Abstract：
UNLABELLED:Giant cell angioblastoma (GCAB) is an extremely rare soft tissue tumor of early childhood and only five cases have been described to date. As such the clinical, pathological, and prognostic features are poorly defined. We prensent here a new case of GCAB in bone of a child aged 4-years old. The lesion was composed of dense and loose cell regions. The dense regions were characterized by nodular, linear, and plexiform aggregates of oval- to spindle-shaped tumor cells around small vascular channels and interspersed with large mononuclear cells and multinucleate giant cells. The loose cell areas were characterized by distributed fibroblasts and abundant myxoid matrix, which diminished with patient age. Infiltrative growth was observed in some areas. Oval-to-spindle cells showed positivity for Vimentin, CD31 and CD34 staining, and partial positivity for smooth muscle actin. Mononuclear cells and multinucleate giant cells showed Vimentin and CD68 positivity. Seventeen months after thorough curettage of the lesion, a local recurrence was found. Based upon the clinical, histological and immunohistochemical findings, infiltrate condition, and prognosis, we classified GCAB into two subtypes. Type I does not infiltrate surrounding tissues and has good prognosis. Type II infiltrates the surrounding tissues, relapses earlier, and has worse prognosis. This report augments the limited GCAB literature to promote our understanding and guide therapy of this rare disease. VIRTUAL SLIDES:The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6699811297488137.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Mao RJ,Jiang ZM,Zhang HZ,Zhu XZ,Zhang QLdoi
10.1186/1746-1596-7-113subject
Has Abstractpub_date
2012-08-29 00:00:00pages
113issn
1746-1596pii
1746-1596-7-113journal_volume
7pub_type
杂志文章abstract：:Over two million Americans are afflicted with schizophrenia, a debilitating mental health disorder with a unique symptomatic and epidemiological profile. Genomics studies have hinted towards candidate schizophrenia susceptibility chromosomal loci and genes. Modern proteomic tools, particularly mass spectrometry and ex...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-1-11
更新日期：2006-07-17 00:00:00
abstract：BACKGROUND:The microRNAs present a class of non-coding RNAs which are usually implicated in tumor biology. Recent report has unraveled that a novel member of microRNA family called miR-1246. However, the functional role and molecular mechanisms of miR-1246 in non-small cell lung cancer (NSCLC) is still elusive. METHOD...
journal_title：Diagnostic pathology
pub_type： 杂志文章,收录出版
doi：10.1186/s13000-015-0366-1
更新日期：2015-07-25 00:00:00
abstract：UNLABELLED:Imaging appearance of cyst-like changes is most frequently described in primary neuroendocrine lesions, especially pancreatic NETs.The imaging finding of a pseudocystic lesion of the liver puts in differential diagnosis many pathologies such as infectious diseases, simple biliary cysts up to biliary cystaden...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/1746-1596-8-148
更新日期：2013-09-13 00:00:00
abstract：BACKGROUND:To quantify the effect of cruciferous vegetable consumption on the incidence of ovarian cancer by meta-analyzing the existing observational studies and provides quantitative and high-level evidence. METHODS:A detailed literature search of Medline and EMBASE for all relevant papers published. A meta-analysis...
journal_title：Diagnostic pathology
pub_type： 杂志文章,meta分析
doi：10.1186/1746-1596-9-7
更新日期：2014-01-20 00:00:00
abstract：BACKGROUND:Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicop...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/s13000-017-0604-9
更新日期：2017-01-19 00:00:00
abstract：:Diagnostic surgical pathology or tissue–based diagnosis still remains the most reliable and specific diagnostic medical procedure. The development of whole slide scanners permits the creation of virtual slides and to work on so-called virtual microscopes. In addition to interactive work on virtual slides approaches ha...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-6-s1-s12
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA b...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-82
更新日期：2012-07-17 00:00:00
abstract：PURPOSE:Patellofemoral pathology is common, and patellofemoral dislocation mainly affects adolescents and young adults. We conducted a meta-analysis exclusively of RCTs to compare the clinical outcomes of patellar dislocation patients managed operatively versus non-operatively. METHODS:After systematic review of elect...
