In vitro antifungal susceptibilities of Sporothrix schenckii in two growth phases.

abstract：:With the rapid spread of antimicrobial resistance in Gram-negative pathogens, biofilm-associated infections are increasingly harder to treat and combination therapy with colistin has become one of the most efficient therapeutic strategies. Our study aimed to evaluate the potential for the synergy of colistin combined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan JH,Vidaillac C,Yam JKH,Chua SL,Givskov M,Yang L

更新日期：2017-06-27 00:00:00

abstract：:Exposure of erythromycin solutions to CO(2) or air for 18 h resulted in minimal deterioration under both conditions. Saturated disks exposed to the two atmospheres resulted in greater erythromycin deterioration, with slightly more deterioration occurring in the presence of CO(2). Reduction of activity was greatest whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Sutter VL

更新日期：1983-02-01 00:00:00

abstract：:Two nitrosoureas, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), with strong carbamoylating and weak alkylating activities, interfered with the induction of potassium leakage and lethal action of amphotericin B (AmB) on Candida albicans. 2-Cyclohexyl isocyanate, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Brajtburg J,Elberg S,Kobayashi GS,Medoff G

更新日期：1988-03-01 00:00:00

abstract：:Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserv...

journal_title：Antimicrobial agents and chemotherapy

authors： Hölzel CS,Harms KS,Schwaiger K,Bauer J

更新日期：2010-03-01 00:00:00

abstract：:The effect of moxalactam and cefuroxime on mitogen-stimulated human peripheral blood mononuclear leukocytes was studied. Mononuclear leukocytes, mitogen, and antibiotic were added to microtiter wells. Cells were cultured for 3 days, pulsed with tritiated thymidine, and then counted. Compared with control cell cultures...

journal_title：Antimicrobial agents and chemotherapy

authors： Manzella JP,Clark JK

更新日期：1983-03-01 00:00:00

abstract：:It has previously been shown that overexpression of the CdMDR1 gene is a major contributor to resistance in fluconazole-resistant isolates of Candida dubliniensis. However, since CdMdr1p does not mediate transport of other azole drugs such as itraconazole, we investigated the molecular mechanisms of stable resistance ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pinjon E,Moran GP,Jackson CJ,Kelly SL,Sanglard D,Coleman DC,Sullivan DJ

更新日期：2003-08-01 00:00:00

abstract：:A penicillin beta-lactamase (PCase) was extracted from Pseudomonas aeruginosa Rms139(+) and purified by means of column chromatography. The isoelectric point of Rms139 PCase was 5.7 and its molecular weight was 22,500 +/- 1,000. The optimal pH for the hydrolysis of benzylpenicillin was 7.0 to 7.5 and the optimal tempe...

journal_title：Antimicrobial agents and chemotherapy

authors： Sawada Y,Yaginuma S,Tai M,Iyobe S,Mitsuhashi S

更新日期：1976-01-01 00:00:00

abstract：:The polyene antifungal amphotericin B (AmB) is widely used to treat life-threatening fungal infections. Even though AmB resistance is exceptionally rare in fungi, most Aspergillus terreus isolates exhibit an intrinsic resistance against the drug in vivo and in vitro. Heat shock proteins perform a fundamental protectiv...

journal_title：Antimicrobial agents and chemotherapy

authors： Blatzer M,Blum G,Jukic E,Posch W,Gruber P,Nagl M,Binder U,Maurer E,Sarg B,Lindner H,Lass-Flörl C,Wilflingseder D

更新日期：2015-07-01 00:00:00

abstract：:Mycobacteria grew rapidly in FST medium (tissue culture medium F12 supplemented with 5% serum and 0.05% Tween 80). Growth of Mycobacterium tuberculosis and other niacin-negative mycobacteria in flat-bottomed, 96-well tissue culture plates was estimable by the naked eye within 3 to 5 days when mycobacteria were inocula...

journal_title：Antimicrobial agents and chemotherapy

authors： Nozawa RT,Yokota T

更新日期：1983-08-01 00:00:00

abstract：:The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both species. In dogs, c...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller WM

