GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15.

abstract：:Non-necrotizing epithelioid granulomas have been described in association with many primary tumors. In such cases, they are designated as sarcoid-like reaction. Although it is more seen in carcinomas than in sarcomas, it is very rarely reported in renal carcinoma. Here, we describe a rare association of prominent peri...

journal_title：Diagnostic pathology

authors： Ouellet S,Albadine R,Sabbagh R

更新日期：2012-03-18 00:00:00

abstract：BACKGROUND:The feasibility of evaluating an objective grading of cervical intraneoplasia lesions (CIN) is attempted using an automatic computerized system able to measure several valuable parameters with special reference to epithelium differentiation. METHODS:4 groups of 10 images each were selected at random from 68...

journal_title：Diagnostic pathology

authors： Jondet M,Agoli-Agbo R,Dehennin L

更新日期：2010-01-22 00:00:00

abstract：BACKGROUND:High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defining feature of associ...

journal_title：Diagnostic pathology

authors： Oramas DM,Bell D,Middleton LP

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies t...

journal_title：Diagnostic pathology

authors： Udall M,Rizzo M,Kenny J,Doherty J,Dahm S,Robbins P,Faulkner E

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:Several studies reported the dysregulation of miR-541 in the progression of some human malignancies. Osteosarcoma (OS) is one of the most common primary malignant bone tumors. This study aimed to assess the expression and clinical significance of miR-541 in OS patients and explore the biological function of ...

journal_title：Diagnostic pathology

authors： Liu C,Yi X

更新日期：2020-07-24 00:00:00

abstract：INTRODUCTION:Necrobiosis lipoidica diabeticorum is a rare disease of unclear etiology, that occurs in about 1% of diabetic patients. CASE REPORT:We present case of granulomatosis disciformis chronica et progressiva Miescher with good response to systemic corticosteroids therapy.Patient 45 years old woman, with primary...

journal_title：Diagnostic pathology

authors： Bergler-Czop B,Brzezińska-Wcisło L,Rogala-Poborska I

更新日期：2009-08-28 00:00:00

abstract：:Perivascular epithelioid cell (PEC) tumors (PEComas) are a family of related mesenchymal tumors composed of PECs which co-express melanocytic and smooth muscle markers. Although their distinctive histologic, immunohistochemical, ultrastructural, and genetic features have been clearly demonstrated, their histogenesis a...

journal_title：Diagnostic pathology

authors： Fang CL,Lin YH,Chen WY

更新日期：2012-09-03 00:00:00

abstract：:Primary pleural angiosarcoma is a rare and clinically aggressive tumor. Patients usually present with chest pain, dyspnea, hemoptysis and/or cough. Radiologic studies reveal diffuse pleural thickening and pleural effusion with or without mass lesion. The clinical and radiological features both resemble those of mesoth...

journal_title：Diagnostic pathology

authors： Kao YC,Chow JM,Wang KM,Fang CL,Chu JS,Chen CL

更新日期：2011-12-30 00:00:00

abstract：BACKGROUND:Somatostatin receptor 2 (SSTR2) encodes somatostatin receptor that can inhibit the cell proliferation of solid tumors. Promoter hypermethylation is likely to silence the expression of SSTR2. The goal of our study was to investigate the association between SSTR2 promoter methylation and the risk and progressi...

journal_title：Diagnostic pathology

authors： Shen Z,Chen X,Li Q,Zhou C,Li J,Ye H,Duan S

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:Prostate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated. PATIENTS AND METHODS:We collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in t...

journal_title：Diagnostic pathology

authors： Wang H,Yao Y,Li B

更新日期：2014-02-20 00:00:00

abstract：:Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, includ...

journal_title：Diagnostic pathology

authors： Wood MD,Halfpenny AM,Moore SR

更新日期：2019-04-09 00:00:00

abstract：UNLABELLED:The differential diagnosis between idiopathic nonspecific interstitial pneumonia(INSIP) and idiopathic pulmonary fibrosis(IPF)/usual interstitial pneumonia(UIP)is tough in both clinicians and pathologists. In this study, we analyzed the lesions of right lung removed from a 58-year-old patient by gross and mi...

journal_title：Diagnostic pathology

authors： Fang X,Luo B,Yi X,Zeng Y,Liu F,Li H,Gu P,Zhu X,Zhang S,Jiang G

更新日期：2012-12-03 00:00:00

abstract：BACKGROUND:Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopa...

journal_title：Diagnostic pathology

authors： Chen W,Swanson BJ,Frankel WL

更新日期：2017-03-04 00:00:00

abstract：UNLABELLED:We report a case of recurrent cutaneous necrotizing eosinophilic vasculitis (RCNEV) in a 57-year-old male. The patient presented with papules and pruritus of the lower limbs of more than 1 month duration, and with angioedema and intensively pruritic, necrotizing lesions of the bilateral anterior tibias and f...

journal_title：Diagnostic pathology

authors： Li W,Cao W,Song H,Ciu Y,Lu X,Zhang F

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:c-MET is an oncogene protein that plays important role in gastric carcinogenesis and has been introduced as a prognostic marker and potential therapeutic target. The aim of this study was to evaluate the frequency of c-MET overexpression and its relationship with clinicopathological variables in gastric canc...

