Cloning and characterization of a DNA fragment that confers sulfonamide resistance in a serogroup B, serotype 15 strain of Neisseria meningitidis.

abstract：:The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there have been increasing recommendations for self-initiated therapy and use of prophylactic drugs for TD. We last examined the in vitro susceptibilities of commonly used antibiotics against TD pathogens in 1997. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ouyang-Latimer J,Jafri S,VanTassel A,Jiang ZD,Gurleen K,Rodriguez S,Nandy RK,Ramamurthy T,Chatterjee S,McKenzie R,Steffen R,DuPont HL

更新日期：2011-02-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:Trimethoprim resistance dihydrofolate reductase genes from plasmids known to be exchanging between human and animal populations were mapped. The dihydrofolate reductase gene has been highly conserved in all plasmids, but differences in the flanking regions provide evidence that the most recent exchange of plasmids bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Campbell IG,Mee BJ

更新日期：1987-09-01 00:00:00

abstract：:With the rapid spread of antimicrobial resistance in Gram-negative pathogens, biofilm-associated infections are increasingly harder to treat and combination therapy with colistin has become one of the most efficient therapeutic strategies. Our study aimed to evaluate the potential for the synergy of colistin combined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan JH,Vidaillac C,Yam JKH,Chua SL,Givskov M,Yang L

更新日期：2017-06-27 00:00:00

abstract：:Kill-kinetic methods were used to provide data on the bactericidal activity of subinhibitory (0.5x MIC), inhibitory (1x MIC), and suprainhibitory (4x MIC) concentrations of LY146032 against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis. These bactericidal activities were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Liu C,Weeks LS

更新日期：1987-08-01 00:00:00

abstract：:The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral do...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramon J,Dautrey S,Farinoti R,Carbon C,Rubinstein E

更新日期：1996-01-01 00:00:00

abstract：:The in vitro activity of gentamicin was compared with its therapeutic efficacy in rabbits with Streptococcus faecalis endocarditis. The test strain was resistant to gentamicin as measured by MICs and MBCs determined in Mueller-Hinton broth alone or in broth supplemented with 50% rabbit serum. Gentamicin also failed to...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullam PM,Täuber MG,Hackbarth CJ,Sande MA

更新日期：1985-02-01 00:00:00

abstract：:The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murin...

journal_title：Antimicrobial agents and chemotherapy

authors： Hosaka M,Gotoh N,Nishino T

更新日期：1995-08-01 00:00:00

abstract：:The global spread of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has been largely associated with sequence type 258 (ST258) and its related variants (clonal group 258 [CG258]). Here we describe the molecular epidemiology of CR-Kp from five tertiary care hospitals in Medellín, the second largest city in Colombia...

journal_title：Antimicrobial agents and chemotherapy

authors： Ocampo AM,Chen L,Cienfuegos AV,Roncancio G,Chavda KD,Kreiswirth BN,Jiménez JN

更新日期：2015-10-26 00:00:00

abstract：:The carbapenem-hydrolyzing class D β-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Girlich D,Damaceno QS,Oliveira AC,Nordmann P

更新日期：2014-05-01 00:00:00

abstract：:Hypermutable Pseudomonas aeruginosa strains are prevalent in patients with cystic fibrosis and rapidly become resistant to antibiotic monotherapies. Combination dosage regimens have not been optimized against such strains using mechanism-based modeling (MBM) and the hollow-fiber infection model (HFIM). The PAO1 wild-t...

journal_title：Antimicrobial agents and chemotherapy

authors： Landersdorfer CB,Rees VE,Yadav R,Rogers KE,Kim TH,Bergen PJ,Cheah SE,Boyce JD,Peleg AY,Oliver A,Shin BS,Nation RL,Bulitta JB

更新日期：2018-03-27 00:00:00

abstract：:Aminoglycoside resistance in Campylobacter has been routinely monitored in the United States in clinical isolates since 1996 and in retail meats since 2002. Gentamicin resistance first appeared in a single human isolate of Campylobacter coli in 2000 and in a single chicken meat isolate in 2007, after which it increase...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen Y,Mukherjee S,Hoffmann M,Kotewicz ML,Young S,Abbott J,Luo Y,Davidson MK,Allard M,McDermott P,Zhao S

