Combination of serum RASSF1A methylation and AFP is a promising non-invasive biomarker for HCC patient with chronic HBV infection.

abstract：BACKGROUND:Carbonic anhydrase IX is a member of α-carbonic anhydrases that is preferentially expressed in solid tumors. It enables bicarbonate transport across the plasma membrane, neutralizing intracellular pH and conferring to cancer cells a survival advantage in hypoxic/acidic microenvironments. Overexpression of ca...

journal_title：Diagnostic pathology

authors： Ambrosio MR,Di Serio C,Danza G,Rocca BJ,Ginori A,Prudovsky I,Marchionni N,Del Vecchio MT,Tarantini F

更新日期：2016-05-25 00:00:00

abstract：BACKGROUND:Gastric mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are infrequently encountered in routine practice. Some gastric neuroendocrine carcinomas (NECs) have a variety of differentiation patterns; however, pancreatic acinar differentiation in gastric NECs is rare. The molecular abnormalities of NEC...

journal_title：Diagnostic pathology

authors： Fujita Y,Uesugi N,Sugimoto R,Eizuka M,Matsumoto T,Sugai T

更新日期：2019-05-10 00:00:00

abstract：BACKGROUND:HER2/neu overexpression and/or amplification has been widely studied in a number of solid tumors, primarily in the breast. In gynecologic neoplasms, determination of HER2/neu status has not been well studied as a predictive biomarker in anti-HER2/neu treatment. METHODS:We systematically evaluated the HER2/n...

journal_title：Diagnostic pathology

authors： Woo JS,Apple SK,Sullivan PS,Rao JY,Ostrzega N,Moatamed NA

更新日期：2016-10-22 00:00:00

abstract：:This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin stained tissue components, especially the RBCs. In the method, a principal component analysis (PCA) w...

journal_title：Diagnostic pathology

authors： Bautista PA,Yagi Y

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Human kallikrein gene 6 (KLK6) is a member of the human kallikrein gene family (Kallikreins, KLKs). Human kallikrein-related peptidase 6 (hK6) is a trypsin-like serine protease encoded by the KLK6, has been reported to be highly expressed in several cancers including gastric cancer. In this study, we investi...

journal_title：Diagnostic pathology

authors： Liu X,Xiong H,Li J,He Y,Yuan X

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition of the tumor-directed T-cell immune response. There are few reports in the literature evaluating PD...

journal_title：Diagnostic pathology

authors： Leite KR,Reis ST,Junior JP,Zerati M,Gomes Dde O,Camara-Lopes LH,Srougi M

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular wall of the SMA may be a contributor, but its pathogenesis is unclear. CASE PRESENTATION:A 57-year...

journal_title：Diagnostic pathology

authors： Akuzawa N,Kurabayashi M,Suzuki T,Yoshinari D,Kobayashi M,Tanahashi Y,Makita F,Saito R

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:Crystalloid podocytopathy with focal segmental glomerulosclerosis in plasma cell myeloma (PCM) is rare. CASE PRESENTATION:We present a case of crystalline deposition in the bone marrow (BM) and various renal cells with only proteinuria as a symptom. As workup for proteinuria, a renal biopsy sample was obtai...

journal_title：Diagnostic pathology

authors： Jeon YL,Lee WI,Choi Y,Kang SY,Kim MH,Lim SJ,Lee SH

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopa...

journal_title：Diagnostic pathology

authors： Chen W,Swanson BJ,Frankel WL

更新日期：2017-03-04 00:00:00

abstract：:Endocervicosis in the urinary bladder is a rare benign condition. We present a case in a 37-year-old woman with classical clinical and pathological features of endocervicosis. The unusual observation of endocervical-like mucinous epithelium in continuity with the urothelium in addition to fully developed endocervicosi...

journal_title：Diagnostic pathology

authors： Cheah PL,Looi LM,Lee GE,Teoh KH,Mun KS,Nazarina AR

更新日期：2011-06-23 00:00:00

abstract：BACKGROUND:The optimal course of clinical follow-up after a diagnosis of breast papillary lesion on a core needle biopsy (CNB) remains elusive. In particular, no reports in literature have addressed this question in African-American population. We describe our experience with breast papillary lesions in a primarily Afr...

