Nucleotide sequence of the beta-lactamase gene from Enterococcus faecalis HH22 and its similarity to staphylococcal beta-lactamase genes.

abstract：:A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and Acinetobacter baumannii complex (n = 199) was analyzed for susceptibility. Xpert Carba-R assay and sequencing for mcr genes were performed for carbapenem- or colistin-re...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu PY,Lee YL,Lu MC,Shao PL,Lu PL,Chen YH,Cheng SH,Ko WC,Lin CY,Wu TS,Yen MY,Wang LS,Liu CP,Lee WS,Chen YS,Wang FD,Tseng SH,Lin CN,Tang HJ,Chen YH,Sheng WH,Lee CM,Liao MH,Hsueh PR

更新日期：2020-09-21 00:00:00

abstract：:The in vitro interaction between triclosan and fluconazole against 24 azole-resistant clinical isolates of Candida albicans was evaluated by the microdilution checkerboard technique. The synergisms were verified by time-killing curves and agar diffusion tests in selected strains. Antagonistic activity was not detected...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu L,Ling G,Deng X,Jin J,Jin Q,Guo N

更新日期：2011-07-01 00:00:00

abstract：:Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent...

journal_title：Antimicrobial agents and chemotherapy

authors： Peltroche-Llacsahuanga H,Goyard S,d'Enfert C,Prill SK,Ernst JF

更新日期：2006-10-01 00:00:00

abstract：:The in vitro activity of HSR-903, an oral quinolone, against 196 recent clinical isolates of respiratory pathogens was evaluated. HSR-903 was 2 to 32 times more active than ofloxacin, ciprofloxacin, and sparfloxacin against Staphylococcus aureus, including methicillin-resistant strains, and Streptococcus pneumoniae an...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanabe A,Tokue Y,Takahashi H,Kikuchi T,Kobayashi T,Gomi K,Fujimura S,Nukiwa T

更新日期：1999-07-01 00:00:00

abstract：:The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estim...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupuis A,Limosin A,Paquereau J,Mimoz O,Couet W,Bouquet S

更新日期：2001-12-01 00:00:00

abstract：:Ex vivo assay systems provide a powerful approach to studying human malaria parasite biology and to testing antimalarials. For rodent malaria parasites, short-term in vitro culture and ex vivo antimalarial susceptibility assays are relatively cumbersome, relying on in vivo passage for synchronization, since ring-stage...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang ZW,Malleret B,Russell B,Rénia L,Claser C

更新日期：2016-10-21 00:00:00

abstract：:The novel 6-substituted acyclouridine derivatives 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT), 1-[(2-hydroxyethoxy)methyl]-6-(3-methylphenylthio)thymine (HEPT-M), 6-cyclohexylthio-1-[(2-hydroxyethoxy) methyl]thymine (HEPT-H), and 1-[(2-hydroxyethoxy)methyl]-6-phenylthio-2- thiothymine (HEPT-S) have proved t...

journal_title：Antimicrobial agents and chemotherapy

authors： Baba M,De Clercq E,Iida S,Tanaka H,Nitta I,Ubasawa M,Takashima H,Sekiya K,Umezu K,Nakashima H

更新日期：1990-12-01 00:00:00

abstract：:Antibiotics are generally not effective against organisms in exopolysaccharide biofilms. A simple method of studying the effect of antibiotics on bacteria in established biofilms is reported. Escherichia coli ATCC 25922 cells grown overnight at 37 degrees C on Mueller-Hinton agar were suspended in buffer and dispensed...

journal_title：Antimicrobial agents and chemotherapy

authors： Prosser BL,Taylor D,Dix BA,Cleeland R

更新日期：1987-10-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV), a paramyxovirus, is a major cause of acute upper and lower respiratory tract infections in infants, young children, and adults. RFI-641 is a novel anti-RSV agent with potent in vitro and in vivo activity. RFI-641 is active against both RSV type A and B strains. The viral specif...

