The microRNA-1246 promotes metastasis in non-small cell lung cancer by targeting cytoplasmic polyadenylation element-binding protein 4.

abstract：UNLABELLED:Cutaneous mast cell tumours (MCTs) are the most common skin tumours in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology are critical for the treatment of this disease. A cytologic diagnosis of m...

journal_title：Diagnostic pathology

authors： Hosseini E,Pedram B,Bahrami AM,Moghaddam MH,Javanbakht J,Ghomi FE,Moghaddam NJ,Koohestani M,Shafiee R

更新日期：2014-01-20 00:00:00

abstract：:This study examined the effect of tissue section thickness and consistency--parameters outside the direct control of the imaging devices themselves--on WSI capture speed and image quality. Preliminary data indicates that thinner, more consistent tissue sectioning (such as those produced by automated tissue sectioning ...

journal_title：Diagnostic pathology

authors： Yagi Y,Gilbertson JR

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Advancing knowledge in molecular pathogenesis of hepatocellular carcinoma (HCC) opens up new horizons in the diagnostic, prognostic and therapeutic perspectives. Assessing the expression of molecular targets prior to definitive treatment is gaining importance in clinical practice. In this study, we investiga...

journal_title：Diagnostic pathology

authors： Lo RC,Leung CO,Chok KS,Ng IO

更新日期：2017-08-01 00:00:00

abstract：UNLABELLED:As rare condition, mucoepidermoid carcinoma may occur in liver although its etiology and pathogenesis is still unclear. We report here a case of intrahepatic mucoepidermoid carcinoma misdiagnosed as cholangiocarcinoma and squamous cell carcinoma by preoperative radiologic and intraoperative histological exam...

journal_title：Diagnostic pathology

authors： Guo XQ,Li B,Li Y,Tian XY,Li Z

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:We report a case of a 33-year-old man who presented with immunoglobulin (Ig)G4-related disease (IgG4-RD) forming a pseudotumor in the left paratesticular region during oral administration of corticosteroid for Wells syndrome, which involves cellulitis with eosinophilia. CASE PRESENTATION:The patient was int...

journal_title：Diagnostic pathology

authors： Karashima T,Taniguchi Y,Shimamoto T,Nao T,Nishikawa H,Fukata S,Kamada M,Inoue K,Oko K,Nakajima H,Sano S,Matsumoto M,Kuroda N,Kamei Y,Shuin T

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical r...

journal_title：Diagnostic pathology

authors： Li C,Jia R,Liu H,Zhang B,Wang C

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Transbronchial needle aspiration (TBNA) is a minimally invasive procedure performed to diagnose lymph node (LN) adenopathy. TBNA with and without endobronchial ultrasound (EBUS) guidance has a high diagnostic yield for malignant LN enlargement, but the value for diagnosing benign LN enlargement has been less...

journal_title：Diagnostic pathology

authors： Shen H,Lou L,Chen T,Zou Y,Wang B,Xu Z,Ye Q,Shen H,Li W,Xia Y

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defining feature of associ...

journal_title：Diagnostic pathology

authors： Oramas DM,Bell D,Middleton LP

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA b...

journal_title：Diagnostic pathology

authors： Nodin B,Fridberg M,Jonsson L,Bergman J,Uhlén M,Jirström K

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polym...

journal_title：Diagnostic pathology

authors： Liu H,Mao P,Xie C,Xie W,Wang M,Jiang H

更新日期：2015-08-07 00:00:00

abstract：:Concurrent hematologic malignancies are relatively rare. We encountered a case of concurrent acute myeloid leukemia (AML) and T lymphoblastic lymphoma. The bone marrow chromosome analysis showed the karyotype 46, XY, t(5;12)(q33;p13), which indicated presence of PDGFRB gene translocations. Therefore, this disease belo...

