Influence of plasma exchange pheresis on plasma elimination of ceftriaxone.


:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone.


Bakken JS,Cavalieri SJ,Gangeness D




Has Abstract


1990-06-01 00:00:00












  • Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis.

    abstract::Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kedar GC,Brown-Driver V,Reyes DR,Hilgers MT,Stidham MA,Shaw KJ,Finn J,Haselbeck RJ

    更新日期:2008-06-01 00:00:00

  • Carbenicillin in the treatment of infections involving anaerobic bacteria.

    abstract::Twenty-one patients with serious infections involving anaerobic bacteria were treated with carbenicillin. Multiple anaerobes were involved in 8 cases, and in 10 cases, facultative anaerobes were also isolated. Bacteroides fragilis was isolated in 10 cases. Results were judged excellent in 7 cases, good in 8 cases, and...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Swenson RM,Lorber B

    更新日期:1976-06-01 00:00:00

  • parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

    abstract::We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Galbraith KM,Ng AC,Eggers BJ,Kuchel CR,Eggers CH,Samuels DS

    更新日期:2005-10-01 00:00:00

  • Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.

    abstract::The gram-positive bacterium Streptomyces noursei ATCC 11455 produces a complex mixture of polyene macrolides generally termed nystatins. Although the structures for nystatins A(1) and A(3) have been reported, the identities of other components of the nystatin complex remain obscure. Analyses of the culture extract fro...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bruheim P,Borgos SE,Tsan P,Sletta H,Ellingsen TE,Lancelin JM,Zotchev SB

    更新日期:2004-11-01 00:00:00

  • Rapid drug susceptibility testing of mycobacteria in tissue culture medium.

    abstract::Mycobacteria grew rapidly in FST medium (tissue culture medium F12 supplemented with 5% serum and 0.05% Tween 80). Growth of Mycobacterium tuberculosis and other niacin-negative mycobacteria in flat-bottomed, 96-well tissue culture plates was estimable by the naked eye within 3 to 5 days when mycobacteria were inocula...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nozawa RT,Yokota T

    更新日期:1983-08-01 00:00:00

  • Use of a temperature-sensitive, protoplast-forming Neurospora crassa strain for the detection of antifungal antibiotics.

    abstract::Protoplasts of the temperature-sensitive osmotic-1 mutant of Neurospora crassa grew and divided as cell wall-less cells when incubated under certain conditions at 37 degrees C. Each protoplast regenerated cell wall and formed a mycelium when the temperature was shifted to 22 degrees C. Cell wall regeneration, but not ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Selitrennikoff CP

    更新日期:1983-05-01 00:00:00

  • Integron-located oxa-32 gene cassette encoding an extended-spectrum variant of OXA-2 beta-lactamase from Pseudomonas aeruginosa.

    abstract::Pseudomonas aeruginosa clinical isolate CY-1, which was resistant to ceftazidime, harbored a conjugative ca. 250-kb plasmid that contained a class 1 integron with two gene cassettes encoding OXA-32, an OXA-2- type beta-lactamase, and the aminoglycoside acetyltransferase AAC(6')Ib(9). OXA-32 differed from OXA-2 by an L...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Poirel L,Gerome P,De Champs C,Stephanazzi J,Naas T,Nordmann P

    更新日期:2002-02-01 00:00:00

  • Multicenter Study of the Relationship between Carbapenem MIC Values and Clinical Outcome of Patients with Acinetobacter Bacteremia.

    abstract::The Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) offer different recommendations for carbapenem MIC susceptibility breakpoints for Acinetobacter species. In addition, the clinical efficacy of the intermediate category remains uncertain. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Yang YS,Wang YC,Kuo SC,Chen CT,Liu CP,Liu YM,Chen TL,Lee YT

    更新日期:2017-08-24 00:00:00

  • Isoniazid induces expression of the antigen 85 complex in Mycobacterium tuberculosis.

    abstract::Exposure to isoniazid induced the expression of several secreted proteins in Mycobacterium tuberculosis H37Rv. Two-dimensional gel electrophoresis and immunoblot analyses indicated that two of the prominent isonicotinic acid hydrazide-inducible polypeptides were members of the antigen 85 complex, recently demonstrated...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Garbe TR,Hibler NS,Deretic V

    更新日期:1996-07-01 00:00:00

  • Determination of robust ocular pharmacokinetic parameters in serum and vitreous humor of albino rabbits following systemic administration of ciprofloxacin from sparse data sets by using IT2S, a population pharmacokinetic modeling program.

    abstract::Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the determination of conce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Drusano GL,Liu W,Perkins R,Madu A,Madu C,Mayers M,Miller MH

