ABCG2 is associated with HER-2 expression, lymph node metastasis and clinical stage in breast invasive ductal carcinoma.

abstract：BACKGROUND:Metadherin (MTDH) has been reported to be associated with cancer progression in various types of human cancers including breast cancer. Whether MTDH contributes to carcinogenesis of breast cancer is still unknown. In the present study, we investigated the expression of MTDH in normal, UDH (usual ductal hyper...

journal_title：Diagnostic pathology

authors： Su P,Zhang Q,Yang Q

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:Ischemia/reperfusion (I/R) injury of heart is one of the major causes of acute cardiac injury, which may result in worsening or even loss of heart function. With novel microRNAs being evolutionarily discovered, numbers of them remained functionally unknown. We aimed to discover novel microRNAs with therapeut...

journal_title：Diagnostic pathology

authors： Chen Y,Ye X,Yan F

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical r...

journal_title：Diagnostic pathology

authors： Li C,Jia R,Liu H,Zhang B,Wang C

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Human kallikrein gene 6 (KLK6) is a member of the human kallikrein gene family (Kallikreins, KLKs). Human kallikrein-related peptidase 6 (hK6) is a trypsin-like serine protease encoded by the KLK6, has been reported to be highly expressed in several cancers including gastric cancer. In this study, we investi...

journal_title：Diagnostic pathology

authors： Liu X,Xiong H,Li J,He Y,Yuan X

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition of the tumor-directed T-cell immune response. There are few reports in the literature evaluating PD...

journal_title：Diagnostic pathology

authors： Leite KR,Reis ST,Junior JP,Zerati M,Gomes Dde O,Camara-Lopes LH,Srougi M

更新日期：2015-10-15 00:00:00

abstract：:Perivascular epithelioid cell tumor (PEComa) is a rare entity originating from mesenchymal tissue, which stains for both melanocytic and smooth muscle markers. We would like to present an unusual case of the PEComa of the mesentery which was unexpected discovery in a female patient with colonic adenocarcinoma. The tum...

journal_title：Diagnostic pathology

authors： Wejman J,Nowak K,Gielniewska L,Komorowska M,Dąbrowski W

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare entity that was first described by Zambrano et al. in 2003 as "Clear cell sarcoma-like tumor of the gastrointestinal tract". It shares some of the histological features of clear cell sarcoma (CCS) but lacks the immunohistochemical r...

journal_title：Diagnostic pathology

authors： Alyousef MJ,Alratroot JA,ElSharkawy T,Shawarby MA,Al Hamad MA,Hashem TM,Alsayyah A

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:Human papillomavirus-associated oropharyngeal carcinoma (HPV-OPC) is clinicopathologically distinct entity from the HPV-unassociated one (nHPV-OPC). This study aimed to determine the relationship between histological subtypes of OPC and HPV status for Japanese cases and to identify histological structures of...

journal_title：Diagnostic pathology

authors： Fujimaki M,Fukumura Y,Mitani K,Kurisaki A,Yokoyama J,Ikeda K,Yao T

更新日期：2013-12-19 00:00:00

abstract：BACKGROUND:High altitude pulmonary edema (HAPE) affects individuals and is characterized by alveolar flooding with protein-rich edema as a consequence of blood-gas barrier disruption. In this study, we hypothesized that aquaporin 5 (AQP5) which is one kind of water channels may play a role in preservation of alveolar e...

journal_title：Diagnostic pathology

authors： She J,Bi J,Tong L,Song Y,Bai C

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:Carbonic anhydrase IX is a member of α-carbonic anhydrases that is preferentially expressed in solid tumors. It enables bicarbonate transport across the plasma membrane, neutralizing intracellular pH and conferring to cancer cells a survival advantage in hypoxic/acidic microenvironments. Overexpression of ca...

journal_title：Diagnostic pathology

authors： Ambrosio MR,Di Serio C,Danza G,Rocca BJ,Ginori A,Prudovsky I,Marchionni N,Del Vecchio MT,Tarantini F

更新日期：2016-05-25 00:00:00

abstract：BACKGROUND:A recently published transcript set is suitable for gene expression-based discrimination of normal colonic and colorectal cancer (CRC) biopsy samples. Our aim was to test the discriminatory power of the CRC-specific transcript set on independent biopsies and on formalin-fixed, paraffin-embedded (FFPE) tissue...

journal_title：Diagnostic pathology

authors： Kalmár A,Wichmann B,Galamb O,Spisák S,Tóth K,Leiszter K,Nielsen BS,Barták BK,Tulassay Z,Molnár B

更新日期：2015-07-25 00:00:00

abstract：BACKGROUND:The novel pandemic A (H1N1) pdm09 virus was first identified in Mexico in April 2009 and since then it spread worldwide over a short period of time. Although the virus infection is generally associated with mild disease and a relatively low mortality, it is projected that mutations in specific regions of the...

journal_title：Diagnostic pathology

authors： Moussi AE,Kacem MA,Pozo F,Ledesma J,Cuevas MT,Casas I,Slim A

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Choriocarcinoma is a highly aggressive, malignant trophoblastic neoplasm that can be gestational or non-gestational in origin. Accurate discrimination between these two subtypes, the causative pregnancy type, and the pregnancy-to-treatment interval for gestational choriocarcinoma are vital for clinical manag...

journal_title：Diagnostic pathology

authors： Zhang X,Yan K,Chen J,Xie X

更新日期：2019-08-17 00:00:00

abstract：BACKGROUND:The aim of this report is related to adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of the spermatic cord leiomyosarcoma. Primary paratesticular tumors are rare, only accounting for 7% to 10% of all intrascrotal tumors. In adults, more than 75% of these le...

