Safety, tolerance, and pharmacokinetics of amphotericin B lipid complex in children with hepatosplenic candidiasis.

abstract：:Primaquine is currently the only drug available for radical cure of Plasmodium vivax and P. ovale liver infection stages, but limited safety data exist for children <10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Betuela I,Bassat Q,Kiniboro B,Robinson LJ,Rosanas-Urgell A,Stanisic D,Siba PM,Alonso PL,Mueller I

更新日期：2012-04-01 00:00:00

abstract：:OPC-20011, a new parenteral 2-oxaisocephem antibiotic, has an oxygen atom at the 2- position of the cephalosporin frame. OPC-20011 had the best antibacterial activities against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, and penicillin-resistant Streptoc...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto M,Tamaoka H,Ishikawa H,Kikuchi M

更新日期：1998-11-01 00:00:00

abstract：:The activity of DX-619 was evaluated against 376 anaerobic isolates using the reference CLSI agar dilution method. Overall, 90% of the strains were susceptible to DX-619 at < or =1 microg/ml. It was more active than the other four compounds tested except for meropenem, which showed virtually identical overall activity...

journal_title：Antimicrobial agents and chemotherapy

authors： Molitoris D,Väisänen ML,Bolaños M,Finegold SM

更新日期：2006-05-01 00:00:00

abstract：:The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Neal SW,Parekh MC,Rice RJ

更新日期：1995-04-01 00:00:00

abstract：:During a 4-month period in late 1988, we isolated ceftazidime-resistant strains of Klebsiella pneumoniae and other members of the family Enterobacteriaceae from 29 patients at a chronic-care facility in Massachusetts. Ceftazidime resistance resulted from two distinct extended-spectrum beta-lactamases of the TEM type w...

journal_title：Antimicrobial agents and chemotherapy

authors： Rice LB,Willey SH,Papanicolaou GA,Medeiros AA,Eliopoulos GM,Moellering RC Jr,Jacoby GA

更新日期：1990-11-01 00:00:00

abstract：:Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the synthesis of both DHBV DNA and DHBV core antigen. Several nucleoside analogs which were previously shown to inhibit the replication of DNA viruses (i.e., herpesviruses) and retroviruses were examined for their inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Yokota T,Konno K,Chonan E,Mochizuki S,Kojima K,Shigeta S,de Clercq E

更新日期：1990-07-01 00:00:00

abstract：:The in vitro activities of GAR-936, the 9-t-butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of

journal_title：Antimicrobial agents and chemotherapy

authors： Boucher HW,Wennersten CB,Eliopoulos GM

更新日期：2000-08-01 00:00:00

abstract：:A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Segatore B,de Massis MR,Riccio ML,Bianchi C,Zollo A,Rossolini GM,Amicosante G

更新日期：2000-09-01 00:00:00

abstract：:Two types of transmissible plasmids which encode resistance to trimethoprim-sulfamethoxazole were found among five animal isolates of Salmonella krefeld. This is the first report of plasmid-mediated resistance to trimethoprim-sulfamethoxazole in Salmonella strains isolated in the United States. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mathewson JJ,Murray BE

更新日期：1983-03-01 00:00:00

abstract：:We assessed the activity and safety of liposomal nystatin, a broad-spectrum antifungal agent, for invasive aspergillosis in patients refractory to or intolerant of amphotericin B. Thirty-three patients were enrolled, received at least one dose of the study drug, and were evaluable for safety. Twenty-six patients had c...

journal_title：Antimicrobial agents and chemotherapy

authors： Offner F,Krcmery V,Boogaerts M,Doyen C,Engelhard D,Ribaud P,Cordonnier C,de Pauw B,Durrant S,Marie JP,Moreau P,Guiot H,Samonis G,Sylvester R,Herbrecht R,EORTC Invasive Fungal Infections Group.

