Comparison of cyclacillin and amoxicillin for therapy for acute maxillary sinusitis.

abstract：:A study was performed to determine the effect of parenteral treatment with four broad-spectrum cephalosporins (cefoperazone, ceftriaxone, ceftazidime, and cefepime) on the number of aerobic gram-negative rods and on the outgrowth of Candida albicans and a multiresistant strain of Citrobacter freundii in the feces of m...

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Guiot HF,Mattie H,van Furth R

更新日期：1991-05-01 00:00:00

abstract：:We report the ultrastructural alterations induced during the proliferative stages of Trypanosoma (Schizotrypanum) cruzi, the causative agent of Chagas' disease, by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, which had previously been shown to be potent growth inhibitors whose effects are pote...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazardi K,Urbina JA,de Souza W

更新日期：1990-11-01 00:00:00

abstract：:The penetration of cefonicid and cefazolin into cardiac tissue was compared after a single 30-mg/kg dose in 30 patients undergoing aortocoronary artery bypass graft surgery. Samples of the right atrial appendage, pericardial fluid, and serum were obtained at various times and assayed for drug content. The concentratio...

journal_title：Antimicrobial agents and chemotherapy

authors： Dudley MN,Nightingale CH,Drezner AD,Low HB,Quintiliani R

更新日期：1984-09-01 00:00:00

abstract：:A gentamicin resistance determinant of a conjugative plasmid from Enterobacter cloacae was cloned on a 3.2-kilobase fragment in the PstI site of pBR322. Substrate profiles for eight aminoglycosides at three concentrations showed that the resistance was due to aminoglycoside-(3)-N-acetyltransferase isoenzyme II. Insert...

journal_title：Antimicrobial agents and chemotherapy

authors： Vliegenthart JS,Ketelaar-van Gaalen PA,van de Klundert JA

更新日期：1989-08-01 00:00:00

abstract：:Compound 2242, also known as 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine, is the first known antivirally active nucleoside analog with the side chain substituted at the N-7 position of the purine ring system. Our purpose was to evaluate its retinal toxicity and assess the efficacy of its highest nontoxic concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Besen G,Chavez-de la Paz E,Tatebayashi M,Flores-Aguilar M,Gangan PA,Munguia D,Wiley CA,Jähne G,Winkler I,Helsberg M

更新日期：1995-07-01 00:00:00

abstract：:The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murin...

journal_title：Antimicrobial agents and chemotherapy

authors： Hosaka M,Gotoh N,Nishino T

更新日期：1995-08-01 00:00:00

abstract：:Enucleated human polymorphonuclear leukocytes (PMN cytoplasts), which have no nuclei and only a few granules, retain many of the functions of intact neutrophils. To better define the mechanisms and intracellular sites of antimicrobial agent accumulation in human neutrophils, we studied the antibiotic uptake process in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hand WL,King-Thompson NL

更新日期：1990-06-01 00:00:00

abstract：:AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification of an Ala141Ser substitution in FabK from spontaneous AG205-resistant mutants indic...

journal_title：Antimicrobial agents and chemotherapy

authors： Takahata S,Iida M,Osaki Y,Saito J,Kitagawa H,Ozawa T,Yoshida T,Hoshiko S

更新日期：2006-08-01 00:00:00

abstract：:Forty-nine clinical isolates of multidrug-resistant Acinetobacter baumannii were obtained from 12 hospitals in 7 prefectures throughout Japan. Molecular phylogenetic analysis revealed the clonal spread of A. baumannii sequence type 208 (ST208) and ST455 isolates harboring the armA gene and ST512 harboring the armA and...

journal_title：Antimicrobial agents and chemotherapy

authors： Tada T,Miyoshi-Akiyama T,Shimada K,Shimojima M,Kirikae T

更新日期：2014-05-01 00:00:00

abstract：:A simple technique with antibiotic-impregnated disks has been developed to demonstrate the antibiotic synergism of penicillins and aminoglycosides against enterococci. The two antibiotic disks are placed on inoculated plates so that the distance between their centers is less than the sum of the two radii of their prev...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee WS,Komarmy L

