Expression of CK-19, galectin-3 and HBME-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis.

abstract：BACKGROUND:Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopa...

journal_title：Diagnostic pathology

authors： Chen W,Swanson BJ,Frankel WL

更新日期：2017-03-04 00:00:00

abstract：:Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, includ...

journal_title：Diagnostic pathology

authors： Wood MD,Halfpenny AM,Moore SR

更新日期：2019-04-09 00:00:00

abstract：BACKGROUND:The transcriptional co-activator, TAZ, is an important effector of the Hippo pathway and is critical for the development of human cancers. However, the expression and prognostic significance of TAZ in retinoblastoma is currently unclear. METHODS:TAZ expression was examined in 43 retinoblastoma samples by im...

journal_title：Diagnostic pathology

authors： Zhang Y,Xue C,Cui H,Huang Z

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS:One hundred breast cancer s...

journal_title：Diagnostic pathology

authors： Romero Q,Bendahl PO,Fernö M,Grabau D,Borgquist S

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:Mixed adeno-neuroendocrine carcinoma (MANEC) of the biliary tract is rare with only a few reported cases. Consequently, knowledge about their pathogenesis, histopathological characteristics and outcomes is sparce. CASE PRESENTATION:A 53-year old man presented with epigastric pain on a background of excessiv...

journal_title：Diagnostic pathology

authors： Zheng SL,Yip VS,Pedica F,Prachalias A,Quaglia A

更新日期：2015-11-20 00:00:00

abstract：BACKGROUND:Integrated molecular pathology (IMP) approaches based on DNA mutational profiling accurately determine pancreatic cyst malignancy risk in patients lacking definitive diagnoses following endoscopic ultrasound imaging with fine-needle aspiration of fluid for cytology. In such cases, IMP 'low-risk' and 'high-ri...

journal_title：Diagnostic pathology

authors： Loren D,Kowalski T,Siddiqui A,Jackson S,Toney N,Malhotra N,Haddad N

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:To quantify the effect of cruciferous vegetable consumption on the incidence of ovarian cancer by meta-analyzing the existing observational studies and provides quantitative and high-level evidence. METHODS:A detailed literature search of Medline and EMBASE for all relevant papers published. A meta-analysis...

journal_title：Diagnostic pathology

authors： Han B,Li X,Yu T

更新日期：2014-01-20 00:00:00

abstract：BACKGROUND:The aim of this report is related to adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of the spermatic cord leiomyosarcoma. Primary paratesticular tumors are rare, only accounting for 7% to 10% of all intrascrotal tumors. In adults, more than 75% of these le...

journal_title：Diagnostic pathology

authors： Galosi AB,Scarpelli M,Mazzucchelli R,Lopez-Beltran A,Giustini L,Cheng L,Montironi R

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and efficiently. A multicenter randomized clinical trial was designed for adult patients to determine if the p...

journal_title：Diagnostic pathology

authors： Berenson JR,Yellin O,Blumenstein B,Bojanower D,Croopnick J,Aboulafia D,Upadhyaya G,Spadaccini C

更新日期：2011-03-23 00:00:00

abstract：OBJECTIVES:Non-Hodgkin's lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. This study describes the clinicopathological features of NHL in the tongue base and the status...

journal_title：Diagnostic pathology

authors： Ren X,Cheng Y,Wu S,Zeng X,Shi X,Ling Q,Li Z,Liang Z,Wang B

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) is one of the most powerful genetic analysis tools for pathological diagnoses. FISH can detect various genetic abnormalities including gene translocation that was specifically found in translocation-related sarcomas (TRSs). Here, we report the use of FISH in expert r...

journal_title：Diagnostic pathology

authors： Sugita S,Asanuma H,Hasegawa T

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual incidence of 5 cases per million. The primary CNS anaplastic variant of DLBCL (A-DLBCL) is even less com...

journal_title：Diagnostic pathology

authors： Xu T,Jia Q,Wang Y,Liu Y,Han D,Li P,Ma J,Fan L,Yan Q,Guo S,Li M,Wang Z

更新日期：2019-05-20 00:00:00

abstract：BACKGROUND:After introduction of the concept of critical value (CV) in laboratory medicine, some efforts were performed to define possible critical values in surgical pathology. Critical diagnosis (critical value) is a concept recently established in surgical pathology and is a challenging issue among pathologists and ...

journal_title：Diagnostic pathology

authors： Mireskandari M

更新日期：2008-07-12 00:00:00

abstract：:This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anapla...

journal_title：Diagnostic pathology

authors： Grayson W,Pantanowitz L

更新日期：2008-07-25 00:00:00

abstract：BACKGROUND:The Eastern Quebec Telepathology Network (called Réseau de Télépathologie de l'Est du Québec in French) was created to provide uniform diagnostic telepathology services in a huge territory with low population density. We report our first 3-year experience. METHODS:The network was funded equally by the Québe...

journal_title：Diagnostic pathology

authors： Têtu B,Perron É,Louahlia S,Paré G,Trudel MC,Meyer J

更新日期：2014-01-01 00:00:00

abstract：:Primary liver tumors in children are rare with malignant hepatoblastoma being the most common neoplasm. In this report, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma. Pathological as...

