Sparfloxacin selects gyrase mutations in first-step Mycoplasma hominis mutants, whereas ofloxacin selects topoisomerase IV mutations.

abstract：:Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour), which has been used as an antimalarial in Chinese traditional medicine for more than 2,000 years. However, intensive study of the properties of febrifugine has been hindered for decades due to its side ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiang S,Zeng Q,Gettayacamin M,Tungtaeng A,Wannaying S,Lim A,Hansukjariya P,Okunji CO,Zhu S,Fang D

更新日期：2005-03-01 00:00:00

abstract：:The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazzarini C,Esposto MC,Prigitano A,Cogliati M,De Lorenzis G,Tortorano AM

更新日期：2015-11-09 00:00:00

abstract：:(E)-(S)-4-((S)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-pent-4-ynoylamino)-5-((S)-2-oxo-pyrrolidin-3-yl)-pent-2-enoic acid ethyl ester (Compound 1) is a novel, irreversible inhibitor of human rhinovirus (HRV) 3C protease {inactivation rate constant (Kobs/[I]) of 223,000 M-1s-1}. In cell-base...

journal_title：Antimicrobial agents and chemotherapy

authors： Patick AK,Brothers MA,Maldonado F,Binford S,Maldonado O,Fuhrman S,Petersen A,Smith GJ 3rd,Zalman LS,Burns-Naas LA,Tran JQ

更新日期：2005-06-01 00:00:00

abstract：:Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, and expressed the wild-type B. gibsoni dhfr-ts gene in Escherichia coli and evaluated the inhib...

journal_title：Antimicrobial agents and chemotherapy

authors： Aboge GO,Jia H,Terkawi MA,Goo YK,Nishikawa Y,Sunaga F,Namikawa K,Tsuji N,Igarashi I,Suzuki H,Fujisaki K,Xuan X

更新日期：2008-11-01 00:00:00

abstract：:The frequencies of tetracycline resistance determinants of the classes A, B, C, and D were determined in 53 non-lactose-fermenting clinical isolates. The most frequent class of determinant in Salmonella typhimurium and Shigella flexneri strains was class B; however, the predominant determinant in Shigella sonnei strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Salazar JM,Alvarez G,Gómez-Eichelmann MC

更新日期：1986-10-01 00:00:00

abstract：:Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-alpha) mRNA expression and TNF-alpha production and consequently HIV replication in human mac...

journal_title：Antimicrobial agents and chemotherapy

authors： Clayette P,Martin M,Beringue V,Dereuddre-Bosquet N,Adjou KT,Seman M,Dormont D

更新日期：2000-02-01 00:00:00

abstract：:The effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on herpes simplex virus type 1 DNA and protein synthesis was studied. Ganciclovir markedly inhibited the synthesis of viral DNA and gamma proteins in a dose-dependent manner. However, the synthesis of viral beta proteins was significantly increased b...

journal_title：Antimicrobial agents and chemotherapy

authors： Chun YS,Park NH

更新日期：1987-02-01 00:00:00

abstract：:A double-blind study was performed to compare the clinical response and the incidence of side effects in 2,581 patients administered ampicillin or cyclacillin for infections of the genitourinary or respiratory tract, infections of the skin and soft tissues, or for otitis media. There was no significant difference in c...

journal_title：Antimicrobial agents and chemotherapy

authors： Gold JA,Hegarty CP,Deitch MW,Walker BR

更新日期：1979-01-01 00:00:00

abstract：:Microbial metabolism studies of the antimalarial drug primaquine, using Streptomyces roseochromogenus (ATCC 13400) have produced an N-acetylated metabolite and a methylene-linked dimeric product, both of which have been previously reported, and a novel sulfur-containing microbial metabolite. The structure of the metab...

journal_title：Antimicrobial agents and chemotherapy

authors： Hufford CD,Baker JK,McChesney JD,Clark AM

更新日期：1986-08-01 00:00:00

abstract：:The single- and multiple-dose pharmacokinetics of and tolerability to a new microfluidized suspension of atovaquone were studied in human immunodeficiency virus-seropositive patients with CD4 counts of < or = 200 cells per mm3 in order to define a dosing regimen for the treatment of Pneumocystis carinii pneumonia. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon R,Pozniak AL,Watt HM,Rolan P,Posner J

