Detection of R factors in naturally occurring Vibrio anguillarum strains.

abstract：:Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active t...

journal_title：Antimicrobial agents and chemotherapy

authors： Edelstein PH,Edelstein MA

更新日期：1993-04-01 00:00:00

abstract：:We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spre...

journal_title：Antimicrobial agents and chemotherapy

authors： Escudero JA,San Millan A,Catalan A,de la Campa AG,Rivero E,Lopez G,Dominguez L,Moreno MA,Gonzalez-Zorn B

更新日期：2007-02-01 00:00:00

abstract：:The need for an accurate and rapid method of testing ampicillin susceptibility of Haemophilus influenzae, especially strains isolated from patients with meningitis and septicemia, is indisputable. Various methods have been employed for this purpose. Each has advantages and disadvantages. This report describes a modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Park CH,Lopez JS,Cook CB

更新日期：1978-02-01 00:00:00

abstract：:beta-Lactamase was purified from a strain of Legionella gormanii. The molecular weight of the purified enzyme was 25,000, and its isoelectric point was 10.5. The enzyme hydrolyzed oxyiminocephalosporins, cephamycins, penicillins, and imipenem. The enzyme activity was inhibited by EDTA, Hg2+, and Cu2+, but not by clavu...

journal_title：Antimicrobial agents and chemotherapy

authors： Fujii T,Sato K,Miyata K,Inoue M,Mitsuhashi S

更新日期：1986-05-01 00:00:00

abstract：:Novel penem molecules with heterocycle substitutions at the 6 position via a methylidene linkage were investigated for their activities and efficacy as beta-lactamase inhibitors. The concentrations of these molecules that resulted in 50% inhibition of enzyme activity were 0.4 to 3.1 nM for the TEM-1 enzyme, 7.8 to 72 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Petersen PJ,Murphy TM,Tardio L,Yang Y,Bradford PA,Venkatesan AM,Abe T,Isoda T,Mihira A,Ushirogochi H,Takasake T,Projan S,O'Connell J,Mansour TS

更新日期：2004-12-01 00:00:00

abstract：:A simple technique for routine, reproducible global surveillance of the drug susceptibility status of the anaerobic protozoa Trichomonas, Entamoeba, and Giardia is described. Data collected using this technique can be readily compared among different laboratories and with previously reported data. The technique employ...

journal_title：Antimicrobial agents and chemotherapy

authors： Upcroft JA,Upcroft P

更新日期：2001-06-01 00:00:00

abstract：:Clostridium difficile causes antibiotic-associated diarrhea and is a major public health concern. Current therapies disrupt the protective intestinal flora, do not reliably prevent recurrent infections, and will be decreasingly effective should less susceptible strains emerge. CRS3123 is an oral agent that inhibits ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Nayak SU,Griffiss JM,Blumer J,O'Riordan MA,Gray W,McKenzie R,Jurao RA,An AT,Le M,Bell SJ,Ochsner UA,Jarvis TC,Janjic N,Zenilman JM

更新日期：2017-07-25 00:00:00

abstract：:Candida glabrata, the second most common cause of Candida infections, is associated with high rates of mortality and often exhibits resistance to the azole class of antifungal agents. Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are the transcriptional regulators of ERG11, the gene encoding ...

journal_title：Antimicrobial agents and chemotherapy

authors： Whaley SG,Caudle KE,Vermitsky JP,Chadwick SG,Toner G,Barker KS,Gygax SE,Rogers PD

更新日期：2014-08-01 00:00:00

abstract：:Ribavirin (RBV) is a broad-spectrum antiviral agent that inhibits the production of infectious Hantaan virus (HTNV). Although the mechanism of action of RBV against HTNV is not understood, RBV is metabolized in human cells to both RBV-5'-monophosphate, which inhibits IMP dehydrogenase, resulting in a decrease in intra...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Chung DH,Chu YK,Jonsson CB,Parker WB

更新日期：2007-01-01 00:00:00

abstract：:We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Bebrone C,Huang TD,Bouchahrouf W,Degheldre Y,Deplano A,Hoffmann K,Glupczynski Y

