Analysis of embCAB mutations associated with ethambutol resistance in multidrug-resistant mycobacterium tuberculosis isolates from China.

abstract：:The pharmacologic parameters and toxicity of netilmicin (6 mg/kg/day) given once daily (qd) or thrice daily (tid) for the treatment of urinary tract infections were studied in a randomized prospective study of 60 cancer patients. The overall efficacy was 96%. Nephrotoxicity, assessed by the measure of urinary excretio...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P,Meunier F,Ibrahim S,Kaufman L,Derde MP,Tulkens PM

更新日期：1991-04-01 00:00:00

abstract：:R factors were detected in Vibrio anguillarum strains from vibrio-diseased freshwater fish, ayu (Plecoglossus altivelis), in Japan. It was found that 65 out of the 68 random isolates from epidemics of vibrio disease in 1973 carried transferable drug resistance factors. The most common type determined resistance to sul...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoki T,Egusa S,Arai T

更新日期：1974-11-01 00:00:00

abstract：:Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of adverse effects. Therefor...

journal_title：Antimicrobial agents and chemotherapy

authors： Berke JM,Vijgen L,Lachau-Durand S,Powdrill MH,Rawe S,Sjuvarsson E,Eriksson S,Götte M,Fransen E,Dehertogh P,Van den Eynde C,Leclercq L,Jonckers TH,Raboisson P,Nilsson M,Samuelsson B,Rosenquist Å,Fanning GC,Lin TI

更新日期：2011-08-01 00:00:00

abstract：:Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of levonadifloxacin fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodvold KA,Gotfried MH,Chugh R,Gupta M,Yeole R,Patel A,Bhatia A

更新日期：2018-02-23 00:00:00

abstract：:The in vitro susceptibilities of 12 strains of Chlamydia pneumoniae to a new quinolone, trovafloxacin, and ofloxacin, doxycycline, erythromycin, and azithromycin were determined. The activity of trovafloxacin was similar to that of ofloxacin, with a MIC at which 90% of the isolates are inhibited and a minimal concentr...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Kutlin A,Hammerschlag MR

更新日期：1997-09-01 00:00:00

abstract：:In 2009, the first high-level ceftriaxone-resistant Neisseria gonorrhoeae strain (H041) was isolated in Kyoto, Japan. The present study describes an intensified surveillance (antimicrobial resistance and molecular typing) of Neisseria gonorrhoeae isolates in Kyoto and its neighboring prefecture Osaka, Japan, in 2010 t...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimuta K,Unemo M,Nakayama S,Morita-Ishihara T,Dorin M,Kawahata T,Ohnishi M,Antibiotic-Resistant Gonorrhea Study Group.

更新日期：2013-11-01 00:00:00

abstract：:We previously reported the development of a prototype antibiotic sensitivity assay to detect drug-resistant Mycobacterium tuberculosis using infection by mycobacteriophage to create a novel nucleic acid transcript, a surrogate marker of mycobacterial viability, detected by reverse transcriptase PCR (M. C. Mulvey et al...

journal_title：Antimicrobial agents and chemotherapy

authors： Mulvey MC,Lemmon M,Rotter S,Lees J,Einck L,Nacy CA

更新日期：2015-01-01 00:00:00

abstract：:The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Paphitou NI,Ostrosky-Zeichner L,Paetznick VL,Rodriguez JR,Chen E,Rex JH

更新日期：2002-04-01 00:00:00

abstract：:A reverse-phase, high-pressure liquid chromatographic method for the rapid and quantitative determination of ketoconazole has been developed. Drug levels from 0.5 to 10 microgram/ml can be determined in either yeast nitrogen base medium or human serum by using an octadecylsilane column. A retention time of 4.9 +/- 0.1...

journal_title：Antimicrobial agents and chemotherapy

authors： Andrews FA,Peterson LR,Beggs WH,Crankshaw D,Sarosi GA

更新日期：1981-01-01 00:00:00

abstract：:Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae. The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Reda A,Marchillo K,Van Hecker J,Craig WA,Andes D

