Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.

abstract：:Mycobacterium tuberculosis and the fast-growing species Mycobacterium abscessus are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug-resistant M. tuberculosis strains and the high level of intrinsic resistance of M....

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta R,Rodrigues Felix C,Akerman MP,Akerman KJ,Slabber CA,Wang W,Adams J,Shaw LN,Tse-Dinh YC,Munro OQ,Rohde KH

更新日期：2018-04-26 00:00:00

abstract：:Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We re...

journal_title：Antimicrobial agents and chemotherapy

authors： Sherry L,Kean R,McKloud E,O'Donnell LE,Metcalfe R,Jones BL,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:In a previous study we have shown that cultured epithelial cell lines can be used to measure the transepithelial passage of antimicrobial agents across the intestine and to obtain information on the mechanisms of transport utilized and predict the bioavailability of the antimicrobial agents after oral administration. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranaldi G,Islam K,Sambuy Y

更新日期：1994-06-01 00:00:00

abstract：:The NS3/4A protease from hepatitis C virus (HCV) plays a key role in viral replication. We report a system for monitoring the activity of this enzyme in single living mammalian cells. We constructed a fluorescence resonance energy transfer (FRET) probe that consists of an enhanced cyan fluorescent protein-citrine fusi...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabariegos R,Picazo F,Domingo B,Franco S,Martinez MA,Llopis J

更新日期：2009-02-01 00:00:00

abstract：:The morphology of cells of the H37Ra strain of Mycobacterium tuberculosis exposed to 0.5 mug of isonicotinic acid hydrazide (isoniazid) per ml was examined by scanning electron microscopy (SEM). Cells that were exposed to isoniazid for 3 h showed no detectable change, whereas cells exposed to the drug for 24 h exhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Takayama K,Wang L,Merkal RS

更新日期：1973-07-01 00:00:00

abstract：:The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

journal_title：Antimicrobial agents and chemotherapy

authors： Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

更新日期：1996-08-01 00:00:00

abstract：:Four large staphylococcal plasmids ranging in size from 31 to 82 kbp have been shown to mediate tetracycline resistance via an integrated copy of the tet(K)-encoding plasmid pT181 which was flanked by copies of the insertion element IS257. In two cases, IS257 elements interrupted the repC reading frame of pT181 and an...

journal_title：Antimicrobial agents and chemotherapy

authors： Werckenthin C,Schwarz S,Roberts MC

更新日期：1996-11-01 00:00:00

abstract：:Subtherapeutic levels of oxytetracycline plus neomycin in animal feeds did not bring about increases in the quantity, prevalence, or shedding of Salmonella typhimurium in swine, calves, or chickens. In fact, the medication generally reduced the proportion of animals carrying S. typhimurium. The medicated groups were f...

journal_title：Antimicrobial agents and chemotherapy

authors： Girard AE,English AR,Evangelisti DG,Lynch JE,Solomons IA

更新日期：1976-07-01 00:00:00

abstract：:Pseudomonas aeruginosa infections represent a serious threat to worldwide health. Proline-rich antimicrobial peptides (PR-AMPs), a particular group of peptide antibiotics, have demonstrated in vitro activity against P. aeruginosa strains. Here we show that the mammalian PR-AMP Bac7(1-35) is active against some multidr...

journal_title：Antimicrobial agents and chemotherapy

authors： Runti G,Benincasa M,Giuffrida G,Devescovi G,Venturi V,Gennaro R,Scocchi M

更新日期：2017-03-24 00:00:00

abstract：:The creation of new chemotherapeutic regimens that permit shortening the duration of treatment is a major priority for antituberculosis drug development. In this study, we used the murine model of experimental tuberculosis therapy to determine whether incorporation of the investigational new nitroimidazopyran PA-824 i...

journal_title：Antimicrobial agents and chemotherapy

authors： Nuermberger E,Rosenthal I,Tyagi S,Williams KN,Almeida D,Peloquin CA,Bishai WR,Grosset JH

