Upregulation of Apoptosis Pathway Genes in Peripheral Blood Mononuclear Cells of HIV-Infected Individuals with Antiretroviral Therapy-Associated Mitochondrial Toxicity.

abstract：:The outer membrane of mycobacteria presents an effective permeability barrier for many antibiotics. Transport pathways across this membrane are unknown for most drugs. Here, we examined which antibiotics utilize the porin pathway across the outer membrane of the model organism Mycobacterium smegmatis. Deletion of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Danilchanka O,Pavlenok M,Niederweis M

更新日期：2008-09-01 00:00:00

abstract：:Our aim was to assess the effect of miconazole oral gel on the pharmacokinetics of oral oxycodone. In an open crossover study with two phases, 12 healthy volunteers took a single oral dose of 10 mg of immediate-release oxycodone with or without thrice-daily 85-mg miconazole oral gel treatment. The plasma concentration...

journal_title：Antimicrobial agents and chemotherapy

authors： Grönlund J,Saari TI,Hagelberg N,Neuvonen PJ,Olkkola KT,Laine K

更新日期：2011-03-01 00:00:00

abstract：:Salmonella spp. are important food-borne pathogens that are demonstrating increasing antimicrobial resistance rates in isolates obtained from food animals and humans. In this study, 10 multidrug-resistant, cephalosporin-resistant Salmonella isolates from bovine, porcine, and human sources from a single geographic regi...

journal_title：Antimicrobial agents and chemotherapy

authors： Winokur PL,Brueggemann A,DeSalvo DL,Hoffmann L,Apley MD,Uhlenhopp EK,Pfaller MA,Doern GV

更新日期：2000-10-01 00:00:00

abstract：:Avibactam is a new non-β-lactam β-lactamase inhibitor that shows promising restoration of ceftazidime activity against microorganisms producing Ambler class A extended-spectrum β-lactamases (ESBLs) and carbapenemases such as KPCs, class C β-lactamases (AmpC), and some class D enzymes. To determine optimal dosing combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berkhout J,Melchers MJ,van Mil AC,Seyedmousavi S,Lagarde CM,Schuck VJ,Nichols WW,Mouton JW

更新日期：2015-11-02 00:00:00

abstract：:The activities of ampicillin, meropenem, azithromycin, gentamicin, ciprofloxacin, and moxifloxacin against intracellular hemolysin-positive Listeria monocytogenes were measured in human THP-1 macrophages and were compared with the extracellular activities observed in broth. All extracellular concentrations were adjust...

journal_title：Antimicrobial agents and chemotherapy

authors： Carryn S,Van Bambeke F,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-07-01 00:00:00

abstract：:Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active t...

journal_title：Antimicrobial agents and chemotherapy

authors： Edelstein PH,Edelstein MA

更新日期：1993-04-01 00:00:00

abstract：:A novel algorithm designed for the screening of carbapenemase-producing Enterobacteriaceae (CPE), based on faropenem and temocillin disks, was compared to that of the Committee of the Antibiogram of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem, and temocillin disks. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dortet L,Bernabeu S,Gonzalez C,Naas T

更新日期：2017-07-25 00:00:00

abstract：:Use of combinations of antimicrobials that together achieve synergistic activities against targeted microorganisms is one potential strategy for overcoming bacterial resistance. As the incidence of infections caused by multidrug-resistant staphylococci and enterococci increases, the importance of devising additional s...

journal_title：Antimicrobial agents and chemotherapy

authors： Allen GP,Cha R,Rybak MJ

更新日期：2002-08-01 00:00:00

abstract：:A vancomycin-resistant Staphylococcus aureus (VRSA) isolate was obtained from a patient in Pennsylvania in September 2002. Species identification was confirmed by standard biochemical tests and analysis of 16S ribosomal DNA, gyrA, and gyrB sequences; all of the results were consistent with the S. aureus identification...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenover FC,Weigel LM,Appelbaum PC,McDougal LK,Chaitram J,McAllister S,Clark N,Killgore G,O'Hara CM,Jevitt L,Patel JB,Bozdogan B