更新日期：1977-07-01 00:00:00

abstract：:Fenpropimorph was shown to inhibit the accumulation of the pyrimidine bases uracil and cytosine from the growth media in Saccharomyces cerevisiae. Uracil prototrophs of S. cerevisiae were more resistant to the growth-inhibitory effects of fenpropimorph than were uracil auxotrophs. High concentrations of uracil rescued...

journal_title：Antimicrobial agents and chemotherapy

authors： Crowley JH,Lorenz RT,Parks LW

更新日期：1994-05-01 00:00:00

abstract：:The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human volunteers. Serum levels of tetracycline were uniformly reduced by approximately 50% by all test meals, whereas serum level...

journal_title：Antimicrobial agents and chemotherapy

authors： Welling PG,Koch PA,Lau CC,Craig WA

更新日期：1977-03-01 00:00:00

abstract：:Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, and expressed the wild-type B. gibsoni dhfr-ts gene in Escherichia coli and evaluated the inhib...

journal_title：Antimicrobial agents and chemotherapy

authors： Aboge GO,Jia H,Terkawi MA,Goo YK,Nishikawa Y,Sunaga F,Namikawa K,Tsuji N,Igarashi I,Suzuki H,Fujisaki K,Xuan X

更新日期：2008-11-01 00:00:00

abstract：:Clinical isolates of Trichomonas vaginalis were obtained from women consecutively enrolled in a study of partner notification. Testing of susceptibility to metronidazole and tinidazole was performed. Resistance to metronidazole and tinidazole was present in 17/178 (9.6%) and 1/178 (0.56%) strains, respectively. In vit...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwebke JR,Barrientes FJ

更新日期：2006-12-01 00:00:00

abstract：:Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC(90)] 1 microg...

journal_title：Antimicrobial agents and chemotherapy

authors： Ruiz-Serrano MJ,Alcalá L,Martínez L,Díaz M,Marín M,González-Abad MJ,Bouza E

更新日期：2000-09-01 00:00:00

abstract：:Filibuvir and VX-222 are nonnucleoside inhibitors (NNIs) that bind to the thumb II allosteric pocket of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. Both compounds have shown significant promise in clinical trials and, therefore, it is relevant to better understand their mechanisms of inhibition. In our s...

journal_title：Antimicrobial agents and chemotherapy

authors： Yi G,Deval J,Fan B,Cai H,Soulard C,Ranjith-Kumar CT,Smith DB,Blatt L,Beigelman L,Kao CC

更新日期：2012-02-01 00:00:00

abstract：:We have quantified the biological cost of VanA-type glycopeptide resistance due to the acquisition of the resistance operon by methicillin-resistant Staphylococcus aureus (MRSA) from Enterococcus sp. Exponential growths of recipient strain HIP11713, its transconjugant VRSA-1, VRSA-5, and VRSA-6 were compared in the ab...

journal_title：Antimicrobial agents and chemotherapy

authors： Foucault ML,Courvalin P,Grillot-Courvalin C

更新日期：2009-06-01 00:00:00

abstract：:An antibody induced in rabbits against a gentamicin-bovine serum albumin conjugate cross-reacted with the chemically related aminoglycoside, sisomicin, facilitating the development of a sisomicin radioimmunoassay. Sisomicin was labeled with (125)I using an acylating agent [3-(4-hydroxyphenyl)propionic acid-N-hydroxy-s...

journal_title：Antimicrobial agents and chemotherapy

authors： Broughton A,Strong JE,Bodey GP

更新日期：1976-02-01 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:The gene ere(A) of the plasmid pIP1100 is larger than originally reported and is organized as an integron gene cassette. The ere(A) gene cassette carries its own promoter and is propagated by a class 2 integron with an insertion sequence element, IS1, inserted upstream of the intI2 gene. The mobility of the ere(A) cas...

journal_title：Antimicrobial agents and chemotherapy

authors： Biskri L,Mazel D

更新日期：2003-10-01 00:00:00

abstract：:The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase (RT) is rapidly selected in tissue culture following serial passage of wild-type virus in the presence of increasing concentrations of lamivudine (3TC). M184V is also associated with several alterations of RT enzymatic function in vitr...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrella M,Oliveira M,Moisi D,Detorio M,Brenner BG,Wainberg MA