更新日期：2014-10-01 00:00:00

abstract：:Chlorhexidine (Hibiscrub; ICI) is generally accepted to be effective as an antiseptic hand wash for methicillin-susceptible Staphylococcus aureus (MSSA), but there is dispute whether the chlorhexidine MIC for methicillin-resistant S. aureus (MRSA) strains is higher than that for MSSA strains and, indeed, whether it is...

journal_title：Antimicrobial agents and chemotherapy

authors： Cookson BD,Bolton MC,Platt JH

更新日期：1991-10-01 00:00:00

abstract：:We report the sequence of a 630-bp fragment of a gene associated with resistance to high levels of vancomycin in a clinical isolate of Enterococcus faecalis which retained susceptibility to teicoplanin. This gene was similar to the recently sequenced vanB and partially homologous with vanA, but it showed less-marked s...

journal_title：Antimicrobial agents and chemotherapy

authors： Gold HS,Unal S,Cercenado E,Thauvin-Eliopoulos C,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1993-08-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans, a pathogen associated with aggressive periodontitis, resists phagocytic killing by polymorphonuclear leukocytes (PMNs). It is susceptible to ciprofloxacin, which PMNs actively accumulate. This study tested the hypothesis that ciprofloxacin-loaded PMNs are more effective at killing...

journal_title：Antimicrobial agents and chemotherapy

authors： Cacchillo DA,Walters JD

更新日期：2002-06-01 00:00:00

abstract：:A potential strategy that can be used to combat the worldwide AIDS epidemic is the development of a vaginal microbicide that prevents the sexual transmission of human immunodeficiency virus type 1 (HIV-1). Certain CC chemokines, including RANTES, MIP-1alpha, and MIP-1beta, might facilitate the development of such micr...

journal_title：Antimicrobial agents and chemotherapy

authors： Kish-Catalone TM,Lu W,Gallo RC,DeVico AL

更新日期：2006-04-01 00:00:00

abstract：:Ceftolozane-tazobactam, a combination of the novel antipseudomonal cephalosporin ceftolozane and the well-established extended-spectrum β-lactamase inhibitor tazobactam, is approved for treating complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults. To determine doses ...

journal_title：Antimicrobial agents and chemotherapy

authors： Larson KB,Patel YT,Willavize S,Bradley JS,Rhee EG,Caro L,Rizk ML

更新日期：2019-05-24 00:00:00

abstract：:Cyclacillin, a new aminosalicylic semisynthetic penicillin, was compared with amoxicillin for the therapy of acute bacterial maxillary sinusitis in 80 patients (ages, 12 to 70 years) in a prospective, double-blind, randomized clinical trial. Direct sinus aspirations for quantitative culture were done for all patients ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scheld WM,Sydnor A Jr,Farr B,Gratz JC,Gwaltney JM Jr

更新日期：1986-09-01 00:00:00

abstract：:The use of gentamicin to control contamination in a tissue culture system for the isolation of Chlamydia was investigated. Gentamicin, at concentrations up to 100 mug/ml, did not appear to inhibit the growth of stock chlamydial strains, as judged by assays for iodine-staining inclusions. When 343 cervical and urethral...

journal_title：Antimicrobial agents and chemotherapy

authors： Wentworth BB

更新日期：1973-06-01 00:00:00

abstract：:A strain of Staphylococcus aureus was planted on filter membranes placed on Trypticase soy agar (BBL). After incubation, the membranes with growing staphylococci were transferred to Trypticase soy agar containing a subinhibitory concentration of penicillin (one-third minimal inhibitory concentration) and again incubat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lorian V

更新日期：1975-06-01 00:00:00

abstract：:The nucleoside analogues acyclovir (ACV) and famciclovir (FCV) reduce the frequency and severity of herpes simplex virus 2 (HSV-2) genital shedding, yet despite their high potency in vitro and a lack of induced drug resistance, frequent episodes of breakthrough mucosal shedding occur. We tested a published stochastic,...