更新日期：2006-08-01 00:00:00

abstract：:Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. enterica serovar Typhi pil operon located in Salmonella pathogenicity island 7, are important in the pathogenic process. In this study, by using...

journal_title：Antimicrobial agents and chemotherapy

authors： Pan Q,Zhang XL,Wu HY,He PW,Wang F,Zhang MS,Hu JM,Xia B,Wu J

更新日期：2005-10-01 00:00:00

abstract：:The caspofungin clinical trial database offers an opportunity to assess susceptibility results for Candida pathogens obtained from patients with candidiasis and allows for correlations between efficacy outcomes and MICs. Candida isolates have been identified from patients enrolled in four studies of esophageal candidi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kartsonis N,Killar J,Mixson L,Hoe CM,Sable C,Bartizal K,Motyl M

更新日期：2005-09-01 00:00:00

abstract：:A clinical isolate of Pseudomonas aeruginosa recovered from the lower respiratory tract of an 81-year-old patient hospitalized in Belgium was sent to the national reference center to determine its resistance mechanism. PCR sequencing identified a new GES variant, GES-18, which differs from the carbapenem-hydrolyzing e...

journal_title：Antimicrobial agents and chemotherapy

authors： Bebrone C,Bogaerts P,Delbrück H,Bennink S,Kupper MB,Rezende de Castro R,Glupczynski Y,Hoffmann KM

更新日期：2013-01-01 00:00:00

abstract：:The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination prevented emergence of the fosfomycin and pefloxacin resistance seen in 36 and 4%, respectively, of animals receiving either a...

journal_title：Antimicrobial agents and chemotherapy

authors： Thauvin C,Lemeland JF,Humbert G,Fillastre JP

更新日期：1988-06-01 00:00:00

abstract：:After vaginal insertion of a 300-mg ovule of tioconazole in 10 patients with vaginal candidiasis, the mean concentration in plasma was 21.2 ng/ml (range, 10.6 to 35.8 ng/ml) at 8 h and was not measurable at 24 h in 9 of 10 patients. The mean vaginal concentration at 24 h was 21.4 mg/liter (range, 2.4 to 50 mg/liter) a...

journal_title：Antimicrobial agents and chemotherapy

authors： Houang ET,Lawrence AG

更新日期：1985-06-01 00:00:00

abstract：:The binding of the outer membrane-disorganizing peptide polymyxin B nonapeptide (PMBN) to gram-negative bacteria was studied by using tritium-labeled PMBN. Smooth Salmonella typhimurium had a binding capacity of ca. 6 nmol of PMBN per mg (dry weight) of bacteria, which corresponds to ca. 1 X 10(6) to 2 X 10(6) molecul...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Viljanen P

更新日期：1985-04-01 00:00:00

abstract：:The safety, tolerance, and pharmacokinetics of amphotericin B lipid complex (ABLC) were studied in a cohort of pediatric cancer patients. Six children with hepatosplenic candidiasis (HSC) received 2.5 mg of ABLC/kg of body weight/day for 6 weeks for a total dosage of 105 mg/kg. Mean serum creatinine (0.85 +/- 0.12 mg/...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh TJ,Whitcomb P,Piscitelli S,Figg WD,Hill S,Chanock SJ,Jarosinski P,Gupta R,Pizzo PA

更新日期：1997-09-01 00:00:00

abstract：:The rabbit kidney cell line LLC-RK1 was tested for its ability to discriminate the toxicities of six cephalosporin antibiotics according to their in vivo nephrotoxic potentials in rabbits. With the exception of cephalothin, which was markedly toxic to kidney cells in vitro, a good correlation between in vitro toxicity...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams PD,Laska DA,Tay LK,Hottendorf GH

更新日期：1988-03-01 00:00:00

abstract：:The pharmacodynamic properties of levofloxacin (an optically active isomer of ofloxacin), ofloxacin, and ciprofloxacin, alone and in combination with rifampin, were evaluated over 24 to 48 h against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA 1199 and MRSA 494, respectively)...