journal_title：Diagnostic pathology

authors： Wang H,Tsang P,D'Cruz C,Clarke K

更新日期：2014-04-24 00:00:00

abstract：:Tumours of ovarian-epithelial type of the testis, including serous borderline tumours, represent very rare entities. They are identical to the surface epithelial tumours of the ovary and have been reported in patients from 14 to 68 years of age. We describe two cases of a 46- and a 39-year old man with incidental find...

journal_title：Diagnostic pathology

authors： Bürger T,Schildhaus HU,Inniger R,Hansen J,Mayer P,Schweyer S,Radzun HJ,Ströbel P,Bremmer F

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Preventive and therapeutic options for renal failure are still limited. Gene expression profile analysis is powerful in the identification of biological differences between end stage renal failure patients and healthy controls. Previous studies mainly used variance/regression analysis without considering var...

journal_title：Diagnostic pathology

authors： Ding S,Xu Y,Hao T,Ma P

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:To identify critical genes and biological pathways in acute lung injury (ALI), a comparative analysis of gene expression profiles of patients with ALI + sepsis compared with patients with sepsis alone were performed with bioinformatic tools. METHODS:GSE10474 was downloaded from Gene Expression Omnibus, incl...

journal_title：Diagnostic pathology

authors： Guo Z,Zhao C,Wang Z

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:To distinguish between malignant and benign lesions of the thyroid gland histological demonstration is often required since the fine-needle aspiration biopsy method applied pre-operatively has some limitations. In an attempt to improve diagnostic accuracy, markers using immunocytochemistry and immunohistoche...

journal_title：Diagnostic pathology

authors： de Matos LL,Del Giglio AB,Matsubayashi CO,de Lima Farah M,Del Giglio A,da Silva Pinhal MA

更新日期：2012-08-13 00:00:00

abstract：UNLABELLED:We report a case of recurrent cutaneous necrotizing eosinophilic vasculitis (RCNEV) in a 57-year-old male. The patient presented with papules and pruritus of the lower limbs of more than 1 month duration, and with angioedema and intensively pruritic, necrotizing lesions of the bilateral anterior tibias and f...

journal_title：Diagnostic pathology

authors： Li W,Cao W,Song H,Ciu Y,Lu X,Zhang F

更新日期：2013-11-07 00:00:00

abstract：:Primary involvement of skeletal muscle is a very rare event in ALK-1 positive anaplastic large cell lymphoma (ALCL). We describe a case of a 10-year old boy presenting with a three week history of pain and a palpable firm swelling at the dorsal aspect of the left thigh. Histological examination of the lesion revealed ...

journal_title：Diagnostic pathology

authors： Gaiser T,Geissinger E,Schattenberg T,Scharf HP,Dürken M,Dinter D,Rosenwald A,Marx A

更新日期：2012-04-12 00:00:00

abstract：:Two studies recently reported around 10% of EGFR activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the EGFR mutation profiles seem to be related to the et...

journal_title：Diagnostic pathology

authors： Lamy PJ,Jacot W

更新日期：2012-02-01 00:00:00

abstract：:We started to use virtual slide (VS) and virtual microscopy (VM) systems for quick frozen intra-operative telepathology diagnosis in Kyoto, Japan. In the system we used a digital slide scanner, VASSALO by CLARO Inc., and a broadband optic fibre provided by NTT West Japan Inc. with the best effort capacity of 100 Mbps....

journal_title：Diagnostic pathology

authors： Tsuchihashi Y,Takamatsu T,Hashimoto Y,Takashima T,Nakano K,Fujita S

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, w...

journal_title：Diagnostic pathology

authors： Zhai P,Ding Y,Li Y

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Several studies reported the dysregulation of miR-541 in the progression of some human malignancies. Osteosarcoma (OS) is one of the most common primary malignant bone tumors. This study aimed to assess the expression and clinical significance of miR-541 in OS patients and explore the biological function of ...

