Novel transferable resistance-nodulation-division pump gene cluster tmexCD2-toprJ2 that confers tigecycline resistance in Raoultella ornithinolytica.

abstract：:The role of pyrazinamide in the current treatment of multidrug-resistant (MDR) tuberculosis (TB) is uncertain. From a territory-wide registry of MDR-TB cases diagnosed between 1995 and 2009, we assembled a cohort of 194 patients with MDR pulmonary TB given fluoroquinolone-containing regimens. Stratified by pyrazinamid...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang KC,Leung CC,Yew WW,Leung EC,Leung WM,Tam CM,Zhang Y

更新日期：2012-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is usually benign in healthy individuals but can cause life-threatening disease in those with compromised immune systems. Approved drugs available to treat HCMV disease, including ganciclovir, cidofovir, and foscarnet, have significant toxicities that limit their use in certain p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel HD,Nikitin P,Gesner T,Lin JJ,Barkan DT,Ciferri C,Carfi A,Akbarnejad Yazdi T,Skewes-Cox P,Wiedmann B,Jarousse N,Zhong W,Feire A,Hebner CM

更新日期：2016-07-22 00:00:00

abstract：:Group B beta-hemolytic streptococci (GB-BHS) frequently cause severe infection in newborns. Previous in vitro studies showed accelerated killing of GB-BHS by ampicillin plus gentamicin as compared with ampicillin alone. To extend the in vitro observations, mice were infected experimentally with GB-BHS and treated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Deveikis A,Schauf V,Mizen M,Riff L

更新日期：1977-05-01 00:00:00

abstract：:Mycobactin biosynthesis in Mycobacterium tuberculosis facilitates iron acquisition, which is required for growth and virulence. The mycobactin biosynthesis inhibitor salicyl-AMS [5'-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. Here, we conducted a single-dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Lun S,Guo H,Adamson J,Cisar JS,Davis TD,Chavadi SS,Warren JD,Quadri LE,Tan DS,Bishai WR

更新日期：2013-10-01 00:00:00

abstract：:Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the po...

journal_title：Antimicrobial agents and chemotherapy

authors： Gendrot M,Diawara S,Madamet M,Kounta MB,Briolant S,Wade KA,Fall M,Benoit N,Nakoulima A,Amalvict R,Diémé Y,Fall B,Wade B,Diatta B,Pradines B

更新日期：2017-02-23 00:00:00

abstract：:A novel trait for transferable resistance to high concentrations of trimethoprim was found to dominate among enterobacteria collected from different parts of Sri Lanka. Drug resistance was a result of the production of dihydrofolate reductase with a decreased sensitivity to antifolates. By characterization of the part...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundström L,Vinayagamoorthy T,Sköld O

更新日期：1987-01-01 00:00:00

abstract：:Acinetobacter baumannii has emerged as a serious problematic pathogen due to the ever-increasing presence of antibiotic resistance, demonstrating a need for novel, broad-spectrum antimicrobial therapeutic options. Antimicrobial nanoemulsions are emulsified mixtures of detergent, oil, and water (droplet size, 100 to 80...

journal_title：Antimicrobial agents and chemotherapy

authors： Hwang YY,Ramalingam K,Bienek DR,Lee V,You T,Alvarez R

更新日期：2013-08-01 00:00:00

abstract：:Despite the documented benefit of voriconazole therapeutic drug monitoring, nonlinear pharmacokinetics make the timing of steady-state trough sampling and appropriate dose adjustments unpredictable by conventional methods. We developed a nonparametric population model with data from 141 previously richly sampled child...

journal_title：Antimicrobial agents and chemotherapy

authors： Neely M,Margol A,Fu X,van Guilder M,Bayard D,Schumitzky A,Orbach R,Liu S,Louie S,Hope W

更新日期：2015-01-01 00:00:00

abstract：:To date, the majority of pharmacokinetic/pharmacodynamic (PK/PD) discussions have focused on PK/PD relationships evaluated at steady-state drug concentrations. However, a concern with reliance upon steady-state drug concentrations is that it ignores events occurring while the pathogen is exposed to intermittent subopt...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez MN,Papich MG,Drusano GL