journal_title：Diagnostic pathology

authors： Chang H,Chuang WY,Sun CF,Barnard MR

更新日期：2012-02-22 00:00:00

abstract：PURPOSE:Patellofemoral pathology is common, and patellofemoral dislocation mainly affects adolescents and young adults. We conducted a meta-analysis exclusively of RCTs to compare the clinical outcomes of patellar dislocation patients managed operatively versus non-operatively. METHODS:After systematic review of elect...

journal_title：Diagnostic pathology

authors： Cheng B,Wu X,Ge H,Qing Sun Y,Zhang Q

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:Integrated molecular pathology (IMP) approaches based on DNA mutational profiling accurately determine pancreatic cyst malignancy risk in patients lacking definitive diagnoses following endoscopic ultrasound imaging with fine-needle aspiration of fluid for cytology. In such cases, IMP 'low-risk' and 'high-ri...

journal_title：Diagnostic pathology

authors： Loren D,Kowalski T,Siddiqui A,Jackson S,Toney N,Malhotra N,Haddad N

更新日期：2016-01-20 00:00:00

abstract：:Primary pleural angiosarcoma is a rare and clinically aggressive tumor. Patients usually present with chest pain, dyspnea, hemoptysis and/or cough. Radiologic studies reveal diffuse pleural thickening and pleural effusion with or without mass lesion. The clinical and radiological features both resemble those of mesoth...

journal_title：Diagnostic pathology

authors： Kao YC,Chow JM,Wang KM,Fang CL,Chu JS,Chen CL

更新日期：2011-12-30 00:00:00

abstract：BACKGROUND:Isolated hypothalamic-pituitary Langerhans cell histiocytosis (HPLCH) is very rare. We investigated the clinicopathological characteristics, endocrine function changes, BRAFV600E mutations and treatments of isolated HPLCH. METHODS:We identified seven patients with isolated HPLCH by reviewing the clinical an...

journal_title：Diagnostic pathology

authors： Huo Z,Lu T,Liang Z,Ping F,Shen J,Lu J,Ma W,Zhao D,Zhong D

更新日期：2016-10-19 00:00:00

abstract：BACKGROUND:World Health Organization (WHO) criteria are commonly used to diagnose plasma cell myeloma (PCM); however, these criteria are complex and require several laboratory parameters. For differentiating reactive plasmacytosis from clonal plasma cell (PC) neoplasms such as PCM, it is important to accurately determi...

journal_title：Diagnostic pathology

authors： Nakayama S,Yokote T,Hirata Y,Iwaki K,Akioka T,Miyoshi T,Takayama A,Nishiwaki U,Masuda Y,Ikemoto T,Tanaka H,Nishimura Y,Tsuji M,Hanafusa T

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:This study is to investigate the expression of progranulin (PGRN) in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid (GC) treatment on its expression. METHODS:Thirty newly diagnosed severe SLE patients and 30 healthy subjects were enrolled in this study. The serum levels of PGRN...

journal_title：Diagnostic pathology

authors： Qiu F,Song L,Ding F,Liu H,Shu Q,Yang N,Liu W,Li X

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:Appendiceal parasites can cause symptoms of appendiceal pain, independent of microscopic evidence of acute inflammation. The diagnosis of a parasitic infestation is generally achieved only after the pathologic examination of the resected appendices. PATIENTS/METHODS:Pathology department records were reviewe...

journal_title：Diagnostic pathology

authors： Aydin O

更新日期：2007-05-24 00:00:00

abstract：:Endocervicosis in the urinary bladder is a rare benign condition. We present a case in a 37-year-old woman with classical clinical and pathological features of endocervicosis. The unusual observation of endocervical-like mucinous epithelium in continuity with the urothelium in addition to fully developed endocervicosi...

journal_title：Diagnostic pathology

authors： Cheah PL,Looi LM,Lee GE,Teoh KH,Mun KS,Nazarina AR

更新日期：2011-06-23 00:00:00

abstract：BACKGROUND:The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after delivery have been reported, there are no report of autopsy cases of PTCL in the puerperal period. CASE PR...

journal_title：Diagnostic pathology

authors： Mizutani K,Yamada S,Guo X,Futatsuya C,Kumagai M,Shioya A,Aikawa A,Nakada S,Kurose N,Minato H,Nojima T