journal_title：Diagnostic pathology

authors： Moll A,Krenauer A,Bierbach U,Till H,Hirsch W,Leuschner I,Schmitz N,Wittekind C,Aigner T

更新日期：2009-11-12 00:00:00

abstract：BACKGROUND:Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polym...

journal_title：Diagnostic pathology

authors： Liu H,Mao P,Xie C,Xie W,Wang M,Jiang H

更新日期：2015-08-07 00:00:00

abstract：BACKGROUND:The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies t...

journal_title：Diagnostic pathology

authors： Udall M,Rizzo M,Kenny J,Doherty J,Dahm S,Robbins P,Faulkner E

更新日期：2018-02-09 00:00:00

abstract：PURPOSE:Patellofemoral pathology is common, and patellofemoral dislocation mainly affects adolescents and young adults. We conducted a meta-analysis exclusively of RCTs to compare the clinical outcomes of patellar dislocation patients managed operatively versus non-operatively. METHODS:After systematic review of elect...

journal_title：Diagnostic pathology

authors： Cheng B,Wu X,Ge H,Qing Sun Y,Zhang Q

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare entity that was first described by Zambrano et al. in 2003 as "Clear cell sarcoma-like tumor of the gastrointestinal tract". It shares some of the histological features of clear cell sarcoma (CCS) but lacks the immunohistochemical r...

journal_title：Diagnostic pathology

authors： Alyousef MJ,Alratroot JA,ElSharkawy T,Shawarby MA,Al Hamad MA,Hashem TM,Alsayyah A

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. The SARS-CoV-2 outbreak is a major challenge for clinicians. In our clinic, w...

journal_title：Diagnostic pathology

authors： Zhai P,Ding Y,Li Y

更新日期：2020-06-29 00:00:00

abstract：:This study examined the effect of tissue section thickness and consistency--parameters outside the direct control of the imaging devices themselves--on WSI capture speed and image quality. Preliminary data indicates that thinner, more consistent tissue sectioning (such as those produced by automated tissue sectioning ...

journal_title：Diagnostic pathology

authors： Yagi Y,Gilbertson JR

更新日期：2008-07-15 00:00:00

abstract：INTRODUCTION:Nemaline myopathy is a rare genetic muscle disorder defined by the presence of nemaline rods in the muscle fibre sarcoplasm. Congenital nemaline myopathy is the most serious form of the disease's spectrum. CASE PRESENTATION:The affected newborn has no spontaneous movement, fractures at birth and respirato...

journal_title：Diagnostic pathology

authors： Waisayarat J,Suriyonplengsaeng C,Khongkhatithum C,Rochanawutanon M

更新日期：2015-04-16 00:00:00

abstract：BACKGROUND:Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients. METHODS:In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73...

journal_title：Diagnostic pathology

authors： De Mello MR,Albuquerque DM,Pereira-Cunha FG,Albanez KB,Pagnano KB,Costa FF,Metze K,Lorand-Metze I

更新日期：2012-06-28 00:00:00

abstract：OBJECTIVE:FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed in our institution, assess the cytomorphologic features that contribute to diagnostic errors and prop...

journal_title：Diagnostic pathology

authors： Zhu Y,Song Y,Xu G,Fan Z,Ren W

更新日期：2020-01-03 00:00:00

abstract：BACKGROUND:The aim of this study was to analyze the frequency of Thyroid Transcription Factor (TTF)-1 expression in small cell lung cancer (SCLC) and its value for the diagnosis of SCLC, the response to first line treatment as well as the prognostic impact on overall survival (OS). METHODS:We analyzed a total of 294 p...

journal_title：Diagnostic pathology

authors： Misch D,Blum T,Boch C,Weiss T,Crolow C,Griff S,Mairinger T,Bauer TT,Kollmeier J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Metastatic spread of tumor through lymphatic vasculature is an important adverse prognostic factor in a variety of human cancer and tumor lymphangiogenesis requires the interplay of several growth factors. Platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C are two import...

journal_title：Diagnostic pathology

authors： Liu J,Liu C,Qiu L,Li J,Zhang P,Sun Y

更新日期：2014-06-27 00:00:00

abstract：BACKGROUND:The optimal course of clinical follow-up after a diagnosis of breast papillary lesion on a core needle biopsy (CNB) remains elusive. In particular, no reports in literature have addressed this question in African-American population. We describe our experience with breast papillary lesions in a primarily Afr...

journal_title：Diagnostic pathology

authors： Wang H,Tsang P,D'Cruz C,Clarke K

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia. It was suggested that mismatched F8 replacement therapy may be a risk factor for the development of anti-factor F8 alloantibodies. Recently four single nucle...

journal_title：Diagnostic pathology

authors： Elmahmoudi H,Belhedi N,Jlizi A,Zahra K,Meddeb B,Ben Ammar Elgaaied A,Gouider E

更新日期：2011-06-17 00:00:00

abstract：BACKGROUND:ABCG2 is an ABC transporter. It has been demonstrated that endogenous ABCG2 expression in certain cancers is a possible reflection of the differentiated phenotype of the cell of origin and likely contributes to intrinsic drug resistance. But little is known about the contribution of ABCG2 to the drug resista...

journal_title：Diagnostic pathology

authors： Xiang L,Su P,Xia S,Liu Z,Wang Y,Gao P,Zhou G

更新日期：2011-09-27 00:00:00