Pharmacokinetic study of an oral cephalosporin, cefdinir, in hemodialysis patients.


:The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in the test without dialysis and for 72 h in the test with dialysis. In the test without dialysis, the maximum plasma concentration (Cmax) was 2.36 +/- 0.53 micrograms/ml (mean +/- standard deviation) and the time to Cmax was 9.00 +/- 2.45 h. The terminal elimination half-life (t1/2) and area under the concentration-time curve (AUC) were 16.95 +/- 1.20 h and 69.05 +/- 14.84 micrograms.h/ml, respectively. In the test with dialysis, t1/2 during hemodialysis decreased approximately to one-sixth of that obtained in the test without dialysis, although t1/2 in the latter elimination phase did not differ from that in the nondialysis test. AUC was reduced to 43% of that in the test without dialysis. The fractional removal of cefdinir by hemodialysis was 61%. These findings indicate that clearance of cefdinir is prolonged in patients with renal failure, and cefdinir is well removed by introduction of hemodialysis, although t1/2 (during hemodialysis) and AUC were two and eight times higher than the data previously reported for healthy volunteers, respectively. The pharmacokinetic data suggest that 100 mg of oral cefdinir once a day would result in a sufficient concentration in plasma in hemodialysis patients, but this remains to be confirmed by multiple-dose studies.


Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A




Has Abstract


1998-07-01 00:00:00












  • In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance.

    abstract::We investigated the evolution of resistance to the antifungal drug itraconazole in replicate populations of Aspergillus fumigatus that were founded from a strain with a genotype of sensitivity to a single drug and then propagated under uniform conditions. For each population, conidia were serially transferred 10 times...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: da Silva Ferreira ME,Capellaro JL,dos Reis Marques E,Malavazi I,Perlin D,Park S,Anderson JB,Colombo AL,Arthington-Skaggs BA,Goldman MH,Goldman GH

    更新日期:2004-11-01 00:00:00

  • Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates.

    abstract::The in vitro activity of a new oral antimicrobial agent, norfloxacin (MK-0366), was compared with those of nalidixic acid, nitrofurantoin, co-trimoxazole, trimethoprim, sulfamethoxazole, cinoxacin, tetracycline, ampicillin, carbenicillin, and cephalexin against 628 urinary bacterial isolates. Norfloxacin was the most ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Khan MY,Gruninger RP,Nelson SM,Klicker RE

    更新日期:1982-05-01 00:00:00

  • Rapid detection of chloramphenicol resistance in Haemophilus influenzae.

    abstract::We compared a rigid (1-h) screening method for the detection of chloramphenicol acetyltransferase (CAT) activity with the standard spectrophotometric CAT assay to determine whether CAT-mediated chloramphenicol resistance in Haemophilus influenzae could be determined upon primary isolation. Of 58 H. influenzae cell son...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Azemun P,Stull T,Roberts M,Smith AL

    更新日期:1981-08-01 00:00:00

  • In Vitro and In Vivo Activity of a Novel Catheter Lock Solution against Bacterial and Fungal Biofilms.

    abstract::Central-line-associated bloodstream infections are increasingly recognized to be associated with intraluminal microbial biofilms, and effective measures for the prevention and treatment of bloodstream infections remain lacking. This report evaluates a new commercially developed antimicrobial catheter lock solution (AC...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chandra J,Long L,Isham N,Mukherjee PK,DiSciullo G,Appelt K,Ghannoum MA

    更新日期:2018-07-27 00:00:00

  • Staphylococcus aureus isolates with reduced susceptibility to glycopeptides belong to accessory gene regulator group I or II.

    abstract::We used multiplex PCR to determine the agr group membership of 18 European glycopeptide heterointermediate and intermediate-resistant Staphylococcus aureus strains. Of the 15 agr group I strains, 13 were resistant and 2 were susceptible to methicillin. The remaining three strains, like the United States and Japanese c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Verdier I,Reverdy ME,Etienne J,Lina G,Bes M,Vandenesch F

    更新日期:2004-03-01 00:00:00

  • Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s.

    abstract::Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (W...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yui Eto K,Firth N,Davis AM,Kwong SM,Krysiak M,Lee YT,O'Brien FG,Grubb WB,Coombs GW,Bond CS,Ramsay JP

    更新日期:2019-10-22 00:00:00

  • Summary of linezolid activity and resistance mechanisms detected during the 2012 LEADER surveillance program for the United States.

    abstract::This study summarizes the linezolid susceptibility testing results for 7,429 Gram-positive pathogens from 60 U.S. sites collected during the 2012 sampling year for the LEADER Program. Linezolid showed potent activity when tested against 2,980 Staphylococcus aureus isolates, inhibiting all but 3 at ≤2 μg/ml. Similarly,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Mendes RE,Flamm RK,Hogan PA,Ross JE,Jones RN

