Chlorhexidine resistance in methicillin-resistant Staphylococcus aureus or just an elevated MIC? An in vitro and in vivo assessment.

abstract：:Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mitchell KF,Taff HT,Cuevas MA,Reinicke EL,Sanchez H,Andes DR

更新日期：2013-04-01 00:00:00

abstract：:Ciprofloxacin, clinafloxacin, PD 131628, sparfloxacin, and trovafloxacin were tested against 236 strains of Streptococcus pneumoniae, most of which were resistant to other agents. Resistance to multiple antibiotics did not affect the organism's susceptibility to the fluoroquinolones. The fluoroquinolones with in vitro...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Fuchs PC,Brown SD

更新日期：1996-10-01 00:00:00

abstract：:The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 microg/ml for 10 species of Enterobacteriaceae (n = 351), from 0.03 to 0.12 microg/ml for oxacillin-susceptible staphylococci (n = 119), from 4 to 32 microg/ml for oxacillin-resistant staphylococci (n = 64), from < or =0.008 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ge Y,Wikler MA,Sahm DF,Blosser-Middleton RS,Karlowsky JA

更新日期：2004-04-01 00:00:00

abstract：:The in vitro activities of two new antimicrobial agents, apalcillin and cefpiramide (SM-1652), were evaluated against 324 strains of anaerobic bacteria. Apalcillin (a penicillin derivative) and cefpiramide (a semisynthetic cephalosporin) were compared with piperacillin, moxalactam, and cefoxitin. Organisms studied inc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler H,Carter WT,Harris B,Finegold SM

更新日期：1984-02-01 00:00:00

abstract：:The most widely used drug for treatment of candidiasis is fluconazole (FCZ). Recently, a new derivative of 1,4-benzothiazine, compound FS5, was developed. FS5 had an appreciable protective effect against murine candidiasis. The present study was designed to dissect the antifungal mechanisms triggered by FS5 and to est...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitzurra L,Fringuelli R,Perito S,Schiaffella F,Barluzzi R,Bistoni F,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:A total of 113 patients were randomly allocated to receive either ticarcillin plus clavulanic acid (total dose, 20.8 g) or clindamycin (total dose, 2.4 g) plus amikacin (total dose, 1 g) as perioperative antimicrobial prophylaxis for major head and neck surgery. The two groups were similar in age, prior antineoplastic...

journal_title：Antimicrobial agents and chemotherapy

authors： Gerard M,Meunier F,Dor P,Andry G,Chantrain G,Van der Auwera P,Daneau D,Klastersky J

更新日期：1988-10-01 00:00:00

abstract：:Time-kill studies examined the activities of telithromycin (HMR 3647), erythromycin A, azithromycin, clarithromycin, roxithromycin, clindamycin, pristinamycin, amoxicillin-clavulanate, and metronidazole against 11 gram-positive and gram-negative anaerobic bacteria. Time-kill studies were carried out with the addition ...

journal_title：Antimicrobial agents and chemotherapy

authors： Credito KL,Ednie LM,Jacobs MR,Appelbaum PC

更新日期：1999-08-01 00:00:00

abstract：:The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a beta-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime bu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lutsar I,Friedland IR,Jafri HS,Wubbel L,Ng W,Ghaffar F,McCracken GH Jr

更新日期：1999-07-01 00:00:00

abstract：:Histatin 5 (Hst 5) is a salivary human antimicrobial peptide that is toxic to the opportunistic yeast Candida albicans. Fungicidal activity of Hst 5 requires intracellular translocation and accumulation to a threshold concentration for it to disrupt cellular processes. Previously, we observed that total cytosolic leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Li R,Kumar R,Tati S,Puri S,Edgerton M

更新日期：2013-04-01 00:00:00

abstract：:By means of a stepwise selection procedure, mutants capable of growing in the presence of relatively high multiplicities of a bacteriocin from Streptococcus mutans GS-5 were obtained from a sensitivie strain of Streptococcus pyogenes. Mutacin-neutralizing activity of cell extracts containing receptor protein was exami...

journal_title：Antimicrobial agents and chemotherapy

authors： Franker CK

更新日期：1980-02-01 00:00:00

abstract：:Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more s...

journal_title：Antimicrobial agents and chemotherapy

authors： Nett JE,Crawford K,Marchillo K,Andes DR

更新日期：2010-08-01 00:00:00

abstract：:Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Beshir K,Sutherland CJ,Merinopoulos I,Durrani N,Leslie T,Rowland M,Hallett RL

更新日期：2010-09-01 00:00:00

abstract：:Treatment failure is a major cause of concern for the Helicobacter pylori-related gastroduodenal diseases like gastritis, peptic ulcer, and gastric cancer. Curcumin, diferuloylmethane from turmeric, has recently been shown to arrest H. pylori growth. The antibacterial activity of curcumin against 65 clinical isolates ...

journal_title：Antimicrobial agents and chemotherapy

authors： De R,Kundu P,Swarnakar S,Ramamurthy T,Chowdhury A,Nair GB,Mukhopadhyay AK

更新日期：2009-04-01 00:00:00

abstract：:Mezlocillin is a new broad-spectrum semisynthetic penicillin that has shown encouraging in vitro activity against the infecting organisms most likely to cause mortality and morbidity in cancer patients receiving chemotherapy. The serum clearances and urine recoveries of mezlocillin, ampicillin, and carbenicillin were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Issell BF,Bodey GP,Weaver S

