Scanning electron microscopy of the H37Ra strain of Mycobacterium tuberculosis exposed to isoniazid.

abstract：:The effects of trifluorothymidine (5-trifluoromethyl-2'-deoxyuridine, F3dThd) on the replication of three mouse cell lines, LM929, Ltk- (and LM929 derivative devoid of cytosolic deoxythymidine [dThd] kinase activity), and Ltk- c139 (a Ltk- derivative which expresses herpes simplex virus type 1-specified dThd kinase su...

journal_title：Antimicrobial agents and chemotherapy

authors： Wigdahl BL,Parkhurst JR

更新日期：1981-05-01 00:00:00

abstract：:Nocardia farcinica, one of the most frequent pathogenic species responsible for nocardiosis, is characterized by frequent brain involvement and resistance to β-lactams mediated by a class A β-lactamase. Kinetic parameters for hydrolysis of various β-lactams by FARIFM10152 from strain IFM 10152 were determined by spect...

journal_title：Antimicrobial agents and chemotherapy

authors： Lebeaux D,Ourghanlian C,Dorchène D,Soroka D,Edoo Z,Compain F,Arthur M

更新日期：2020-01-27 00:00:00

abstract：:Stenotrophomonas maltophilia is an opportunistic pathogen observed in nosocomial infections. Due to biofilm production and resistance to numerous antimicrobials, eradication is difficult. This study evaluated outcomes for monomicrobial S. maltophilia infections. Seventy-six patients were included, with 45 patients on ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nys C,Cherabuddi K,Venugopalan V,Klinker KP

更新日期：2019-10-22 00:00:00

abstract：:The pharmacokinetics of cefprozil were determined with 12 volunteers (8 received cefprozil and 4 received a placebo) after oral administration of 500 mg every 12 h over an 8-day period in a randomized, double-blind, placebo-controlled design. Concentrations in serum and urine were measured by high-pressure liquid chro...

journal_title：Antimicrobial agents and chemotherapy

authors： Lode H,Müller C,Borner K,Nord CE,Koeppe P

更新日期：1992-01-01 00:00:00

abstract：:The National Committee for Clinical Laboratory Standards has proposed a reference broth macrodilution method for in vitro antifungal susceptibility testing of yeasts (the M27-P method). This method is cumbersome and time-consuming and includes MIC endpoint determination by visual and subjective inspection of growth in...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Tudela JL,Berenguer J,Martínez-Suárez JV,Sanchez R

更新日期：1996-09-01 00:00:00

abstract：:GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since treatment of infected cells results in an elevation of two-long terminal repeat circles and a decrease...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones GS,Yu F,Zeynalzadegan A,Hesselgesser J,Chen X,Chen J,Jin H,Kim CU,Wright M,Geleziunas R,Tsiang M

更新日期：2009-03-01 00:00:00

abstract：:For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrow...

journal_title：Antimicrobial agents and chemotherapy

authors： Rudin JE,Norden CW,Shinners EM

更新日期：1984-10-01 00:00:00

abstract：:Approximately 39% of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 239 (ST239)-like bloodstream isolates from Liverpool Hospital (obtained between 1997 and 2008) carry an arginine catabolic mobile element (ACME). Whole-genome sequencing revealed that an ACME II variant is located between orfX and SC...

journal_title：Antimicrobial agents and chemotherapy

authors： Espedido BA,Steen JA,Barbagiannakos T,Mercer J,Paterson DL,Grimmond SM,Cooper MA,Gosbell IB,van Hal SJ,Jensen SO

更新日期：2012-06-01 00:00:00

abstract：:Recovery of gentamicin from renal cortical tissue (assayed by fluorescence polarization immunoassay) was highest (P less than 0.05) when using a sodium hydroxide (NaOH) digestion procedure without homogenization (90.0 +/- 5.4%), followed by homogenization with NaOH digestion (85.8 +/- 7.7%) and homogenization with tri...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown SA,Sugimoto K,Smith GG,Garry FB