更新日期：1975-01-01 00:00:00

abstract：:The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes with intravenous minocycline-based com...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang D,Yu B,Diep JK,Sharma R,Dudley M,Monteiro J,Kaye KS,Pogue JM,Abboud CS,Rao GG

更新日期：2017-06-27 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence the killing activity of fluconazole, we sought to identify transcriptio...

journal_title：Antimicrobial agents and chemotherapy

authors： Vasicek EM,Berkow EL,Bruno VM,Mitchell AP,Wiederhold NP,Barker KS,Rogers PD

更新日期：2014-11-01 00:00:00

abstract：:In determining the quality control limits for the Clinical Laboratory Standards Institute-recommended quality control organisms with tigecycline, a number of inconsistencies in the results were encountered that appeared to be related to the age of the Mueller-Hinton broth II. This study was performed to examine the ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Petersen PJ,Bradford PA

更新日期：2005-09-01 00:00:00

abstract：:The need for an accurate and rapid method of testing ampicillin susceptibility of Haemophilus influenzae, especially strains isolated from patients with meningitis and septicemia, is indisputable. Various methods have been employed for this purpose. Each has advantages and disadvantages. This report describes a modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Park CH,Lopez JS,Cook CB

更新日期：1978-02-01 00:00:00

abstract：:The polyene antifungal amphotericin B (AmB) is widely used to treat life-threatening fungal infections. Even though AmB resistance is exceptionally rare in fungi, most Aspergillus terreus isolates exhibit an intrinsic resistance against the drug in vivo and in vitro. Heat shock proteins perform a fundamental protectiv...

journal_title：Antimicrobial agents and chemotherapy

authors： Blatzer M,Blum G,Jukic E,Posch W,Gruber P,Nagl M,Binder U,Maurer E,Sarg B,Lindner H,Lass-Flörl C,Wilflingseder D

更新日期：2015-07-01 00:00:00

abstract：:Resistance to the recently approved nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) commonly involves substitutions at positions E138K and K101E in HIV-1 reverse transcriptase (RT), together with an M184I substitution that is associated with resistance to coutilized emtricitabine (FTC). Previou...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu HT,Colby-Germinario SP,Huang W,Oliveira M,Han Y,Quan Y,Petropoulos CJ,Wainberg MA

更新日期：2013-11-01 00:00:00

abstract：:High-dose clindamycin (CLDM) and benzylpenicillin (PCG) are the recommended chemotherapeutic remedies for toxic shock-like syndrome caused by group A streptococci. One reason for this is that it has been shown that CLDM suppresses the expression of some exoproteins, e.g., SpeB, SpeA, and streptolysin O (Slo). We analy...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka M,Hasegawa T,Okamoto A,Torii K,Ohta M

更新日期：2005-01-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) of second-line antituberculosis drugs would allow for optimal individualized dosage adjustments and improve drug safety and therapeutic outcomes. To evaluate the pharmacokinetic (PK) characteristics of clinically relevant, multidrug treatment regimens and to improve the feasibility of...

journal_title：Antimicrobial agents and chemotherapy

authors： Park SI,Oh J,Jang K,Yoon J,Moon SJ,Park JS,Lee JH,Song J,Jang IJ,Yu KS,Chung JY

更新日期：2015-08-01 00:00:00

abstract：:Spiramycins are clinically important 16-member macrolide antibiotics produced by Streptomyces ambofaciens. Biosynthetic studies have established that the earliest lactonic intermediate in spiramycin biosynthesis, the macrolactone platenolide I, is synthesized by a type I modular polyketide synthase (PKS). Platenolide ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen HC,Darbon E,Thai R,Pernodet JL,Lautru S

更新日期：2013-08-01 00:00:00

abstract：:Hydroxamate-based chelators of iron are potent inhibitors of in vitro growth of Plasmodium falciparum. Two types of such chelators, the natural desferrioxamine and the synthetic reversed siderophore RSFileum2, are prototypes of antimalarial agents whose action spectra differ in the speed of action, stage dependence, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Golenser J,Tsafack A,Amichai Y,Libman J,Shanzer A,Cabantchik ZI

