Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones.

abstract：:Six strains of ampicillin-resistant Haemophilus influenzae type b were studied in vitro for synergy between ampicillin and nafcillin. The minimal inhibitory concentrations for these strains with 10(4) colony-forming units per ml were 6.25 to 12.5 microgram of ampicillin per ml and 6.25 to 25 microgram of nafcillin per...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Burkholder E,Davis AT

更新日期：1980-03-01 00:00:00

abstract：:Treatment failure is a major cause of concern for the Helicobacter pylori-related gastroduodenal diseases like gastritis, peptic ulcer, and gastric cancer. Curcumin, diferuloylmethane from turmeric, has recently been shown to arrest H. pylori growth. The antibacterial activity of curcumin against 65 clinical isolates ...

journal_title：Antimicrobial agents and chemotherapy

authors： De R,Kundu P,Swarnakar S,Ramamurthy T,Chowdhury A,Nair GB,Mukhopadhyay AK

更新日期：2009-04-01 00:00:00

abstract：:The minimal inhibitory concentration of temocillin (BRL 17421) against 476 clinical isolates was determined by an agar dilution method. Temocillin was active against most of the Enterobacteriaceae, Haemophilus, and Neisseria strains tested. The compound showed low activity or was inactive against Bacteroides, Campylob...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Landuyt HW,Pyckavet M,Lambert A,Boelaert J

更新日期：1982-10-01 00:00:00

abstract：:Viridans group streptococci (VGS) are part of the normal flora that may cause bacteremia, often leading to endocarditis. We evaluated daptomycin against four clinical strains of VGS (MICs = 1 or 2 μg/ml) using an in vitro-simulated endocardial vegetation model, a simulated bacteremia model, and kill curves. Daptomycin...

journal_title：Antimicrobial agents and chemotherapy

authors： Akins RL,Katz BD,Monahan C,Alexander D

更新日期：2015-04-01 00:00:00

abstract：:Isavuconazole, the active moiety of the prodrug isavuconazonium sulfate, has potent activity against a wide spectrum of fungal pathogens and is approved for the treatment of invasive aspergillosis, yet little is known about the tissue penetration of isavuconazole at the target sites of infection. Here, we explored the...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee A,Prideaux B,Lee MH,Zimmerman M,Dolgov E,Perlin DS,Zhao Y

更新日期：2019-05-24 00:00:00

abstract：:The association of an IS440-sul3 platform with Tn21 class 1 integrons carried by IncI1 plasmids encoding extended-spectrum β-lactamases (ESBLs; mainly SHV-12 and CTX-M-14) among worldwide Escherichia coli clones of phylogroups A (ST10, ST23, and ST46), B1 (ST155, ST351, and ST359), and D/B2 (ST131) is reported. An in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Curiao T,Cantón R,Garcillán-Barcia MP,de la Cruz F,Baquero F,Coque TM

更新日期：2011-05-01 00:00:00

abstract：:Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are an important cause of morbidity and mortality in hospital patients. Moreover, increased incidences of outpatient MRSA have been recently reported. This study investigated the bactericidal activity of dalbavancin, a novel, semisynthetic glycopepti...

journal_title：Antimicrobial agents and chemotherapy

authors： Jabés D,Candiani G,Romanó G,Brunati C,Riva S,Cavaleri M

更新日期：2004-04-01 00:00:00

abstract：:The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Koup JR,Lau AH,Brodsky B,Slaughter RL

更新日期：1979-05-01 00:00:00

abstract：:A new method for the analysis of serum chloramphenicol by reversed-phase, high-performance liquid chromatography (HPLC) is described. The method involves a preliminary extraction of 0.1 ml of serum with ethyl acetate containing an internal standard, chromatography with a reversed-phase C18 microparticulate column with...

journal_title：Antimicrobial agents and chemotherapy

authors： Koup JR,Brodsky B,Lau A,Beam TR Jr

更新日期：1978-09-01 00:00:00

abstract：:A double-blind study was performed to compare the clinical response and the incidence of side effects in 2,581 patients administered ampicillin or cyclacillin for infections of the genitourinary or respiratory tract, infections of the skin and soft tissues, or for otitis media. There was no significant difference in c...

