Interaction of Rifampin and Darunavir-Ritonavir or Darunavir-Cobicistat In Vitro.

abstract：:The effect of ethambutol (EMB) is primarily on polymerization steps in the biosynthesis of the arabinan component of cell wall arabinogalactan (AG) of Mycobacterium smegmatis. Inhibition of the synthesis of the arabinan of lipoarabinomannan (LAM) occurred later, and thus in the cases of AG and LAM, the polymerization ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mikusová K,Slayden RA,Besra GS,Brennan PJ

更新日期：1995-11-01 00:00:00

abstract：:Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus Candida albicans, which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN s...

journal_title：Antimicrobial agents and chemotherapy

authors： Willems HME,Stultz JS,Coltrane ME,Fortwendel JP,Peters BM

更新日期：2019-10-22 00:00:00

abstract：:Study of the antimicrobial spectrum of valinomycin revealed that, in addition to the gram-positive bacteria reported in literature, Streptococcus pyogenes and Clostridium sporogenes are also susceptible to this antibiotic. The minimal inhibitory concentrations (MIC) of the antibiotic for S. pyogenes grown aerobically ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seshachalam D,Frahm DH,Ferraro FM

更新日期：1973-01-01 00:00:00

abstract：:Penicillin-binding proteins (PBPs) of 15 selected penicillin- and amoxicillin-resistant Streptococcus pneumoniae isolates (MICs of 2 to 8 and 8 to 16 microg/ml, respectively) were studied. In addition to typical changes in PBPs 1A and 2X, these strains had 10 unique changes in PBP 2B, including a (618)A-G substitution...

journal_title：Antimicrobial agents and chemotherapy

authors： Kosowska K,Jacobs MR,Bajaksouzian S,Koeth L,Appelbaum PC

更新日期：2004-10-01 00:00:00

abstract：:There is a high prevalence of beta-lactam- and macrolide-resistant Streptococcus pneumoniae in Taiwan. To understand the in vitro susceptibilities of recent isolates of S. pneumoniae to fluoroquinolones and telithromycin (which is not available in Taiwan), the MICs of 23 antimicrobial agents for 936 clinical isolates ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hsueh PR,Teng LJ,Wu TL,Yang D,Huang WK,Shyr JM,Chuang YC,Wan JH,Yan JJ,Lu JJ,Wu JJ,Ko WC,Chang FY,Yang YC,Lau YJ,Liu YC,Lee CM,Leu HS,Liu CY,Luh KT,SMART Program 2001 Data.

更新日期：2003-07-01 00:00:00

abstract：:Two new fluorinated oxazolidinones, U-100592 and U-100766, were evaluated against more than 659 gram-positive and -negative organisms and compared with glycopeptides, erythromycin, clindamycin, clinafloxacin, and chloramphenicol. U-100592 and U-100766 were usually equally potent, but the MICs at which 90% of the isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Johnson DM,Erwin ME

更新日期：1996-03-01 00:00:00

abstract：:Piperacillin is a new semisynthetic, expanded-spectrum penicillin with marked activity against Pseudomonas aeruginosa. The biliary excretion of piperacillin was studied in patients undergoing cholecystectomy. Concentrations of piperacillin in common duct bile at 35 to 90 min postinfusion of 1-g doses ranged from 31 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Giron JA,Meyers BR,Hirschman SZ

更新日期：1981-02-01 00:00:00

abstract：:Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pandori M,Barry PM,Wu A,Ren A,Whittington WL,Liska S,Klausner JD

更新日期：2009-09-01 00:00:00

abstract：:Sulfobutylether-beta-cyclodextrin (SBECD), a large cyclic oligosaccharide that is used to solubilize voriconazole (VRC) for intravenous administration, is eliminated mainly by renal excretion. The pharmacokinetics of SBECD and voriconazole in patients undergoing extracorporeal renal replacement therapies are not well ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hafner V,Czock D,Burhenne J,Riedel KD,Bommer J,Mikus G,Machleidt C,Weinreich T,Haefeli WE

更新日期：2010-06-01 00:00:00

abstract：:We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total, were highly cefoxitin resistant and had minimum inhibitory concentrations of greater than or equal to 64 micrograms/ml. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuchural GJ Jr,Tally FP,Jacobus NV,Marsh PK,Mayhew JW

