Abstract:
BACKGROUND:Maspin is a unique member of the serine protease inhibitor superfamily and its expression is found in myoepithelial cells of normal mammary glands; therefore, it has been considered to be a myoepithelial marker. We previously reported that maspin was frequently expressed in biologically aggressive breast cancers. In turn, triple-negative (TN) breast cancer is a subtype of tumor with aggressive clinical behavior and shows frequent expression of basal markers. We hypothesized that maspin expression may be frequent and correlate with basal rather than myoepithelial markers in TN breast cancer. METHODS:Paraffin-embedded 135 TN invasive ductal carcinoma tissue samples were immunohistochemically investigated using the Dako Envision+ kit and primary antibodies for maspin, basal (CK5/6, EGFR, CK14) and myoepithelial markers (p63, CD10). The correlation between maspin expression and relapse-free survival (RFS) was investigated by the log-rank test. RESULTS:The positive rate for maspin was 85.9% and significantly correlated with younger age (P=0.0015), higher histological grade (P=0.0013), CK5/6 positivity (P<0.0001), CK14 positivity (P=0.0034) and the basal-like subtype defined by CK5/6, EGFR and CK14 positivity (P=0.013). The positive rates for CK5/6, EGFR, CK14, CD10 and p63 were 59.2%, 48.9%, 34.1%, 17.8% and 12.6%, respectively. There was no significant correlation between maspin expression and RFS. CONCLUSIONS:The positive rate for maspin is the highest among known basal and myoepithelial markers, and strongly correlates with basal markers in TN breast cancer. These results suggested that maspin could be a candidate for a therapeutic target for TN breast cancer.
journal_name
Diagn Patholjournal_title
Diagnostic pathologyauthors
Umekita Y,Ohi Y,Souda M,Rai Y,Sagara Y,Sagara Y,Tamada S,Tanimoto Adoi
10.1186/1746-1596-6-36subject
Has Abstractpub_date
2011-04-16 00:00:00pages
36issn
1746-1596pii
1746-1596-6-36journal_volume
6pub_type
杂志文章abstract::Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T-cell lymphoma (I...
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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journal_title:Diagnostic pathology
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更新日期:2015-06-10 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-01-20 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2012-04-12 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
doi:10.1186/1746-1596-9-86
更新日期:2014-04-24 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-11-20 00:00:00
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更新日期:2012-06-28 00:00:00
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journal_title:Diagnostic pathology
pub_type: 杂志文章
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更新日期:2018-09-20 00:00:00
abstract::Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by recurrent coma, ventricular tachycardias and the replacement of the myocardium with fatty and fibrous tissue. We described a 42-year-old female patient without clinical arrhythmias which was diagnosed as ARVC by magnetic resonance imaging (MRI)...
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pub_type: 杂志文章
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更新日期:2012-06-12 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-07-09 00:00:00