更新日期：2013-11-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of antimicrobial drug use, gastric acid-suppressive agent use, and infection control practices on the incidence of Clostridium difficile-associated diarrhea (CDAD) in a 426-bed general teaching hospital in Northern Ireland. The study was retrospective and ecologi...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldeyab MA,Harbarth S,Vernaz N,Kearney MP,Scott MG,Funston C,Savage K,Kelly D,Aldiab MA,McElnay JC

更新日期：2009-05-01 00:00:00

abstract：:An oligonucleoside methylphosphonate (ONMP) complementary to the splice acceptor site of immediate-early (IE) pre-mRNAs 4 and 5 (IE4,5SA) inhibits herpes simplex virus type 1 (HSV-1) growth in vitro and in infected animals. The antiviral effect appears to be due to inhibition of IE pre-mRNA 4 and 5 splicing and/or IE4...

journal_title：Antimicrobial agents and chemotherapy

authors： Kulka M,Smith CC,Levis J,Fishelevich R,Hunter JC,Cushman CD,Miller PS,Ts'o PO,Aurelian L

更新日期：1994-04-01 00:00:00

abstract：:In a previous work, we described the possible relationship between a defect of purine-cytosine permease and the acquisition of a cross-resistance to the antifungal combination flucytosine (5FC) and fluconazole (FLC) in Candida lusitaniae (T. Noël, F. François, P. Paumard, C. Chastin, D. Brethes, and J. Villard, Antimi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chapeland-Leclerc F,Bouchoux J,Goumar A,Chastin C,Villard J,Noël T

更新日期：2005-08-01 00:00:00

abstract：:The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus strain in the rabbit model of endocarditis. Trovafloxacin was more effective than vancomycin (CFU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard deviation]; P < 0.05) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim YS,Liu Q,Chow LL,Chambers HF,Täuber MG

更新日期：1998-12-01 00:00:00

abstract：:Meropenem is a broad-spectrum carbapenem antibacterial agent. In order to optimize levels in plasma relative to the MICs, the ideal dose level and dosage regimen need to be determined. The pharmacokinetics of meropenem were studied in two groups, each comprising eight healthy volunteers who received the following dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Krueger WA,Bulitta J,Kinzig-Schippers M,Landersdorfer C,Holzgrabe U,Naber KG,Drusano GL,Sörgel F

更新日期：2005-05-01 00:00:00

abstract：:2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analog active against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains in vitro. F-ddA is presently undergoing a phase I clinical trial at the National Cancer Institute. We induced HIV-1 variants re...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka M,Srinivas RV,Ueno T,Kavlick MF,Hui FK,Fridland A,Driscoll JS,Mitsuya H

更新日期：1997-06-01 00:00:00

abstract：:A case-control study of the effect of antiretroviral therapy (ART) on apoptosis pathway genes comprising 16 cases (HIV infected with mitochondrial toxicity) and 16 controls (HIV uninfected) was conducted. A total of 26 of 84 genes of the apoptosis pathway were differentially expressed. Two of the upregulated genes, DF...

journal_title：Antimicrobial agents and chemotherapy

authors： Foli Y,Ghebremichael M,Li M,Paintsil E

更新日期：2017-07-25 00:00:00

abstract：:A prospective, randomized, and double-blind study comparing teicoplanin with vancomycin in the initial management of febrile neutropenic patients was conducted. Teicoplanin was administered at 6 mg per kg of body weight every 24 h (q24h) intravenously (i.v.) after initial loading at 6 mg/kg q12h for three doses. Vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Kureishi A,Jewesson PJ,Rubinger M,Cole CD,Reece DE,Phillips GL,Smith JA,Chow AW

更新日期：1991-11-01 00:00:00

abstract：:A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in D...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitzgibbon JE,John JF,Delucia JL,Dubin DT