    更新日期:1995-08-01 00:00:00

  • Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans.

    abstract::The 18-amino-acid cationic, tryptophan-rich ApoEdpL-W peptide derived from human ApoE apolipoprotein was shown to have antifungal activity against pathogenic yeasts of the Candida genus (except C. glabrata). ApoEdpL-W was active against planktonic cells and early-stage biofilms but less active against mature biofilms,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rossignol T,Kelly B,Dobson C,d'Enfert C

    更新日期:2011-10-01 00:00:00

  • Nephrotoxicity in Patients with or without Cystic Fibrosis Treated with Polymyxin B Compared to Colistin.

    abstract::Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity of polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 h was conducted. The p...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Crass RL,Rutter WC,Burgess DR,Martin CA,Burgess DS

    更新日期:2017-03-24 00:00:00

  • Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis.

    abstract::Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli are present and persist in an extracellular microenvironment within the necrotic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Driver ER,Ryan GJ,Hoff DR,Irwin SM,Basaraba RJ,Kramnik I,Lenaerts AJ

    更新日期:2012-06-01 00:00:00

  • Once-weekly micafungin therapy is as effective as daily therapy for disseminated candidiasis in mice with persistent neutropenia.

    abstract::The effect of micafungin dose scheduling on the treatment of candidemia is unknown. Neutropenic mice with disseminated Candida glabrata infection were treated with single intraperitoneal micafungin doses of 0 to 100 mg/kg of body weight and sacrificed 7 days later. The maximal decline in kidney fungal burden was 5.8 l...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gumbo T,Drusano GL,Liu W,Kulawy RW,Fregeau C,Hsu V,Louie A

    更新日期:2007-03-01 00:00:00

  • Artifacts in dilution pharmacokinetic models caused by adherent bacteria.

    abstract::Liquid cultures of a Pseudomonas aeruginosa strain in Mueller-Hinton broth diluted at rates higher than the bacterial growth rate showed the expected decrease in CFU only for 1 to 2 h. Later the CFU started to increase. This phenomenon can be explained by a hypothesis that assumes that the bacteria multiply in two dif...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Haag R,Lexa P,Werkhäuser I

    更新日期:1986-05-01 00:00:00

  • Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States.

    abstract::The Infectious Diseases Society of America advocates trimethoprim-sulfamethoxazole (SXT) as initial therapy for females with acute uncomplicated bacterial cystitis in settings where the prevalence of SXT resistance does not exceed 10 to 20%. To determine trends in the activities of SXT, ampicillin, ciprofloxacin, and ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Karlowsky JA,Kelly LJ,Thornsberry C,Jones ME,Sahm DF

    更新日期:2002-08-01 00:00:00

  • In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.

    abstract::The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of common aerobic gram-positive and anaerobic organisms was determined. MDL 62,879 was highly active against staphylococci (MI...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: King A,Bethune L,Phillips I

    更新日期:1993-04-01 00:00:00

  • Pharmacokinetic-pharmacodynamic modeling of electroencephalogram effect of imipenem in rats with acute renal failure.

    abstract::The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estim...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Dupuis A,Limosin A,Paquereau J,Mimoz O,Couet W,Bouquet S

    更新日期:2001-12-01 00:00:00

  • Pharmacokinetics of cefotetan in normal subjects and patients with impaired renal function.

    abstract::The elimination kinetics of cefotetan (YM09330), a new parenteral semisynthetic cephamycin derivative, were studied in eight healthy volunteers and 41 patients with renal insufficiency after the administration of a single 500-mg dose intravenously. Concentrations of cefotetan in serum and urine were determined by both...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ohkawa M,Hirano S,Tokunaga S,Motoi I,Shoda R,Ikeda A,Sugata T,Sawaki M,Shimamura M,Okasho A,Kuroda K

    更新日期:1983-01-01 00:00:00

  • Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir.

    abstract::Minocycline and valproic acid are potential adjuvant therapies for the treatment of human immunodeficiency virus (HIV)-associated cognitive impairment. The purpose of this study was to determine whether minocycline alone or in combination with valproic acid affected atazanavir plasma concentrations. Twelve adult HIV-i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: DiCenzo R,Peterson DR,Cruttenden K,Mariuz P,Rezk NL,Hochreiter J,Gelbard H,Schifitto G

    更新日期:2008-09-01 00:00:00

  • Risk factors for new detection of vancomycin-resistant enterococci in acute-care hospitals that employ strict infection control procedures.