更新日期：2012-06-01 00:00:00

abstract：:Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6...

journal_title：Antimicrobial agents and chemotherapy

authors： Hou X,Xiao M,Wang H,Yu SY,Zhang G,Zhao Y,Xu YC

更新日期：2018-05-25 00:00:00

abstract：:A remarkably high rate of adverse events is associated with the use of trimethoprim-sulfamethoxazole in patients with human immunodeficiency virus type 1 infection. We examined the efficacies of sulfonamides alone in the prevention of Pneumocystis carinii pneumonitis, with the assumption that at least some of the adve...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes WT,Killmar J

更新日期：1996-04-01 00:00:00

abstract：:The in vitro activity of the investigational siderophore cephalosporin, cefiderocol (formerly S-649266), was determined against a 2014-2016, 52-country, worldwide collection of clinical isolates of carbapenem-nonsusceptible Enterobacteriaceae (n = 1,022), multidrug-resistant (MDR) Acinetobacter baumannii (n = 368), MD...

journal_title：Antimicrobial agents and chemotherapy

authors： Hackel MA,Tsuji M,Yamano Y,Echols R,Karlowsky JA,Sahm DF

更新日期：2018-01-25 00:00:00

abstract：:HMR 3647 (telithromycin), a new ketolide, is active on intracellular pathogens. It was previously demonstrated that it inhibits superoxide anion production in a time- and concentration-dependent manner, at concentrations which inhibit 50% of the control response of about 55 microg/ml (5 min) to 30 microg/ml (30 min); ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vazifeh D,Abdelghaffar H,Labro MT

更新日期：2002-05-01 00:00:00

abstract：:The ST5 lineage of methicillin-resistant Staphylococcus aureus (MRSA) is one of the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and is carried by medica...

journal_title：Antimicrobial agents and chemotherapy

authors： Takano T,Hung WC,Shibuya M,Higuchi W,Iwao Y,Nishiyama A,Reva I,Khokhlova OE,Yabe S,Ozaki K,Takano M,Yamamoto T

更新日期：2013-04-01 00:00:00

abstract：:Acinetobacter baumannii is a Gram-negative bacterium that causes nosocomial infections worldwide. This microbe's propensity to form biofilms allows it to persist and to survive on clinical abiotic surfaces for long periods. In fact, A. baumannii biofilm formation and its multidrug-resistant nature severely compromise ...

journal_title：Antimicrobial agents and chemotherapy

authors： Krishnamoorthy S,Shah BP,Lee HH,Martinez LR

更新日期：2015-10-12 00:00:00

abstract：:The most widely used drug for treatment of candidiasis is fluconazole (FCZ). Recently, a new derivative of 1,4-benzothiazine, compound FS5, was developed. FS5 had an appreciable protective effect against murine candidiasis. The present study was designed to dissect the antifungal mechanisms triggered by FS5 and to est...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitzurra L,Fringuelli R,Perito S,Schiaffella F,Barluzzi R,Bistoni F,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:The endoperoxides are a new class of antimalarial agents, of which artemisinin (qinghaosu) is the prototype. We have previously shown that artemisinin is capable of alkylating proteins in model reactions. In the present study, we showed that when Plasmodium falciparum-infected erythrocytes are treated with a radiolabe...

journal_title：Antimicrobial agents and chemotherapy

authors： Asawamahasakda W,Ittarat I,Pu YM,Ziffer H,Meshnick SR

更新日期：1994-08-01 00:00:00

abstract：:The in vitro activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066 Staphylococcus aureus isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant S. aureus (MRSA) percentages ranged from 46% (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Biedenbach DJ,Hoban DJ,Reiszner E,Lahiri SD,Alm RA,Sahm DF,Bouchillon SK,Ambler JE

更新日期：2015-12-01 00:00:00

abstract：:Generation of pharmacodynamic relationships in the clinical arena requires estimation of pharmacokinetic parameter values for individual patients. When the target population is severely ill, the ability to obtain traditional intensive blood sampling schedules is curtailed. Population modeling guided by optimal samplin...

