Worldwide variations in EGFR somatic mutations: a challenge for personalized medicine.

abstract：:This study examined the effect of tissue section thickness and consistency--parameters outside the direct control of the imaging devices themselves--on WSI capture speed and image quality. Preliminary data indicates that thinner, more consistent tissue sectioning (such as those produced by automated tissue sectioning ...

journal_title：Diagnostic pathology

authors： Yagi Y,Gilbertson JR

更新日期：2008-07-15 00:00:00

abstract：:Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade d...

journal_title：Diagnostic pathology

authors： Kannuna H,Rubio CA,Silverio PC,Girardin M,Goossens N,Rubbia-Brandt L,Puppa G

更新日期：2015-07-09 00:00:00

abstract：:Concurrent hematologic malignancies are relatively rare. We encountered a case of concurrent acute myeloid leukemia (AML) and T lymphoblastic lymphoma. The bone marrow chromosome analysis showed the karyotype 46, XY, t(5;12)(q33;p13), which indicated presence of PDGFRB gene translocations. Therefore, this disease belo...

journal_title：Diagnostic pathology

authors： Chang H,Chuang WY,Sun CF,Barnard MR

更新日期：2012-02-22 00:00:00

abstract：BACKGROUND:Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tumor heterogeneity, frequent material scarcity, and the large number of loci to be investigated, must ...

journal_title：Diagnostic pathology

authors： Bonaparte E,Pesenti C,Fontana L,Falcone R,Paganini L,Marzorati A,Ferrero S,Nosotti M,Mendogni P,Bareggi C,Sirchia SM,Tabano S,Bosari S,Miozzo M

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:Metastatic spread of tumor through lymphatic vasculature is an important adverse prognostic factor in a variety of human cancer and tumor lymphangiogenesis requires the interplay of several growth factors. Platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C are two import...

journal_title：Diagnostic pathology

authors： Liu J,Liu C,Qiu L,Li J,Zhang P,Sun Y

更新日期：2014-06-27 00:00:00

abstract：BACKGROUND:Morphine has been widely used as a clinical anesthetic and analgesic. However, abuse of morphine might result in psychological and physiological dependence. Previous studies have indicated that memory mechanisms play critical roles in morphine dependence. METHODS:Morphine dependence was established in mice ...

journal_title：Diagnostic pathology

authors： Ye J,Yang Z,Li C,Cai M,Zhou D,Zhang Q,Wei Y,Wang T,Liu Y

更新日期：2014-07-10 00:00:00

abstract：BACKGROUND:Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual incidence of 5 cases per million. The primary CNS anaplastic variant of DLBCL (A-DLBCL) is even less com...

journal_title：Diagnostic pathology

authors： Xu T,Jia Q,Wang Y,Liu Y,Han D,Li P,Ma J,Fan L,Yan Q,Guo S,Li M,Wang Z

更新日期：2019-05-20 00:00:00

abstract：PURPOSE:Patellofemoral pathology is common, and patellofemoral dislocation mainly affects adolescents and young adults. We conducted a meta-analysis exclusively of RCTs to compare the clinical outcomes of patellar dislocation patients managed operatively versus non-operatively. METHODS:After systematic review of elect...

journal_title：Diagnostic pathology

authors： Cheng B,Wu X,Ge H,Qing Sun Y,Zhang Q

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:Crowdsourcing, i.e., the outsourcing of tasks typically performed by a few experts to a large crowd as an open call, has been shown to be reasonably effective in many cases, like Wikipedia, the Chess match of Kasparov against the world in 1999, and several others. The aim of the present paper is to describe ...

journal_title：Diagnostic pathology

authors： Della Mea V,Maddalena E,Mizzaro S,Machin P,Beltrami CA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). METHODS:LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. RE...

journal_title：Diagnostic pathology

authors： Liu Y,Bian T,Zhang Y,Zheng Y,Zhang J,Zhou X,Xie J

更新日期：2019-09-04 00:00:00

abstract：BACKGROUND:The histopathological subtype, nuclear grade and presence or absence of comedonecrosis are established as critical elements in the reporting of ductal carcinoma in situ (DCIS) of the breast. The aims of this study were to determine the frequencies of morphological subtypes of DCIS, nuclear grade and comedone...