journal_title：Antimicrobial agents and chemotherapy

authors： Huntley CC,Weiss WJ,Gazumyan A,Buklan A,Feld B,Hu W,Jones TR,Murphy T,Nikitenko AA,O'Hara B,Prince G,Quartuccio S,Raifeld YE,Wyde P,O'Connell JF

更新日期：2002-03-01 00:00:00

abstract：:Conventional therapy for human cytomegalovirus (CMV) relies on inhibition of the viral DNA polymerase. Ganciclovir (GCV) is the first-line therapy, but when GCV-resistant strains emerge, alternative therapies are extremely limited and are associated with significant toxicities. Combination of anti-CMV agents that act ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai H,Kapoor A,He R,Venkatadri R,Forman M,Posner GH,Arav-Boger R

更新日期：2014-01-01 00:00:00

abstract：:Serial passage of Pseudomonas aeruginosa ATCC 27853 or Escherichia coli ATCC 25922 on agar with subinhibitory concentrations of norfloxacin rapidly produced isolates with minimal inhibitory concentrations (MICs) of norfloxacin up to 512-fold higher than that for the original strain. Although MICs of seven unrelated an...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenney JH,Maack RW,Chippendale GR

更新日期：1983-01-01 00:00:00

abstract：:The rapid infusion of hyperosmolar solutions into the internal carotid artery transiently disrupts the integrity of the blood-brain barrier, permitting entry of substances normally excluded from the nervous system. This study examined the effect of such an infusion on the penetration of vancomycin and tobramycin into ...

journal_title：Antimicrobial agents and chemotherapy

authors： Perkins BA,Strausbaugh LJ

更新日期：1983-09-01 00:00:00

abstract：:Gentamicin was successfully incorporated into neutral, anionic, and cationic liposomes, and the percentage of gentamicin incorporated was found to be a function of lipid concentration. Gentamicin did not leak out of the liposomes over a 3-week period at 4 degrees C. When liposome-associated gentamicin was administered...

journal_title：Antimicrobial agents and chemotherapy

authors： Morgan JR,Williams KE

更新日期：1980-04-01 00:00:00

abstract：:The treatment of dermatophytoses, including onychomycosis, has come a long way over the past few decades with the introduction of oral antifungals (e.g., terbinafine and itraconazole). However, with these advancements in oral therapies come several undesirable effects, such as kidney and liver toxicity, along with dru...

journal_title：Antimicrobial agents and chemotherapy

authors： Long L,Hager C,Ghannoum M

更新日期：2016-03-25 00:00:00

abstract：:Strains of Pseudomonas aeruginosa resistant to either gentamicin or carbenicillin have been noted since their introduction into clinical use. During a 6-month period, twice-weekly cultures were obtained from all patients treated with either gentamicin or carbenicillin and from all patients with a positive culture for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaman W,Cates C,Snelling CF,Lank B,Ronald AR

更新日期：1976-03-01 00:00:00

abstract：:The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazzarini C,Esposto MC,Prigitano A,Cogliati M,De Lorenzis G,Tortorano AM

更新日期：2015-11-09 00:00:00

abstract：:Tobramycin-resistant burn wound isolates of Klebsiella pneumoniae and Enterobacter cloacae, together with Escherichia coli K-12 transconjugants from these two strains, were examined for plasmid deoxyribonucleic acid (DNA). All the resistant strains contained a common, high-molecular-weight, covalently closed circular ...

journal_title：Antimicrobial agents and chemotherapy

authors： Elwell LP,Inamine JM,Minshew BH

更新日期：1978-02-01 00:00:00

abstract：:Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility agains...

journal_title：Antimicrobial agents and chemotherapy

authors： Oliveira ER,Fothergill AW,Kirkpatrick WR,Coco BJ,Patterson TF,Redding SW

更新日期：2005-08-01 00:00:00

abstract：:The relationship between the structures of quinolones and their anti-Mycobacterium avium activities has been previously derived by using the Multiple Computer-Automated Structure Evaluation program. A number of substructural constraints required to overcome the resistance of most of the strains have been identified. N...

