DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization.

Abstract:

:Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia. The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence. A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.

journal_name

Diagn Pathol

journal_title

Diagnostic pathology

authors

Kannuna H,Rubio CA,Silverio PC,Girardin M,Goossens N,Rubbia-Brandt L,Puppa G

doi

10.1186/s13000-015-0305-1

subject

Has Abstract

pub_date

2015-07-09 00:00:00

pages

92

issn

1746-1596

pii

10.1186/s13000-015-0305-1

journal_volume

10

pub_type

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