journal_title：Antimicrobial agents and chemotherapy

authors： Gold JA,Hegarty CP,Deitch MW,Walker BR

更新日期：1979-01-01 00:00:00

abstract：:Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resist...

journal_title：Antimicrobial agents and chemotherapy

authors： Theys K,Libin PJK,Van Laethem K,Abecasis AB

更新日期：2019-07-25 00:00:00

abstract：:In vivo antiherpesvirus effects of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) were tested in two mouse model infections with herpes simplex virus type 1 (HSV-1) strains which showed different degrees of virulence in mice. Successful efficacies of oral and intraperitoneal (i.p.) treatments with brova...

journal_title：Antimicrobial agents and chemotherapy

authors： Machida H,Takezawa J

更新日期：1990-05-01 00:00:00

abstract：:Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus...

journal_title：Antimicrobial agents and chemotherapy

authors： Reig M,Galan J,Baquero F,Perez-Diaz JC

更新日期：2001-02-01 00:00:00

abstract：:Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercia...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett JE,Jennings AE

更新日期：1978-04-01 00:00:00

abstract：:Antibiotic therapy with penicillin, doxycycline, and ceftriaxone has proven to be effective for the treatment of Lyme borreliosis. In some patients, however, it was noticed that borreliae can survival in the tissues in spite of seemingly adequate therapy. For a better understanding of this phenomenon, we investigated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kersten A,Poitschek C,Rauch S,Aberer E

更新日期：1995-05-01 00:00:00

abstract：:Whole and fractionated latex of Asclepias syriaca was tested for antimicrobial or growth-promoting activity with 16 genera and species of bacteria. Latex and extracted fractions (distilled water, acetic acid, sodium bicarbonate, sulfuric acid, and ethyl ether) possessed no detectable antimicrobial activity. Comparison...

journal_title：Antimicrobial agents and chemotherapy

authors： McCay S,Mahlberg P

更新日期：1973-02-01 00:00:00

abstract：:The effect of moxalactam and cefuroxime on mitogen-stimulated human peripheral blood mononuclear leukocytes was studied. Mononuclear leukocytes, mitogen, and antibiotic were added to microtiter wells. Cells were cultured for 3 days, pulsed with tritiated thymidine, and then counted. Compared with control cell cultures...

journal_title：Antimicrobial agents and chemotherapy

authors： Manzella JP,Clark JK

更新日期：1983-03-01 00:00:00

abstract：:The Candida albicans CDR1 and CDR2 genes code for highly homologous ATP-binding cassette (ABC) transporters which are overexpressed in azole-resistant clinical isolates and which confer resistance to multiple drugs by actively transporting their substrates out of the cells. These transporters are formed by two homolog...

journal_title：Antimicrobial agents and chemotherapy

authors： Gauthier C,Weber S,Alarco AM,Alqawi O,Daoud R,Georges E,Raymond M

更新日期：2003-05-01 00:00:00

abstract：:Most ampicillin-resistant Shigella are susceptible to cephalexin. Randomized treatment with cephalexin or ampicillin was given to 154 infants and children with acute diarrhea. Rectal swab cultures revealed Shigella in 42%, Salmonella in 6%, enteropathogenic Escherichia coli in 2%, and no pathogen in 50%. Cephalexin fa...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson JD,Haltalin KC

更新日期：1975-04-01 00:00:00

abstract：:The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeabl...

journal_title：Antimicrobial agents and chemotherapy

authors： Billman-Jacobe H,Haites RE,Coppel RL

更新日期：1999-12-01 00:00:00

abstract：:We conducted a randomized controlled trial of orally administered amifloxacin versus trimethoprimsulfamethoxazole (TMP-SMX) as treatments of acute uncomplicated urinary tract infection in women. Amifloxacin at a dosage of 200 mg twice a day appeared as safe and effective as TMP-SMX, but amifloxacin at 400 mg twice a d...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyko EJ,Iravani A,Silverman MH,Schelling DJ,Wright RA

