Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review.

Abstract:

:Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T-cell lymphoma (IVNKL) have been reported. Our case is A 47-year-old female presented with erythematous patches and plaques on the lower extremities mimicking panniculitis clinically. A skin biopsy revealed intravascular lymphoma (IVL) with a NK/T cell phenotype (positive for CD3, and granzyme B and negative for CD20, CD4, CD8, CD5). The lymphoma cells were also positive for Epstein-Barr virus by Epstein-Barr virus-encoded RNA in situ hybridization test. Because this type of lymphoma is extremely rare, our case is documented and compared with the previously reported cases.

journal_name

Diagn Pathol

journal_title

Diagnostic pathology

authors

Alhumidi A

doi

10.1186/s13000-015-0330-0

subject

Has Abstract

pub_date

2015-07-16 00:00:00

pages

107

issn

1746-1596

pii

10.1186/s13000-015-0330-0

journal_volume

10

pub_type

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