更新日期：1996-03-01 00:00:00

abstract：:The emergence in the United States of resistance to expanded-spectrum cephalosporin (e.g., ceftriaxone) within the salmonellae has been associated primarily with three large (>100-kb) plasmids (designated types A, B, and C) and one 10.1-kb plasmid (type D) that carry the blaCMY-2 gene. In the present study, the distri...

journal_title：Antimicrobial agents and chemotherapy

authors： Giles WP,Benson AK,Olson ME,Hutkins RW,Whichard JM,Winokur PL,Fey PD

更新日期：2004-08-01 00:00:00

abstract：:The methionyl-tRNA synthetase (MetRS) is a novel drug target for the protozoan pathogen Giardia intestinalis. This protist contains a single MetRS that is distinct from the human cytoplasmic MetRS. A panel of MetRS inhibitors was tested against recombinant Giardia MetRS, Giardia trophozoites, and mammalian cell lines....

journal_title：Antimicrobial agents and chemotherapy

authors： Ranade RM,Zhang Z,Gillespie JR,Shibata S,Verlinde CL,Hol WG,Fan E,Buckner FS

更新日期：2015-11-01 00:00:00

abstract：:Cryptococcus gattii isolates from the Pacific Northwest have exhibited higher fluconazole MICs than isolates from other sites. The mechanism of fluconazole resistance in C. gattii is unknown. We sought to determine the role of the efflux pumps Mdr1 and Pdr11 in fluconazole susceptibility. Using biolistic transformatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang ML,Uhrig J,Vu K,Singapuri A,Dennis M,Gelli A,Thompson GR 3rd

更新日期：2015-12-07 00:00:00

abstract：:In patients with polytrauma or major surgery, severe bacterial infections leading to septic shock and multiorgan failure are still a major cause of death. Prevention of septic shock in patients at risk would be an alternative to treatment of patients with overt septic shock. We therefore conducted a trial with the mon...

journal_title：Antimicrobial agents and chemotherapy

authors： Passlick B,Labeta MO,Izbicki JR,Ostertag P,Löffler T,Siebeck M,Pichlmeier U,Schweiberer L,Ziegler-Heitbrock HW

更新日期：1995-11-01 00:00:00

abstract：:Piperacillin is a new semisynthetic, expanded-spectrum penicillin with marked activity against Pseudomonas aeruginosa. The biliary excretion of piperacillin was studied in patients undergoing cholecystectomy. Concentrations of piperacillin in common duct bile at 35 to 90 min postinfusion of 1-g doses ranged from 31 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Giron JA,Meyers BR,Hirschman SZ

更新日期：1981-02-01 00:00:00

abstract：:A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation a...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Mugnaioli C,Luzzaro F,Fiore M,Stefani S,Rossolini GM,Amicosante G

更新日期：2005-04-01 00:00:00

abstract：:The pharmacokinetics of teicoplanin were determined after multiple 30-min intravenous infusions of 10 to 15 mg/kg every 12 to 24 h in 11 intravenous drug abuse (IVDA) patients being treated for bacterial endocarditis. Multiple serum samples were obtained over 7 to 14 days. Twenty-four-hour urine collections were obtai...

journal_title：Antimicrobial agents and chemotherapy

authors： Rybak MJ,Lerner SA,Levine DP,Albrecht LM,McNeil PL,Thompson GA,Kenny MT,Yuh L

更新日期：1991-04-01 00:00:00

abstract：:The in vitro activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066 Staphylococcus aureus isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant S. aureus (MRSA) percentages ranged from 46% (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Biedenbach DJ,Hoban DJ,Reiszner E,Lahiri SD,Alm RA,Sahm DF,Bouchillon SK,Ambler JE

更新日期：2015-12-01 00:00:00

abstract：:Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of both NTPase isoforms (...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai T,Takeuchi T,Diffenderfer J,Sibley LD

更新日期：2002-08-01 00:00:00

abstract：:An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals with a novel mechanism of action. Here we report the identification and characterization of two novel zinc-attenuating compounds, Z...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohrt KAO,Marín L,Kjellerup L,Clausen JD,Dalby-Brown W,Calera JA,Winther AL

更新日期：2018-04-26 00:00:00

abstract：:KBP-7072 is a novel aminomethylcycline antibiotic in clinical development for community-acquired pneumonia. The goal of present studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) parameter magnitude correlated with efficacy in the murine pneumonia infection model against Staphylococcus aureus and S...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Liu Q,Wang P,Wang Y,Bader JC,Ambrose PG,Andes DR

