In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics.

abstract：:The antimicrobial efflux system encoded by the operon mef(E)-mel on the mobile genetic element MEGA in Streptococcus pneumoniae and other Gram-positive bacteria is inducible by macrolide antibiotics and antimicrobial peptides. Induction may affect the clinical response to the use of macrolides. We developed mef(E) rep...

journal_title：Antimicrobial agents and chemotherapy

authors： Chancey ST,Zhou X,Zähner D,Stephens DS

更新日期：2011-07-01 00:00:00

abstract：:Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The objective of this study was to characterize the dose-response relationship of ceftaroline fosamil against S. aureus in an immunocompromised murine pneumonia model, as ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhalodi AA,Crandon JL,Biek D,Nicolau DP

更新日期：2012-12-01 00:00:00

abstract：:A DNA probe was developed by inserting, in the SmaI site of pBluescript sK, a 528-bp fragment of the gene responsible for intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus (mec determinant). The mec probe provided a useful tool for the rapid identification of the intrinsic resistance trait and f...

journal_title：Antimicrobial agents and chemotherapy

authors： Ligozzi M,Rossolini GM,Tonin EA,Fontana R

更新日期：1991-03-01 00:00:00

abstract：:The effects of renal impairment on the pharmacokinetics of ceftriaxone in humans were examined after intravenous infusion of a 1-g dose over 15 min to 30 renally impaired patients. The study included 12 dialysis patients and 18 patients with severe, moderate, or mild renal impairment. Plasma and, where appropriate, ur...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel IH,Sugihara JG,Weinfeld RE,Wong EG,Siemsen AW,Berman SJ

更新日期：1984-04-01 00:00:00

abstract：:The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmucoid strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis. Twenty-three clinical strains, includ...

journal_title：Antimicrobial agents and chemotherapy

authors： Li J,Turnidge J,Milne R,Nation RL,Coulthard K

更新日期：2001-03-01 00:00:00

abstract：:Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria. Nebulization seems to be a promising form of administration, but colistin is administered as an inactive prodrug, colistin methanesulfon...

journal_title：Antimicrobial agents and chemotherapy

authors： Boisson M,Jacobs M,Grégoire N,Gobin P,Marchand S,Couet W,Mimoz O

更新日期：2014-12-01 00:00:00

abstract：:The influence of five antibiotics (netilmicin, ceftriaxone, cefepime, fleroxacin, and ciprofloxacin) on capsular polysaccharide distribution and on opsonophagocytosis by human polymorphonuclear leukocytes of unencapsulated and encapsulated Escherichia coli strains was studied. Unencapsulated E. coli strains were readi...

journal_title：Antimicrobial agents and chemotherapy

authors： Raponi G,Keller N,Overbeek BP,Rozenberg-Arska M,van Kessel KP,Verhoef J

更新日期：1990-02-01 00:00:00

abstract：:Temafloxacin, a new fluoroquinolone, alone or in combination with tobramycin, was compared with penicillin, tobramycin, and their combination in the therapy of rabbits with endocarditis caused by Streptococcus adjacens GaDT, a new species of nutritionally variant streptococci. Animals were injected intramuscularly for...

journal_title：Antimicrobial agents and chemotherapy

authors： Cremieux AC,Saleh-Mghir A,Vallois JM,Maziere B,Muffat-Joly M,Devine C,Bouvet A,Pocidalo JJ,Carbon C

更新日期：1992-10-01 00:00:00

abstract：:The aminoglycoside-modifying enzymes present in the first 120 clinical isolates harboring extended-spectrum beta-lactamases isolated in Spain were studied. Most of these isolates (84%) were gentamicin resistant. The enzymes most frequently associated and cotransferred with SHV-2 or TEM-type beta-lactamases were AAC(3)...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandez-Rodriguez A,Canton R,Perez-Diaz JC,Martinez-Beltran J,Picazo JJ,Baquero F