更新日期：1990-04-01 00:00:00

abstract：:Antimicrobial resistance (AMR) is an ever-growing public health problem worldwide. The low rate of antibiotic discovery coupled with the rapid spread of drug-resistant bacterial pathogens is causing a global health crisis. To facilitate the drug discovery processes, we present a large-scale study of reference antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Rourke A,Beyhan S,Choi Y,Morales P,Chan AP,Espinoza JL,Dupont CL,Meyer KJ,Spoering A,Lewis K,Nierman WC,Nelson KE

更新日期：2020-02-21 00:00:00

abstract：:As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast also shares with most pathogenic fungi a susceptibility of its cytochrome P-450-dependent ergosterol synthesis to nanomolar concentrations of itraconazole. Fifty percent inhibition of ergoste...

journal_title：Antimicrobial agents and chemotherapy

authors： Vanden Bossche H,Marichal P,Le Jeune L,Coene MC,Gorrens J,Cools W

更新日期：1993-10-01 00:00:00

abstract：:Seventeen oral streptococci and 18 enterococci were tested for the presence of DNA sequences homologous to the conjugative transposon Tn916 encoding tetracycline resistance. All the strains were resistant to tetracyclines, including minocycline, and most of them were resistant to other antibiotics. Tn916-like structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Bentorcha F,Clermont D,de Cespédès G,Horaud T

更新日期：1992-01-01 00:00:00

abstract：:Emtricitabine [(-)FTC] [(-)-beta-2', 3'-dideoxy-5-fluoro-3'-thiacytidine] has been shown to be an effective inhibitor of hepatitis B virus (HBV) in cell culture, with a potency and selectivity that are essentially identical to those of lamivudine. The antiviral activity of oral administration of (-)FTC against WHV rep...

journal_title：Antimicrobial agents and chemotherapy

authors： Korba BE,Schinazi RF,Cote P,Tennant BC,Gerin JL

更新日期：2000-06-01 00:00:00

abstract：:Ten patients received a loading dose of tobramycin of 60 mg/m2 intravenously over 0.5 h followed immediately by 60 mg/m2 over 2 h every 4 h. The highest mean serum concentration (at the end of the loading dose) was 6.0 +/- 0.3 microgram/ml (range, 3.2 to 10.9 microgram/ml). The mean serum concentration 2 h after the e...

journal_title：Antimicrobial agents and chemotherapy

authors： Lawson RD,Bodey GP,Pan T,Smith TL

更新日期：1980-05-01 00:00:00

abstract：:Gentamicin is a commonly used antibiotic for the treatment of gram-negative-bacterial infections. Bacterial endotoxin is liberated during antibiotic therapy, and we have shown that endotoxemic animals accumulate more aminoglycosides in their renal parenchyma than normal animals. Vasoactive mediators, such as prostagla...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron MG,Bergeron Y,Tardif M,Marchand S,Beauchamp D

更新日期：1989-08-01 00:00:00

abstract：:We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts ...

journal_title：Antimicrobial agents and chemotherapy

authors： Palomares F,Palencia G,Pérez R,González-Esquivel D,Castro N,Cook HJ

更新日期：2004-06-01 00:00:00

abstract：:The resistome of P. aeruginosa for three β-lactam antibiotics, namely, ceftazidime, imipenem, and meropenem, was deciphered by screening a comprehensive PA14 mutant library for mutants with increased or reduced susceptibility to these antimicrobials. Confirmation of the phenotypes of all selected mutants was performed...

journal_title：Antimicrobial agents and chemotherapy

authors： Alvarez-Ortega C,Wiegand I,Olivares J,Hancock RE,Martínez JL

更新日期：2010-10-01 00:00:00

abstract：:Two methods for testing the susceptibility of Mycobacterium tuberculosis to rifapentine have been developed: the agar proportion method and the radiometric BACTEC technique. A critical concentration of 0.5 microg of rifapentine per ml is proposed for both methods since it provides a reliable means of distinguishing be...

journal_title：Antimicrobial agents and chemotherapy

authors： Heifets L,Sanchez T,Vanderkolk J,Pham V

更新日期：1999-01-01 00:00:00