更新日期：2018-05-22 00:00:00

abstract：BACKGROUND:GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied. METHODS:Here we investigated immunohistochemical expression of GATA3 in 72 primary genital EMPDs (35 from female...

journal_title：Diagnostic pathology

authors： Zhao M,Zhou L,Sun L,Song Y,Guo Y,Zhang X,Zhao F,Wang P,Yue J,Niu D,Li Z,Huang X,Kang Q,Jia L,Lai J,Cao D

更新日期：2017-07-10 00:00:00

abstract：:Endometriosis is a clinical entity characterized by the presence of normal endometrial mucosa abnormally implanted in locations other than the uterine cavity. Endometriosis can be either endopelvic or extrapelvic depending on the location of endometrial tissue implantation. Despite the rarity of extrapelvic endometrio...

journal_title：Diagnostic pathology

authors： Machairiotis N,Stylianaki A,Dryllis G,Zarogoulidis P,Kouroutou P,Tsiamis N,Katsikogiannis N,Sarika E,Courcoutsakis N,Tsiouda T,Gschwendtner A,Zarogoulidis K,Sakkas L,Baliaka A,Machairiotis C

更新日期：2013-12-02 00:00:00

abstract：BACKGROUND:High altitude pulmonary edema (HAPE) affects individuals and is characterized by alveolar flooding with protein-rich edema as a consequence of blood-gas barrier disruption. In this study, we hypothesized that aquaporin 5 (AQP5) which is one kind of water channels may play a role in preservation of alveolar e...

journal_title：Diagnostic pathology

authors： She J,Bi J,Tong L,Song Y,Bai C

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, IL4Rα and IL13Rα1 were reported to have roles in cancer progression and suggested as potential prognostic markers. However, studies on IL4Rα and IL13Rα1 in soft-tissue sarcomas have been limited. METHODS:This study investigated the im...

journal_title：Diagnostic pathology

authors： Kim KM,Hussein UK,Park SH,Moon YJ,Zhang Z,Ahmed AG,Ahn AR,Park HS,Kim JR,Jang KY

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer. METHODS:Literature databases incl...

journal_title：Diagnostic pathology

authors： Wang W,Chen J,Zhao F,Zhang B,Yu H

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Osteosarcoma is the most common primary bone malignancy with high local aggressiveness and rapid metastasizing potential, resulting in poor survival. Increasing reports suggest that deregulated microRNAs (miRNAs) might provide novel therapeutic targets for cancers. However, the expression of miR-26a and miR-...

journal_title：Diagnostic pathology

authors： Taheriazam A,Bahador R,Karbasy SH,Jamshidi SM,Torkaman A,Yahaghi E,Shakeri M

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirr...

journal_title：Diagnostic pathology

authors： Lan YT,Wang ZL,Tian P,Gong XN,Fan YC,Wang K

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicop...

journal_title：Diagnostic pathology

authors： Yamada S,Kirishima M,Hiraki T,Higashi M,Hatanaka K,Tanimoto A

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:The transcriptional co-activator, TAZ, is an important effector of the Hippo pathway and is critical for the development of human cancers. However, the expression and prognostic significance of TAZ in retinoblastoma is currently unclear. METHODS:TAZ expression was examined in 43 retinoblastoma samples by im...

journal_title：Diagnostic pathology

authors： Zhang Y,Xue C,Cui H,Huang Z

更新日期：2015-10-13 00:00:00

abstract：:Central neurocytoma/extraventricular neurocytoma is a central nervous system (CNS) tumor composed of uniform round cells with neuronal differentiation. The typical lesions of central neurocytoma/extraventricular neurocytoma are at the interventricular foramen of the lateral ventricles (central neurocytoma) or brain pa...

journal_title：Diagnostic pathology

authors： Yu JH,Yang LH,Lin XY,Dai SD,Qiu XS,Wang EH

更新日期：2015-09-17 00:00:00