Antibacterial activity of matrix-bound ovotransferrin.

abstract：:To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline a...

journal_title：Antimicrobial agents and chemotherapy

authors： Tang HJ,Chen CC,Cheng KC,Wu KY,Lin YC,Zhang CC,Weng TC,Yu WL,Chiu YH,Toh HS,Chiang SR,Su BA,Ko WC,Chuang YC

更新日期：2013-11-01 00:00:00

abstract：:Previous studies on tetracycline transport into Staphylococcus aureus identified a high-affinity, saturable uptake system for the antibiotic (Km, 4.76 microM) (B.L. Hutchings, Biochim. Biophys. Acta 174:734-738, 1969). However, the earlier results could not be confirmed using conditions that permitted energy-dependent...

journal_title：Antimicrobial agents and chemotherapy

authors： Chopra I,Ismail S,Oliva B

更新日期：1991-12-01 00:00:00

abstract：:The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Idelevich EA,Kriegeskorte A,Schleimer N,Peters G,von Eiff C,Becker K

更新日期：2018-03-27 00:00:00

abstract：:The rabbit kidney cell line LLC-RK1 was tested for its ability to discriminate the toxicities of six cephalosporin antibiotics according to their in vivo nephrotoxic potentials in rabbits. With the exception of cephalothin, which was markedly toxic to kidney cells in vitro, a good correlation between in vitro toxicity...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams PD,Laska DA,Tay LK,Hottendorf GH

更新日期：1988-03-01 00:00:00

abstract：:Despite being genetically monomorphic, the limited genetic diversity within the Mycobacterium tuberculosis complex (MTBC) has practical consequences for molecular methods for drug susceptibility testing and for the use of current antibiotics and those in clinical trials. It renders some representatives of MTBC intrins...

journal_title：Antimicrobial agents and chemotherapy

authors： Köser CU,Feuerriegel S,Summers DK,Archer JA,Niemann S

更新日期：2012-12-01 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ittarat I,Asawamahasakda W,Bartlett MS,Smith JW,Meshnick SR

更新日期：1995-02-01 00:00:00

abstract：:Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the bactericidal efficacy of liposome-entrapped aminoglycosides against resistant clin...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugabe C,Halwani M,Azghani AO,Lafrenie RM,Omri A

更新日期：2006-06-01 00:00:00

abstract：:The antibiotic cerulenin markedly inhibits the growth of Escherichia coli. The effects of the antibiotic on cellular syntheses were studied by measuring the incorporation of labeled precursors into lipids and macromolecules. During the first 40 min after the addition of cerulenin to a culture of growing cells, lipid s...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldberg I,Walker JR,Bloch K

更新日期：1973-05-01 00:00:00

abstract：:Ex vivo assay systems provide a powerful approach to studying human malaria parasite biology and to testing antimalarials. For rodent malaria parasites, short-term in vitro culture and ex vivo antimalarial susceptibility assays are relatively cumbersome, relying on in vivo passage for synchronization, since ring-stage...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang ZW,Malleret B,Russell B,Rénia L,Claser C

更新日期：2016-10-21 00:00:00

abstract：:Sordarin and its derivatives are antifungal compounds of potential clinical interest. Despite the highly conserved nature of the fungal and mammalian protein synthesis machineries, sordarin is a selective inhibitor of protein synthesis in fungal organisms. In cells sensitive to sordarin, its mode of action is through ...

journal_title：Antimicrobial agents and chemotherapy

authors： Botet J,Rodríguez-Mateos M,Ballesta JP,Revuelta JL,Remacha M

更新日期：2008-05-01 00:00:00

abstract：:The activities of ampicillin, meropenem, azithromycin, gentamicin, ciprofloxacin, and moxifloxacin against intracellular hemolysin-positive Listeria monocytogenes were measured in human THP-1 macrophages and were compared with the extracellular activities observed in broth. All extracellular concentrations were adjust...

journal_title：Antimicrobial agents and chemotherapy

authors： Carryn S,Van Bambeke F,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-07-01 00:00:00

abstract：:The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 8...

journal_title：Antimicrobial agents and chemotherapy

authors： Fu KP,Neu HC

更新日期：1978-06-01 00:00:00

abstract：:The effects of free amphotericin B (as Fungizone) and amphotericin B (AMB) incorporated into liposomes on the proliferation of lymphocytes were determined. Freshly obtained guinea pig and rat antigen-specific lymphocytes were compared with rat T-lymphocyte cell lines cultured for a long period of time. Incorporation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Boggs JM,Chang NH,Goundalkar A

更新日期：1991-05-01 00:00:00

abstract：:Metronidazole is now being used with increasing frequency for various infectious conditions in patients with renal failure. It is commonly administered to septic patients who have developed acute renal failure requiring hemodialysis. The hemodialysis clearances of metronidazole and its metabolites were evaluated in ni...

journal_title：Antimicrobial agents and chemotherapy

authors： Lau AH,Chang CW,Sabatini S

更新日期：1986-02-01 00:00:00

abstract：:An indirect mouse model was utilized to evaluate the antiviral activity of several compounds against Venezuelan equine encephalomyelitis (VEE) virus infection in mice. Mice were given various dosages of lysine-stabilized polyriboinosinic acid-polyribocytidylic acid, a tilorone analogue, kethoxal, or mepacrine before a...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuehne RW,Pannier WL,Stephen EL

更新日期：1977-04-01 00:00:00

abstract：:Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246, a small-molecule inhibitor of virus egress, has been shown to provide protection against severe disease and death induced by se...