更新日期：1988-04-01 00:00:00

abstract：:Respiratory infection with Burkholderia cenocepacia is associated with accelerated decline in lung function and increased mortality in cystic fibrosis (CF) patients (A. M. Jones, M. E. Dodd, J. R. W. Govan, V. Barcus, C. J. Doherty, J. Morris, and A. K. Webb, Thorax 59:948-951, 2004, http://dx.doi.org/10.1136/thx.2003...

journal_title：Antimicrobial agents and chemotherapy

authors： Balwan A,Nicolau DP,Wungwattana M,Zuckerman JB,Waters V

更新日期：2015-12-31 00:00:00

abstract：:Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (W...

journal_title：Antimicrobial agents and chemotherapy

authors： Yui Eto K,Firth N,Davis AM,Kwong SM,Krysiak M,Lee YT,O'Brien FG,Grubb WB,Coombs GW,Bond CS,Ramsay JP

更新日期：2019-10-22 00:00:00

abstract：:Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in vivo. For three cyclosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Ptak RG,Gallay PA,Jochmans D,Halestrap AP,Ruegg UT,Pallansch LA,Bobardt MD,de Béthune MP,Neyts J,De Clercq E,Dumont JM,Scalfaro P,Besseghir K,Wenger RM,Rosenwirth B

更新日期：2008-04-01 00:00:00

abstract：:Mannopeptimycins alpha, beta, gamma, delta, and epsilon are new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98. Mannopeptimycins gamma, delta, and epsilon, which have an isovaleryl substitution at various positions on the terminal mannose of the disaccharide moiety, demonstrated moderat...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Janso JE,Luckman SW,Lenoy EB,Bradford PA,Testa RT,Greenstein M

更新日期：2003-01-01 00:00:00

abstract：:The Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) offer different recommendations for carbapenem MIC susceptibility breakpoints for Acinetobacter species. In addition, the clinical efficacy of the intermediate category remains uncertain. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang YS,Wang YC,Kuo SC,Chen CT,Liu CP,Liu YM,Chen TL,Lee YT

更新日期：2017-08-24 00:00:00

abstract：:We describe the clinical outcome of 17 patients with secondary Acinetobacter bacteremia whose isolates had a tigecycline MIC of ≤2 mg/liter and who received tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the tigecycline cohort was 41.2% (7/17), which was significantly higher than that of t...

journal_title：Antimicrobial agents and chemotherapy

authors： Liou BH,Lee YT,Kuo SC,Liu PY,Fung CP

更新日期：2015-01-01 00:00:00

abstract：:Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoyle BD,Alcantara J,Costerton JW

更新日期：1992-09-01 00:00:00

abstract：:For six clinical isolates of Chlamydia trachomatis, in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C (Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populat...

journal_title：Antimicrobial agents and chemotherapy

authors： Misyurina OY,Chipitsyna EV,Finashutina YP,Lazarev VN,Akopian TA,Savicheva AM,Govorun VM

更新日期：2004-04-01 00:00:00

abstract：:Azoles are widely used antifungals; however, their efficacy is compromised by fungistatic activity and selection of resistant strains during treatment. Recent studies demonstrated roles for the protein kinase C and calcium signaling pathways in modulating azole activity. Here we explored a role for the signaling pathw...

journal_title：Antimicrobial agents and chemotherapy

authors： Jain P,Akula I,Edlind T

更新日期：2003-10-01 00:00:00

abstract：:Mining existing agents that enhance the therapeutic potential of ergosterol biosynthesis inhibitors (EBI) is a promising approach to improve Chagas disease chemotherapy. In this study, we evaluated the effect of ravuconazole, an EBI, combined with amlodipine, a calcium channel blocker, upon Trypanosoma cruzi experimen...

journal_title：Antimicrobial agents and chemotherapy

authors： Machado YA,Bahia MT,Caldas IS,Mazzeti AL,Novaes RD,Vilas Boas BR,Santos LJS,Martins-Filho OA,Marques MJ,Diniz LF