更新日期：2012-06-01 00:00:00

abstract：:DNA microarrays were used to analyze Candida glabrata oropharyngeal isolates from seven hematopoietic stem cell transplant recipients whose isolates developed azole resistance while the recipients received fluconazole prophylaxis. Transcriptional profiling of the paired isolates revealed 19 genes upregulated in the ma...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsai HF,Sammons LR,Zhang X,Suffis SD,Su Q,Myers TG,Marr KA,Bennett JE

更新日期：2010-08-01 00:00:00

abstract：:Pseudomonas aeruginosa pneumonia remains a difficult therapeutic problem. Optimal doses and modes of administration of single agents often do not result in acceptable outcomes. Further, emergence of resistance occurs frequently in this setting with single-agent chemotherapy. The purpose of these experiments was to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Liu W,Fikes S,Brown D,Drusano GL

更新日期：2013-06-01 00:00:00

abstract：:The pharmacokinetics and tolerability of a new parenteral carbapenem antibiotic, biapenem (L-627), were studied in healthy elderly volunteers aged 65 to 74 years (71.6 +/- 2.7 years [mean +/- standard deviation], n = 5; group B) and > or = 75 years (77.8 +/- 1.9 years, n = 5; group C), following single intravenous dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Takiguchi Y,Matsumoto S,Minamoto M,Niida Y,Yokokawa M,Nagashima S,Kanamaru M

更新日期：1998-06-01 00:00:00

abstract：:Candida infections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of <3 months of age receiving intravenous amphotericin B for documented or highly suspected candidiasis wer...

journal_title：Antimicrobial agents and chemotherapy

authors： Sáez-Llorens X,Macias M,Maiya P,Pineros J,Jafri HS,Chatterjee A,Ruiz G,Raghavan J,Bradshaw SK,Kartsonis NA,Sun P,Strohmaier KM,Fallon M,Bi S,Stone JA,Chow JW

更新日期：2009-03-01 00:00:00

abstract：:Neisseria meningitidis has been relatively slow to acquire resistance to penicillin. We previously reported an increase in the incidence of invasive meningococcal disease (IMD) strains with decreased susceptibility to penicillin (DSP) in Ontario. Our objectives were to evaluate trends in IMD with DSP, to identify case...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown EM,Fisman DN,Drews SJ,Dolman S,Rawte P,Brown S,Jamieson F

更新日期：2010-03-01 00:00:00

abstract：:3-Decynoyl-N-acetylcystamine is known to inhibit the in vitro growth of Escherichia coli but not of yeasts or mammalian cells. Neither the free acid nor the 2 positional isomer is active (L. R. Kass, J. Biol. Chem. 243:3223-3228, 1968). Other studies have shown that 2-hexadecynoic acid is fungitoxic whereas most of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Konthikamee W,Gilbertson JR,Langkamp H,Gershon H

更新日期：1982-11-01 00:00:00

abstract：:The nucleotide sequence of the constitutively produced beta-lactamase (Bla) gene from Enterococcus faecalis HH22 was shown to be identical to the published sequences of three of four staphylococcal type A beta-lactamase genes; more differences were seen with the genes for staphylococcal type C and D enzymes. One hundr...

journal_title：Antimicrobial agents and chemotherapy

authors： Zscheck KK,Murray BE

更新日期：1991-09-01 00:00:00

abstract：:beta-Lactamases from Aeromonas hydrophila and A. sobria were purified and characterized. Both species produced beta-lactamases that were inducible by either cefoxitin or imipenem. These species were resistant to ampicillin and cephalothin but not imipenem. Isoelectric focusing of sonic extracts revealed one band at pI...

journal_title：Antimicrobial agents and chemotherapy

authors： Iaconis JP,Sanders CC

更新日期：1990-01-01 00:00:00

abstract：:Aminoglycoside acetyltransferase was detected in Mycobacterium kansasii and M. fortuitum but not in M. avium-M. intracellulare when they were screened by a radioassay. Aminoglycoside phosphotransferase and nucleotidyltransferase activities were absent from all three species tested. Acetyltransferases from both M. kans...

