Abstract:
BACKGROUND:Adult granulosa cell tumors of the ovary (GCTs) are sex cord stromal tumors of unpredictable behaviour. Up to now, the prediction of the relapsing/malignant potential remains difficult. CD56 (NCAM) in GCTs was previously described in only two studies. However, the expression of its isoforms was not examined. METHODS:30 GCTs (16 primaries, 14 relapses) were investigated immunohistochemically with antibodies against Pan-CD56 (CD56Pan) and the isoform with 140/180 kDa length (CD56140/180 kDa). The reaction was assessed with respect to percentage of positive cells and intensity of staining. RESULTS:In all GCTs, CD56Pan was expressed, but differences were found between primaries and relapses. The percentage of CD56Pan positive tumor cells was lower in relapses, whereas CD56140/180 kDa showed a higher staining intensity in the latter. CONCLUSION:Expression of CD56 is an additional sensitive and helpful immunohistochemical tool for histopathologists diagnosing a GCT. It does not seem possible to provide a validly individual risk assessment. However, the different expression of CD56 isoforms might indicate important changes in the course to a more malignant behaviour.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Völker HU,Engert S,Cramer A,Schmidt M,Kämmerer U,Müller-Hermelink HK,Gattenlöhner Sdoi
10.1186/1746-1596-3-29subject
Has Abstractpub_date
2008-07-09 00:00:00pages
29issn
1746-1596pii
1746-1596-3-29journal_volume
3pub_type
杂志文章abstract::A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-year-old woman without a previous history of gravida or para, presented with intermittent abdominal pain at 26 we...
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:Diagnostic pathology
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pub_type: 杂志文章
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