00:00
abstract：:A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-year-old woman without a previous history of gravida or para, presented with intermittent abdominal pain at 26 we...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/s13000-015-0385-y
更新日期：2015-09-04 00:00:00
abstract：UNLABELLED:CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray photography, computed t...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-16
更新日期：2012-02-14 00:00:00
abstract：UNLABELLED:Imaging appearance of cyst-like changes is most frequently described in primary neuroendocrine lesions, especially pancreatic NETs.The imaging finding of a pseudocystic lesion of the liver puts in differential diagnosis many pathologies such as infectious diseases, simple biliary cysts up to biliary cystaden...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/1746-1596-8-148
更新日期：2013-09-13 00:00:00
abstract：:Bronchoalveolar lavage (BAL) is a useful diagnostic tool in interstitial lung diseases (ILD). However, differential cell counts are often non specific and immunocytochemistry is time consuming. Staining of glycoproteins by periodic acid Schiff (PAS) reaction may help in discriminating different forms of ILD. In additi...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-4-13
更新日期：2009-04-23 00:00:00
abstract：UNLABELLED:Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promising approach to prolong the otherwise very poor prognosis of patients with advanced UICC stages. Ep...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-146
更新日期：2012-10-22 00:00:00
abstract：BACKGROUND:The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, w...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-00994-0
更新日期：2020-06-29 00:00:00
abstract：BACKGROUND:HER2/neu overexpression and/or amplification has been widely studied in a number of solid tumors, primarily in the breast. In gynecologic neoplasms, determination of HER2/neu status has not been well studied as a predictive biomarker in anti-HER2/neu treatment. METHODS:We systematically evaluated the HER2/n...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-016-0553-8
更新日期：2016-10-22 00:00:00
abstract：:Meningioma, craniopharyngeoma and glioma are mainly intracranial lesions. Nevertheless, in rare cases these entities may occur solely as extracranial lesions that may present as intranasal/sinusoidal masses, with headaches and nasal obstruction. We present three cases of common intracranial tumors, with purely extracr...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-3-14
更新日期：2008-04-16 00:00:00
abstract：UNLABELLED:A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary lining, that expressed cytokeratins 7, 5/6 and calretinin as well as nuclear WT-1 and apical membra...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-8-162
更新日期：2013-09-25 00:00:00
abstract：OBJECTIVE:FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed in our institution, assess the cytomorphologic features that contribute to diagnostic errors and prop...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-019-0924-z
更新日期：2020-01-03 00:00:00
abstract：BACKGROUND:Crowdsourcing, i.e., the outsourcing of tasks typically performed by a few experts to a large crowd as an open call, has been shown to be reasonably effective in many cases, like Wikipedia, the Chess match of Kasparov against the world in 1999, and several others. The aim of the present paper is to describe ...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-S1-S6
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS:One hundred breast cancer s...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-118
更新日期：2014-06-16 00:00:00
abstract：BACKGROUND:Evaluation of core needle biopsies (CNB) is a standard procedure for the diagnosis of breast cancer. However, tissue processing and image preparation is a time- consuming procedure and instant on-site availability of high-quality images could substantially improve the efficacy of the diagnostic procedure. Co...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-019-0835-z
更新日期：2019-06-15 00:00:00