更新日期：1992-11-01 00:00:00

abstract：:A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

journal_title：Antimicrobial agents and chemotherapy

authors： Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

更新日期：2000-06-01 00:00:00

abstract：:R factors were detected in Vibrio anguillarum strains from vibrio-diseased freshwater fish, ayu (Plecoglossus altivelis), in Japan. It was found that 65 out of the 68 random isolates from epidemics of vibrio disease in 1973 carried transferable drug resistance factors. The most common type determined resistance to sul...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoki T,Egusa S,Arai T

更新日期：1974-11-01 00:00:00

abstract：:The in vitro activities of tigecycline and selected antimicrobials were evaluated against a variety of multiple-drug-resistant clinical isolates, including extended-spectrum beta-lactamase- and/or metallo-beta-lactamase-producing gram-negative strains, colistin-resistant strains, vancomycin- and/or linezolid-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Souli M,Kontopidou FV,Koratzanis E,Antoniadou A,Giannitsioti E,Evangelopoulou P,Kannavaki S,Giamarellou H

更新日期：2006-09-01 00:00:00

abstract：:In a crossover study, single doses of netilmicin and gentamicin were administered intramuscularly, each at 1.0 and 2.5 mg/kg. The serum concentrations, analyzed by a two-compartment open model with a first-order absorption, indicated that the pharmacokinetics of the drugs are essentially the same. Both drugs were rapi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chung M,Costello R,Symchowicz S

更新日期：1980-02-01 00:00:00

abstract：:Antiviral drugs do not currently exist for the treatment of enterovirus infections, which are often severe and potentially life-threatening. We conducted high-throughput molecular screening and identified a structurally diverse set of compounds that inhibit the replication of coxsackievirus B3, a commonly encountered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zuo J,Kye S,Quinn KK,Cooper P,Damoiseaux R,Krogstad P

更新日期：2015-12-28 00:00:00

abstract：:We assessed the pharmacokinetics and interactions of steady-state micafungin (Mycamine) or placebo with steady-state voriconazole in 35 volunteers. The 90% confidence intervals around the least-squares mean ratios for micafungin pharmacokinetic parameters and placebo-corrected voriconazole pharmacokinetic parameters w...

journal_title：Antimicrobial agents and chemotherapy

authors： Keirns J,Sawamoto T,Holum M,Buell D,Wisemandle W,Alak A

更新日期：2007-02-01 00:00:00

abstract：:There has been a marked increase in the resistance of Neisseria gonorrhoeae isolated in Korea to penicillin, ampicillin, and tetracycline. In contrast, there has been no increased resistance to spectinomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson C,Rose DL,Tramont EC

更新日期：1976-04-01 00:00:00

abstract：:In vitro surveys of antimicrobial resistance among clinically important anaerobes are an important source of information that can be used for clinical decisions in the choice of empiric antimicrobial therapy. This study surveyed the susceptibilities of 556 clinical anaerobic isolates from four large medical centers us...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft D,Cambre K,Pierson CL,Jenkins SG,Rosenblatt JE

更新日期：2001-04-01 00:00:00

abstract：:Attachment of giardias to intestinal cells has been difficult to study because of a lack of a convenient in vitro model. We developed an assay for attachment of radiolabeled trophozoites to IEC-6 cells that can be done in microtiter trays. Attachment was confirmed by scanning and transmission electron microscopy. Trop...

journal_title：Antimicrobial agents and chemotherapy

authors： McCabe RE,Yu GS,Conteas C,Morrill PR,McMorrow B

更新日期：1991-01-01 00:00:00

abstract：:Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Cane PA,Cook P,Ratcliffe D,Mutimer D,Pillay D

更新日期：1999-07-01 00:00:00

abstract：:Forty-nine clinical isolates of multidrug-resistant Acinetobacter baumannii were obtained from 12 hospitals in 7 prefectures throughout Japan. Molecular phylogenetic analysis revealed the clonal spread of A. baumannii sequence type 208 (ST208) and ST455 isolates harboring the armA gene and ST512 harboring the armA and...

journal_title：Antimicrobial agents and chemotherapy

authors： Tada T,Miyoshi-Akiyama T,Shimada K,Shimojima M,Kirikae T

更新日期：2014-05-01 00:00:00

abstract：:The beta-lactamases in 154 clinical Mycobacterium tuberculosis strains were studied. Susceptibilities to beta-lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24 M. tuberculosis strains susceptible to antimycobacterial drugs and in nine multiresistant strains. A...

journal_title：Antimicrobial agents and chemotherapy

authors： Segura C,Salvadó M,Collado I,Chaves J,Coira A

更新日期：1998-06-01 00:00:00

abstract：:Management of treatment-experienced human immunodeficiency virus patients has become complex, and therapy may need to include two protease inhibitors at therapeutic doses. The objective of this study was to characterize the pharmacokinetics in serum of saquinavir (1,000 mg twice daily [b.i.d.]), lopinavir (400 mg b.i....