更新日期：2019-02-26 00:00:00

abstract：:18F-labeled fleroxacin was used to measure the pharmacokinetics of fleroxacin in healthy and infected animals by positron emission tomography (PET) and tissue radioactivity measurements. In all experiments, a pharmacological dose of unlabeled drug (10 mg/kg) was coinjected with the tracer. The pharmacokinetics of [18F...

journal_title：Antimicrobial agents and chemotherapy

authors： Fischman AJ,Livni E,Babich J,Alpert NM,Liu YY,Thom E,Cleeland R,Prosser BL,Callahan RJ,Correia JA

更新日期：1992-10-01 00:00:00

abstract：:Ceftolozane-tazobactam (C/T) is a novel cephalosporin with in vitro activity against Pseudomonas aeruginosa that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C/T in treatment of Pseudomonas pneumonia, we investigated the pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Petraitis V,Petraitiene R,Naing E,Aung T,Thi WP,Kavaliauskas P,Win Maung BB,Michel AO,Ricart Arbona RJ,DeRyke AC,Culshaw DL,Nicolau DP,Satlin MJ,Walsh TJ

更新日期：2019-08-23 00:00:00

abstract：:Trimethoprim resistance dihydrofolate reductase genes from plasmids known to be exchanging between human and animal populations were mapped. The dihydrofolate reductase gene has been highly conserved in all plasmids, but differences in the flanking regions provide evidence that the most recent exchange of plasmids bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Campbell IG,Mee BJ

更新日期：1987-09-01 00:00:00

abstract：:High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grégoire M,Dailly E,Le Turnier P,Garot D,Guimard T,Bernard L,Tattevin P,Vandamme YM,Hoff J,Lemaitre F,Verdier MC,Deslandes G,Bellouard R,Sébille V,Chiffoleau A,Boutoille D,Navas D,Asseray N

更新日期：2019-08-23 00:00:00

abstract：:Guanylhydrazones are cationic heteroaromatic drugs similar to the diamidines which are effective in the treatment of African trypanosomiasis and pneumocystosis. On the basis of their antitrypanosomal activity, different guanylhydrazones were selected for evaluation in a rat model of Pneumocystis carinii pneumonia. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Walzer PD,Foy J,Runck J,Steele P,White M,Klein RS,Otter BA,Sundberg RJ

更新日期：1994-11-01 00:00:00

abstract：:The pharmacokinetic (PK) properties of intravenous (i.v.) benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as they have been unknown until now. A system-specific modeling approach was applied, in which our recently developed covariate model describing developme...

journal_title：Antimicrobial agents and chemotherapy

authors： Bijleveld YA,de Haan TR,van der Lee JH,Groenendaal F,Dijk PH,van Heijst A,de Jonge RCJ,Dijkman KP,van Straaten HLM,Rijken M,Zonnenberg IA,Cools F,Zecic A,Nuytemans DHGM,van Kaam AH,Mathôt RAA,PharmaCool Study Group.

更新日期：2018-03-27 00:00:00

abstract：:A model of orogastric candidosis in SCID mice, which mimics disease seen in AIDS patients, was used to evaluate ravuconazole in comparison with fluconazole for treatment. Mice were infected orally with Candida albicans and received either no treatment or oral treatment once daily for 12 days with 1, 5, or 25 mg of rav...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Stevens DA

更新日期：2001-12-01 00:00:00

abstract：:The aim of the study was to identify the plasmid-encoded factors contributing to the emergence and spread of epidemic IncI1-Iγ plasmids obtained from Escherichia coli and Salmonella enterica isolates from animal and human reservoirs. For this, 251 IncI1-Iγ plasmids carrying various extended-spectrum β-lactamase (ESBL)...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith H,Bossers A,Harders F,Wu G,Woodford N,Schwarz S,Guerra B,Rodríguez I,van Essen-Zandbergen A,Brouwer M,Mevius D

更新日期：2015-09-01 00:00:00

abstract：:Nucleobase and nucleoside transporters play central roles in the biochemistry of parasitic protozoa, as they lack the ability to synthesize purines de novo and are absolutely reliant upon purine salvage from their hosts. Furthermore, such transporters are potentially critical to the pharmacology of these important hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Salabi MI,de Koning HP

更新日期：2005-09-01 00:00:00