journal_title：Antimicrobial agents and chemotherapy

authors： Schiffer JT,Swan DA,Corey L,Wald A

更新日期：2013-12-01 00:00:00

abstract：:A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdon R,Polianski J,Gaudebout C,Marche C,Garry L,Pocidalo JJ

更新日期：1994-07-01 00:00:00

abstract：:The simian immunodeficiency virus (SIV)-newborn rhesus macaque model of AIDS can be used to study directly the virulence of viral mutants which are resistant to antiviral drugs. A viral mutant called SIVmac79A6.1, isolated from an SIV-infected macaque after prolonged zidovudine treatment, was found to have a double-ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rompay KK,Greenier JL,Marthas ML,Otsyula MG,Tarara RP,Miller CJ,Pedersen NC

更新日期：1997-02-01 00:00:00

abstract：:Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrighi RB,Ebikeme C,Jiang Y,Ranford-Cartwright L,Barrett MP,Langel U,Faye I

更新日期：2008-09-01 00:00:00

abstract：:The cyclohexane triones are a novel group of synthetic antibacterial agents that are active against gram-positive bacteria, Haemophilus influenzae, and Mycobacterium smegmatis. In general, these compounds behaved in a manner similar to that of hexachlorophene, inhibiting the transport of low-molecular-weight hydrophil...

journal_title：Antimicrobial agents and chemotherapy

authors： Lloyd WJ,Broadhurst AV,Hall MJ,Andrews KJ,Barber WE,Wong-Kai-In P

更新日期：1988-06-01 00:00:00

abstract：:Endoplasmic reticulum (ER)-resident glucosidases I and II sequentially trim the three terminal glucose moieties on the N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Because m...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao X,Guo F,Comunale MA,Mehta A,Sehgal M,Jain P,Cuconati A,Lin H,Block TM,Chang J,Guo JT

更新日期：2015-01-01 00:00:00

abstract：:We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

更新日期：2002-02-01 00:00:00

abstract：:Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage Plasmodium parasites, but details about its function during malaria's elusive liver stage are unclear...

journal_title：Antimicrobial agents and chemotherapy

authors： Posfai D,Eubanks AL,Keim AI,Lu KY,Wang GZ,Hughes PF,Kato N,Haystead TA,Derbyshire ER

更新日期：2018-03-27 00:00:00

abstract：:The in vitro antifungal activities of two N-aminoacyl derivatives of amphotericin B methyl ester (AME) were compared by tube dilution with those of amphotericin B and AME, using 60 isolates representing 10 yeast species. A total of 70% of the strains were inhibited by concentrations of the N-aminoacyl AME derivatives ...

journal_title：Antimicrobial agents and chemotherapy

authors： Oblack DL,Hewitt WL,Martin WJ

更新日期：1981-01-01 00:00:00

abstract：:An outbreak due to extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) was detected from May 1993 to June 1995. A total of 145 patients, particularly patients in intensive care units (ICUs) (107 patients [72%]), were colonized or infected. Infection developed in 92 (63%) patients, and primary ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Peña C,Pujol M,Ardanuy C,Ricart A,Pallares R,Liñares J,Ariza J,Gudiol F

更新日期：1998-01-01 00:00:00

abstract：:The respiratory syncytial virus (RSV) L protein is a viral RNA-dependent RNA polymerase that contains multiple enzyme activities required for RSV replication. The RSV L inhibitors described in literature are limited by their cytotoxicity or the lack of RSV B subtype coverage. Here, we characterize a new RSV L inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Tiong-Yip CL,Aschenbrenner L,Johnson KD,McLaughlin RE,Fan J,Challa S,Xiong H,Yu Q

更新日期：2014-07-01 00:00:00

abstract：:We previously demonstrated that ginsenosides Rg1 and Re enhanced the immune response in C3H/HeB mice but not in C3H/HeJ mice carrying a mutation in the Tlr4 gene. The results of the present study showed that both Rg1 and Re inhibited mRNA expression and production of proinflammatory mediators that included tumor necro...

journal_title：Antimicrobial agents and chemotherapy

authors： Su F,Xue Y,Wang Y,Zhang L,Chen W,Hu S

更新日期：2015-09-01 00:00:00