更新日期：2004-12-01 00:00:00

abstract：:Saccharomicins A and B, two new heptadecaglycoside antibiotics, were isolated from the fermentation broth of the rare actinomycete Saccharothrix espanaensis. They represent a novel class of bactericidal antibiotics that are active both in vitro and in vivo against bacteria and yeast (MICs: Staphylococcus aureus, <0.12...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Kong F,Greenstein M

更新日期：2000-08-01 00:00:00

abstract：:Pyrazinamide (PZA) has important sterilizing activity in tuberculosis (TB) chemotherapy. We describe trends, risk factors, and molecular epidemiology associated with PZA-resistant (PZA(r)) Mycobacterium tuberculosis in New York City (NYC). From 2001 to 2008, all incident culture-positive TB cases reported by the NYC D...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdugo D,Fallows D,Ahuja S,Schluger N,Kreiswirth B,Mathema B

更新日期：2015-10-01 00:00:00

abstract：:The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen YT,Liao TL,Liu YM,Lauderdale TL,Yan JJ,Tsai SF

更新日期：2009-03-01 00:00:00

abstract：:Five recombinant alpha interferons and two recombinant beta interferons have been tested for their ability to inhibit yields of herpes simplex virus types 1 and 2 and human cytomegalovirus in human embryonic lung cells. All of the alpha species and both of the beta forms (cysteine and serine) were active against the h...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen LE,Chen PT,Merigan TC

更新日期：1984-10-01 00:00:00

abstract：:Xylitol is effective in preventing acute otitis media by inhibiting the growth of Streptococcus pneumoniae. To clarify this inhibition we used fructose, which is known to block similar growth inhibition observed in Streptococcus mutans. In addition, we evaluated the efficacy of sorbitol in inhibiting the growth of pne...

journal_title：Antimicrobial agents and chemotherapy

authors： Tapiainen T,Kontiokari T,Sammalkivi L,Ikäheimo I,Koskela M,Uhari M

更新日期：2001-01-01 00:00:00

abstract：:Pseudomonas aeruginosa 455, isolated in Ankara, Turkey, produced a pI 6.2 beta-lactamase determined by plasmid pMLH53 and resisted all beta-lactams except carbapenems. This beta-lactamase, named OXA-14, corresponded to OXA-10 (PSE-2) except that aspartate replaced glycine at position 157 and thus is intermediate betwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Danel F,Hall LM,Gur D,Livermore DM

更新日期：1995-08-01 00:00:00

abstract：:The in vitro interactions between amikacin, netilmicin, tobramycin, gentamicin, and various antipseudomonal beta-lactams were studied by the agar dilution checkerboard technique against 30 Pseudomonas aeruginosa strains resistant to all tested antibiotics. Amikacin produced more frequent synergy both at the total and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellou H,Zissis NP,Tagari G,Bouzos J

更新日期：1984-04-01 00:00:00

abstract：:A cytochrome P-450-deficient mutant of Candida albicans, strain D10, was employed to study the mode of action of imidazole antifungal agents. This mutant accumulates exclusively 14-alpha-methylsterols, resulting in a sterol profile which mimics that of azole-treated wild-type strains. Since the widely accepted primary...

journal_title：Antimicrobial agents and chemotherapy

authors： Lees ND,Broughton MC,Sanglard D,Bard M

更新日期：1990-05-01 00:00:00

abstract：:Paradoxical growth of some Candida isolates occurs at concentrations above the MIC for echinocandins. In 60 Candida bloodstream isolates from cancer patients (20 C. albicans isolates and 10 isolates each of C. parapsilosis, C. tropicalis, C. krusei, and C. glabrata), paradoxical growth was more frequent with caspofung...

journal_title：Antimicrobial agents and chemotherapy

authors： Chamilos G,Lewis RE,Albert N,Kontoyiannis DP

更新日期：2007-06-01 00:00:00

abstract：:Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for the treatment of and prophylaxis against influenza. In this paper, the new potent NA inhibitor R-125489 is reported for the first time. R-125489 inhibited the NA activities of various type A and B influen...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamashita M,Tomozawa T,Kakuta M,Tokumitsu A,Nasu H,Kubo S

