Abstract:
:Mycobactin biosynthesis in Mycobacterium tuberculosis facilitates iron acquisition, which is required for growth and virulence. The mycobactin biosynthesis inhibitor salicyl-AMS [5'-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. Here, we conducted a single-dose pharmacokinetic study and a monotherapy study of salicyl-AMS with mice. Intraperitoneal injection yielded much better pharmacokinetic parameter values than oral administration did. Monotherapy of salicyl-AMS at 5.6 or 16.7 mg/kg significantly inhibited M. tuberculosis growth in the mouse lung, providing the first in vivo proof of concept for this novel antibacterial strategy.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Lun S,Guo H,Adamson J,Cisar JS,Davis TD,Chavadi SS,Warren JD,Quadri LE,Tan DS,Bishai WRdoi
10.1128/AAC.00918-13subject
Has Abstractpub_date
2013-10-01 00:00:00pages
5138-40issue
10eissn
0066-4804issn
1098-6596pii
AAC.00918-13journal_volume
57pub_type
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