journal_title：Diagnostic pathology
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1746-1596-9-60
更新日期：2014-03-18 00:00:00
abstract：BACKGROUND:Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common mesonephric adenocarcinoma (MAC), which mostly arises the uterine cervix. Despite the similarities b...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-01012-z
更新日期：2020-07-21 00:00:00
abstract：BACKGROUND:Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAFV600E mutations and treatments of isolated HPLCH. METHODS:We identified seven patients with isolated HPLCH by reviewing the clinical an...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-016-0548-5
更新日期：2016-10-19 00:00:00
abstract：BACKGROUND:High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defining feature of associ...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-01050-7
更新日期：2020-11-20 00:00:00
abstract：BACKGROUND:Choriocarcinoma is a highly aggressive, malignant trophoblastic neoplasm that can be gestational or non-gestational in origin. Accurate discrimination between these two subtypes, the causative pregnancy type, and the pregnancy-to-treatment interval for gestational choriocarcinoma are vital for clinical manag...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-019-0866-5
更新日期：2019-08-17 00:00:00
abstract：OBJECTIVES:Non-Hodgkin's lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. This study describes the clinicopathological features of NHL in the tongue base and the status...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-020-00936-w
更新日期：2020-04-01 00:00:00
abstract：:Epstein-Barr virus (EBV)-associated B-cell post-transplantation lymphoproliferative disorder (PTLD) is a severe complication following stem cell transplantation. This is believed to occur as a result of iatrogenic immunosuppression leading to a relaxation of T-cell control of EBV infection and thus allowing viral reac...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-5-21
更新日期：2010-03-31 00:00:00
abstract：BACKGROUND:Crowdsourcing, i.e., the outsourcing of tasks typically performed by a few experts to a large crowd as an open call, has been shown to be reasonably effective in many cases, like Wikipedia, the Chess match of Kasparov against the world in 1999, and several others. The aim of the present paper is to describe ...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-S1-S6
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Advancing knowledge in molecular pathogenesis of hepatocellular carcinoma (HCC) opens up new horizons in the diagnostic, prognostic and therapeutic perspectives. Assessing the expression of molecular targets prior to definitive treatment is gaining importance in clinical practice. In this study, we investiga...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-017-0649-9
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:ALCAM (activated leukocyte cell adhesion molecule, CD166, MEMD) is a transmembrane protein of immunoglobulin superfamily (Ig-SF) and plays an important role in human malignant melanoma progression and formation of locoregional and distant metastases. The study using melanoma cell lines showed that overexpres...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-015-0331-z
更新日期：2015-07-02 00:00:00
abstract：BACKGROUND:The histopathological subtype, nuclear grade and presence or absence of comedonecrosis are established as critical elements in the reporting of ductal carcinoma in situ (DCIS) of the breast. The aims of this study were to determine the frequencies of morphological subtypes of DCIS, nuclear grade and comedone...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-014-0227-3
更新日期：2014-12-03 00:00:00
abstract：:A 42-year-old male presented right upper abdomen pain for more than 6 days, which misdiagnose calculus of intrahepatic duct and acute cholecystitis. An approximately 1.5 cm x 1.0 cm x 1.0 cm nodule was found and resected in left lateral lobe of hepatic. Pathological examination showed spindle cell and fibroblast -like...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/1746-1596-8-195
更新日期：2013-12-02 00:00:00
abstract：UNLABELLED:Since first reported in 1986, 14 cases of extrauterine adenomyoma have been reported in the English literature, most often occurring in the ovaries. In this report, we present the first case of extrauterine adenomyoma involving the liver in a 29-year-old woman who presented with a 2-year history of low back ...