更新日期：2004-01-01 00:00:00

abstract：:The in vitro activity of moxifloxacin against 923 recent anaerobic isolates obtained from pretreatment cultures in patients with complicated intra-abdominal infections was studied using the CLSI M11-A-6 agar dilution method. Moxifloxacin was active against 87% (96 of 110) Bacteroides fragilis strains at < or = 1 micro...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Warren YA,Tyrrell KL,Merriam CV,Fernandez H

更新日期：2006-01-01 00:00:00

abstract：:Bactericidal activity in serum produced after administration of 1-g intravenous doses of cefoperazone, cefotaxime, ceftizoxime, and moxalactam was ascertained in six healthy subjects. The assay organisms were a strain of Staphylococcus aureus which was moderately susceptible to the drugs (MBC, 2 to 8 micrograms/ml) an...

journal_title：Antimicrobial agents and chemotherapy

authors： Barriere SL,Ozasa DC,Mordenti J

更新日期：1985-07-01 00:00:00

abstract：:Colistin is increasingly used as a salvage therapy for nosocomial infections caused by multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. However, the available pharmacokinetic (PK) data for colistin are limited to guide dosing. The aim of this study was to develop a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee J,Han S,Jeon S,Hong T,Song W,Woo H,Yim DS

更新日期：2013-05-01 00:00:00

abstract：:Oral Fusobacterium nucleatum populations from 20 young, healthy children were examined for beta-lactamase production. Ten children (50%) harbored, altogether, 25 beta-lactamase-positive F. nucleatum isolates that were identified as F. nucleatum subsp. polymorphum, F. nucleatum subsp. nucleatum, and F. nucleatum subsp....

journal_title：Antimicrobial agents and chemotherapy

authors： Könönen E,Kanervo A,Salminen K,Jousimies-Somer H

更新日期：1999-05-01 00:00:00

abstract：:Sterol delta22-desaturase has been purified from a strain of Candida glabrata with a disruption in the gene encoding sterol 14alpha-demethylase (cytochrome P-45051; CYP51). The purified cytochrome P-450 exhibited sterol delta22-desaturase activity in a reconstituted system with NADPH-cytochrome P-450 reductase in dila...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamb DC,Maspahy S,Kelly DE,Manning NJ,Geber A,Bennett JE,Kelly SL

更新日期：1999-07-01 00:00:00

abstract：:Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm Echinococcus multilocularis Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new antiechinococcosis drugs. Metformin is an antihyperglycemic and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Loos JA,Dávila VA,Brehm K,Cumino AC

更新日期：2020-08-20 00:00:00

abstract：:A study was performed to determine the effect of parenteral treatment with four broad-spectrum cephalosporins (cefoperazone, ceftriaxone, ceftazidime, and cefepime) on the number of aerobic gram-negative rods and on the outgrowth of Candida albicans and a multiresistant strain of Citrobacter freundii in the feces of m...

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Guiot HF,Mattie H,van Furth R

更新日期：1991-05-01 00:00:00

abstract：:The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

journal_title：Antimicrobial agents and chemotherapy

authors： Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

更新日期：2012-06-01 00:00:00

abstract：:Ethambutol (EMB) plays a pivotal role in the chemotherapy of drug-resistant tuberculosis (TB), including multidrug-resistant tuberculosis (MDR-TB). Resistance to EMB is considered to be caused by mutations in the embCAB operon (embC, embA, and embB). In this study, we analyzed the embCAB mutations among 139 MDR-TB iso...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao LL,Sun Q,Liu HC,Wu XC,Xiao TY,Zhao XQ,Li GL,Jiang Y,Zeng CY,Wan KL