journal_title：Diagnostic pathology

authors： Perez AA,Balabram D,Salles Mde A,Gobbi H

更新日期：2014-12-03 00:00:00

abstract：BACKGROUND:Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polym...

journal_title：Diagnostic pathology

authors： Liu H,Mao P,Xie C,Xie W,Wang M,Jiang H

更新日期：2015-08-07 00:00:00

abstract：BACKGROUND/OBJECTIVE:Metastatic adenocarcinoma from an unknown primary site is a common clinical problem. Determining the cytokeratin (CK) 7/CK20 pattern of tumors is one of the most helpful procedures for this purpose since the CK7-/CK20+ pattern is typical of colorectal adenocarcinomas. CDX2, a critical nuclear trans...

journal_title：Diagnostic pathology

authors： Bayrak R,Haltas H,Yenidunya S

更新日期：2012-01-23 00:00:00

abstract：BACKGROUND:Reduced DNA repair capacities due to inherited polymorphisms may increase the susceptibility to cancers including gastric cancer. Previous studies investigating the association between Xeroderma Pigmentosum group C (XPC) gene polymorphisms and gastric cancer risk reported inconsistent results. We performed a...

journal_title：Diagnostic pathology

authors： Peng Q,Chen Z,Lu Y,Lao X,Mo C,Li R,Qin X,Li S

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:To identify critical genes and biological pathways in acute lung injury (ALI), a comparative analysis of gene expression profiles of patients with ALI + sepsis compared with patients with sepsis alone were performed with bioinformatic tools. METHODS:GSE10474 was downloaded from Gene Expression Omnibus, incl...

journal_title：Diagnostic pathology

authors： Guo Z,Zhao C,Wang Z

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:To investigate the therapeutic effect of p38-MAPK inhibitor, SB203580, on dry eye in a mouse model of Sjögren's syndrome (MRL/lpr mice). METHODS:18 female BALB/c mice and 44 female MRL/lpr mice were included. Mice were randomly assigned to the control or treatment group. The expression of phospho-p38 MAPK i...

journal_title：Diagnostic pathology

authors： Ma X,Zou J,He L,Zhang Y

更新日期：2014-01-20 00:00:00

abstract：BACKGROUND:This study is to investigate the expression of progranulin (PGRN) in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid (GC) treatment on its expression. METHODS:Thirty newly diagnosed severe SLE patients and 30 healthy subjects were enrolled in this study. The serum levels of PGRN...

journal_title：Diagnostic pathology

authors： Qiu F,Song L,Ding F,Liu H,Shu Q,Yang N,Liu W,Li X

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present study was aimed to determine the relationship between Treg/Th17 and hepatitis B-associated liver cirr...

journal_title：Diagnostic pathology

authors： Lan YT,Wang ZL,Tian P,Gong XN,Fan YC,Wang K

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defining feature of associ...

journal_title：Diagnostic pathology

authors： Oramas DM,Bell D,Middleton LP

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Carbonic anhydrase IX is a member of α-carbonic anhydrases that is preferentially expressed in solid tumors. It enables bicarbonate transport across the plasma membrane, neutralizing intracellular pH and conferring to cancer cells a survival advantage in hypoxic/acidic microenvironments. Overexpression of ca...

journal_title：Diagnostic pathology

authors： Ambrosio MR,Di Serio C,Danza G,Rocca BJ,Ginori A,Prudovsky I,Marchionni N,Del Vecchio MT,Tarantini F

更新日期：2016-05-25 00:00:00

abstract：BACKGROUND:70-80% of sporadic endometrial carcinomas are defined as endometrioid carcinoma (EC). Early-stage, well differentiated endometrial carcinomas usually retain expression of estrogen and progesterone receptors (ER and PR, respectively), as advanced stage, poorly differentiated tumors often lack one or both of t...