journal_title：Antimicrobial agents and chemotherapy

authors： Tam VH,Preston SL,Drusano GL

更新日期：2003-09-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) involved in the development of resistance represent powerful markers for the rapid detection of first- and second-line resistance in clinical Mycobacterium tuberculosis complex (MTBC) isolates. However, the association between particular mutations and phenotypic resistance is not...

journal_title：Antimicrobial agents and chemotherapy

authors： Feuerriegel S,Köser C,Trübe L,Archer J,Rüsch Gerdes S,Richter E,Niemann S

更新日期：2010-11-01 00:00:00

abstract：:The production of an L1 metallo-β-lactamase and an L2 serine active-site β-lactamase precludes the use of β-lactams for the treatment of Stenotrophomonas maltophilia infections. Preclinical data suggest that cefiderocol is the first approved β-lactam with reliable activity against S. maltophilia, but data on strains r...

journal_title：Antimicrobial agents and chemotherapy

authors： Biagi M,Vialichka A,Jurkovic M,Wu T,Shajee A,Lee M,Patel S,Mendes RE,Wenzler E

更新日期：2020-08-20 00:00:00

abstract：:Pharmacodynamic parameters have become increasingly important for the determination of the optimal dosing schedules of antibiotics. In this study, the postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA SMEs), and the sub-MIC effects (SMEs) of roxithromycin, clarithromycin, and azithromycin on refere...

journal_title：Antimicrobial agents and chemotherapy

authors： Odenholt-Tornqvist I,Löwdin E,Cars O

更新日期：1995-01-01 00:00:00

abstract：:The minimal inhibiting concentrations (MIC) of ampicillin, trisulfapyrimidines, and various combinations of these drugs were determined for four clinical isolates of Nocardia asteroides on Mueller-Hinton agar. The combination of ampicillin and sulfonamides was found to be synergistic for three of the four isolates whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Orfanakis MG,Wilcox HG,Smith CB

更新日期：1972-03-01 00:00:00

abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

更新日期：2015-11-01 00:00:00

abstract：:While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of c...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcone M,Russo A,Shindo Y,Farcomeni A,Pieralli F,Cangemi R,Liu J,Xia J,Okumura J,Sano M,Jones C,Vannucchi V,Mancone M,Micek S,Xu F,Violi F,Kollef M

更新日期：2019-01-29 00:00:00

abstract：:The time course of plasma drug levels and urinary recovery for two lipopeptide antifungal antibiotics, L-671,329 and cilofungin, were measured in male rhesus monkeys (Macaca mulatta) and in female DBA/2 mice. The antibiotics were administered intravenously at 10 mg/kg of body weight in phosphate-buffered saline-26% po...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundelof JG,Hajdu R,Cleare WJ,Onishi J,Kropp H

更新日期：1992-03-01 00:00:00

abstract：:A series of quaternary ammonium compounds that are esters of betaine and fatty alcohols with hydrocarbon chain lengths of 10 to 18 carbon atoms were tested with respect to antimicrobial activities and rates of hydrolysis. When the tetradecyl derivative was tested against some selected microorganisms, the killing effec...

journal_title：Antimicrobial agents and chemotherapy

authors： Lindstedt M,Allenmark S,Thompson RA,Edebo L

更新日期：1990-10-01 00:00:00

abstract：:Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy volunteers showed that once...

journal_title：Antimicrobial agents and chemotherapy

authors： Dietze R,Teixeira L,Rocha LM,Palaci M,Johnson JL,Wells C,Rose L,Eisenach K,Ellner JJ

更新日期：2001-07-01 00:00:00

abstract：:Streptonigrin, a quinone antitumor antibiotic, has been reported to be effective in human trials. A sensitive and precise microbiological assay for the determination of distribution and concentrations of streptonigrin in the body fluids and tissues of treated mice has been developed in an attempt to supplement success...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1974-01-01 00:00:00