journal_title：Antimicrobial agents and chemotherapy

authors： Ho II,Chan CY,Cheng AF

更新日期：2000-01-01 00:00:00

abstract：:Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to multiple antibiotics did not affect the organism's susceptibility to the fluoroquinolones. The fluoroquinolones with in vitro...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Fuchs PC,Brown SD

更新日期：1996-10-01 00:00:00

abstract：:Staphylococcin 462 is a proteinaceous inhibitor produced by Staphylococcus aureus strain 462. In broth cultures, susceptible S. aureus strain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hale EM,Hinsdill RD

更新日期：1975-01-01 00:00:00

abstract：:Several non-beta-lactam compounds were active against various gram-positive and gram-negative bacterial strains. The MICs of arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones were lower than those of ampicillin and cefotaxime for methicillin-resistant Staphylococcus aureus MI339 and vancomycin-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Zervosen A,Lu WP,Chen Z,White RE,Demuth TP Jr,Frère JM

更新日期：2004-03-01 00:00:00

abstract：:Linezolid is the first synthetic oxazolidone agent to treat infections caused by Gram-positive pathogens. Infected patients with liver dysfunction (LD) are more likely to suffer from adverse reactions, such as thrombocytopenia, when standard-dose linezolid is used than patients with LD who did not use linezolid. Curre...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang SH,Zhu ZY,Chen Z,Li Y,Zou Y,Yan M,Xu Y,Wang F,Liu MZ,Zhang M,Zhang BK

更新日期：2020-05-21 00:00:00

abstract：:HMR 3647 (telithromycin), a new ketolide, is active on intracellular pathogens. It was previously demonstrated that it inhibits superoxide anion production in a time- and concentration-dependent manner, at concentrations which inhibit 50% of the control response of about 55 microg/ml (5 min) to 30 microg/ml (30 min); ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vazifeh D,Abdelghaffar H,Labro MT

更新日期：2002-05-01 00:00:00

abstract：:The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both species. In dogs, c...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller WM

更新日期：1977-07-01 00:00:00

abstract：:Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The objective of this study was to characterize the dose-response relationship of ceftaroline fosamil against S. aureus in an immunocompromised murine pneumonia model, as ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhalodi AA,Crandon JL,Biek D,Nicolau DP

更新日期：2012-12-01 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:Candida albicans is an opportunistic human fungal pathogen and a causative agent of oropharyngeal candidiasis (OPC), the most frequent opportunistic infection among patients with AIDS. Fluconazole and other azole antifungal agents have proven effective in the management of OPC; however, with increased use of these age...

journal_title：Antimicrobial agents and chemotherapy

authors： Rogers PD,Barker KS

更新日期：2003-04-01 00:00:00

abstract：:We found that cells of Vibrio parahaemolyticus possess an energy-dependent efflux system for norfloxacin. We cloned a gene for a putative norfloxacin efflux protein from the chromosomal DNA of V. parahaemolyticus by using an Escherichia coli mutant lacking the major multidrug efflux system AcrAB as the host and sequen...

journal_title：Antimicrobial agents and chemotherapy

authors： Morita Y,Kodama K,Shiota S,Mine T,Kataoka A,Mizushima T,Tsuchiya T

更新日期：1998-07-01 00:00:00

abstract：:The in vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 μM. The growth of an amikacin-resistant Klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikacin was supplemented by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiem K,Fuentes BA,Lin DL,Tran T,Jackson A,Ramirez MS,Tolmasky ME

更新日期：2015-09-01 00:00:00

abstract：:Gatifloxacin (GTX), a new fluoroquinolone with extended antibacterial activity, is an interesting candidate for the treatment of chronic bacterial prostatitis (CBP). Besides the antibacterial spectrum, the concentrations in the target tissues and fluids are crucial for the treatment of CBP. Thus, it was of interest to...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber CK,Steghafner M,Kinzig-Schippers M,Sauber C,Sörgel F,Stahlberg HJ,Naber KG

更新日期：2001-01-01 00:00:00