Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China.

abstract：:The single- and multiple-dose pharmacokinetics of and tolerability to a new microfluidized suspension of atovaquone were studied in human immunodeficiency virus-seropositive patients with CD4 counts of < or = 200 cells per mm3 in order to define a dosing regimen for the treatment of Pneumocystis carinii pneumonia. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon R,Pozniak AL,Watt HM,Rolan P,Posner J

更新日期：1996-03-01 00:00:00

abstract：:Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott JA,Mwarumba S,Ngetsa C,Njenga S,Lowe BS,Slack MP,Berkley JA,Mwangi I,Maitland K,English M,Marsh K

更新日期：2005-07-01 00:00:00

abstract：:Emergence of resistance to pentavalent antimonials has become a severe obstacle in the treatment of visceral leishmaniasis (VL) on the Indian subcontinent. The mechanisms operating in laboratory-generated strains are somewhat known, but the determinants of clinical antimony resistance are not well understood. By utili...

journal_title：Antimicrobial agents and chemotherapy

authors： Ashutosh,Garg M,Sundar S,Duncan R,Nakhasi HL,Goyal N

更新日期：2012-01-01 00:00:00

abstract：:A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorabl...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Baldassarri I,Marigliano A,Arzeni D,Giannini D,Scalise G

更新日期：2004-10-01 00:00:00

abstract：:3-O-(3',3'-Dimethylsuccinyl) betulinic acid (DSB), also known as PA-457, bevirimat (BVM), or MPC-4326, is a novel HIV-1 maturation inhibitor. Unlike protease inhibitors, BVM blocks the cleavage of the Gag capsid precursor (CA-SP1) to mature capsid (CA) protein, resulting in the release of immature, noninfectious viral...

journal_title：Antimicrobial agents and chemotherapy

authors： Lu W,Salzwedel K,Wang D,Chakravarty S,Freed EO,Wild CT,Li F

更新日期：2011-07-01 00:00:00

abstract：:One hundred thirty nonimmune subjects living in Yaoundé, Cameroon, completed an 18-month prospective study on the efficacy and safety of weekly chloroquine and daily proguanil (chloroguanide) (Ch-P) in malaria prevention. A total of 9 of 78 Ch-P-treated subjects and 26 of 52 subjects who received no prophylaxis contra...

journal_title：Antimicrobial agents and chemotherapy

authors： Gozal D,Hengy C,Fadat G

更新日期：1991-02-01 00:00:00

abstract：:Seventy-two (54.5%) out of 132 fecal samples from a group of yellow-legged gulls in Barcelona, Spain, were positive for Escherichia coli producing either extended-spectrum β-lactamases (ESBL) (51.5%), carbapenemase (1.5%), or cephamycinase (1.5%). The isolation of two carbapenemase-producing E. coli strains is a matte...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Pitart C,Montalvo T,Roca I,Sabaté S,Hurtado JC,Planell R,Marco F,Ramírez B,Peracho V,de Simón M,Vila J

更新日期：2017-01-24 00:00:00

abstract：:We evaluated the pharmacodynamic activities of fluconazole and amphotericin B given alone and in combination against Candida albicans by using an in vitro model of bloodstream infection that simulates human serum pharmacokinetic parameters for these antifungals. Fluconazole was administered as a bolus into the model t...

journal_title：Antimicrobial agents and chemotherapy

authors： Lewis RE,Lund BC,Klepser ME,Ernst EJ,Pfaller MA

更新日期：1998-06-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00

abstract：:The in vitro susceptibility of 406 clinical isolates to BMY-28142, a new semisynthetic cephem, was evaluated and compared with cefpimizole, HR 810, ceftazidime, cefotaxime, moxalactam, and cefoperazone in a broth microdilution assay. On a weight basis, the activity of BMY-28142 against Escherichia coli, Proteus specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuji A,Maniatis A,Bertram MA,Young LS

更新日期：1985-04-01 00:00:00

abstract：:Analysis of the transport functions of individual Candida albicans plasma membrane drug efflux pumps is hampered by the multitude of endogenous transporters. We have stably expressed C. albicans Cdr1p, the major pump implicated in multiple-drug-resistance phenotypes, from the genomic PDR5 locus in a Saccharomyces cere...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura K,Niimi M,Niimi K,Holmes AR,Yates JE,Decottignies A,Monk BC,Goffeau A,Cannon RD

更新日期：2001-12-01 00:00:00

abstract：:A new SHV-derived extended-spectrum beta-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 3...

journal_title：Antimicrobial agents and chemotherapy

authors： Kurokawa H,Yagi T,Shibata N,Shibayama K,Kamachi K,Arakawa Y

更新日期：2000-06-01 00:00:00

abstract：:Protoplasts of the temperature-sensitive osmotic-1 mutant of Neurospora crassa grew and divided as cell wall-less cells when incubated under certain conditions at 37 degrees C. Each protoplast regenerated cell wall and formed a mycelium when the temperature was shifted to 22 degrees C. Cell wall regeneration, but not ...

journal_title：Antimicrobial agents and chemotherapy

authors： Selitrennikoff CP

更新日期：1983-05-01 00:00:00

abstract：:Ampicillin and erythromycin were shown to act synergistically in vitro against the majority of strains of Nocardia asteroides tested. With these strains, the minimal inhibiting concentration (MIC) of each drug when combined was reduced 4- to more than 512-fold as compared with the MIC of each antibiotic acting individ...