更新日期：1983-12-01 00:00:00

abstract：:The pharmacodynamic properties of levofloxacin (an optically active isomer of ofloxacin), ofloxacin, and ciprofloxacin, alone and in combination with rifampin, were evaluated over 24 to 48 h against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA 1199 and MRSA 494, respectively)...

journal_title：Antimicrobial agents and chemotherapy

authors： Kang SL,Rybak MJ,McGrath BJ,Kaatz GW,Seo SM

更新日期：1994-12-01 00:00:00

abstract：:Nephrotoxicity is the main complication of gentamicin (GM) treatment. GM induces renal damage by overproduction of reactive oxygen species and inflammation in proximal tubular cells. Phenolic compounds from ginger, called gingerols, have been demonstrated to have antioxidant and anti-inflammatory effects. We investiga...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodrigues FA,Prata MM,Oliveira IC,Alves NT,Freitas RE,Monteiro HS,Silva JA,Vieira PC,Viana DA,Libório AB,Havt A

更新日期：2014-01-01 00:00:00

abstract：:The in vitro activities of four fluoroquinolone compounds were tested against 92 Escherichia coli strains of ovine and caprine origin under aerobic and anaerobic incubation conditions. The four fluoroquinolones proved to be highly effective against the E. coli isolates tested. When bacteria were cultured anaerobically...

journal_title：Antimicrobial agents and chemotherapy

authors： Cid D,Piriz S,Ruiz-Santa-Quiteria JA,Valle J,Garcia S,Vadillo S,de la Fuente R

更新日期：1994-10-01 00:00:00

abstract：:The rapid infusion of hyperosmolar solutions into the internal carotid artery transiently disrupts the integrity of the blood-brain barrier, permitting entry of substances normally excluded from the nervous system. This study examined the effect of such an infusion on the penetration of vancomycin and tobramycin into ...

journal_title：Antimicrobial agents and chemotherapy

authors： Perkins BA,Strausbaugh LJ

更新日期：1983-09-01 00:00:00

abstract：:An efficient and reproducible procedure was developed for extracting aminoglycosides from renal cortical tissue. It involves a double homogenization and two rinsings with trichloroacetic acid. A higher recovery is obtained compared with that of other previously reported methods. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giuliano RA,Verpooten GA,Pollet DE,Verbist L,Scharpé SL,De Broe ME

更新日期：1984-06-01 00:00:00

abstract：:Chronic wound infections are associated with biofilm formation, which in turn has been correlated with drug resistance. However, the mechanism by which bacteria form biofilms in clinical environments is not clearly understood. This study was designed to investigate the biofilm formation potency of Acinetobacter bauman...

journal_title：Antimicrobial agents and chemotherapy

authors： He X,Lu F,Yuan F,Jiang D,Zhao P,Zhu J,Cheng H,Cao J,Lu G

更新日期：2015-08-01 00:00:00

abstract：:Emergence of resistance to pentavalent antimonials has become a severe obstacle in the treatment of visceral leishmaniasis (VL) on the Indian subcontinent. The mechanisms operating in laboratory-generated strains are somewhat known, but the determinants of clinical antimony resistance are not well understood. By utili...

journal_title：Antimicrobial agents and chemotherapy

authors： Ashutosh,Garg M,Sundar S,Duncan R,Nakhasi HL,Goyal N

更新日期：2012-01-01 00:00:00

abstract：:Expression of high-level beta-lactam resistance is known to be thermosensitive in many methicillin-resistant Staphylococcus aureus (MRSA) strains, including strain COL, in which the high methicillin MIC for cultures grown at 37 degrees C (800 microg/ml) was reduced to 12 microg/ml at 42 degrees C. COL grew faster at 4...

journal_title：Antimicrobial agents and chemotherapy

authors： Sieradzki K,Chung M,Tomasz A

更新日期：2008-02-01 00:00:00

abstract：:Artermisinin and its derivatives are now the mainstays of antimalarial treatment; however, their mechanism of action is only poorly understood. We report on the synthesis of a novel series of epoxy-endoperoxides that can be prepared in high yields from simple starting materials. Endoperoxides that are disubstituted wi...

journal_title：Antimicrobial agents and chemotherapy

authors： del Pilar Crespo M,Avery TD,Hanssen E,Fox E,Robinson TV,Valente P,Taylor DK,Tilley L

