Multiple low-level antibiotic resistance in Aeromonas salmonicida.

abstract：:Staphylococcal biofilms on surgical implants are the underlying cause of a lack of response to antimicrobial treatment. We investigated the effects of vancomycin (VAN), daptomycin (DAP), fosfomycin (FOS), tigecycline (TGC), and ceftriaxone (CRX), alone and in combination with azithromycin (AZI), on established biofilm...

journal_title：Antimicrobial agents and chemotherapy

authors： Presterl E,Hajdu S,Lassnigg AM,Hirschl AM,Holinka J,Graninger W

更新日期：2009-08-01 00:00:00

abstract：:This study analyzed the enzymatic basis and molecular epidemiology of amoxicillin-clavulanate-resistant Escherichia coli isolated by the microbiology laboratory of a United States tertiary care hospital. From October 1998 to December 1999, all E. coli isolates were screened for ampicillin-sulbactam resistance. Of 283 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye KS,Gold HS,Schwaber MJ,Venkataraman L,Qi Y,De Girolami PC,Samore MH,Anderson G,Rasheed JK,Tenover FC

更新日期：2004-05-01 00:00:00

abstract：:Phosphorothioate oligonucleotides complementary to mRNA of the human cytomegalovirus (HCMV) DNA polymerase gene or to RNA transcripts of the major immediate-early regions 1 and 2 (IE1 and IE2) of HCMV were evaluated for antiviral activity in a 96-well immunoassay with primary human dermal fibroblasts as host cells. Ol...

journal_title：Antimicrobial agents and chemotherapy

authors： Azad RF,Driver VB,Tanaka K,Crooke RM,Anderson KP

更新日期：1993-09-01 00:00:00

abstract：:An ultrasensitive assay utilizing high-pressure liquid chromatography and mass spectrometry detection was developed and validated for the quantification of the antiretrovirals atazanavir (ATV), darunavir (DRV), lopinavir (LPV), ritonavir (RTV), and efavirenz (EFV) in human mononuclear cell (MNC) extracts. The assay ut...

journal_title：Antimicrobial agents and chemotherapy

authors： Podany AT,Winchester LC,Robbins BL,Fletcher CV

更新日期：2014-05-01 00:00:00

abstract：:Acanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Contact lens wearers are most at risk and account for some 95% of cases. Hydrogen peroxide is used for contact lens disinfection due to its broad antimicrobial activity. Lenses must be neutralized before use to avoid pronounce...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes R,Kilvington S

更新日期：2001-07-01 00:00:00

abstract：:Pradimicin S (PRM-S) is a highly water-soluble, negatively charged derivative of the antibiotic pradimicin A (PRM-A) in which the terminal xylose moiety has been replaced by 3-sulfated glucose. PRM-S does not prevent human immunodeficiency virus (HIV) adsorption on CD4(+) T cells, but it blocks virus entry into its ta...

journal_title：Antimicrobial agents and chemotherapy

authors： Balzarini J,François KO,Van Laethem K,Hoorelbeke B,Renders M,Auwerx J,Liekens S,Oki T,Igarashi Y,Schols D

更新日期：2010-04-01 00:00:00

abstract：:The National Committee for Clinical Laboratory Standards has proposed a reference broth macrodilution method for in vitro antifungal susceptibility testing of yeasts (the M27-P method). This method is cumbersome and time-consuming and includes MIC endpoint determination by visual and subjective inspection of growth in...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Tudela JL,Berenguer J,Martínez-Suárez JV,Sanchez R

更新日期：1996-09-01 00:00:00

abstract：:(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-diaminopurine [(S)-HPMPDAP], cyclic (S)-HPMPA [(S)-cHPMPA], 9-(2-phosphonylmethoxyethoxyethyl)-2,6-diaminopurine (PMEDAP), and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were examined fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin JC,De Clercq E,Pagano JS

更新日期：1991-11-01 00:00:00

abstract：:Using J774 macrophages, the intracellular activities of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) against Staphylococcus aureus (strain ATCC 25923) have been quantitatively assessed in a 24-h model. S. aureus was positively localized in phagolysosomes by confocal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Van Bambeke F,Tulkens PM

