Abstract:
OBJECTIVE:FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed in our institution, assess the cytomorphologic features that contribute to diagnostic errors and propose improvement measures. METHODS:A total of 2781 FNACs were included in the study, and 1122 cases were compared with their histological diagnoses. We retrospectively reexamined our discordant (both false-negative and false-positive) cases and performed a systematic review of previous studies on causes of misdiagnoses. RESULTS:When DC V and DC VI were both considered cytologic-positive, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy were 98.3, 30.9, 94.9, 58.3 and 93.5%, respectively. If DC VI was considered cytologic-positive, the sensitivity, specificity, PPV, NPV and diagnostic accuracy of FNAC were 98.0, 84.0, 99.4, 58.3, and 97.5% respectively. The main cause of false-negative diagnoses was sampling error (13/15, 86.7%), while interpretation error led to the majority of the false-positive diagnoses (38/47, 80.9%). Overlapping cytological features in adenomatous hyperplasia, thyroiditis and cystic lesions were the major factors contributing to interpretation errors, while the size and number of nodules may have led to false-negative diagnoses because of heterogeneity and unsampled areas. CONCLUSIONS:The sensitivity and PPV of thyroid FNAC in our institution were higher than those in the published data, while the specificity and NPV were lower. Regarding the FNA category DC V, a frozen section analysis during diagnostic lobectomy is necessary. Multiple passes should be performed in various parts of a large nodule or from different nodules to reduce the risk of false-negative findings. Cytopathologists should strengthen their criteria for the identification of adenomatous hyperplasia, thyroiditis and cystic lesions to avoid false-positive diagnoses. NIFTP has little effect on diagnostic accuracy and the distribution of diagnostic errors.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Zhu Y,Song Y,Xu G,Fan Z,Ren Wdoi
10.1186/s13000-019-0924-zsubject
Has Abstractpub_date
2020-01-03 00:00:00pages
1issue
1issn
1746-1596pii
10.1186/s13000-019-0924-zjournal_volume
15pub_type
杂志文章abstract:BACKGROUND:A recently published transcript set is suitable for gene expression-based discrimination of normal colonic and colorectal cancer (CRC) biopsy samples. Our aim was to test the discriminatory power of the CRC-specific transcript set on independent biopsies and on formalin-fixed, paraffin-embedded (FFPE) tissue...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0363-4
更新日期:2015-07-25 00:00:00
abstract:BACKGROUND:This study is to investigate the expression of progranulin (PGRN) in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid (GC) treatment on its expression. METHODS:Thirty newly diagnosed severe SLE patients and 30 healthy subjects were enrolled in this study. The serum levels of PGRN...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-88
更新日期:2013-05-23 00:00:00
abstract:BACKGROUND:This study is an analysis of the prevalence of polymorphous low grade adenocarcinoma (PLGA) in epidemiological surveys of salivary tumors published in the English language from 1992 to 2012. METHODS:These surveys included studies from different researchers, countries and continents. The 57 surveys for which...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/1746-1596-8-6
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:To identify critical genes and biological pathways in acute lung injury (ALI), a comparative analysis of gene expression profiles of patients with ALI + sepsis compared with patients with sepsis alone were performed with bioinformatic tools. METHODS:GSE10474 was downloaded from Gene Expression Omnibus, incl...
journal_title:Diagnostic pathology
pub_type: 撤回出版物,收录出版
doi:10.1186/s13000-014-0176-x
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Assessment of hemoglobin is one of the most reliable indicators for anemia, and is widely used to screen for anemia among pregnant women. The HemoCue® has been widely used for as a point-of-care device for hemoglobin estimation in health facilities. Previous studies showed contradictory results regarding the...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-30
更新日期:2012-03-21 00:00:00
abstract:BACKGROUND:Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS:One hundred breast cancer s...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-118
更新日期:2014-06-16 00:00:00
abstract:BACKGROUND:The polymorphism Pro12Ala in peroxisome proliferator-activated receptor-γ2 gene (PPARγ2) has been reported to be associated with diabetic nephropathy (DN) in some studies, though the results remain inconclusive. To explore this relationship between PPARγ2 Pro12Ala polymorphism and the susceptibility for DN, ...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1746-1596-8-118
更新日期:2013-07-15 00:00:00
abstract:BACKGROUND:Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polym...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0378-x
更新日期:2015-08-07 00:00:00
abstract::We started to use virtual slide (VS) and virtual microscopy (VM) systems for quick frozen intra-operative telepathology diagnosis in Kyoto, Japan. In the system we used a digital slide scanner, VASSALO by CLARO Inc., and a broadband optic fibre provided by NTT West Japan Inc. with the best effort capacity of 100 Mbps....
