Abstract:
:The in vitro activity of moxifloxacin against 923 recent anaerobic isolates obtained from pretreatment cultures in patients with complicated intra-abdominal infections was studied using the CLSI M11-A-6 agar dilution method. Moxifloxacin was active against 87% (96 of 110) Bacteroides fragilis strains at < or = 1 microg/ml and 87% (79 of 90) B. thetaiotaomicron strains at < or = 2 microg/ml. Species variation was seen, with B. uniformis, B. vulgatus, Clostridium clostridioforme, and C. symbiosum being least susceptible and accounting for most of the resistant isolates; excluding the aforementioned four resistant species, 86% (303 of 363) of Bacteroides species isolates and 94% (417 of 450) of all other genera and species were susceptible to < or = 2 microg/ml of moxifloxacin. Overall, moxifloxacin was active against 763 of 923 (83%) of strains at < or = 2 microg/ml, supporting its use as a monotherapy for some community-acquired intra-abdominal infections.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Goldstein EJ,Citron DM,Warren YA,Tyrrell KL,Merriam CV,Fernandez Hdoi
10.1128/AAC.50.1.148-155.2006subject
Has Abstractpub_date
2006-01-01 00:00:00pages
148-55issue
1eissn
0066-4804issn
1098-6596pii
50/1/148journal_volume
50pub_type
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journal_title:Antimicrobial agents and chemotherapy
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doi:10.1128/aac.22.5.805
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