Influence of plasma exchange pheresis on plasma elimination of ceftriaxone.

abstract：:The racemic nucleoside analogue 2'-deoxy-3'-oxa-4'-thiocytidine (dOTC) is in clinical development for the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection. dOTC is structurally related to lamivudine (3TC), but the oxygen and sulfur in the furanosyl ring are transposed. Intracellular metabolism ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Muys JM,Gourdeau H,Nguyen-Ba N,Taylor DL,Ahmed PS,Mansour T,Locas C,Richard N,Wainberg MA,Rando RF

更新日期：1999-08-01 00:00:00

abstract：:A penicillin beta-lactamase (PCase) was extracted from Pseudomonas aeruginosa Rms139(+) and purified by means of column chromatography. The isoelectric point of Rms139 PCase was 5.7 and its molecular weight was 22,500 +/- 1,000. The optimal pH for the hydrolysis of benzylpenicillin was 7.0 to 7.5 and the optimal tempe...

journal_title：Antimicrobial agents and chemotherapy

authors： Sawada Y,Yaginuma S,Tai M,Iyobe S,Mitsuhashi S

更新日期：1976-01-01 00:00:00

abstract：:Antibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with...

journal_title：Antimicrobial agents and chemotherapy

authors： LaCuran AE,Pegg KM,Liu EM,Bethel CR,Ai N,Welsh WJ,Bonomo RA,Oelschlaeger P

更新日期：2015-12-01 00:00:00

abstract：:The antileprosy effect of rifampin was evaluated by a newly developed rapid in vitro assay wherein 31 human-derived strains and 1 armadillo-derived strain of Mycobacterium leprae were maintained for 2 and 3 weeks, respectively, in murine and human macrophages in the presence of [3H]thymidine. Of these strains, 27 show...

journal_title：Antimicrobial agents and chemotherapy

authors： Mittal A,Seshadri PS,Prasad HK,Sathish M,Nath I

更新日期：1983-10-01 00:00:00

abstract：:A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes MR,McCulloch JA,Vianello MA,Moura Q,Pérez-Chaparro PJ,Esposito F,Sartori L,Dropa M,Matté MH,Lira DP,Mamizuka EM,Lincopan N

更新日期：2016-09-23 00:00:00

abstract：:Bone concentrations of seven antimicrobial agents were determined after parenteral administration. Antibiotics were administered in large doses at customary intervals for 12 to 20 h before total hip or knee replacement; anticipated levels of each drug were achieved in the serum. Methicillin, carbenicillin, and clindam...

journal_title：Antimicrobial agents and chemotherapy

authors： Smilack JD,Flittie WH,Williams TW Jr

更新日期：1976-01-01 00:00:00

abstract：:Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses, only a restricted ...

journal_title：Antimicrobial agents and chemotherapy

authors： Keller P,Müller C,Engelhardt I,Hiller E,Lemuth K,Eickhoff H,Wiesmüller KH,Burger-Kentischer A,Bracher F,Rupp S

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this investigation was to assess the influence that treatment with antacid and ranitidine had on the pharmacokinetics of oral cefetamet pivoxil in 18 healthy male volunteers. Each subject received, in an open-labeled, randomized, three-way crossover design, a single oral dose of 1,000 mg (two tablets) o...

journal_title：Antimicrobial agents and chemotherapy

authors： Blouin RA,Kneer J,Ambros RJ,Stoeckel K

更新日期：1990-09-01 00:00:00

abstract：:Triazoles are first-line agents for treating aspergillosis. The prevalence of azole resistance in Aspergillus fumigatus is increasing, and cross-resistance is a growing concern. In this study, the susceptibilities of 40 A. fumigatus clinical isolates were tested by using the CLSI method with amphotericin B, itraconazo...

journal_title：Antimicrobial agents and chemotherapy

authors： Gregson L,Goodwin J,Johnson A,McEntee L,Moore CB,Richardson M,Hope WW,Howard SJ

更新日期：2013-11-01 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:Metronidazole (MDZ) and related 5-nitroimidazoles are the recommended drugs for treatment of trichomoniasis, a sexually transmitted disease caused by the protozoan parasite Trichomonas vaginalis. However, novel treatment options are needed, as recent reports have claimed resistance to these drugs in T. vaginalis isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Mallo N,Lamas J,Leiro JM

