Crystalloid podocytopathy with focal segmental glomerulosclerosis in PCM: a case report.

Abstract:

BACKGROUND:Crystalloid podocytopathy with focal segmental glomerulosclerosis in plasma cell myeloma (PCM) is rare. CASE PRESENTATION:We present a case of crystalline deposition in the bone marrow (BM) and various renal cells with only proteinuria as a symptom. As workup for proteinuria, a renal biopsy sample was obtained. EM showed multiple crystalline depositions in renal tubular cells and podocytes. Focal segmental glomerulosclerosis with crystalloid podocytopathy was diagnosed. Because monoclonal gammopathy was detected in the serum and urine, a BM study was also performed. Plasma cells with needle-shaped inclusion bodies were observed. The crystalline deposits in the plasma cells and podocytes were positive for Masson's trichrome and kappa light-chain staining. These findings indicated that the crystalline deposits originated from paraprotein. The case showed a rare process of focal segmental glomerulosclerosis via crystalline deposition in podocytes in plasma cell myeloma. CONCLUSIONS:Crystalloid podocytopathy is a likely cause of renal damage such as FSGS in PCM, although it is an uncommon mechanism for myeloma kidney.

journal_name

Diagn Pathol

journal_title

Diagnostic pathology

authors

Jeon YL,Lee WI,Choi Y,Kang SY,Kim MH,Lim SJ,Lee SH

doi

10.1186/s13000-015-0448-0

subject

Has Abstract

pub_date

2015-12-16 00:00:00

pages

213

issn

1746-1596

pii

10.1186/s13000-015-0448-0

journal_volume

10

pub_type

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