更新日期：1978-02-01 00:00:00

abstract：:The Michaelis-Menten inhibitory constants (Kis) and the concentrations required for 50% inhibition of the Plasmodium falciparum dihydropteroate synthetase were determined for six sulfa drugs. These drugs inhibited the in vitro growth of P. falciparum (50% lethal concentration) at concentrations of 30 to 500 nM; these ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Meshnick SR

更新日期：1991-02-01 00:00:00

abstract：:We sought to determine whether there was an interaction between aminoglycoside use and shock in their effect on renal function among seriously ill patients suspected of having gram-negative sepsis. Serial serum creatinine determinations were used to estimate changes in creatinine clearance rates in 179 patients entere...

journal_title：Antimicrobial agents and chemotherapy

authors： Ambinder RF,Moore RD,Smith CR,Mellits ED,Lietman PS

更新日期：1985-02-01 00:00:00

abstract：:We compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of Chlamydia pneumoniae. Gemifloxacin was the most active quinolone tested, with a MIC at which 90% of the isolates are inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Reznik T,Kutlin A,Hammerschlag MR

更新日期：1999-11-01 00:00:00

abstract：:It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptom...

journal_title：Antimicrobial agents and chemotherapy

authors： Iwai Y,Ono H,Takeshima H,Yamaguchi N,Omura S

更新日期：1973-09-01 00:00:00

abstract：:The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination prevented emergence of the fosfomycin and pefloxacin resistance seen in 36 and 4%, respectively, of animals receiving either a...

journal_title：Antimicrobial agents and chemotherapy

authors： Thauvin C,Lemeland JF,Humbert G,Fillastre JP

更新日期：1988-06-01 00:00:00

abstract：:A self-transferable plasmid of ca. 80 kb, pIP1204, conferred multiple-antibiotic resistance to Klebsiella pneumoniae BM4536, which was isolated from a urinary tract infection. Resistance to beta-lactams was due to the bla(TEM1) and bla(CTX-M) genes, resistance to trimethroprim was due to the dhfrXII gene, resistance t...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Courvalin P,Lambert T

更新日期：2003-08-01 00:00:00

abstract：:Heteroresistance is the coexistence of populations with differing nucleotides at a drug resistance locus within a sample of organisms. Although Sanger sequencing is the gold standard for sequencing, it may be less sensitive than deep sequencing for detecting fluoroquinolone heteroresistance in Mycobacterium tuberculos...

journal_title：Antimicrobial agents and chemotherapy

authors： Eilertson B,Maruri F,Blackman A,Herrera M,Samuels DC,Sterling TR

更新日期：2014-06-01 00:00:00

abstract：:We examined the influences of different pH levels and three different buffers on flucytosine activity against 12 isolates of Candida albicans in two synthetic media, yeast nitrogen base (YNB) and synthetic amino acid medium-fungal (SAAMF), using broth dilution techniques and measuring the endpoints of visual MICs and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Calhoun DL,Galgiani JN

更新日期：1984-09-01 00:00:00

abstract：:New drugs are needed to shorten the duration of tuberculosis treatment. R207910, a diarylquinoline, is very active against Mycobacterium tuberculosis both in vitro and in mice. In healthy volunteers, the coadministration of R207910 and rifampin induced the increased metabolism of R207910, resulting in a 50% reduction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Gevers T,Van Den Berg J,Andries K

更新日期：2008-10-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Quinolone ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spangler SK,Lin G,Jacobs MR,Appelbaum PC

更新日期：1998-05-01 00:00:00

abstract：:The aim of this study was to investigate the variability of the voriconazole plasma level and its relationships with clinical outcomes and adverse events among liver transplant recipients to optimize the efficacy and safety of their treatment. Liver transplant recipients treated with voriconazole were included, and vo...

journal_title：Antimicrobial agents and chemotherapy

authors： Hashemizadeh Z,Badiee P,Malekhoseini SA,Raeisi Shahraki H,Geramizadeh B,Montaseri H

更新日期：2017-11-22 00:00:00

abstract：:Analogues based on the insect cecropin-bee melittin hybrid peptide (CEME) were studied and analyzed for activity and salt resistance. The new variants were designed to have an increase in amphipathic alpha-helical content (CP29 and CP26) and in overall positive charge (CP26). The alpha-helicity of these peptides was d...

journal_title：Antimicrobial agents and chemotherapy

authors： Friedrich C,Scott MG,Karunaratne N,Yan H,Hancock RE

更新日期：1999-07-01 00:00:00

abstract：:The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murin...

journal_title：Antimicrobial agents and chemotherapy

authors： Hosaka M,Gotoh N,Nishino T

更新日期：1995-08-01 00:00:00

abstract：:INX-08189 is an aryl-phosphoramidate of 6-O-methyl-2'-C-methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10±6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral replication was rapid, with a 50% effective concentration (EC50) of 35±8 nM at ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vernachio JH,Bleiman B,Bryant KD,Chamberlain S,Hunley D,Hutchins J,Ames B,Gorovits E,Ganguly B,Hall A,Kolykhalov A,Liu Y,Muhammad J,Raja N,Walters CR,Wang J,Williams K,Patti JM,Henson G,Madela K,Aljarah M,Gilles

更新日期：2011-05-01 00:00:00

abstract：:Single amino acid substitutions in the Ω loop of KPC β-lactamases are known to lead to resistance to the ceftazidime-avibactam combination. Here, we investigate this mechanism of resistance in CTX-M enzymes, which are the most widely spread extended-spectrum β-lactamases worldwide. Nine single amino acid polymorphisms...

journal_title：Antimicrobial agents and chemotherapy

authors： Compain F,Dorchène D,Arthur M

更新日期：2018-08-27 00:00:00