    更新日期:2014-01-01 00:00:00

  • Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype typhimurium.

    abstract::The presence and genetic content of integrons were investigated for 37 epidemiologically unrelated multiple-drug-resistant strains of Salmonella enterica serotype Typhimurium from humans. All isolates were resistant to ampicillin, chloramphenicol, kanamycin, streptomycin, sulfonamides, and trimethoprim, as well as to ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tosini F,Visca P,Luzzi I,Dionisi AM,Pezzella C,Petrucca A,Carattoli A

    更新日期:1998-12-01 00:00:00

  • SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.

    abstract::A carbapenem-resistant Serratia marcescens strain, 10mdr148, was identified in a Japanese hospital in 2010. The carbapenem resistance of this strain was attributed to the production of a novel metallo-β-lactamase (MBL), named SMB-1 (Serratia metallo-β-lactamase). SMB-1 possessed a zinc binding motif, H(Q)XHXDH (residu...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wachino J,Yoshida H,Yamane K,Suzuki S,Matsui M,Yamagishi T,Tsutsui A,Konda T,Shibayama K,Arakawa Y

    更新日期:2011-11-01 00:00:00

  • Effect of 3'-azido-3'-deoxythymidine on human immunodeficiency virus type 1 replication in human fetal brain macrophages.

    abstract::We investigated whether cells derived from the fetal central nervous system can support productive infection by a human immunodeficiency virus type 1 (HIV-1) isolate termed UHC-1, produced by a cellular clone derived from HIV-1 strain HIV-IIIB chronically infected U-937 promonocytic cells, and what the effect of nucle...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Geleziunas R,Arts EJ,Boulerice F,Goldman H,Wainberg MA

    更新日期:1993-06-01 00:00:00

  • In vitro and in vivo activities of azithromycin, a new azalide antibiotic, against chlamydia.

    abstract::The in vitro and in vivo activities of azithromycin against chlamydia were investigated. The MIC of azithromycin for five standard strains of different species of chlamydia and six wild-type strains of Chlamydia pneumoniae was 0.125 microgram/ml, which was superior to that of erythromycin but inferior to those of clar...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Niki Y,Kimura M,Miyashita N,Soejima R

    更新日期:1994-10-01 00:00:00

  • Inhibition of herpes simplex virus type 1 replication by halothane.

    abstract::Halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) inhibited herpes simplex virus type 1 (HSV-1) replication, although HSV-1 DNA was synthesized at normal levels in Vero cells. Viral capsids and extracellular virions were inhibited, and HSV-1 protein synthesis decreased by 50%, although no specific HSV-1 protein faile...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bedows E,Holland TC,Knight PR

    更新日期:1986-05-01 00:00:00

  • 24-Hour Pharmacokinetic Relationships for Vancomycin and Novel Urinary Biomarkers of Acute Kidney Injury.

    abstract::Vancomycin has been associated with acute kidney injury in preclinical and clinical settings; however, the precise exposure profiles associated with vancomycin-induced acute kidney injury have not been defined. We sought to determine pharmacokinetic/pharmacodynamics indices associated with the development of acute kid...

    journal_title:Antimicrobial agents and chemotherapy

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    authors: O'Donnell JN,Rhodes NJ,Lodise TP,Prozialeck WC,Miglis CM,Joshi MD,Venkatesan N,Pais G,Cluff C,Lamar PC,Briyal S,Day JZ,Gulati A,Scheetz MH

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  • Enhanced killing of Candida albicans by cultured peritoneal exudate cells treated with SM-1213, a synthetic immunomodulator.

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Morrison CJ,Gordon P,Hashimoto T

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  • Novel OXA-10-derived extended-spectrum beta-lactamases selected in vivo or in vitro.

    abstract::A clinical isolate of Pseudomonas aeruginosa, PAe191, was found to be highly resistant to all anti-Pseudomonas beta-lactam antibiotics (except imipenem) and resistant also to aminoglycosides. It produced a beta-lactamase (with an apparent pI of 7.6) which was not inhibited by clavulanic acid. Cloning and characterizat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mugnier P,Casin I,Bouthors AT,Collatz E

    更新日期:1998-12-01 00:00:00

  • Synergy of penicillin and decreasing concentration of aminoglycosides against enterococci from patients with infective endocarditis.

    abstract::To determine whether low concentrations of aminoglycosides in combination with penicillin could effectively kill enterococci in vitro, we tested penicillin (20 micrograms/ml) in combination with decreasing concentrations of either streptomycin (20, 10, 5, and 1 micrograms/ml) or gentamicin (5, 3, 1, and 0.5 micrograms...