journal_title：Antimicrobial agents and chemotherapy

authors： Finland M,Bach MC,Garner C,Gold O

更新日期：1974-03-01 00:00:00

abstract：:Two clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of beta-lactamase in resistance was investigated by eliminating t...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Martínez L,Pascual A,Hernández-Allés S,Alvarez-Díaz D,Suárez AI,Tran J,Benedí VJ,Jacoby GA

更新日期：1999-07-01 00:00:00

abstract：:Given that tedizolid exhibits substantial lung penetration, we hypothesize that it could achieve good efficacy against Streptococcus pneumoniae lung infections. We evaluated the pharmacodynamics of tedizolid for treatment of S. pneumoniae lung infections and compared the efficacies of tedizolid human-simulated epithel...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelraouf K,Nicolau DP

更新日期：2016-12-27 00:00:00

abstract：:Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants ...

journal_title：Antimicrobial agents and chemotherapy

authors： Markham PN

更新日期：1999-04-01 00:00:00

abstract：:Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

更新日期：2014-01-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:Twelve healthy volunteers participated in this randomized crossover study to compare the concentrations and recovery levels of fleroxacin and pefloxacin in urine and to assess their bactericidal activities against 12 strains of urinary pathogens with different susceptibilities over a wide range of MICs. The volunteers...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Theuretzbacher U,Kinzig M,Savov O,Sörgel F

更新日期：1998-07-01 00:00:00

abstract：:In vitro activities of erythromycin A, telithromycin, and two investigational ketolides, JNJ-17155437 and JNJ-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. Against 46 macrolide-susceptible and -resistant Streptococcus pneumoniae strains, the MIC(90)...

journal_title：Antimicrobial agents and chemotherapy

authors： Abbanat D,Webb G,Foleno B,Li Y,Macielag M,Montenegro D,Wira E,Bush K

更新日期：2005-01-01 00:00:00

abstract：:A novel algorithm designed for the screening of carbapenemase-producing Enterobacteriaceae (CPE), based on faropenem and temocillin disks, was compared to that of the Committee of the Antibiogram of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem, and temocillin disks. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dortet L,Bernabeu S,Gonzalez C,Naas T

更新日期：2017-07-25 00:00:00

abstract：:Norfloxacin is a quinolone (pyridonecarboxylic acid derivative) effective against Pseudomonas aeruginosa infections. We studied the effects of this drug on DNA metabolism in P. aeruginosa. Norfloxacin inhibits DNA replication immediately on its addition to a logarithmically growing culture of P. aeruginosa. It inhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Benbrook DM,Miller RV

更新日期：1986-01-01 00:00:00

abstract：:The susceptibilities of 87 periodontitis-associated strains of Actinobacillus actinomycetemcomitans to clarithromycin and erythromycin were determined by standard methodology recommended for Haemophilus influenzae. For clarithromycin the MIC at which 90% of the isolates were inhibited was

journal_title：Antimicrobial agents and chemotherapy

authors： Piccolomini R,Catamo G,Di Bonaventura G

更新日期：1998-11-01 00:00:00

abstract：:Cytomegalovirus can cause debilitating and life-threatening disease in newborns infected in utero and immunocompromised individuals, including transplant recipients. RG7667 is a unique combination of two monoclonal antibodies that binds glycoprotein complexes on the surface of cytomegalovirus and inhibits its entry in...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishida JH,Burgess T,Derby MA,Brown PA,Maia M,Deng R,Emu B,Feierbach B,Fouts AE,Liao XC,Tavel JA

更新日期：2015-08-01 00:00:00

abstract：:Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to...

journal_title：Antimicrobial agents and chemotherapy

authors： Batty KT,Law AS,Stirling V,Moore BR

更新日期：2007-12-01 00:00:00

abstract：:Fluroquinolone antibiotics have been reported to have antiviral properties against RNA viruses, including hepatitis C virus (HCV). In the present study, five patients with advanced liver disease secondary to chronic HCV received 500 mg daily of oral ciprofloxacin for 30 days. Serum HCV-RNA levels and liver enzyme abno...

journal_title：Antimicrobial agents and chemotherapy

authors： Kojima H,Kaita KD,Hawkins K,Uhanova J,Minuk GY

更新日期：2002-10-01 00:00:00

abstract：:Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Sidwell RW,Huffman JH,Call EW,Alaghamandan H,Cook PD,Robins RK

更新日期：1985-09-01 00:00:00

abstract：:An Ambler class A β-lactamase gene, bla(CIA-1), was cloned from the reference strain Chryseobacterium indologenes ATCC 29897 and expressed in Escherichia coli BL21. The bla(CIA-1) gene encodes a novel extended-spectrum β-lactamase (ESBL) that shared 68% and 60% identities with the CGA-1 and CME-1 β-lactamases, respect...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto T,Nagata M,Ishimine N,Kawasaki K,Yamauchi K,Hidaka E,Kasuga E,Horiuchi K,Oana K,Kawakami Y,Honda T

更新日期：2012-01-01 00:00:00

abstract：:Free-living amoebae of the genus Acanthamoeba are causing serious chronic conditions such as destructive keratitis in contact lens wearers or granulomatous amoebic encephalitis in individuals with compromised immune systems. Both are characterized by the lack of availability of sufficiently effective and uncomplicated...

journal_title：Antimicrobial agents and chemotherapy

authors： Walochnik J,Duchêne M,Seifert K,Obwaller A,Hottkowitz T,Wiedermann G,Eibl H,Aspöck H

更新日期：2002-03-01 00:00:00