更新日期：2008-01-01 00:00:00

abstract：:Antibiotic resistance of biofilm-grown bacteria contributes to chronic infections, such as marginal and periapical periodontitis, which are strongly associated with Porphyromonas gingivalis. Concurrent azithromycin (AZM) administration and mechanical debridement improve the clinical parameters of periodontal tissue in...

journal_title：Antimicrobial agents and chemotherapy

authors： Maezono H,Noiri Y,Asahi Y,Yamaguchi M,Yamamoto R,Izutani N,Azakami H,Ebisu S

更新日期：2011-12-01 00:00:00

abstract：:By cloning studies and complementation experiments, the sulfonamide resistance gene of a serogroup B and serotype 15 (B:15) strain of Neisseria meningitidis was localized to a 1.2-kb chromosomal SspI fragment expressing a drug-resistant dihydropteroate synthase. The fragment hybridized to DNA from both resistant and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kristiansen BE,Rådström P,Jenkins A,Ask E,Facinelli B,Sköld O

更新日期：1990-11-01 00:00:00

abstract：:Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic...

journal_title：Antimicrobial agents and chemotherapy

authors： Skinner-Adams T,Davis TM

更新日期：1999-05-01 00:00:00

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:Recently, strains of Neisseria gonorrhoeae have been isolated which are highly resistant to tetracycline (MICs of 16 to 64 micrograms/ml). This resistance was due to the acquisition of the resistance determinant tetM, a transposon-borne determinant initially found in the genus Streptococcus and more recently in Mycopl...

journal_title：Antimicrobial agents and chemotherapy

authors： Morse SA,Johnson SR,Biddle JW,Roberts MC

更新日期：1986-11-01 00:00:00

abstract：:Bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. We have developed a poly(U) mRNA-directed aminoacylation/translation protein synthesis system composed of phenyl-tRNA synthetases, ribosomes, and ribosomal factors from Escherichia coli. This system, utilizing purified c...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribble W,Hill WE,Ochsner UA,Jarvis TC,Guiles JW,Janjic N,Bullard JM

更新日期：2010-11-01 00:00:00

abstract：:Minimal inhibitory concentrations of carbenicillin, chloramphenicol, tetracycline, gentamicin, tobramycin, and trimethoprim-sulfamethoxazole were determined for rough, smooth, and mucoid Pseudomonas sp. isolates from sputa collected from 40 cystic fibrosis patients. Ninety-four percent of the minimal inhibitory concen...

journal_title：Antimicrobial agents and chemotherapy

authors： Maybury BA,Blessing-Moore J,deWit SA,Lewiston NJ,Yeager AS

更新日期：1979-03-01 00:00:00

abstract：:During a 6-month period, 21 pairs of Pseudomonas aeruginosa isolates susceptible (pretherapy) and resistant (posttherapy) to antipseudomonal beta-lactam antibiotics were isolated from hospitalized patients. In vivo emergence of beta-lactam resistance was associated with the overexpression of AmpC beta-lactamase in 10 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziha-Zarifi I,Llanes C,Köhler T,Pechere JC,Plesiat P

更新日期：1999-02-01 00:00:00

abstract：:As the site of insertion of the aadB gene cassette on pRAY, from a clinical isolate of Acinetobacter, is almost identical to the preferred site on integrons, the composite 59-base element (59-BE) associated with this cassette is potentially recombinationally active. By using a conduction assay to quantitate site activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Segal H,Francia MV,Lobo JM,Elisha G

更新日期：1999-10-01 00:00:00

abstract：:We investigated a possible synergistic effect of a macrolide and beta-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin E,Stanek RJ,Mufson MA

更新日期：2003-03-01 00:00:00

abstract：:The aromatic diamidines represent a class of compounds with broad-spectrum antimicrobial activity; however, their development is hindered by a lack of understanding of their mechanism of antimicrobial action. DB75 [2,5-bis(4-amidinophenyl)furan] is a trypanocidal aromatic diamidine that was originally developed as a s...

journal_title：Antimicrobial agents and chemotherapy

authors： Lanteri CA,Trumpower BL,Tidwell RR,Meshnick SR

更新日期：2004-10-01 00:00:00