Purine nucleobase transport in amastigotes of Leishmania mexicana: involvement in allopurinol uptake.

abstract：:Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy agains...

journal_title：Antimicrobial agents and chemotherapy

authors： Zarember KA,Cruz AR,Huang CY,Gallin JI

更新日期：2009-06-01 00:00:00

abstract：:Pefloxacin has been shown to have good intraocular penetration when given systemically. In order to extend its clinical use, we have assessed the tolerability, kinetics, and efficacy of subconjunctival pefloxacin in phakic pigmented rabbits. The tolerability of a single subconjunctival injection of pefloxacin (0.8, 1....

journal_title：Antimicrobial agents and chemotherapy

authors： Marrakchi-Benjaafar S,Cochereau I,D'Hermies F,Pocidalo JJ

更新日期：1995-04-01 00:00:00

abstract：:The effects of sub-MICs of certain antibiotics, namely, penicillin G, tetracycline, and trimethoprim-sulfamethoxazole, on the cell surface characteristics and the virulences of two toxigenic isolates of Pasteurella multocida representing capsular types A and D were evaluated. Expression of proteins, in particular, out...

journal_title：Antimicrobial agents and chemotherapy

authors： Lebrun A,Caya M,Jacques M

更新日期：1992-10-01 00:00:00

abstract：:To identify the polymyxin receptor molecules in the membranes of living microorganisms, fusion of intact Acholeplasma laidlawii B with lipid vesicles was investigated according to the procedure of Grant and McConnell (1973). The naturally polymyxin-resistant A. laidlawii B was treated with phospholipid vesicles prepar...

journal_title：Antimicrobial agents and chemotherapy

authors： Teuber M,Bader J

更新日期：1976-01-01 00:00:00

abstract：:A portion of the Mycobacterium tuberculosis gene encoding the beta subunit of RNA polymerase (rpoB) was amplified by PCR using degenerate oligonucleotides and used as a hybridization probe to isolate plasmid clones carrying the entire rpoB gene of M. tuberculosis H37Rv, a virulent, rifampin-susceptible strain. Sequenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller LP,Crawford JT,Shinnick TM

更新日期：1994-04-01 00:00:00

abstract：:Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational an...

journal_title：Antimicrobial agents and chemotherapy

authors： Gutiérrez O,Juan C,Pérez JL,Oliver A

更新日期：2004-09-01 00:00:00

abstract：:A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also r...

journal_title：Antimicrobial agents and chemotherapy

authors： McKellar RC,McKenzie CN,Kushner KJ

更新日期：1976-10-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetra...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1986-07-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were studied in 10 cystic fibrosis patients, ranging in age from 11 to 28 years. The patients received a 9- to 23-day course of 350 mg of azlocillin per kg in four or six divided daily doses in combination with am aminoglycoside. Blood and urine samples were collected at specified ti...

journal_title：Antimicrobial agents and chemotherapy

authors： Bosso JA,Saxon BA,Herbst JJ,Matsen JM

更新日期：1984-05-01 00:00:00

abstract：:We performed the characterization of a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins WMBS,Martins ER,de Andrade LK,Farzana R,Walsh TR,Toleman MA,Nogueira MCL,Gales AC

更新日期：2020-12-14 00:00:00

abstract：:The continued evolution of bacterial resistance to the β-lactam class of antibiotics has necessitated countermeasures to ensure continued effectiveness in the treatment of infections caused by bacterial pathogens. One relatively successful approach has been the development of new β-lactam analogs with advantages over ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cotroneo N,Rubio A,Critchley IA,Pillar C,Pucci MJ

更新日期：2020-07-22 00:00:00

abstract：:Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizushima T,Matsuo M,Sekimizu K

更新日期：1997-01-01 00:00:00

abstract：:Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized, and their activity against influenza A and B viruses has been studied and compared with that of a series of carrageenans, marine polysaccharides of well-documented anti-influenza activity. NS...

journal_title：Antimicrobial agents and chemotherapy

authors： Ciejka J,Milewska A,Wytrwal M,Wojarski J,Golda A,Ochman M,Nowakowska M,Szczubialka K,Pyrc K

更新日期：2016-03-25 00:00:00

abstract：:Biapenem, formerly LJC 10,627 or L-627, a carbapenem antibiotic, was studied in its interactions with 12 beta-lactamases belonging to the four molecular classes proposed by R. P. Ambler (Philos. Trans. R. Soc. Lond. Biol. Sci. 289:321-331, 1980). Kinetic parameters were determined. Biapenem was readily inactivated by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Felici A,Perilli M,Segatore B,Franceschini N,Setacci D,Oratore A,Stefani S,Galleni M,Amicosante G

更新日期：1995-06-01 00:00:00

abstract：:We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming ...

journal_title：Antimicrobial agents and chemotherapy

authors： D'Souza R,Pinto NA,Higgins PG,Hwang I,Yong D,Choi J,Lee K,Chong Y

更新日期：2017-04-24 00:00:00

abstract：:Nikkomycins are nucleoside-peptide antibiotics produced by Streptomyces species with antifungal activities through the inhibition of chitin synthesis. We investigated the antifungal activities of nikkomycin Z alone and in combination with fluconazole and itraconazole. Checkerboard synergy studies were carried out by a...

