Abstract:
:Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae. The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance mechanisms. The times above the MIC (T>MIC) targets for stasis and 1- and 2-log reductions were 31%, 39%, and 42% for P. aeruginosa and 18%, 24%, and 27% for S. pneumoniae, respectively. The 1-log endpoint was achieved for strains with MICs as high as 16 μg/ml.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Lepak AJ,Reda A,Marchillo K,Van Hecker J,Craig WA,Andes Ddoi
10.1128/AAC.03572-14subject
Has Abstractpub_date
2014-10-01 00:00:00pages
6311-4issue
10eissn
0066-4804issn
1098-6596pii
AAC.03572-14journal_volume
58pub_type
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