更新日期：1998-08-01 00:00:00

abstract：:Selected cephalosporins, including cefamandole, cephaloridine, cephaloglycin, and cefoxitin, were examined for their ability to inhibit the enzymatic activity of and act as substrates for beta-lactamases produced by Enterobacter cloacae and Staphylococcus aureus. Enzyme inhibition was determined by Michaelis-Menten ki...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahoney DF,Koppel GA,Turner JR

更新日期：1976-09-01 00:00:00

abstract：:Dialyzed extracts of the gentamicin producer Micromonospora purpurea catalyze reactions which represent transaminations proposed for 2-deoxystreptamine biosynthesis. To determine whether these transaminations were catalyzed by a single aminotransferase or by multiple enzymes, we purified and characterized an L-glutami...

journal_title：Antimicrobial agents and chemotherapy

authors： Lucher LA,Chen YM,Walker JB

更新日期：1989-04-01 00:00:00

abstract：:The emergence of Neisseria gonorrhoeae isolates displaying resistance to antimicrobial agents is a major public health concern and a serious issue related to the occurrence of further untreatable gonorrhea infections. A retrospective analysis on 1,430 N. gonorrhoeae isolates, collected from 2003 through 2012, for anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Carannante A,Renna G,Dal Conte I,Ghisetti V,Matteelli A,Prignano G,Impara G,Cusini M,D'Antuono A,Vocale C,Antonetti R,Gaino M,Busetti M,Latino MA,Mencacci A,Bonanno C,Cava MC,Giraldi C,Stefanelli P

更新日期：2014-10-01 00:00:00

abstract：:The in vitro activity of trimethoprim plus dapsone against oxacillin-resistant Staphylococcus aureus was comparable to that of trimethoprim plus sulfamethoxazole. Because of its different pharmacologic properties, dapsone may be a useful agent in combination with trimethoprim for the treatment of patients colonized wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Lambertus MW,Kwok RY,Mulligan ME

更新日期：1990-07-01 00:00:00

abstract：:An efficient and reproducible procedure was developed for extracting aminoglycosides from renal cortical tissue. It involves a double homogenization and two rinsings with trichloroacetic acid. A higher recovery is obtained compared with that of other previously reported methods. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giuliano RA,Verpooten GA,Pollet DE,Verbist L,Scharpé SL,De Broe ME

更新日期：1984-06-01 00:00:00

abstract：:Ceftaroline-avibactam and comparator agents were tested by the broth microdilution method against 20,089 isolates consecutively collected in 2010 and 2011 from 75 U.S. medical centers. Ceftaroline-avibactam was active against Enterobacteriaceae (4,908 strains; MIC90, 0.25 μg/ml; highest MIC, 4 μg/ml), including merope...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Flamm RK,Jones RN

更新日期：2013-04-01 00:00:00

abstract：:Histatin 5 (Hst 5) is a salivary human antimicrobial peptide that is toxic to the opportunistic yeast Candida albicans. Fungicidal activity of Hst 5 requires intracellular translocation and accumulation to a threshold concentration for it to disrupt cellular processes. Previously, we observed that total cytosolic leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Li R,Kumar R,Tati S,Puri S,Edgerton M

更新日期：2013-04-01 00:00:00

abstract：:The association of an IS440-sul3 platform with Tn21 class 1 integrons carried by IncI1 plasmids encoding extended-spectrum β-lactamases (ESBLs; mainly SHV-12 and CTX-M-14) among worldwide Escherichia coli clones of phylogroups A (ST10, ST23, and ST46), B1 (ST155, ST351, and ST359), and D/B2 (ST131) is reported. An in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Curiao T,Cantón R,Garcillán-Barcia MP,de la Cruz F,Baquero F,Coque TM

更新日期：2011-05-01 00:00:00

abstract：:An in vitro investigation of the structure-activity profiles for a range of 9-anilinoacridines on drug-resistant Plasmodium falciparum is reported. C-3, 6-diamino substitution, low lipophilicity, and high pKa values substantially increased the activities of the 9-anilinoacridines tested. There appeared to be no correl...

journal_title：Antimicrobial agents and chemotherapy

authors： Chavalitshewinkoon P,Wilairat P,Gamage S,Denny W,Figgitt D,Ralph R

更新日期：1993-03-01 00:00:00