Antimicrobial Activities of Ceftazidime-Avibactam and Comparator Agents against Clinical Bacteria Isolated from Patients with Cancer.


:A total of 521 unique clinical isolates from cancer patients with primarily (>90%) bloodstream infections were tested for susceptibility to ceftazidime-avibactam and comparators using broth microdilution methods. Ceftazidime-avibactam inhibited 97.8% of all Enterobacteriaceae (n = 321) at the susceptibility breakpoint of ≤8/4 μg/ml (there were 7 nonsusceptible strains). It was also active against Pseudomonas aeruginosa (91.7% isolates susceptible, n = 121), including many isolates not susceptible to meropenem, cefepime, ceftazidime, piperacillin-tazobactam, or other comparators.


Hachem R,Reitzel R,Rolston K,Chaftari AM,Raad I




Has Abstract


2017-03-24 00:00:00












  • In vitro activity of Bay 12-8039, a new 8-methoxyquinolone.

    abstract::MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-f...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fass RJ

    更新日期:1997-08-01 00:00:00

  • Effects of azithromycin in combination with vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on Staphylococcus epidermidis biofilms.

    abstract::Staphylococcal biofilms on surgical implants are the underlying cause of a lack of response to antimicrobial treatment. We investigated the effects of vancomycin (VAN), daptomycin (DAP), fosfomycin (FOS), tigecycline (TGC), and ceftriaxone (CRX), alone and in combination with azithromycin (AZI), on established biofilm...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Presterl E,Hajdu S,Lassnigg AM,Hirschl AM,Holinka J,Graninger W

    更新日期:2009-08-01 00:00:00

  • Action of a basic copolymer of ornithine and leucine on cells of Staphylococcus aureus.

    abstract::A basic, random copolymer of l-ornithine and l-leucine (OL; molar ratios 1:1) was bactericidal to a sensitive (S) strain of Staphylococcus aureus at low concentration. Resistant cells (R) were selected from the culture medium and, after serial transfers to solutions containing increasing amounts of the polymer, grew w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shenfeld A,Flowers HM,Katchalski E

    更新日期:1974-02-01 00:00:00

  • Cefepime versus imipenem-cilastatin for treatment of nosocomial pneumonia in intensive care unit patients: a multicenter, evaluator-blind, prospective, randomized study.

    abstract::In a randomized, evaluator-blind, multicenter trial, we compared cefepime (2 g three times a day) with imipenem-cilastatin (500 mg four times a day) for the treatment of nosocomial pneumonia in 281 intensive care unit patients from 13 centers in six European countries. Of 209 patients eligible for per-protocol analysi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Zanetti G,Bally F,Greub G,Garbino J,Kinge T,Lew D,Romand JA,Bille J,Aymon D,Stratchounski L,Krawczyk L,Rubinstein E,Schaller MD,Chiolero R,Glauser MP,Cometta A,Cefepime Study Group,.

    更新日期:2003-11-01 00:00:00

  • Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish.

    abstract::The structure-activity relations of myxinidin, a peptide derived from epidermal mucus of hagfish, Myxine glutinosa L., were investigated. Analysis of key residues allowed us to design new peptides with increased efficiency. Antimicrobial activity of native and modified peptides demonstrated the key role of uncharged r...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cantisani M,Leone M,Mignogna E,Kampanaraki K,Falanga A,Morelli G,Galdiero M,Galdiero S

    更新日期:2013-11-01 00:00:00

  • Action of chlorhexidine digluconate against yeast and filamentous forms in an early-stage Candida albicans biofilm.

    abstract::An in situ method for sensitive detection of differences in the action of chlorhexidine against subpopulations of cells in Candida albicans biofilms is described. Detection relies on monitoring the kinetics of propidium iodide (PI) penetration into the cytoplasm of individual cells during dosing with chlorhexidine. Ac...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Suci PA,Tyler BJ

    更新日期:2002-11-01 00:00:00

  • 100 Years of Suramin.

    abstract::Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma bruceirhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. Suramin is also an e...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,评审


    authors: Wiedemar N,Hauser DA,Mäser P

    更新日期:2020-02-21 00:00:00

  • Standardization of disk diffusion test and its clinical significance for susceptibility testing of metronidazole against Helicobacter pylori.

    abstract::Susceptibilities of 121 clinical Helicobacter pylori strains to metronidazole were determined by both a 5-micrograms metronidazole disk diffusion test and a plate dilution method in duplicate and after different periods of incubation. The distribution of MICs of metronidazole against H. pylori among the strains was fo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Xia H,Keane CT,Beattie S,O'Morain CA

    更新日期:1994-10-01 00:00:00

  • Doravirine and the Potential for CYP3A-Mediated Drug-Drug Interactions.

