Abstract:
BACKGROUND:Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract, which originates from mesonephric duct remnants. Its diagnosis is pathologically challenging, because MNAC may exhibit a mixture of morphological patterns that complicates the differential diagnosis. CASE PRESENTATION:The patient in this case was a 48-year-old woman with a polypoid mass protruding into the endocervical canal. The patient underwent a total hysterectomy outside the institution. During biopsy, the mass showed a cerebroid aspect. Histological study revealed a tumor with a predominantly tubular and ductal growth pattern. The immunoprofile showed negative staining for calretinin, carcinoembryonic antigen (CEAm), estrogen receptors (ER), and progesterone receptors (PR), and positive staining for CD10, p16, and PAX2. The Ki-67 score was 46%. Using a next-generation sequencing assay, we documented genomic alterations in KRAS and CTNNB1, low tumor mutation burden (TMB), and an absence of microsatellite instability. In addition, gain of the long arm of chromosome 1 (1q) was also documented using chomogenic in situ hybridization (CISH). Three years later, the patient presented pulmonary nodules in the lingula and left basal lobe that were resected by thoracotomy. The histopathologic study of the pulmonary nodules confirmed the presence of metastases. CONCLUSION:Carcinomas of mesonephric origin are among the rarest subtypes of cervical tumors. We report the first case of mesonephric adenocarcinoma of the cervix with lung metastases showing a CTNNB1 gene mutation.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Montalvo N,Redrobán L,Galarza Ddoi
10.1186/s13000-019-0847-8subject
Has Abstractpub_date
2019-07-03 00:00:00pages
71issue
1issn
1746-1596pii
10.1186/s13000-019-0847-8journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Although often associated with holoprosencephaly, little detail of the histopathology of cyclopia is available. Here, we describe the ocular findings in a case of trisomy 13 to better understand the histogenesis of the rosettes, or tubules, characteristic of the retinal dysplasia associated with this conditi...
journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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doi:10.1186/s13000-014-0227-3
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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更新日期:2013-04-15 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2008-07-25 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-5-52
更新日期:2010-08-11 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-015-0385-y
更新日期:2015-09-04 00:00:00
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journal_title:Diagnostic pathology
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更新日期:2012-08-29 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-31
更新日期:2013-02-20 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-7-57
更新日期:2012-05-28 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-8-88
更新日期:2013-05-23 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-019-0802-8
更新日期:2019-04-09 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2019-06-15 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2011-03-30 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2012-09-03 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/1746-1596-8-148
更新日期:2013-09-13 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-6-s1-s12
更新日期:2011-01-01 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-137
更新日期:2014-07-05 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
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更新日期:2015-07-16 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/s13000-015-0395-9
更新日期:2015-09-05 00:00:00
abstract::Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor. We report a case of a dome-type carcinoma of the cecum in a 57 year old female. The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade d...
journal_title:Diagnostic pathology
pub_type: 杂志文章,评审
doi:10.1186/s13000-015-0305-1
更新日期:2015-07-09 00:00:00