更新日期：2009-01-01 00:00:00

abstract：:Meropenem is a broad-spectrum carbapenem antibacterial agent. In order to optimize levels in plasma relative to the MICs, the ideal dose level and dosage regimen need to be determined. The pharmacokinetics of meropenem were studied in two groups, each comprising eight healthy volunteers who received the following dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Krueger WA,Bulitta J,Kinzig-Schippers M,Landersdorfer C,Holzgrabe U,Naber KG,Drusano GL,Sörgel F

更新日期：2005-05-01 00:00:00

abstract：:Ceftriaxone in short courses has emerged as an effective alternative to chloramphenicol for the treatment of typhoid fever. To study the pharmacokinetics of ceftriaxone in acute typhoid fever, 10 febrile Nepalese adolescents and young adults with blood culture-positive illness were treated with 3 g of ceftriaxone (int...

journal_title：Antimicrobial agents and chemotherapy

authors： Acharya G,Crevoisier C,Butler T,Ho M,Tiwari M,Stoeckel K,Bradley CA

更新日期：1994-10-01 00:00:00

abstract：:We previously reported that the multidrug-resistant (MDR) Acinetobacter baumannii strain MDR-ZJ06, belonging to European clone II, was widely spread in China. In this study, we report the whole-genome sequence of this clinically important strain. A 38.6-kb AbaR-type genomic resistance island (AbaR22) was identified in...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou H,Zhang T,Yu D,Pi B,Yang Q,Zhou J,Hu S,Yu Y

更新日期：2011-10-01 00:00:00

abstract：:The effect of antacid on the bioavailability of cefprozil was investigated in a two-way crossover study. Eight healthy male subjects received a single 500-mg oral dose of cefprozil with and without coadministration of 30 ml of an antacid suspension containing magnesium hydroxide and aluminum hydroxide (Maalox). Cefpro...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Wilber RB,Pittman KA,Barbhaiya RH

更新日期：1992-05-01 00:00:00

abstract：:In this study, we characterized two tigecycline-resistant Klebsiella pneumoniae isolates from dog urine samples. The isolates were genetically unrelated, belonging to sequence type 11 (ST11) and ST147, both classically related to human isolates. To the best of our knowledge, this is the first identification of tigecyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Ovejero CM,Escudero JA,Thomas-Lopez D,Hoefer A,Moyano G,Montero N,Martin-Espada C,Gonzalez-Zorn B

更新日期：2017-05-24 00:00:00

abstract：:Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. He...

journal_title：Antimicrobial agents and chemotherapy

authors： Kalle AM,Rizvi A

更新日期：2011-01-01 00:00:00

abstract：:The linkage between the macrolide efflux gene mef(I) and the chloramphenicol inactivation gene catQ was first described in Streptococcus pneumoniae (strain Spn529), where the two genes are located in a module designated IQ element. Subsequently, two different defective IQ elements were detected in Streptococcus pyogen...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Morroni G,Giovanetti E,Del Grosso M,Pantosti A,Varaldo PE

更新日期：2014-10-01 00:00:00

abstract：:Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm Echinococcus multilocularis Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new antiechinococcosis drugs. Metformin is an antihyperglycemic and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Loos JA,Dávila VA,Brehm K,Cumino AC

更新日期：2020-08-20 00:00:00

abstract：:The pharmacokinetics, distribution, and plasma and renal clearance of a new aminoglycoside antibiotic, tobramycin, was studied in the treatment of 18 elderly male patients (average age, 69 years) with urinary tract infections. Ten of these patients had normal renal function and eight had impaired renal function of var...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Westenfelder SR,Madsen PO

更新日期：1973-04-01 00:00:00

abstract：:(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-dioxolane guanine (DXG). In vitro, APD and ACPD are converted to DXG by x...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen H,Boudinot FD,Chu CK,Mcclure HM,Schinazi RF

更新日期：1996-10-01 00:00:00