journal_title：Diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1186/1746-1596-8-131
更新日期：2013-08-05 00:00:00
abstract：BACKGROUND:Osteosarcoma is the most common primary bone malignancy with high local aggressiveness and rapid metastasizing potential, resulting in poor survival. Increasing reports suggest that deregulated microRNAs (miRNAs) might provide novel therapeutic targets for cancers. However, the expression of miR-26a and miR-...
journal_title：Diagnostic pathology
pub_type： 杂志文章,收录出版
doi：10.1186/s13000-015-0400-3
更新日期：2015-09-17 00:00:00
abstract：BACKGROUND:Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular wall of the SMA may be a contributor, but its pathogenesis is unclear. CASE PRESENTATION:A 57-year...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-017-0664-x
更新日期：2017-10-16 00:00:00
abstract：UNLABELLED:Seven percent of renal cell carcinoma (RCC) cases are diagnosed as "unclassified" RCC by morphology. Genetic profiling of RCCs helps define renal tumor subtypes, especially in cases where morphologic diagnosis is inconclusive. This report describes a patient with synchronous clear cell RCC (ccRCC) and a tubu...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-7-21
更新日期：2012-02-27 00:00:00
abstract：BACKGROUND:The polymorphism Pro12Ala in peroxisome proliferator-activated receptor-γ2 gene (PPARγ2) has been reported to be associated with diabetic nephropathy (DN) in some studies, though the results remain inconclusive. To explore this relationship between PPARγ2 Pro12Ala polymorphism and the susceptibility for DN, ...
journal_title：Diagnostic pathology
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1746-1596-8-118
更新日期：2013-07-15 00:00:00
abstract：:Tumours of ovarian-epithelial type of the testis, including serous borderline tumours, represent very rare entities. They are identical to the surface epithelial tumours of the ovary and have been reported in patients from 14 to 68 years of age. We describe two cases of a 46- and a 39-year old man with incidental find...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-015-0342-9
更新日期：2015-07-22 00:00:00
abstract：BACKGROUND:70-80% of sporadic endometrial carcinomas are defined as endometrioid carcinoma (EC). Early-stage, well differentiated endometrial carcinomas usually retain expression of estrogen and progesterone receptors (ER and PR, respectively), as advanced stage, poorly differentiated tumors often lack one or both of t...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-9-77
更新日期：2014-03-31 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate how differences in expression of HER2 between primary gastric cancers (PGCs) and their corresponding metastatic lymph nodes (LMNs) might affect its potential as a prognostic indicator in treatments including anti-HER2 agents. METHODS:The analysis was conducted in 102...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-8-191
更新日期：2013-11-21 00:00:00
abstract：BACKGROUND:Kombucha, a fermented tea (KT) is claimed to possess many beneficial properties. The aim of this study was to evaluate clinical and histopathological alterations of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rat. METHODS:In present study 24 Wister -albino rats weighing 150-...
journal_title：Diagnostic pathology
pub_type： 杂志文章,收录出版
doi：10.1186/1746-1596-8-120
更新日期：2013-07-17 00:00:00
abstract：BACKGROUND:Integrated molecular pathology (IMP) approaches based on DNA mutational profiling accurately determine pancreatic cyst malignancy risk in patients lacking definitive diagnoses following endoscopic ultrasound imaging with fine-needle aspiration of fluid for cytology. In such cases, IMP 'low-risk' and 'high-ri...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/s13000-016-0462-x
更新日期：2016-01-20 00:00:00
abstract：:Complement C4d component deposition in kidney allograft biopsies is an established marker of antibody-mediated rejection. In the Banff 07 classification of renal allograft pathology, semi-quantitative evaluation of the proportion of C4d-positive peritubular capilaries (PTC) is used. We aimed to explore the potential o...
journal_title：Diagnostic pathology
pub_type： 杂志文章
doi：10.1186/1746-1596-6-S1-S5
更新日期：2011-03-30 00:00:00