    abstract::Accurate assessment of the risk factors for colonization with vancomycin-resistant enterococci (VRE) among high-risk patients is often confounded by nosocomial VRE transmission. We undertook a 15-month prospective cohort study of adults admitted to high-risk units (hematology, renal, transplant, and intensive care) in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Padiglione AA,Wolfe R,Grabsch EA,Olden D,Pearson S,Franklin C,Spelman D,Mayall B,Johnson PD,Grayson ML

    更新日期:2003-08-01 00:00:00

  • Effect of certain polypeptides on the biological activities of Measles virus.

    abstract::The effect of a selected tripeptide, Z-d-Phe-Phe-Arg(NO(2)) (SV-4814) on the kinetics of lysis of green monkey erythrocytes by measles virus hemolysin suggested conditions of competitive inhibition. SV-4814 prevented not only hemoglobin release, but also the preceding leakage of K(+) through the cell membrane. The cap...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Norrby E,Sievertsson H

    更新日期:1974-04-01 00:00:00

  • Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.

    abstract::LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett, S. M. Galloway, S....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mdluli KE,Witte PR,Kline T,Barb AW,Erwin AL,Mansfield BE,McClerren AL,Pirrung MC,Tumey LN,Warrener P,Raetz CR,Stover CK

    更新日期:2006-06-01 00:00:00

  • Quantification of cell-associated atazanavir, darunavir, lopinavir, ritonavir, and efavirenz concentrations in human mononuclear cell extracts.

    abstract::An ultrasensitive assay utilizing high-pressure liquid chromatography and mass spectrometry detection was developed and validated for the quantification of the antiretrovirals atazanavir (ATV), darunavir (DRV), lopinavir (LPV), ritonavir (RTV), and efavirenz (EFV) in human mononuclear cell (MNC) extracts. The assay ut...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Podany AT,Winchester LC,Robbins BL,Fletcher CV

    更新日期:2014-05-01 00:00:00

  • Antibiotic metabolites from a marine pseudomonad.

    abstract::An antibiotic-producing pseudomonad was isolated from a seawater sample from a La Jolla, Calif., tidepool. The pseudomonad produces two novel antibacterial compounds, 2-n-pentyl-4-quinolinol and 2-n-heptyl-4-quinolinol. It also synthesizes indole-3-carboxaldehyde, 6-bromoindole-3-carboxaldehyde, and the known antibiot...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wratten SJ,Wolfe MS,Andersen RJ,Faulkner DJ

    更新日期:1977-03-01 00:00:00

  • Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s.

    abstract::Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (W...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yui Eto K,Firth N,Davis AM,Kwong SM,Krysiak M,Lee YT,O'Brien FG,Grubb WB,Coombs GW,Bond CS,Ramsay JP

    更新日期:2019-10-22 00:00:00

  • Safety, Pharmacokinetics, and Drug-Drug Interaction Potential of Intravenous Durlobactam, a β-Lactamase Inhibitor, in Healthy Subjects.

    abstract::Durlobactam (DUR; also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii The safety and pharmacokinetics (PK) of DUR alone and with ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lickliter JD,Lawrence K,O'Donnell J,Isaacs R

    更新日期:2020-06-23 00:00:00

  • Potent in vitro antimalarial activity of metacycloprodigiosin isolated from Streptomyces spectabilis BCC 4785.

    abstract::Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A(1), and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Isaka M,Jaturapat A,Kramyu J,Tanticharoen M,Thebtaranonth Y

    更新日期:2002-04-01 00:00:00

  • beta-Lactam resistance in Serratia marcescens: comparison of action of benzylpenicillin, Apalcillin, Cefazolin, and ceftizoxime.

    abstract::The intrinsic mechanisms of resistance to beta-lactam antibiotics in Serratia marcescens IFO 12648 were investigated, comparing the action of benzylpenicillin, apalcillin, cefazolin, and ceftizoxime. The minimal inhibitory concentrations for this strain were 1,600, 3.13, 6,400, and 0.05 microgram/ml, respectively. The...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Takata N,Suginaka H,Kotani S,Ogawa M,Kosaki G

    更新日期:1981-03-01 00:00:00

  • Six groups of the OXY beta-Lactamase evolved over millions of years in Klebsiella oxytoca.

    abstract::The diversity and evolution of the class A OXY beta-lactamase from Klebsiella oxytoca were investigated and compared to housekeeping gene diversity. The entire bla(OXY) coding region was sequenced in 18 clinical isolates representative of the four K. oxytoca beta-lactamase gene groups bla(OXY-1) to bla(OXY-4) and of t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fevre C,Jbel M,Passet V,Weill FX,Grimont PA,Brisse S

    更新日期:2005-08-01 00:00:00