    abstract::Identifying and understanding potential drug-drug interactions (DDIs) are vital for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. This article discusses DDIs between doravirine, a nonnucleoside reverse transcriptase inhibitor (NNRTI), and cytochrome P450 3A (CYP3A) substrates and drugs that m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Khalilieh SG,Yee KL,Sanchez RI,Fan L,Anderson MS,Sura M,Laethem T,Rasmussen S,van Bortel L,van Lancker G,Iwamoto M

    更新日期:2019-04-25 00:00:00

  • Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans.

    abstract::Platelet microbicidal proteins (PMPs) are believed to be integral to host defense against endovascular infection. We previously demonstrated that susceptibility to thrombin-induced PMP 1 (tPMP-1) in vitro negatively influences Candida albicans virulence in the rabbit model of infective endocarditis (IE). This study ev...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yeaman MR,Cheng D,Desai B,Kupferwasser LI,Xiong YQ,Gank KD,Edwards JE Jr,Bayer AS

    更新日期:2004-08-01 00:00:00

  • Pharmacokinetics, safety, and tolerability of faldaprevir in patients with renal impairment.

    abstract::Faldaprevir is a potent hepatitis C virus (HCV) NS3/4A protease inhibitor with negligible urinary excretion. We assessed the pharmacokinetics and safety of a single oral dose of faldaprevir (480 mg) in 32 HCV-negative subjects with renal impairment or normal renal function. Compared with subjects with normal renal fun...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Huang F,Moschetti V,Lang B,Halabi A,Petersen-Sylla M,Yong CL,Elgadi M

    更新日期:2015-01-01 00:00:00

  • Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155

    abstract::TEM- and SHV-type extended-spectrum beta-lactamases (ESBLs) are the most common ESBLs found in the United States and are prevalent throughout the world. Amino acid substitutions at a number of positions in TEM-1 lead to the ESBL phenotype, although substitutions at residues 104 (E to K), 164 (R to S or H), 238 (G to S...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jones CH,Ruzin A,Tuckman M,Visalli MA,Petersen PJ,Bradford PA

    更新日期:2009-03-01 00:00:00

  • Mechanism of Pseudomonas aeruginosa persistence during treatment with broad-spectrum cephalosporins of lung infections in patients with cystic fibrosis.

    abstract::Beta-lactam resistance in Pseudomonas aeruginosa detected only during ceftazidime therapy of cystic fibrosis patients was studied. Evaluation of resistant and susceptible isolates from one patient and resistant laboratory derivatives indicated that elevated beta-lactamase levels were the primary determinant of resista...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Schryvers AB,Ogunariwo J,Chamberland S,Godfrey AJ,Rabin HR,Bryan LE

    更新日期:1987-09-01 00:00:00

  • Determination of robust ocular pharmacokinetic parameters in serum and vitreous humor of albino rabbits following systemic administration of ciprofloxacin from sparse data sets by using IT2S, a population pharmacokinetic modeling program.

    abstract::Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the determination of conce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Drusano GL,Liu W,Perkins R,Madu A,Madu C,Mayers M,Miller MH

    更新日期:1995-08-01 00:00:00

  • Quality assessment of U.S. marketplace vancomycin for injection products using high-resolution liquid chromatography-mass spectrometry and potency assays.

    abstract::In response to a published concern about the potency and quality of generic vancomycin products, the United States Food and Drug Administration investigated a small sampling of the vancomycin products available in North America with regard to purity, content, and potency. To facilitate identification of impurities, a ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hadwiger ME,Sommers CD,Mans DJ,Patel V,Boyne MT 2nd

    更新日期:2012-06-01 00:00:00

  • Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains.

    abstract::PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sader HS,Fritsche TR,Kaniga K,Ge Y,Jones RN

    更新日期:2005-08-01 00:00:00

  • 8-aminoquinolines effective against Pneumocystis carinii in vitro and in vivo.

    abstract::The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Queener SF,Bartlett MS,Nasr M,Smith JW

    更新日期:1993-10-01 00:00:00

  • Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice.

    abstract::The comparative activities of azithromycin (AZI) and clarithromycin (CLA) against eight Mycobacterium avium complex (MAC) isolates were evaluated in the beige mouse model of disseminated infection. Mice were infected intravenously with approximately 10(7) viable MAC isolate. AZI at 100 or 200 mg/kg of body weight or C...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cynamon MH,Klemens SP,Grossi MA

    更新日期:1994-07-01 00:00:00

  • Plasmid-mediated penicillin beta-lactamases in Pseudomonas aeruginosa.

    abstract::A penicillin beta-lactamase (PCase) was extracted from Pseudomonas aeruginosa Rms139(+) and purified by means of column chromatography. The isoelectric point of Rms139 PCase was 5.7 and its molecular weight was 22,500 +/- 1,000. The optimal pH for the hydrolysis of benzylpenicillin was 7.0 to 7.5 and the optimal tempe...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sawada Y,Yaginuma S,Tai M,Iyobe S,Mitsuhashi S