    journal_title:Antimicrobial agents and chemotherapy

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    authors: Matsumoto JY,Wilson WR,Wright AJ,Geraci JE,Washington JA 2nd

    更新日期:1980-12-01 00:00:00

  • Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.

    abstract::Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor (LEDGF) protein, might restrain an early step of the vir...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Badia R,Pauls E,Riveira-Munoz E,Clotet B,Esté JA,Ballana E

    更新日期:2014-08-01 00:00:00

  • Evolution and global dissemination of macrolide-resistant group A streptococci.

    abstract::Macrolide-resistant group A streptococci (MRGAS) have been recovered from many countries worldwide. However, the strain typing information that is available has been insufficient for estimating the total number of macrolide-resistant clones, their geographic distributions, and their evolutionary relationships. In this...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Robinson DA,Sutcliffe JA,Tewodros W,Manoharan A,Bessen DE

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  • Comparison of the antibacterial efficacies of ampicillin and ciprofloxacin against experimental infections with Listeria monocytogenes in hydrocortisone-treated mice.

    abstract::The efficacies of ciprofloxacin and ampicillin against Listeria monocytogenes in an immunosuppressed mouse model of listeriosis were compared. Immunosuppression was achieved by administration of 2.5 mg of hydrocortisone acetate daily. Both ciprofloxacin and ampicillin were effective in reducing the number of viable L....

    journal_title:Antimicrobial agents and chemotherapy

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    authors: van Ogtrop ML,Mattie H,Sekh BR,van Strijen E,van Furth R

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  • Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes.

    abstract::The linkage between the macrolide efflux gene mef(I) and the chloramphenicol inactivation gene catQ was first described in Streptococcus pneumoniae (strain Spn529), where the two genes are located in a module designated IQ element. Subsequently, two different defective IQ elements were detected in Streptococcus pyogen...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mingoia M,Morici E,Morroni G,Giovanetti E,Del Grosso M,Pantosti A,Varaldo PE

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  • Impact of MIC range for Pseudomonas aeruginosa and Streptococcus pneumoniae on the ceftolozane in vivo pharmacokinetic/pharmacodynamic target.

    abstract::Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae. The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lepak AJ,Reda A,Marchillo K,Van Hecker J,Craig WA,Andes D

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  • Novel type of plasmid-borne resistance to trimethoprim.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sundström L,Vinayagamoorthy T,Sköld O

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  • Inhibition of ribonucleic acid polymerase by a bacteriocin from Bacteroides fragilis.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mossie KG,Robb FT,Jones DT,Woods DR

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  • Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.

    abstract::Using the techniques of gap misrepair mutagenesis and site-directed mutagenesis, we have generated two novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein. DNA sequencing showed these mutations to be Ser-83----Ala and Gln-106----Arg. The mutant proteins were overproduced and purified, and...

    journal_title:Antimicrobial agents and chemotherapy

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    authors: Hallett P,Maxwell A

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  • In vitro activity of systemic antifungal agents against Malassezia furfur.

    abstract::The activity of four antifungal agents against 15 systemic (blood and vascular catheter) and 10 superficial (skin) Malassezia furfur isolates was evaluated. MIC ranges were similar for the two groups of organisms: amphotericin B, 0.3 to 2.5 micrograms/ml; flucytosine, greater than 100 micrograms/ml; miconazole, 0.4 to...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Marcon MJ,Durrell DE,Powell DA,Buesching WJ

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bayer AS,Cheng D,Yeaman MR,Corey GR,McClelland RS,Harrel LJ,Fowler VG Jr

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  • Pharmacodynamics and Biodistribution of Single-Dose Liposomal Amphotericin B at Different Stages of Experimental Visceral Leishmaniasis.

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    pub_type: 杂志文章


    authors: Voak AA,Harris A,Qaiser Z,Croft SL,Seifert K

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  • Piperaquine pharmacodynamics and parasite viability in a murine malaria model.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Moore BR,Ilett KF,Page-Sharp M,Jago JD,Batty KT

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Goldstein EJ,Kwok YY,Sutter VL

    更新日期:1983-09-01 00:00:00

  • In vitro synergism between cefotaxime and minocycline against Vibrio vulnificus.

    abstract::We conducted time-kill studies to evaluate the inhibitory activities of either cefotaxime or minocycline alone and the two drugs in combination against a clinical strain of Vibrio vulnificus. The MICs of cefotaxime and minocycline were 0.03 and 0.06 microg/ml, respectively. When approximately 5 x 10(5) CFU of V. vulni...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chuang YC,Liu JW,Ko WC,Lin KY,Wu JJ,Huang KY

    更新日期:1997-10-01 00:00:00