journal_title：Diagnostic pathology

authors： Sotoudeh K,Hashemi F,Madjd Z,Sadeghipour A,Molanaei S,Kalantary E

更新日期：2012-05-28 00:00:00

abstract：BACKGROUND:Human kallikrein gene 6 (KLK6) is a member of the human kallikrein gene family (Kallikreins, KLKs). Human kallikrein-related peptidase 6 (hK6) is a trypsin-like serine protease encoded by the KLK6, has been reported to be highly expressed in several cancers including gastric cancer. In this study, we investi...

journal_title：Diagnostic pathology

authors： Liu X,Xiong H,Li J,He Y,Yuan X

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS:One hundred breast cancer s...

journal_title：Diagnostic pathology

authors： Romero Q,Bendahl PO,Fernö M,Grabau D,Borgquist S

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, w...

journal_title：Diagnostic pathology

authors： Zhai P,Ding Y,Li Y

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Integrated molecular pathology (IMP) approaches based on DNA mutational profiling accurately determine pancreatic cyst malignancy risk in patients lacking definitive diagnoses following endoscopic ultrasound imaging with fine-needle aspiration of fluid for cytology. In such cases, IMP 'low-risk' and 'high-ri...

journal_title：Diagnostic pathology

authors： Loren D,Kowalski T,Siddiqui A,Jackson S,Toney N,Malhotra N,Haddad N

更新日期：2016-01-20 00:00:00

abstract：:Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T-cell lymphoma (I...

journal_title：Diagnostic pathology

authors： Alhumidi A

更新日期：2015-07-16 00:00:00

abstract：BACKGROUND:Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA b...

journal_title：Diagnostic pathology

authors： Nodin B,Fridberg M,Jonsson L,Bergman J,Uhlén M,Jirström K

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E-box-binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial-mesenchyma...

journal_title：Diagnostic pathology

authors： Takada-Owada A,Nozawa Y,Onozaki M,Noda S,Jamiyan T,Tokura Y,Nakazato Y,Kamai T,Ishida K

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and efficiently. A multicenter randomized clinical trial was designed for adult patients to determine if the p...

journal_title：Diagnostic pathology

authors： Berenson JR,Yellin O,Blumenstein B,Bojanower D,Croopnick J,Aboulafia D,Upadhyaya G,Spadaccini C

更新日期：2011-03-23 00:00:00

abstract：BACKGROUND:Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirr...

journal_title：Diagnostic pathology

authors： Lan YT,Wang ZL,Tian P,Gong XN,Fan YC,Wang K

更新日期：2019-10-21 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated B-cell post-transplantation lymphoproliferative disorder (PTLD) is a severe complication following stem cell transplantation. This is believed to occur as a result of iatrogenic immunosuppression leading to a relaxation of T-cell control of EBV infection and thus allowing viral reac...

journal_title：Diagnostic pathology

authors： Krenauer A,Moll A,Pönisch W,Schmitz N,Niedobitek G,Niederwieser D,Aigner T

更新日期：2010-03-31 00:00:00

abstract：BACKGROUND:PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition of the tumor-directed T-cell immune response. There are few reports in the literature evaluating PD...

journal_title：Diagnostic pathology

authors： Leite KR,Reis ST,Junior JP,Zerati M,Gomes Dde O,Camara-Lopes LH,Srougi M

更新日期：2015-10-15 00:00:00

abstract：:Over two million Americans are afflicted with schizophrenia, a debilitating mental health disorder with a unique symptomatic and epidemiological profile. Genomics studies have hinted towards candidate schizophrenia susceptibility chromosomal loci and genes. Modern proteomic tools, particularly mass spectrometry and ex...

journal_title：Diagnostic pathology

authors： Lakhan SE

更新日期：2006-07-17 00:00:00

abstract：OBJECTIVE:MicroRNA-100 (miR-100) has been demonstrated to be downregulated in bladder cancer tissues, and enforced expression of this miRNA may inhibit cell growth and colony formation of human bladder cancer 5637 cells in vitro. However, the clinical significance of miR-100 in human bladder cancer has not yet been elu...

journal_title：Diagnostic pathology

authors： Wang S,Xue S,Dai Y,Yang J,Chen Z,Fang X,Zhou W,Wu W,Li Q

更新日期：2012-11-22 00:00:00

abstract：BACKGROUND:Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual incidence of 5 cases per million. The primary CNS anaplastic variant of DLBCL (A-DLBCL) is even less com...

journal_title：Diagnostic pathology

authors： Xu T,Jia Q,Wang Y,Liu Y,Han D,Li P,Ma J,Fan L,Yan Q,Guo S,Li M,Wang Z

更新日期：2019-05-20 00:00:00

abstract：:Perivascular epithelioid cell tumor (PEComa) is a rare entity originating from mesenchymal tissue, which stains for both melanocytic and smooth muscle markers. We would like to present an unusual case of the PEComa of the mesentery which was unexpected discovery in a female patient with colonic adenocarcinoma. The tum...

journal_title：Diagnostic pathology

authors： Wejman J,Nowak K,Gielniewska L,Komorowska M,Dąbrowski W

更新日期：2015-04-18 00:00:00