journal_title：Antimicrobial agents and chemotherapy

authors： Berhanu A,King DS,Mosier S,Jordan R,Jones KF,Hruby DE,Grosenbach DW

更新日期：2009-12-01 00:00:00

abstract：:The role of linezolid in empirical therapy of suspected bacteremia remains unclear. The aim of this study was to evaluate the influence of empirical use of linezolid or glycopeptides in addition to other antibiotics on the 30-day mortality rates in patients with Gram-negative bacteremia. For this purpose, 1,126 patien...

journal_title：Antimicrobial agents and chemotherapy

authors： Ternavasio-de la Vega HG,Mateos-Díaz AM,Martinez JA,Almela M,Cobos-Trigueros N,Morata L,De-la-Calle C,Sala M,Mensa J,Marcos M,Soriano A

更新日期：2014-12-01 00:00:00

abstract：:Letermovir, GW275175X (a benzimidazole), and tomeglovir (Bay38-4766) are chemically unrelated human cytomegalovirus (CMV) terminase complex inhibitors that have been tested in human subjects. UL56 gene mutations are the dominant pathway of letermovir resistance, while UL89 and UL56 mutations are known to confer benzim...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S

更新日期：2017-10-24 00:00:00

abstract：:In this study, our objective was to determine whether a synergistic antimicrobial combination in vitro would be beneficial in the downregulation of pneumococcal virulence genes and whether the associated inflammation of the lung tissue induced by multidrug-resistant Streptococcus pneumoniae infection in vivo needs to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Majhi A,Adhikary R,Bhattacharyya A,Mahanti S,Bishayi B

更新日期：2014-09-01 00:00:00

abstract：:Emtricitabine (FTC) is approved for the treatment of human immunodeficiency virus. FTC and clevudine (CLV) have activity against hepatitis B virus (HBV). This report summarizes the results of a double-blind, multicenter study of patients with chronic hepatitis B who had completed a phase 3 study of FTC and were random...

journal_title：Antimicrobial agents and chemotherapy

authors： Lim SG,Krastev Z,Ng TM,Mechkov G,Kotzev IA,Chan S,Mondou E,Snow A,Sorbel J,Rousseau F

更新日期：2006-05-01 00:00:00

abstract：:Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 microg/ml. These MICs were lower than those of other quinolones (< or = 0.008 to > 32 microg/ml). Beta-lactam MICs were between < or = 0.008 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kosowska-Shick K,Smith K,Bogdanovich T,Ednie LM,Jones RN,Appelbaum PC

更新日期：2006-12-01 00:00:00

abstract：:The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DN...

journal_title：Antimicrobial agents and chemotherapy

authors： Fourel I,Hantz O,Watanabe KA,Jacquet C,Chomel B,Fox JJ,Trepo C

更新日期：1990-03-01 00:00:00

abstract：:The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively (with an MBC/MIC ratio of 1 to 2), and against 18 of the 21 species tested,...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Labrousse V,Goh KS,De Sousa JP

更新日期：1991-12-01 00:00:00

abstract：:Concomitant treatment of tuberculosis (TB) and HIV is recommended and improves outcomes. Bedaquiline is a novel drug for the treatment of multidrug-resistant (MDR) TB; combined use with antiretroviral drugs, nevirapine, or ritonavir-boosted lopinavir (LPV/r) is anticipated, but no clinical data from coinfected patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Svensson EM,Dooley KE,Karlsson MO

更新日期：2014-11-01 00:00:00

abstract：:Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including c...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen B,Noller HF,Daubresse G,Oliva B,Misulovin Z,Rothstein DM,Ellestad GA,Gluzman Y,Tally FP,Chopra I

更新日期：1991-11-01 00:00:00

abstract：:The effects of an antacid containing magnesium and aluminum hydroxide on the pharmacokinetics of pefloxacin in 10 healthy volunteers were investigated. In a randomized crossover design, each subject received an oral dose of 400 mg of pefloxacin either with or without multiple doses of the antacid. The concentrations o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaehde U,Sörgel F,Stephan U,Schunack W

更新日期：1994-05-01 00:00:00

abstract：:Streptococcus agalactiae (group B Streptococcus [GBS]) is a Gram-positive bacterium that colonizes the cervicovaginal tract in approximately 25% of healthy women. Although colonization is asymptomatic, GBS can be vertically transmitted to newborns peripartum, causing severe disease such as pneumonia and meningitis. Cu...

journal_title：Antimicrobial agents and chemotherapy

authors： Cavaco CK,Patras KA,Zlamal JE,Thoman ML,Morgan EL,Sanderson SD,Doran KS

更新日期：2013-11-01 00:00:00

abstract：:A unique group of viridans streptococci has been found in South Africa. These organisms were isolated in close temporal and physical proximity to the isolation of penicillin-resistant pneumococci. The strains were resistant to penicillin, oxacillin, the cephalosporins (all generations), piperacillin, azlocillin, and m...

journal_title：Antimicrobial agents and chemotherapy

authors： Farber BF,Eliopoulos GM,Ward JI,Ruoff KL,Syriopoulou V,Moellering RC Jr

更新日期：1983-11-01 00:00:00

abstract：:The antibacterial drug nalidixic acid (Nal) can suppress the growth of Candida albicans at levels of the drug normally found in urine. Growth suppression increases as drug levels are increased, and Nal also causes a similar proportional inhibition of the synthesis of all cellular macromolecules. However, growth temper...

journal_title：Antimicrobial agents and chemotherapy

authors： Sobieski RJ,Brewer AR

更新日期：1976-03-01 00:00:00

abstract：:The in vitro activity of rosamicin and erythromycin was compared at various pH values against 311 strains of bacteria representing common urinary tract pathogens. Alkalinization of the media consistently and significantly increased the antibacterial activity of rosamicin against all of the organisms tested. This was a...

journal_title：Antimicrobial agents and chemotherapy

authors： Eickhoff TC,Ehret JM

更新日期：1979-07-01 00:00:00