journal_title：Diagnostic pathology

authors： Kreizman-Shefer H,Pricop J,Goldman S,Elmalah I,Shalev E

更新日期：2014-03-31 00:00:00

abstract：BACKGROUND:Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients. METHODS:In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73...

journal_title：Diagnostic pathology

authors： De Mello MR,Albuquerque DM,Pereira-Cunha FG,Albanez KB,Pagnano KB,Costa FF,Metze K,Lorand-Metze I

更新日期：2012-06-28 00:00:00

abstract：BACKGROUND:Assessment of hemoglobin is one of the most reliable indicators for anemia, and is widely used to screen for anemia among pregnant women. The HemoCue® has been widely used for as a point-of-care device for hemoglobin estimation in health facilities. Previous studies showed contradictory results regarding the...

journal_title：Diagnostic pathology

authors： Adam I,Ahmed S,Mahmoud MH,Yassin MI

更新日期：2012-03-21 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is a useful diagnostic tool in interstitial lung diseases (ILD). However, differential cell counts are often non specific and immunocytochemistry is time consuming. Staining of glycoproteins by periodic acid Schiff (PAS) reaction may help in discriminating different forms of ILD. In additi...

journal_title：Diagnostic pathology

authors： Hauber HP,Zabel P

更新日期：2009-04-23 00:00:00

abstract：BACKGROUND:Although synovial sarcoma is the 3rd most commonly occurring mesenchymal tumor in young adults, usually with a highly aggressive clinical course; remarkable differences can be seen regarding the clinical outcome. According to comparative genomic hybridization (CGH) data published in the literature, the simpl...

journal_title：Diagnostic pathology

authors： Balogh Z,Szemlaky Z,Szendroi M,Antal I,Pápai Z,Fónyad L,Papp G,Changchien YC,Sápi Z

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:Rhabdoid colorectal tumor (RCT) is a rare, highly aggressive neoplasm recurrent in elderly patients, commonly at the caecum. The molecular mechanisms underlying RCT pathogenesis remain poorly elucidated. The differential diagnosis is with the malignant rhabdoid tumors of infancy characterized by genetic inac...

journal_title：Diagnostic pathology

authors： Pancione M,Remo A,Sabatino L,Zanella C,Votino C,Fucci A,Di Blasi A,Lepore G,Daniele B,Fenizia F,Molinari E,Normanno N,Manfrin E,Vendraminelli R,Colantuoni V

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied. METHODS:Here we investigated immunohistochemical expression of GATA3 in 72 primary genital EMPDs (35 from female...

journal_title：Diagnostic pathology

authors： Zhao M,Zhou L,Sun L,Song Y,Guo Y,Zhang X,Zhao F,Wang P,Yue J,Niu D,Li Z,Huang X,Kang Q,Jia L,Lai J,Cao D

更新日期：2017-07-10 00:00:00

abstract：UNLABELLED:Seven percent of renal cell carcinoma (RCC) cases are diagnosed as "unclassified" RCC by morphology. Genetic profiling of RCCs helps define renal tumor subtypes, especially in cases where morphologic diagnosis is inconclusive. This report describes a patient with synchronous clear cell RCC (ccRCC) and a tubu...

journal_title：Diagnostic pathology

authors： Quiroga-Garza G,Piña-Oviedo S,Cuevas-Ocampo K,Goldfarb R,Schwartz MR,Ayala AG,Monzon FA

更新日期：2012-02-27 00:00:00

abstract：BACKGROUND:After introduction of the concept of critical value (CV) in laboratory medicine, some efforts were performed to define possible critical values in surgical pathology. Critical diagnosis (critical value) is a concept recently established in surgical pathology and is a challenging issue among pathologists and ...

journal_title：Diagnostic pathology

authors： Mireskandari M

更新日期：2008-07-12 00:00:00

abstract：BACKGROUND:Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common mesonephric adenocarcinoma (MAC), which mostly arises the uterine cervix. Despite the similarities b...

journal_title：Diagnostic pathology

authors： Dundr P,Gregová M,Němejcová K,Bártů M,Hájková N,Hojný J,Stružinská I,Fischerová D

更新日期：2020-07-21 00:00:00