    更新日期:1976-01-01 00:00:00

  • Antifungal activities of natural and synthetic iron chelators alone and in combination with azole and polyene antibiotics against Aspergillus fumigatus.

    abstract::Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy agains...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zarember KA,Cruz AR,Huang CY,Gallin JI

    更新日期:2009-06-01 00:00:00

  • Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection.

    abstract::Groups of mice infected intravenously with Candida albicans were treated intraperitoneally with amphotericin B, caspofungin, or fluconazole, starting at intervals before and after challenge. Survival was longest and tissue burdens were most reduced with early treatment, and survival times fell proportionately as treat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: MacCallum DM,Odds FC

    更新日期:2004-12-01 00:00:00

  • Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin (AeroVanc) in Volunteers and Patients with Cystic Fibrosis: a New Approach to Therapy for Methicillin-Resistant Staphylococcus aureus.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has become a significant acute and chronic respiratory pathogen. While vancomycin is effective against MRSA, its relatively poor penetration into lung secretions and dose-limiting renal toxicity make it less effective in the respiratory setting. As inhaled administrat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Waterer G,Lord J,Hofmann T,Jouhikainen T

    更新日期:2020-02-21 00:00:00

  • In vitro intracellular activity and in vivo efficacy of modithromycin, a novel bicyclolide, against Legionella pneumophila.

    abstract::The in vitro and in vivo activities of modithromycin, a novel bicyclolide, against Legionella pneumophila were compared with those of telithromycin, clarithromycin, azithromycin, and levofloxacin. All the test agents decreased the intracellular growth of viable L. pneumophila bacteria over 96 h of incubation in both t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sato T,Tateda K,Kimura S,Ishii Y,Yamaguchi K

    更新日期:2011-04-01 00:00:00

  • Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.

    abstract::Both recombinant alpha A interferon and azidothymidine inhibit the replication of human immunodeficiency virus in peripheral blood mononuclear cells. Combinations of recombinant alpha A interferon and azidothymidine at concentrations that are easily achievable in patients synergistically inhibit human immunodeficiency...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hartshorn KL,Vogt MW,Chou TC,Blumberg RS,Byington R,Schooley RT,Hirsch MS

    更新日期:1987-02-01 00:00:00

  • Accuracy of Kirby-Bauer susceptibility tests read at 4, 8, and 12 hours of incubation: comparison with readings at 18 to 20 hours.

    abstract::Disk diffusion antibiotic susceptibility tests as performed by the hospital diagnostic microbiology laboratory were read at 4, 8, and 12 h of incubation and compared to the traditional 18-h readings. Both the zone size in millimeters and a judgement of susceptible or resistant were recorded by the investigator at each...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kluge RM

    更新日期:1975-08-01 00:00:00

  • Low levels of pyrazinamide and ethambutol in children with tuberculosis and impact of age, nutritional status, and human immunodeficiency virus infection.

    abstract::Recent pharmacokinetic studies that included children found that serum drug levels were low compared to those of adults for whom the same dosages were used. This study aimed to characterize the pharmacokinetics of pyrazinamide and ethambutol in Malawian children and to examine the impact of age, nutritional status, an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Graham SM,Bell DJ,Nyirongo S,Hartkoorn R,Ward SA,Molyneux EM

    更新日期:2006-02-01 00:00:00

  • In vitro activity of p-hydroxybenzyl penicillin (penicillin X) and five other penicillins against Neisseria gonorrhoeae: comparisons of strains from patients with uncomplicated infections and from women with pelvic inflammatory disease.

    abstract::Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of Neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strain...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sackel SG,Alpert S,Rosner B,McCormack WM,Finland M

    更新日期:1977-07-01 00:00:00

  • Complete Sequences of mcr-1-Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae.

    abstract::Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Li A,Yang Y,Miao M,Chavda KD,Mediavilla JR,Xie X,Feng P,Tang YW,Kreiswirth BN,Chen L,Du H

    更新日期:2016-06-20 00:00:00

  • Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance.

    abstract::The rapid and global emergence of azole resistance in the human pathogen Aspergillus fumigatus has drawn attention. Thus, a thorough understanding of its mechanisms of drug resistance requires extensive exploration. In this study, we found that the loss of the putative calcium-dependent protein-encoding gene algA caus...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wei X,Chen P,Gao R,Li Y,Zhang A,Liu F,Lu L

    更新日期:2016-12-27 00:00:00

  • Neutralizing viruses in suspensions by copper oxide-based filters.

    abstract::We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses fou...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Borkow G,Sidwell RW,Smee DF,Barnard DL,Morrey JD,Lara-Villegas HH,Shemer-Avni Y,Gabbay J

    更新日期:2007-07-01 00:00:00