更新日期：2004-11-01 00:00:00

abstract：:Routine in vitro screening of a new synthetic series of 3,5-substituted 2-methylisoxazolidines revealed that three imidazole analogs (PR 967-248, PR 967-234, and PR 969-566) and, to a lesser extent, a triazole analog (PR 988-399) exerted rather potent antifungal activity against three systemic and four dermatophytic c...

journal_title：Antimicrobial agents and chemotherapy

authors： Palmer GC,Ordy MJ,Simmons RD,Strand JC,Radov LA,Mullen GB,Kinsolving CR,St Georgiev V,Mitchell JT,Allen SD

更新日期：1989-06-01 00:00:00

abstract：:The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamashita K,Kawabe H,Mitsuhashi S

更新日期：1981-07-01 00:00:00

abstract：:Mecillinam is an amidino penicillinate derivative with a broad spectrum of activity against many gram-negative bacilli. Moreover, marked in vitro synergy against these organisms occurs when mecillinam is combined with other beta-lactam antibiotics. The purpose of this study was to determine the pharmacokinetic disposi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gambertoglio JG,Barriere SL,Lin ET,Conte JE Jr

更新日期：1980-12-01 00:00:00

abstract：:We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B....

journal_title：Antimicrobial agents and chemotherapy

authors： Kontoyiannis DP,Lewis RE,Sagar N,May G,Prince RA,Rolston KV

更新日期：2000-10-01 00:00:00

abstract：:This is a substudy of a larger randomized controlled trial on HIV-infected Zambian children, which revealed that cotrimoxazole prophylaxis reduced morbidity and mortality despite a background of high cotrimoxazole resistance. The impact of cotrimoxazole on the carriage and antibiotic resistance of Streptococcus pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mwenya DM,Charalambous BM,Phillips PP,Mwansa JC,Batt SL,Nunn AJ,Walker S,Gibb DM,Gillespie SH

更新日期：2010-09-01 00:00:00

abstract：:A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and Acinetobacter baumannii complex (n = 199) was analyzed for susceptibility. Xpert Carba-R assay and sequencing for mcr genes were performed for carbapenem- or colistin-re...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu PY,Lee YL,Lu MC,Shao PL,Lu PL,Chen YH,Cheng SH,Ko WC,Lin CY,Wu TS,Yen MY,Wang LS,Liu CP,Lee WS,Chen YS,Wang FD,Tseng SH,Lin CN,Tang HJ,Chen YH,Sheng WH,Lee CM,Liao MH,Hsueh PR

更新日期：2020-09-21 00:00:00

abstract：:A sensitive and specific high-pressure liquid chromatographic method is described for the determination of the antibacterial drug flumequine and a major metabolite, 7-hydroxyflumequine, in human plasma and urine. The assay was linear over a concentration range of 1 to 120 micrograms/ml for both compounds. This method ...

journal_title：Antimicrobial agents and chemotherapy

authors： Harrison LI,Schuppan D,Rohlfing SR,Hansen AR,Hansen CS,Funk ML,Collins SH,Ober RE

更新日期：1984-03-01 00:00:00

abstract：:The effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on herpes simplex virus type 1 DNA and protein synthesis was studied. Ganciclovir markedly inhibited the synthesis of viral DNA and gamma proteins in a dose-dependent manner. However, the synthesis of viral beta proteins was significantly increased b...

journal_title：Antimicrobial agents and chemotherapy

authors： Chun YS,Park NH

更新日期：1987-02-01 00:00:00

abstract：:The time course of plasma drug levels and urinary recovery for two lipopeptide antifungal antibiotics, L-671,329 and cilofungin, were measured in male rhesus monkeys (Macaca mulatta) and in female DBA/2 mice. The antibiotics were administered intravenously at 10 mg/kg of body weight in phosphate-buffered saline-26% po...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundelof JG,Hajdu R,Cleare WJ,Onishi J,Kropp H

更新日期：1992-03-01 00:00:00