更新日期：2015-04-01 00:00:00

abstract：:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry DR,Holmes DJ

更新日期：2008-03-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT) is a potent inactivator of the enveloped bacterial virus ø6 at concentrations as low as 3 x 10(-5) M. The viral envelope is not removed by BHT treatment, in contrast to the effects of exposure to the detergent Triton X-100. BHT-treated viruses are morphologically indistinguishable from c...

journal_title：Antimicrobial agents and chemotherapy

authors： Wanda P,Cupp J,Snipes W,Deith A,Rucinsky T,Polish L,Sands J

更新日期：1976-07-01 00:00:00

abstract：:The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

更新日期：1995-02-01 00:00:00

abstract：:Thirteen normal subjects were given 2, 3, or 4 g of ceftizoxime intravenously in a prospective single-blinded study. Serum and urine concentrations were measured for 48 h. The beta-phase serum half-life ranged from 1.4 to 1.7 h. Approximately 100% of the agent was recovered unchanged in the urine over 48 h. Six of 13 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Peterson LR,Gerding DN,Van Etta LL,Eckfeldt JH,Larson TA

更新日期：1982-11-01 00:00:00

abstract：:The present study was designed to determine the temporal changes in tobramycin nephrotoxicity during the dark and the light periods of the day and to look for the mechanisms of such changes. Female Sprague-Dawley rats (9 to 11 weeks old) were housed in a 14-h-light-10-h-dark cycle (lights on 0600 to 2000 h). A bolus o...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin L,Grenier L,Bergeron Y,Simard M,Bergeron MG,Labrecque G,Beauchamp D

更新日期：1994-01-01 00:00:00

abstract：:We investigated the evolution of resistance to the antifungal drug itraconazole in replicate populations of Aspergillus fumigatus that were founded from a strain with a genotype of sensitivity to a single drug and then propagated under uniform conditions. For each population, conidia were serially transferred 10 times...

journal_title：Antimicrobial agents and chemotherapy

authors： da Silva Ferreira ME,Capellaro JL,dos Reis Marques E,Malavazi I,Perlin D,Park S,Anderson JB,Colombo AL,Arthington-Skaggs BA,Goldman MH,Goldman GH

更新日期：2004-11-01 00:00:00

abstract：:We analyzed the didanosine (ddI) arm of the randomized, placebo-controlled Jaguar trial in order to define a genotypic score for ddI associated with virologic response. In this arm, 111 patients experiencing virologic failure received ddI in addition to their current combination therapy for 4 weeks. The impact of muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Marcelin AG,Flandre P,Pavie J,Schmidely N,Wirden M,Lada O,Chiche D,Molina JM,Calvez V,AI454-176 Jaguar Study Team.

更新日期：2005-05-01 00:00:00

abstract：:Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of both NTPase isoforms (...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai T,Takeuchi T,Diffenderfer J,Sibley LD

更新日期：2002-08-01 00:00:00

abstract：:Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Suzuki S,Yamazaki T,Narita M,Okazaki N,Suzuki I,Andoh T,Matsuoka M,Kenri T,Arakawa Y,Sasaki T

更新日期：2006-02-01 00:00:00

abstract：:AmBisome (ABLP) is a unilamellar liposomal preparation of amphotericin B that has demonstrated an improved safety profile compared to conventional amphotericin B. Single- and multiple-dose pharmacokinetics were determined by using noncompartmental methods for rats administered ABLP at 1, 3, 9, and 20 mg/kg/day. The to...

journal_title：Antimicrobial agents and chemotherapy

authors： Boswell GW,Bekersky I,Buell D,Hiles R,Walsh TJ

更新日期：1998-02-01 00:00:00

abstract：:There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. This blinded dose-escalation safety st...

journal_title：Antimicrobial agents and chemotherapy

authors： Tannous A,Levinson SL,Bolognese J,Opal SM,DiNubile MJ

更新日期：2020-09-21 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00