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Lopez RM,Diaz M,Pou L,Ruiz L,Falcó V,Crespo M,Azuaje C,Ruiz I,Ocaña I,Clotet B,Pahissa A

更新日期：2004-11-01 00:00:00

abstract：:A practical preclinical model for the hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors has been developed. Indinavir and atazanavir produced significant hyperbilirubinemia, whereas amprenavir, the negative control, was indistinguishable from the ritonavir booster dose. This model was use...

journal_title：Antimicrobial agents and chemotherapy

authors： Kempf DJ,Waring JF,Morfitt DC,Werner P,Ebert B,Mitten M,Nguyen B,Randolph JT,DeGoey DA,Klein LL,Marsh K

更新日期：2006-02-01 00:00:00

abstract：:The residual antibiotic concentration of vancomycin (2 mg/ml)- or ceftazidime (2 mg/ml)-heparin solutions instilled in ports in pediatric hematology-oncology patients 1 to 34 days earlier was measured. Antibiotic concentrations of > or = 100 microg of either antibiotic per ml persisted for at least 21 days. For treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Haimi-Cohen Y,Husain N,Meenan J,Karayalcin G,Lehrer M,Rubin LG

更新日期：2001-05-01 00:00:00

abstract：:The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A

更新日期：1998-07-01 00:00:00

abstract：:This analysis was conducted to determine whether the hepatitis C virus (HCV) viral kinetics (VK) model can predict viral load (VL) decreases for nonnucleoside polymerase inhibitors (NNPolIs) and protease inhibitors (PIs) after 3-day monotherapy studies of patients infected with genotype 1 chronic HCV. This analysis in...

journal_title：Antimicrobial agents and chemotherapy

authors： Reddy MB,Morcos PN,Le Pogam S,Ou Y,Frank K,Lave T,Smith P

更新日期：2012-06-01 00:00:00

abstract：:The substituted benzimidazole omeprazole, used for the treatment of human peptic ulcer disease, inhibits the growth of the metronidazole-resistant bovine pathogen Tritrichomonas foetus in vitro (MIC at which the growth of parasite cultures is inhibited by 50%, 22 microg/ml [63 microM]). The antitrichomonad activity ap...

journal_title：Antimicrobial agents and chemotherapy

authors： Sutak R,Tachezy J,Kulda J,Hrdý I

更新日期：2004-06-01 00:00:00

abstract：:Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST...

journal_title：Antimicrobial agents and chemotherapy

authors： Li A,Yang Y,Miao M,Chavda KD,Mediavilla JR,Xie X,Feng P,Tang YW,Kreiswirth BN,Chen L,Du H

更新日期：2016-06-20 00:00:00

abstract：:Multidrug-resistant bacteria pose a major challenge to the clinical management of infections in resource-poor settings. Although nontyphoidal Salmonella (NTS) bacteria cause predominantly enteric self-limiting illness in developed countries, NTS is responsible for a huge burden of life-threatening bloodstream infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Kariuki S,Okoro C,Kiiru J,Njoroge S,Omuse G,Langridge G,Kingsley RA,Dougan G,Revathi G

更新日期：2015-01-01 00:00:00

abstract：:Stenotrophomonas maltophilia is increasingly being isolated from the respiratory tract of individuals with cystic fibrosis, and, because of its multidrug-resistant nature, the selection of suitable treatment regimens can be problematical. Etest methodology was used to facilitate MIC and antimicrobial combination testi...

journal_title：Antimicrobial agents and chemotherapy

authors： Milne KE,Gould IM

更新日期：2012-08-01 00:00:00