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-3-S1-S6
更新日期:2008-07-15 00:00:00
abstract::Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, includ...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-019-0802-8
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:MicroRNA-100 (miR-100) has been demonstrated to be downregulated in bladder cancer tissues, and enforced expression of this miRNA may inhibit cell growth and colony formation of human bladder cancer 5637 cells in vitro. However, the clinical significance of miR-100 in human bladder cancer has not yet been elu...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-159
更新日期:2012-11-22 00:00:00
abstract:UNLABELLED:Imaging appearance of cyst-like changes is most frequently described in primary neuroendocrine lesions, especially pancreatic NETs.The imaging finding of a pseudocystic lesion of the liver puts in differential diagnosis many pathologies such as infectious diseases, simple biliary cysts up to biliary cystaden...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/1746-1596-8-148
更新日期:2013-09-13 00:00:00
abstract:BACKGROUND:Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in Rheumatoid Arthritis. The Multidrug resistance Related Protein and Multi Drug Resistance protein 1,...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0447-1
更新日期:2015-12-30 00:00:00
abstract:BACKGROUND:The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. These malignancies include endometrial intraepithelial carcinoma (EIC). PATIENTS AND METHODS:Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-25
更新日期:2013-02-15 00:00:00
abstract:BACKGROUND:Metastatic spread of tumor through lymphatic vasculature is an important adverse prognostic factor in a variety of human cancer and tumor lymphangiogenesis requires the interplay of several growth factors. Platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C are two import...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-128
更新日期:2014-06-27 00:00:00
abstract:BACKGROUND:To quantify the effect of cruciferous vegetable consumption on the incidence of ovarian cancer by meta-analyzing the existing observational studies and provides quantitative and high-level evidence. METHODS:A detailed literature search of Medline and EMBASE for all relevant papers published. A meta-analysis...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析
doi:10.1186/1746-1596-9-7
更新日期:2014-01-20 00:00:00
abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) is one of the most powerful genetic analysis tools for pathological diagnoses. FISH can detect various genetic abnormalities including gene translocation that was specifically found in translocation-related sarcomas (TRSs). Here, we report the use of FISH in expert r...
journal_title:Diagnostic pathology
pub_type: 杂志文章,多中心研究
doi:10.1186/s13000-016-0486-2
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:Mixed adeno-neuroendocrine carcinoma (MANEC) of the biliary tract is rare with only a few reported cases. Consequently, knowledge about their pathogenesis, histopathological characteristics and outcomes is sparce. CASE PRESENTATION:A 53-year old man presented with epigastric pain on a background of excessiv...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-015-0439-1
更新日期:2015-11-20 00:00:00
abstract::Diagnostic surgical pathology or tissue–based diagnosis still remains the most reliable and specific diagnostic medical procedure. The development of whole slide scanners permits the creation of virtual slides and to work on so-called virtual microscopes. In addition to interactive work on virtual slides approaches ha...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-s1-s12
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, gen...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-54
更新日期:2014-03-12 00:00:00
abstract:BACKGROUND:IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, IL4Rα and IL13Rα1 were reported to have roles in cancer progression and suggested as potential prognostic markers. However, studies on IL4Rα and IL13Rα1 in soft-tissue sarcomas have been limited. METHODS:This study investigated the im...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-020-01066-z
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) remains a major worldwide cause of cancer-related morbidity and mortality largely due to the insidious onset of the disease. The current clinical procedures utilized for disease diagnosis are invasive, unpleasant, and inconvenient. Hence, the need for simple blood tests that could be ...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-53
更新日期:2014-03-12 00:00:00
abstract:BACKGROUND:The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia. It was suggested that mismatched F8 replacement therapy may be a risk factor for the development of anti-factor F8 alloantibodies. Recently four single nucle...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-54
更新日期:2011-06-17 00:00:00
abstract:BACKGROUND:Sinonasal renal cell-like carcinoma (SRCLC) is an extremely rare low malignant tumor arising in the sinonasal tract, with histological mimicry of renal cell carcinoma. CASE PRESENTATION:We present a case of sinonasal renal cell-like carcinoma in a 63-year-old male patient. Computer tomography(CT) scanning r...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-017-0660-1
更新日期:2017-10-17 00:00:00
abstract:UNLABELLED:Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promising approach to prolong the otherwise very poor prognosis of patients with advanced UICC stages. Ep...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-146
更新日期:2012-10-22 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs), a type of mesenchymal tumor in the gastrointestinal tract, are believed to be closely associated with PDGFRA and C-KIT mutations. Schwannoma in the stomach, which is an unusual location, is a rare disorder. The simultaneous occurrence of the two diseases is rarer than...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-019-0898-x
更新日期:2019-10-23 00:00:00
abstract:BACKGROUND:Kombucha, a fermented tea (KT) is claimed to possess many beneficial properties. The aim of this study was to evaluate clinical and histopathological alterations of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rat. METHODS:In present study 24 Wister -albino rats weighing 150-...
journal_title:Diagnostic pathology
pub_type: 杂志文章,收录出版
doi:10.1186/1746-1596-8-120
更新日期:2013-07-17 00:00:00
abstract:BACKGROUND:Prostate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated. PATIENTS AND METHODS:We collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in t...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-35
更新日期:2014-02-20 00:00:00
abstract:PURPOSE:Patellofemoral pathology is common, and patellofemoral dislocation mainly affects adolescents and young adults. We conducted a meta-analysis exclusively of RCTs to compare the clinical outcomes of patellar dislocation patients managed operatively versus non-operatively. METHODS:After systematic review of elect...
journal_title:Diagnostic pathology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1746-1596-9-60
更新日期:2014-03-18 00:00:00
abstract::Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by recurrent coma, ventricular tachycardias and the replacement of the myocardium with fatty and fibrous tissue. We described a 42-year-old female patient without clinical arrhythmias which was diagnosed as ARVC by magnetic resonance imaging (MRI)...
journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-67
更新日期:2012-06-12 00:00:00