更新日期：2003-07-01 00:00:00

abstract：:A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of...

journal_title：Antimicrobial agents and chemotherapy

authors： Espuelas S,Legrand P,Loiseau PM,Bories C,Barratt G,Irache JM

更新日期：2000-08-01 00:00:00

abstract：:MK-0991 (L-743,872) is a potent antifungal agent featuring long half-life pharmacokinetics. The pharmacokinetics of MK-0991 administered intravenously to mice, rats, rhesus monkeys, and chimpanzees is presented. Unique to MK-0991 is its consistent cross-species performance. The range of values for the pharmacokinetic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hajdu R,Thompson R,Sundelof JG,Pelak BA,Bouffard FA,Dropinski JF,Kropp H

更新日期：1997-11-01 00:00:00

abstract：:The susceptibilities of 216 strains of Neisseria gonorrhoeae to a new fluoroquinolone, CP-99,219 were determined. For strains for which the MICs of ciprofloxacin were < or = 0.06 microgram/ml, the MICs at which 90% of the isolates are inhibited (MIC90s) of CP-99,219, ciprofloxacin, and ofloxacin were 0.008, 0.015, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Neal SW,Parekh MC,Rice RJ

更新日期：1995-04-01 00:00:00

abstract：:Serratia marcescens S-95, which displayed an unusually high degree of resistance to aminoglycosides, including kanamycins and gentamicins, was isolated in 2002 from a patient in Japan. The resistance was mediated by a large plasmid which was nonconjugative but transferable to an Escherichia coli recipient by transform...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Yokoyama K,Yamane K,Wachino J,Shibata N,Yagi T,Shibayama K,Kato H,Arakawa Y

更新日期：2004-02-01 00:00:00

abstract：:The post-β-lactamase-inhibitor effect (PBLIE) of tazobactam combined with ceftolozane was evaluated by time-kill assays on two clinical Escherichia coli strains producing CTX-M-15 with or without TEM-1. The organisms were exposed (2 h) to 4 μg/ml/4 μg/ml of ceftolozane-tazobactam (4× MIC), 4 μg/ml of ceftolozane, and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Rhomberg PR,Jones RN

更新日期：2014-01-01 00:00:00

abstract：:The association of an IS440-sul3 platform with Tn21 class 1 integrons carried by IncI1 plasmids encoding extended-spectrum β-lactamases (ESBLs; mainly SHV-12 and CTX-M-14) among worldwide Escherichia coli clones of phylogroups A (ST10, ST23, and ST46), B1 (ST155, ST351, and ST359), and D/B2 (ST131) is reported. An in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Curiao T,Cantón R,Garcillán-Barcia MP,de la Cruz F,Baquero F,Coque TM

更新日期：2011-05-01 00:00:00

abstract：:The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murin...

journal_title：Antimicrobial agents and chemotherapy

authors： Hosaka M,Gotoh N,Nishino T

更新日期：1995-08-01 00:00:00

abstract：:The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultraso...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins-Leite P,Gazzinelli G,Alves-Oliveira LF,Gazzinelli A,Malaquias LC,Correa-Oliveira R,Teixeira-Carvalho A,Silveira AM

更新日期：2008-08-01 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00

abstract：:With the aim of investigating home therapy for enterococcal endocarditis, we compared the efficacy of teicoplanin combined with gentamicin given once a day or in three daily doses (t.i.d.) with the standard treatment, ampicillin plus gentamicin administered t.i.d., for treating experimental enterococcal endocarditis. ...

journal_title：Antimicrobial agents and chemotherapy

authors： López P,Gavaldà J,Martin MT,Almirante B,Gomis X,Azuaje C,Borrell N,Pou L,Falcó V,Pigrau C,Pahissa A

更新日期：2001-05-01 00:00:00

abstract：:The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label, randomized, balan...

journal_title：Antimicrobial agents and chemotherapy

authors： Brophy DF,Israel DS,Pastor A,Gillotin C,Chittick GE,Symonds WT,Lou Y,Sadler BM,Polk RE