更新日期：2020-07-22 00:00:00

abstract：:Twelve healthy volunteers participated in this randomized crossover study to compare the concentrations and recovery levels of fleroxacin and pefloxacin in urine and to assess their bactericidal activities against 12 strains of urinary pathogens with different susceptibilities over a wide range of MICs. The volunteers...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Theuretzbacher U,Kinzig M,Savov O,Sörgel F

更新日期：1998-07-01 00:00:00

abstract：:Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Stockbauer KE,Williams DL,Kreiswirth BN,Musser JM

更新日期：1996-04-01 00:00:00

abstract：:Enzymes in the ergosterol-biosynthetic pathway are the targets of a number of antifungal agents including azoles, allylamines, and morpholines. In order to understand the response of Saccharomyces cerevisiae to perturbations in the ergosterol pathway, genome-wide transcript profiles following exposure to a number of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Bammert GF,Fostel JM

更新日期：2000-05-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes serious illness (lower respiratory illness) in preterm infants. RSV antibody-enriched immunoglobulin (RSVIG) that was lyophilized (LYO) protected against RSV lower respiratory illness. The Food and Drug Administration now requires an additional viral inactivation step (VI). We ...

journal_title：Antimicrobial agents and chemotherapy

authors： Groothuis JR,Simoes EA,Lehr MV,Kramer AA,Hemming VG,Rodriguez WJ,Arrobio J,Welliver RC,Siber GR

更新日期：1995-03-01 00:00:00

abstract：:Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and the immunocompromised population. Although several anti-HCMV therapies are available, the development of new anti-HCMV agents is highly desired. There is growing interest in identifying compounds that might inhibit HCMV b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kapoor A,Cai H,Forman M,He R,Shamay M,Arav-Boger R

更新日期：2012-09-01 00:00:00

abstract：:Wild-type strains of the bacterial phytopathogen Erwinia amylovora (the cause of fire blight disease of apples and pears) are markedly susceptible to novobiocin, deoxycholate, and sodium dodecyl (= lauryl) sulfate. The inhibitory concentration, expressed as the concentration causing a 99% inhibition of growth, of thes...

journal_title：Antimicrobial agents and chemotherapy

authors： Chatterjee AK,Buss RF,Starr MP

更新日期：1977-05-01 00:00:00

abstract：:The spread of antibiotic resistance among Gram-negative bacteria is a serious clinical threat, and infections with these organisms are a leading cause of mortality worldwide. Traditional novel drug development inevitably leads to the emergence of new resistant strains, rendering the new drugs ineffective. Therefore, r...

journal_title：Antimicrobial agents and chemotherapy

authors： Soren O,Brinch KS,Patel D,Liu Y,Liu A,Coates A,Hu Y

更新日期：2015-10-01 00:00:00

abstract：:The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos t...

journal_title：Antimicrobial agents and chemotherapy

authors： Lindegardh N,Davies GR,Tran TH,Farrar J,Singhasivanon P,Day NP,White NJ

更新日期：2006-09-01 00:00:00

abstract：:While Candida albicans remains the most common Candida isolate, Candida glabrata accounts for approximately 15 to 20% of all Candida infections in the United States. In this study we used immunosuppressed mice infected with C. glabrata to investigate the efficacy of liposomal amphotericin B alone or in combination wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Olson JA,Adler-Moore JP,Smith PJ,Proffitt RT

更新日期：2005-12-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:Quinolones, in addition to their antibacterial activities, act as immunomodulators. Osteopontin (OPN), a member of the extracellular matrix proteins, was found to play a role in the immune and inflammatory response. We found that quinolones significantly enhanced OPN secretion, namely, garenoxacin (220%), moxifloxacin...

journal_title：Antimicrobial agents and chemotherapy

authors： Shiratori B,Zhang J,Usami O,Chagan-Yasutan H,Suzuki Y,Nakajima C,Uede T,Hattori T

更新日期：2012-06-01 00:00:00