更新日期：2013-06-01 00:00:00

abstract：:Acanthamoeba spp. are the causative agents of Acanthamoeba keratitis (AK), which mainly occurs in contact lens wearers, and of skin lesions, granulomatous amoebic encephalitis (GAE), and disseminating diseases in the immunocompromised host. AK therapy is complex and irritating for the eye, skin lesions are difficult t...

journal_title：Antimicrobial agents and chemotherapy

authors： Fürnkranz U,Nagl M,Gottardi W,Köhsler M,Aspöck H,Walochnik J

更新日期：2008-02-01 00:00:00

abstract：:This study analyzed the enzymatic basis and molecular epidemiology of amoxicillin-clavulanate-resistant Escherichia coli isolated by the microbiology laboratory of a United States tertiary care hospital. From October 1998 to December 1999, all E. coli isolates were screened for ampicillin-sulbactam resistance. Of 283 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye KS,Gold HS,Schwaber MJ,Venkataraman L,Qi Y,De Girolami PC,Samore MH,Anderson G,Rasheed JK,Tenover FC

更新日期：2004-05-01 00:00:00

abstract：:There are several major differences between the penicillin-binding proteins (PBPs) of highly penicillin-resistant and -susceptible strains of pneumococci. The highest-molecular-size PBP 1a (98 kilodaltons [kDa]) of susceptible pneumococci is not detectable in resistant bacteria. Instead, resistant strains contain a PB...

journal_title：Antimicrobial agents and chemotherapy

authors： Hakenbeck R,Ellerbrok H,Briese T,Handwerger S,Tomasz A

更新日期：1986-10-01 00:00:00

abstract：:Burkholderia cepacia is recognized as an important pathogen in the lung infections of patients with cystic fibrosis. An inducible beta-lactamase activity has been associated with increased resistance to beta-lactam antibiotics in clinical isolates of B. cepacia. In this study, we report the revised sequence of the pen...

journal_title：Antimicrobial agents and chemotherapy

authors： Trépanier S,Prince A,Huletsky A

更新日期：1997-11-01 00:00:00

abstract：:Quadruple mutations in the Plasmodium falciparum dihydrofolate reductase (PFDHFR) enzyme give rise to the highest level of pyrimethamine resistance leading to treatment failures. We describe here the presence of these quadruple mutations in a majority of P. falciparum isolates from Car Nicobar (Andaman and Nicobar) Is...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahmed A,Das MK,Dev V,Saifi MA,Wajihullah,Sharma YD

更新日期：2006-04-01 00:00:00

abstract：:Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserv...

journal_title：Antimicrobial agents and chemotherapy

authors： Hölzel CS,Harms KS,Schwaiger K,Bauer J

更新日期：2010-03-01 00:00:00

abstract：:Properties of a population of carbenicillin- and gentamicin-resistant, tobramycin-susceptible Pseudomonas aeruginosa at Veteran's Administration Hospital, Cincinnati, Ohio, have been followed during a 16-month period. As originally described, the strains were isolated from patients with urinary tract colonizations and...

journal_title：Antimicrobial agents and chemotherapy

authors： Korfhagen TR,Ferrel JA,Menefee CL,Loper JC

更新日期：1976-05-01 00:00:00

abstract：:Acyclovir, known as an antiherpetic agent, showed an inhibitory effect on the propagation of pseudorabies virus in BHK-21 cells. The antiviral effect of acyclovir was observed by plaque reduction, as well as by the inhibition of the virus-stimulated uptake of thymidine by BHK-21 cells. Amphotericin B potentiated the a...

journal_title：Antimicrobial agents and chemotherapy

authors： Malewicz B,Momsen M,Jenkin HM

更新日期：1983-01-01 00:00:00

abstract：:We report 2 cases of recurrent Campylobacter coli enteritis caused by macrolide- and fluoroquinolone-resistant strains in 2 patients with hypogammaglobulinemia, successfully treated with a prolonged course of fosfomycin-tromethamine with no side effects. Fosfomycin-tromethamine may be a feasible alternative therapy fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aguilar-Company J,Los-Arcos I,Pigrau C,Rodríguez-Pardo D,Larrosa MN,Rodríguez-Garrido V,Sihuay-Diburga D,Almirante B