journal_title：Antimicrobial agents and chemotherapy

authors： Li RK,Rinaldi MG

更新日期：1999-06-01 00:00:00

abstract：:Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculosis strains from divers...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Stockbauer KE,Pan X,Kreiswirth BN,Moghazeh SL,Jacobs WR Jr,Telenti A,Musser JM

更新日期：1997-08-01 00:00:00

abstract：:The novel 6-substituted acyclouridine derivatives 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT), 1-[(2-hydroxyethoxy)methyl]-6-(3-methylphenylthio)thymine (HEPT-M), 6-cyclohexylthio-1-[(2-hydroxyethoxy) methyl]thymine (HEPT-H), and 1-[(2-hydroxyethoxy)methyl]-6-phenylthio-2- thiothymine (HEPT-S) have proved t...

journal_title：Antimicrobial agents and chemotherapy

authors： Baba M,De Clercq E,Iida S,Tanaka H,Nitta I,Ubasawa M,Takashima H,Sekiya K,Umezu K,Nakashima H

更新日期：1990-12-01 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:Chagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug re...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldasoro E,Pinazo MJ,Oliveira I,Munoz J,Posada E,Requena-Méndez A,Serret N,Gascon J

更新日期：2015-01-01 00:00:00

abstract：:Extensive biochemical testing and 16S rRNA and rpoB sequence analysis revealed that clinical strain CF01Ent1, initially identified as Buttiauxella agrestis by the use of Api 32 biochemical strips, is a new organism in the Enterobacteriaceae family. It produced an inducible AmpC-type beta-lactamase whose sequence share...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonnet R,Chanal C,Ageron E,Sirot D,De Champs C,Grimont P,Sirot J

更新日期：2002-10-01 00:00:00

abstract：:Among respiratory tract isolates of Streptococcus pneumoniae from children, resistance to penicillins, cephalosporins, macrolides, and trimethoprim-sulfamethoxazole (SXT) increases on an annual basis. Pediatric patients who do not respond to conventional therapy for respiratory tract infections someday may be treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Karlowsky JA,Thornsberry C,Critchley IA,Jones ME,Evangelista AT,Noel GJ,Sahm DF

更新日期：2003-06-01 00:00:00

abstract：:This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In this observational study, serial blood samples were taken over several dosing intervals of intravenous fosfomycin treatment. Blood samples were analyzed using a validated liquid chromatography-tandem mass spectrometry tec...

journal_title：Antimicrobial agents and chemotherapy

authors： Parker SL,Frantzeskaki F,Wallis SC,Diakaki C,Giamarellou H,Koulenti D,Karaiskos I,Lipman J,Dimopoulos G,Roberts JA

更新日期：2015-10-01 00:00:00

abstract：:PER-2 was the first detected and the second most prevalent extended-spectrum beta-lactamase in clinical pathogens isolated in Argentina and was also reported only in other South American countries. Citrobacter freundii 33587 was isolated in 1999 in Buenos Aires and was resistant to all tested beta-lactams except cepha...

journal_title：Antimicrobial agents and chemotherapy

authors： Power P,Di Conza J,Rodríguez MM,Ghiglione B,Ayala JA,Casellas JM,Radice M,Gutkind G

更新日期：2007-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) inhibitors include direct-acting antivirals (DAAs) such as NS3 serine protease inhibitors, nucleoside and nonnucleoside polymerase inhibitors, and host-targeting antivirals (HTAs) such as cyclophilin inhibitors that have been developed in recent years. Drug-resistant HCV variants have been repo...

journal_title：Antimicrobial agents and chemotherapy

authors： Delang L,Vliegen I,Froeyen M,Neyts J

更新日期：2011-09-01 00:00:00

abstract：:Mutants with multiple low-level antibiotic resistance were isolated from virulent wild-type Aeromonas salmonicida strains exposed to a low concentration of any one of several low-molecular-mass (approximately 635 daltons or less) antibiotics. Multiple resistance was toward beta-lactam compounds (penicillin G, ampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Wood SC,McCashion RN,Lynch WH

更新日期：1986-06-01 00:00:00

abstract：:An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium clavulanate and oxacillin, distinguished type I chromosomally mediated enzymes from other beta-lactamases of gram-negative bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr,Moland ES

更新日期：1986-12-01 00:00:00

abstract：:Although ampicillin has been suggested as a useful agent for the treatment of nocardiosis in man, little is known regarding the presence of beta-lactamase in Nocardia or its possible role in determining resistance to ampicillin and the other beta-lactam antibiotics. We have evaluated 55 isolates of Nocardia for suscep...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallace RJ Jr,Vance P,Weissfeld A,Martin RR

更新日期：1978-11-01 00:00:00

abstract：:Stenotrophomonas maltophilia is an emerging nosocomial pathogen that displays high-level intrinsic resistance to a variety of structurally unrelated antimicrobial agents. Efflux mechanisms are known to contribute to acquired multidrug resistance in this organism, and indeed, one such multidrug efflux system, SmeDEF, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang L,Li XZ,Poole K

更新日期：2001-12-01 00:00:00