journal_title：Antimicrobial agents and chemotherapy

authors： Klopman G,Li JY,Wang S,Pearson AJ,Chang K,Jacobs MR,Bajaksouzian S,Ellner JJ

更新日期：1994-08-01 00:00:00

abstract：:Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite of AQ, in plasma bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Adjei GO,Kristensen K,Goka BQ,Hoegberg LC,Alifrangis M,Rodrigues OP,Kurtzhals JA

更新日期：2008-12-01 00:00:00

abstract：:Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model. A single ajoene dose of 50 mg/kg, on the day of infection, suppressed the development of parasitemia; there w...

journal_title：Antimicrobial agents and chemotherapy

authors： Perez HA,De la Rosa M,Apitz R

更新日期：1994-02-01 00:00:00

abstract：:Platelet-activating factor (PAF) is a potent endogenous proinflammatory mediator implicated in the pathogenesis of septic shock. A double-blind randomized placebo-controlled trial of an intravenous PAF receptor antagonist (lexipafant) was conducted with 131 adult Thai patients with suspected severe sepsis (66 of whom ...

journal_title：Antimicrobial agents and chemotherapy

authors： Suputtamongkol Y,Intaranongpai S,Smith MD,Angus B,Chaowagul W,Permpikul C,Simpson JA,Leelarasamee A,Curtis L,White NJ

更新日期：2000-03-01 00:00:00

abstract：:We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-09-01 00:00:00

abstract：:Heteroresistance is the coexistence of populations with differing nucleotides at a drug resistance locus within a sample of organisms. Although Sanger sequencing is the gold standard for sequencing, it may be less sensitive than deep sequencing for detecting fluoroquinolone heteroresistance in Mycobacterium tuberculos...

journal_title：Antimicrobial agents and chemotherapy

authors： Eilertson B,Maruri F,Blackman A,Herrera M,Samuels DC,Sterling TR

更新日期：2014-06-01 00:00:00

abstract：:The antibiotic tolerances of bacterial persisters have been attributed to transient dormancy. While persisters have been observed to be growth inhibited prior to antibiotic exposure, we sought to determine whether such a trait was essential to the phenotype. Furthermore, we sought to provide direct experimental eviden...

journal_title：Antimicrobial agents and chemotherapy

authors： Orman MA,Brynildsen MP

更新日期：2013-07-01 00:00:00

abstract：:The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bauernfeind A,Stemplinger I,Jungwirth R,Giamarellou H

更新日期：1996-01-01 00:00:00

abstract：:Few studies have estimated the excess inpatient costs due to nosocomial cultures of Gram-negative bacteria (GNB), and those that do are often subject to time-dependent bias. Our objective was to generate estimates of the attributable costs of the underlying infections associated with nosocomial cultures by using a uni...

journal_title：Antimicrobial agents and chemotherapy

authors： Nelson RE,Stevens VW,Jones M,Khader K,Schweizer ML,Perencevich EN,Rubin MA,Samore MH

更新日期：2018-10-24 00:00:00

abstract：:Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the bactericidal efficacy of liposome-entrapped aminoglycosides against resistant clin...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugabe C,Halwani M,Azghani AO,Lafrenie RM,Omri A

更新日期：2006-06-01 00:00:00

abstract：:The oxazolidinones are a novel class of antibiotics that inhibit initiation of protein synthesis in bacteria. In order to investigate their novel mechanism of action, the interactions of several oxazolidinones with bacterial 70S ribosomes, 50S subunits, and 30S subunits have been characterized by (1)H nuclear magnetic...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou CC,Swaney SM,Shinabarger DL,Stockman BJ

更新日期：2002-03-01 00:00:00

abstract：:This study explored metronidazole and hydroxymetronidazole distribution in the cerebrospinal fluid (CSF) of brain-injured patients. Four brain-injured patients with external ventricular drain received 500 mg of metronidazole over 0.5 h every 8 h. CSF and blood samples were collected at steady state over 8 h, and the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Frasca D,Dahyot-Fizelier C,Adier C,Mimoz O,Debaene B,Couet W,Marchand S

更新日期：2014-01-01 00:00:00