更新日期：2016-06-20 00:00:00

abstract：:The efficiencies of two dosage schedules of amikacin (2 x 10 mg/kg of body weight per 24 h and 1 x 20 mg/kg/24 h intramuscularly for 5 days) against Pseudomonas aeruginosa sepsis in rabbits were compared. Blood samples were drawn at various times after the first application, and amikacin concentrations in serum were a...

journal_title：Antimicrobial agents and chemotherapy

authors： Staneva M,Markova B,Atanasova I,Terziivanov D

更新日期：1994-05-01 00:00:00

abstract：:Ten beta-lactamase-producing Enterococcus faecalis isolates were examined for the presence of the staphylococcal beta-lactamase repressor and antirepressor genes. Four isolates, previously shown to be unrelated to each other by pulsed-field gel electrophoresis analysis, were positive for both genes by PCR, although be...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomayko JF,Zscheck KK,Singh KV,Murray BE

更新日期：1996-05-01 00:00:00

abstract：:Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significan...

journal_title：Antimicrobial agents and chemotherapy

authors： Vieira JLF,Rivera JGB,de Sena LWP,Ferreira MVD

更新日期：2020-02-21 00:00:00

abstract：:Cytochrome aa3 concentrations in the cytoplasmic membrane of Bacillus subtilis were altered by growth conditions, and the effects on the membrane potential (delta psi) in whole cells were measured. When cytochrome aa3 was absent, the magnitude of delta psi was not diminished by comparison with the delta psi measured i...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrow AS,Taber HW

更新日期：1986-01-01 00:00:00

abstract：:Mycobactin biosynthesis in Mycobacterium tuberculosis facilitates iron acquisition, which is required for growth and virulence. The mycobactin biosynthesis inhibitor salicyl-AMS [5'-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. Here, we conducted a single-dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Lun S,Guo H,Adamson J,Cisar JS,Davis TD,Chavadi SS,Warren JD,Quadri LE,Tan DS,Bishai WR

更新日期：2013-10-01 00:00:00

abstract：:The use of gentamicin to control contamination in a tissue culture system for the isolation of Chlamydia was investigated. Gentamicin, at concentrations up to 100 mug/ml, did not appear to inhibit the growth of stock chlamydial strains, as judged by assays for iodine-staining inclusions. When 343 cervical and urethral...

journal_title：Antimicrobial agents and chemotherapy

authors： Wentworth BB

更新日期：1973-06-01 00:00:00

abstract：:Staphylococcin 462 is a proteinaceous inhibitor produced by Staphylococcus aureus strain 462. In broth cultures, susceptible S. aureus strain 140 and 19 respond to treatment with the bacteriocin by stopping growth and cell division. Examination of macromolecular synthesis by measuring the incorporation of radioactive ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hale EM,Hinsdill RD

更新日期：1975-01-01 00:00:00

abstract：:The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a beta-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime bu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lutsar I,Friedland IR,Jafri HS,Wubbel L,Ng W,Ghaffar F,McCracken GH Jr

更新日期：1999-07-01 00:00:00

abstract：:Isoprinosine has been reported to decrease progression to AIDS, primarily by preventing Pneumocystis carinii pneumonia (PCP), in human immunodeficiency virus-infected patients, but the mechanism of action is unknown. para-Acetamidobenzoic acid (PAcBA), one component of isoprinosine, is structurally related to para-ami...

journal_title：Antimicrobial agents and chemotherapy

authors： Kovacs JA,Powell F,Voeller D,Allegra CJ

更新日期：1993-06-01 00:00:00

abstract：:Clinical isolates of Trichomonas vaginalis were obtained from women consecutively enrolled in a study of partner notification. Testing of susceptibility to metronidazole and tinidazole was performed. Resistance to metronidazole and tinidazole was present in 17/178 (9.6%) and 1/178 (0.56%) strains, respectively. In vit...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwebke JR,Barrientes FJ

更新日期：2006-12-01 00:00:00