journal_title：Antimicrobial agents and chemotherapy

authors： Kang SL,Rybak MJ,McGrath BJ,Kaatz GW,Seo SM

更新日期：1994-12-01 00:00:00

abstract：:Here, we report the isolation of 31 Acinetobacter baumannii strains producing OXA-253 in a single large Brazilian city. These strains belonged to five different sequence types (STs), including 4 STs not previously associated with blaOXA-253 In all strains, the blaOXA-253 gene was located in a plasmid within a genetic ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Sá Cavalcanti FL,Mendes-Marques CL,Vasconcelos CR,de Lima Campos T,Rezende AM,Xavier DE,Leal NC,de-Melo-Neto OP,de Morais MM,Leal-Balbino TC

更新日期：2016-12-27 00:00:00

abstract：:The ribosome-targeting antimicrobial, spectinomycin (SPC), strongly induced the mexXY genes of the MexXY-OprM multidrug efflux system in Pseudomonas aeruginosa and increased susceptibility to the polycationic antimicrobials polymyxin B and polymyxin E, concomitant with a decrease in expression of the polymyxin resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Poole K,Lau CH,Gilmour C,Hao Y,Lam JS

更新日期：2015-12-01 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakken JS,Cavalieri SJ,Gangeness D

更新日期：1990-06-01 00:00:00

abstract：:Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevot...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

更新日期：2006-11-01 00:00:00

abstract：:Phosphonoformate (PF) at a concentration of 5 to 10 mug/ml inhibited the growth of type 1 strains of herpes simplex virus (HSV) in tissue culture, whereas 20 to 30 mug/ml was required for inhibition of type 2 strains and about 50 mug/ml was required for murine cytomegalovirus. In mice inoculated intraperitoneally or i...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Glasgow LA,Overall JC Jr,Reno JM,Boezi JA

更新日期：1978-12-01 00:00:00

abstract：:The prevalence of three plasmid-mediated quinolone resistance determinants, QnrA, QnrB, and QnrS, among 526 nonreplicate clinical isolates of Enterobacter cloacae collected at a Taiwanese university hospital in 2004 was determined by PCR and colony hybridization, and the association of Qnr with the IMP-8 metallo-beta-...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu JJ,Ko WC,Tsai SH,Yan JJ

更新日期：2007-04-01 00:00:00

abstract：:Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis that is characterized by hyphal bronchopneumonia, aerosol amphotericin B (aero-AmB; 1.6 mg/kg given 2 days before infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt HJ,Bernard EM,Häuser M,Armstrong D

更新日期：1988-11-01 00:00:00

abstract：:Candida albicans, an opportunistic fungus, and Staphylococcus aureus, a bacterial pathogen, are two clinically relevant biofilm-forming microbes responsible for a majority of catheter-related infections, with such infections often resulting in catheter loss and removal. Not only do these pathogens cause a substantial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Peters BM,Ward RM,Rane HS,Lee SA,Noverr MC

更新日期：2013-01-01 00:00:00

abstract：:Tn5801, originally detected in Staphylococcus aureus Mu50, is a Tn916 family element in which a unique int gene (int5801) replaces the int and xis genes in Tn916 (int916 and xis916). Among 62 tet(M)-positive tetracycline-resistant Streptococcus agalactiae isolates, 43 harbored Tn916, whereas 19 harbored a Tn5801-like ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Tili E,Giovanetti E,Montanari MP,Varaldo PE

更新日期：2013-09-01 00:00:00

abstract：:Nocardia farcinica, one of the most frequent pathogenic species responsible for nocardiosis, is characterized by frequent brain involvement and resistance to β-lactams mediated by a class A β-lactamase. Kinetic parameters for hydrolysis of various β-lactams by FARIFM10152 from strain IFM 10152 were determined by spect...

journal_title：Antimicrobial agents and chemotherapy

authors： Lebeaux D,Ourghanlian C,Dorchène D,Soroka D,Edoo Z,Compain F,Arthur M

更新日期：2020-01-27 00:00:00