journal_title：Diagnostic pathology

authors： Liu C,Yi X

更新日期：2020-07-24 00:00:00

abstract：BACKGROUND:Glomus tumors typically occur in the subcutaneous tissue of distal extremities, but rarely in visceral organs. Most glomus tumors are benign, while others have been reported to have malignant potential. Herein, a unique case of a liver glomus tumor with atypical histological features is reported. CASE PRESE...

journal_title：Diagnostic pathology

authors： Hirose K,Matsui T,Nagano H,Eguchi H,Marubashi S,Wada H,Morii E

更新日期：2015-07-19 00:00:00

abstract：:Epstein-Barr virus (EBV)-associated B-cell post-transplantation lymphoproliferative disorder (PTLD) is a severe complication following stem cell transplantation. This is believed to occur as a result of iatrogenic immunosuppression leading to a relaxation of T-cell control of EBV infection and thus allowing viral reac...

journal_title：Diagnostic pathology

authors： Krenauer A,Moll A,Pönisch W,Schmitz N,Niedobitek G,Niederwieser D,Aigner T

更新日期：2010-03-31 00:00:00

abstract：BACKGROUND:Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding...

journal_title：Diagnostic pathology

authors： Lund-Iversen M,Grøholt KK,Helland Å,Borgen E,Brustugun OT

更新日期：2015-09-05 00:00:00

abstract：BACKGROUND:In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and efficiently. A multicenter randomized clinical trial was designed for adult patients to determine if the p...

journal_title：Diagnostic pathology

authors： Berenson JR,Yellin O,Blumenstein B,Bojanower D,Croopnick J,Aboulafia D,Upadhyaya G,Spadaccini C

更新日期：2011-03-23 00:00:00

abstract：OBJECTIVES:Non-Hodgkin's lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. This study describes the clinicopathological features of NHL in the tongue base and the status...

journal_title：Diagnostic pathology

authors： Ren X,Cheng Y,Wu S,Zeng X,Shi X,Ling Q,Li Z,Liang Z,Wang B

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The microRNAs present a class of non-coding RNAs which are usually implicated in tumor biology. Recent report has unraveled that a novel member of microRNA family called miR-1246. However, the functional role and molecular mechanisms of miR-1246 in non-small cell lung cancer (NSCLC) is still elusive. METHOD...

journal_title：Diagnostic pathology

authors： Huang W,Li H,Luo R

更新日期：2015-07-25 00:00:00

abstract：UNLABELLED:Cutaneous mast cell tumours (MCTs) are the most common skin tumours in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology are critical for the treatment of this disease. A cytologic diagnosis of m...

journal_title：Diagnostic pathology

authors： Hosseini E,Pedram B,Bahrami AM,Moghaddam MH,Javanbakht J,Ghomi FE,Moghaddam NJ,Koohestani M,Shafiee R

更新日期：2014-01-20 00:00:00

abstract：OBJECTIVES:RAD51 gene plays an important role in the pathogenesis of squamous cell carcinoma of the head and neck (SCCHN), colorectal cancer, ovarian cancer and acute leukaemia. A number of studies assessed the association between RAD51 135G/C polymorphism and the risk of these cancers in different population. However,...

journal_title：Diagnostic pathology

authors： Cheng D,Shi H,Zhang K,Yi L,Zhen G

更新日期：2014-01-23 00:00:00

abstract：BACKGROUND:Rapid ("warm") autopsies of patients with advanced metastatic cancer provide important insight into the natural history, pathobiology and histomorphology of disease in treatment-resistant tumors. Plasmacytoid urothelial carcinoma (PUC) is a rare variant of urothelial carcinoma characterized by neoplastic cel...

journal_title：Diagnostic pathology

authors： Simon CT,Skala SL,Killen PD,Siddiqui J,Cao X,Qiao Y,Al-Ahmadie H,Camelo-Piragua SI,Jentzen J,Chinnaiyan AM,Dhanasekaran SM,Reichert ZR,Mehra R

更新日期：2019-10-21 00:00:00