journal_title：Diagnostic pathology

authors： Galosi AB,Scarpelli M,Mazzucchelli R,Lopez-Beltran A,Giustini L,Cheng L,Montironi R

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E-box-binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial-mesenchyma...

journal_title：Diagnostic pathology

authors： Takada-Owada A,Nozawa Y,Onozaki M,Noda S,Jamiyan T,Tokura Y,Nakazato Y,Kamai T,Ishida K

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:Although synovial sarcoma is the 3rd most commonly occurring mesenchymal tumor in young adults, usually with a highly aggressive clinical course; remarkable differences can be seen regarding the clinical outcome. According to comparative genomic hybridization (CGH) data published in the literature, the simpl...

journal_title：Diagnostic pathology

authors： Balogh Z,Szemlaky Z,Szendroi M,Antal I,Pápai Z,Fónyad L,Papp G,Changchien YC,Sápi Z

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:To distinguish between malignant and benign lesions of the thyroid gland histological demonstration is often required since the fine-needle aspiration biopsy method applied pre-operatively has some limitations. In an attempt to improve diagnostic accuracy, markers using immunocytochemistry and immunohistoche...

journal_title：Diagnostic pathology

authors： de Matos LL,Del Giglio AB,Matsubayashi CO,de Lima Farah M,Del Giglio A,da Silva Pinhal MA

更新日期：2012-08-13 00:00:00

abstract：:Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade d...

journal_title：Diagnostic pathology

authors： Kannuna H,Rubio CA,Silverio PC,Girardin M,Goossens N,Rubbia-Brandt L,Puppa G

更新日期：2015-07-09 00:00:00

abstract：BACKGROUND:The association between the Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene and lung cancer risk remains controversial and inconclusive. Therefore, the meta-analysis was performed to provide a quality reevaluation of the association between the COMT Val158Met polymorphism and the risk ...

journal_title：Diagnostic pathology

authors： Tan X,Chen M

更新日期：2014-10-04 00:00:00

abstract：:Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, includ...

journal_title：Diagnostic pathology

authors： Wood MD,Halfpenny AM,Moore SR

更新日期：2019-04-09 00:00:00

abstract：BACKGROUND:Congenital alveolar rhabdomyosarcoma is an extremely uncommon and invariably fatal tumor with the current therapy. Less than 25% of patients present with evidence of cutaneous metastasis. CASE PRESENTATION:We report a case of congenital alveolar rhabdomyosarcoma in an 18-month-old male who presented with a ...

journal_title：Diagnostic pathology

authors： Vankalakunti M,Das A,Rao NK

更新日期：2006-10-17 00:00:00

abstract：:This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anapla...

journal_title：Diagnostic pathology

authors： Grayson W,Pantanowitz L

更新日期：2008-07-25 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated B-cell post-transplantation lymphoproliferative disorder (PTLD) is a severe complication following stem cell transplantation. This is believed to occur as a result of iatrogenic immunosuppression leading to a relaxation of T-cell control of EBV infection and thus allowing viral reac...

journal_title：Diagnostic pathology

authors： Krenauer A,Moll A,Pönisch W,Schmitz N,Niedobitek G,Niederwieser D,Aigner T

更新日期：2010-03-31 00:00:00

abstract：:Tumours of ovarian-epithelial type of the testis, including serous borderline tumours, represent very rare entities. They are identical to the surface epithelial tumours of the ovary and have been reported in patients from 14 to 68 years of age. We describe two cases of a 46- and a 39-year old man with incidental find...

journal_title：Diagnostic pathology

authors： Bürger T,Schildhaus HU,Inniger R,Hansen J,Mayer P,Schweyer S,Radzun HJ,Ströbel P,Bremmer F

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular wall of the SMA may be a contributor, but its pathogenesis is unclear. CASE PRESENTATION:A 57-year...

journal_title：Diagnostic pathology

authors： Akuzawa N,Kurabayashi M,Suzuki T,Yoshinari D,Kobayashi M,Tanahashi Y,Makita F,Saito R

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, IL4Rα and IL13Rα1 were reported to have roles in cancer progression and suggested as potential prognostic markers. However, studies on IL4Rα and IL13Rα1 in soft-tissue sarcomas have been limited. METHODS:This study investigated the im...

journal_title：Diagnostic pathology

authors： Kim KM,Hussein UK,Park SH,Moon YJ,Zhang Z,Ahmed AG,Ahn AR,Park HS,Kim JR,Jang KY

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:Hypermethylation of the promoter region of the RAS association domain family 1A gene (RASSF1A) occurs widely in hepatocellular carcinoma (HCC) tissues. While the diagnostic performance of the use of RASSF1A methylation as a serum or plasma marker in patients with HCC has varied largely in the literature,we c...

journal_title：Diagnostic pathology

authors： Dong X,He H,Zhang W,Yu D,Wang X,Chen Y

更新日期：2015-08-04 00:00:00

abstract：BACKGROUND:Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS:One hundred breast cancer s...

journal_title：Diagnostic pathology

authors： Romero Q,Bendahl PO,Fernö M,Grabau D,Borgquist S

更新日期：2014-06-16 00:00:00

abstract：OBJECTIVES:This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC) in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. M...

journal_title：Diagnostic pathology

authors： Zhou Q,Chang H,Zhang H,Han Y,Liu H

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Branchial cleft anomalies constitute a frequently encountered and commonly non-lethal disease in otolaryngology, and result from aberrant embryonic development. The third branchial cleft fistula is one of the four known specific types of branchial cleft anomalies, and always presents as recurrent neck absces...

journal_title：Diagnostic pathology

authors： Tong F,Liang Y,Khan MF,Zhang L,Li W,Mahmoodurrahman M,Zhou Y

更新日期：2016-09-15 00:00:00