更新日期：2000-04-01 00:00:00

abstract：:Echinocandins are recommended as the first-line drugs for the treatment of systemic candidiasis. Cas5 is a key transcription factor involved in the response to cell wall damage induced by echinocandins. In this study, through a genetic screen, we identified a second transcription factor, Efg1, that is also crucial for...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong K,Su C,Sun Q,Lu Y

更新日期：2021-01-20 00:00:00

abstract：:Two methods for testing the susceptibility of Mycobacterium tuberculosis to rifapentine have been developed: the agar proportion method and the radiometric BACTEC technique. A critical concentration of 0.5 microg of rifapentine per ml is proposed for both methods since it provides a reliable means of distinguishing be...

journal_title：Antimicrobial agents and chemotherapy

authors： Heifets L,Sanchez T,Vanderkolk J,Pham V

更新日期：1999-01-01 00:00:00

abstract：:The new oral 200-mg rifamycin SV MMX modified-release tablets, designed to deliver rifamycin SV directly into the colonic lumen, offer considerable advantages over the existing immediate-release antidiarrheic formulations. In two pharmacokinetics studies of healthy volunteers, the absorption, urinary excretion, and fe...

journal_title：Antimicrobial agents and chemotherapy

authors： Di Stefano AF,Rusca A,Loprete L,Dröge MJ,Moro L,Assandri A

更新日期：2011-05-01 00:00:00

abstract：:Wild-type Proteus strains are usually resistant to colistin. We have observed an increase in the level of colistin resistance in four clinical isolates of P. vulgaris, P. morganii, and P. rettgeri by prior treatment with subinhibitory concentrations of the drug. The enhanced resistance in these strains was lost after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu S,Iyobe S,Mitsuhashi S

更新日期：1977-07-01 00:00:00

abstract：:The frequencies of tetracycline resistance determinants of the classes A, B, C, and D were determined in 53 non-lactose-fermenting clinical isolates. The most frequent class of determinant in Salmonella typhimurium and Shigella flexneri strains was class B; however, the predominant determinant in Shigella sonnei strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Salazar JM,Alvarez G,Gómez-Eichelmann MC

更新日期：1986-10-01 00:00:00

abstract：:Preliminary studies showed that roxithromycin possessed significant in vitro activity against a variety of atypical mycobacteria such as the Mycobacterium avium complex, M. scrofulaceum, M. szulgai, M. malmoense, M. xenopi, M. marinum, and M. kansasii and rare pathogens such as M. chelonae and M. fortuitum. In this in...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Goh KS,Bryskier A

更新日期：1994-06-01 00:00:00

abstract：:Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplification in culture-adapte...

journal_title：Antimicrobial agents and chemotherapy

authors： Preechapornkul P,Imwong M,Chotivanich K,Pongtavornpinyo W,Dondorp AM,Day NP,White NJ,Pukrittayakamee S

更新日期：2009-04-01 00:00:00

abstract：:Retrocyclins are humanized versions of the -defensin peptides expressed by the leukocytes of several nonhuman primates. Previous studies, performed in serum-free media, determined that retrocyclins 1 (RC1) and RC2 could prevent successful germination of Bacillus anthracis spores, kill vegetative B. anthracis cells, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Welkos S,Cote CK,Hahn U,Shastak O,Jedermann J,Bozue J,Jung G,Ruchala P,Pratikhya P,Tang T,Lehrer RI,Beyer W

更新日期：2011-09-01 00:00:00

abstract：:Burkholderia pseudomallei, the causative agent of melioidosis, is inherently resistant to a variety of antibiotics including aminoglycosides, macrolides, polymyxins, and beta-lactam antibiotics. Despite resistance to many beta-lactams, ceftazidime and beta-lactamase inhibitor-beta-lactam combinations are commonly used...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Moore RA,Baker P,Woods DE

更新日期：2003-07-01 00:00:00

abstract：:We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This r...

journal_title：Antimicrobial agents and chemotherapy

authors： Gollapudi SV,Chuah SK,Harvey T,Thadepalli HD,Thadepalli H

更新日期：1993-08-01 00:00:00