更新日期：1995-01-01 00:00:00

abstract：:The most deadly outbreak of Escherichia coli O104:H4 occurred in Europe in 2011. Here, we evaluated the effects of the retrograde trafficking inhibitor Retro-2(cycl) in a murine model of E. coli O104:H4 infection. Systemic treatment with Retro-2(cycl) significantly reduced body weight loss and improved clinical scores...

journal_title：Antimicrobial agents and chemotherapy

authors： Secher T,Shima A,Hinsinger K,Cintrat JC,Johannes L,Barbier J,Gillet D,Oswald E

更新日期：2015-08-01 00:00:00

abstract：:The ST5 lineage of methicillin-resistant Staphylococcus aureus (MRSA) is one of the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and is carried by medica...

journal_title：Antimicrobial agents and chemotherapy

authors： Takano T,Hung WC,Shibuya M,Higuchi W,Iwao Y,Nishiyama A,Reva I,Khokhlova OE,Yabe S,Ozaki K,Takano M,Yamamoto T

更新日期：2013-04-01 00:00:00

abstract：:Two coumarins, inhibitors of the B subunit of DNA gyrase, and six quinolones, inhibitors of the A subunit, were tested against Escherichia coli topoisomerase I-catalyzed DNA relaxation. Coumarins had no effect, whereas quinolones were inhibitors of the enzyme. This inhibition was compared with that of DNA gyrase and c...

journal_title：Antimicrobial agents and chemotherapy

authors： Tabary X,Moreau N,Dureuil C,Le Goffic F

更新日期：1987-12-01 00:00:00

abstract：:Whole-genome sequencing of trimethoprim-resistant Escherichia coli clinical isolates identified a member of the trimethoprim-resistant type II dihydrofolate reductase gene family (dfrB). The dfrB4 gene was located within a class I integron flanked by multiple resistance genes. This arrangement was previously reported ...

journal_title：Antimicrobial agents and chemotherapy

authors： Toulouse JL,Edens TJ,Alejaldre L,Manges AR,Pelletier JN

更新日期：2017-04-24 00:00:00

abstract：:Clostridium difficile is the leading cause of hospital-acquired infectious diarrhea. LFF571 is a novel inhibitor of the prokaryotic translation elongation factor Tu and is active against a range of bacterial species, including C. difficile. This first-in-human study investigated the safety and pharmacokinetics of sing...

journal_title：Antimicrobial agents and chemotherapy

authors： Ting LS,Praestgaard J,Grunenberg N,Yang JC,Leeds JA,Pertel P

更新日期：2012-11-01 00:00:00

abstract：:Flaviviruses comprise several medically important viruses, including Japanese encephalitis virus, West Nile virus, dengue virus (DENV), yellow fever virus, and Zika virus (ZIKV). A large outbreak of DENV and ZIKV occurred recently, leading to many cases of illness and death. However, despite decades of effort, we have...

journal_title：Antimicrobial agents and chemotherapy

authors： Chuang FK,Huang SM,Liao CL,Lee AR,Lien SP,Chiu YL,Chang TH,Tsai PL,Lin RJ,Shih CC,Tsai YJ,Lin GJ,Yen LC

更新日期：2019-12-20 00:00:00

abstract：:The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fletcher CV,Collier AC,Rhame FS,Bennett D,Para MF,Beatty CC,Jones CE,Balfour HH Jr

更新日期：1994-03-01 00:00:00

abstract：:CL 188,624, CL 190,294, and CL 191,121 are novel aminomethyl tetrahydrofuranyl (THF)-1 beta-methylcarbapenems. The in vitro antibacterial activities of these THF carbapenems were evaluated and compared with those of biapenem, imipenem, and meropenem against 554 recent clinical isolates obtained from geographically dis...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Petersen PJ,Jacobus NV,Lin YI,Bitha P,Testa RT

更新日期：1999-03-01 00:00:00

abstract：:Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine...

journal_title：Antimicrobial agents and chemotherapy

authors： Robert MG,Foguim Tsombeng F,Gendrot M,Mosnier J,Amalvict R,Benoit N,Torrentino-Madamet M,Pradines B,French National Reference Centre for Imported Malaria Study Group.

更新日期：2018-10-24 00:00:00