Activities of roxithromycin used alone and in combination with ethambutol, rifampin, amikacin, ofloxacin, and clofazimine against Mycobacterium avium complex.

abstract：:Heat shock protein 90 (Hsp90) is an essential chaperone involved in the fungal stress response that can be harnessed as a novel antifungal target for the treatment of invasive aspergillosis. We previously showed that genetic repression of Hsp90 reduced Aspergillus fumigatus virulence and potentiated the effect of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Asfaw YG,Steinbach WJ

更新日期：2014-01-01 00:00:00

abstract：:The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC beta-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpC...

journal_title：Antimicrobial agents and chemotherapy

authors： Okamoto K,Gotoh N,Nishino T

更新日期：2002-08-01 00:00:00

abstract：:Current data indicate that once-daily aminoglycoside therapy is as efficacious as traditional multiple daily dosing and equally or less toxic. Our experience with once-daily gentamicin, 6 mg/kg of body weight led to a 10% (3 of 33 patients) occurrence of documented ototoxicity after prolonged aminoglycoside exposure. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Singer C,Smith C,Krieff D

更新日期：1996-09-01 00:00:00

abstract：:Rates of metallo-beta-lactamase and 16S rRNA methylase production were investigated in 51 imipenem-resistant Pseudomonas aeruginosa clinical isolates collected from hospitals in São Paulo, Brazil. Of them, 57% and 75% produced SPM-1 and RmtD, respectively. Of note, 51% produced both enzymes, suggesting that their copr...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Ghilardi AC,Adams J,de Oliveira Garcia D,Paterson DL

更新日期：2007-09-01 00:00:00

abstract：:The pharmacodynamic effects of metronidazole on Trichomonas vaginalis have been poorly characterized. The present in vitro study was performed to characterize the relationship between killing of trichomonads and metronidazole exposure (metronidazole concentration and time of exposure). Five laboratory strains and five...

journal_title：Antimicrobial agents and chemotherapy

authors： Nix DE,Tyrrell R,Müller M

更新日期：1995-08-01 00:00:00

abstract：:Burkholderia cepacia is recognized as an important pathogen in the lung infections of patients with cystic fibrosis. An inducible beta-lactamase activity has been associated with increased resistance to beta-lactam antibiotics in clinical isolates of B. cepacia. In this study, we report the revised sequence of the pen...

journal_title：Antimicrobial agents and chemotherapy

authors： Trépanier S,Prince A,Huletsky A

更新日期：1997-11-01 00:00:00

abstract：:Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquin...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan AA,Slifer T,Araujo FG,Polzer RJ,Remington JS

更新日期：1997-05-01 00:00:00

abstract：:Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the fre...

journal_title：Antimicrobial agents and chemotherapy

authors： Leib DA,Ruffner KL,Hildebrand C,Schaffer PA,Wright GE,Coen DM

更新日期：1990-06-01 00:00:00

abstract：:The Helicobacter pylori SS1 mouse model was used to characterize the development of resistance in H. pylori after treatment with metronidazole monotherapy and to examine the effect of prior exposure to metronidazole on the efficacy of a metronidazole-containing eradication regimen. Mice colonized with the metronidazol...

journal_title：Antimicrobial agents and chemotherapy

authors： Jenks PJ,Labigne A,Ferrero RL

更新日期：1999-04-01 00:00:00

abstract：:During the second quarter each of 1988, 1989, and 1990, a French collaborative study group, including 12 university hospital laboratories, surveyed the resistance to beta-lactams of clinical isolates from hospitalized patients: consecutively, 10,641, 10,692, and 9,382 isolates were tested. The distribution of bacteria...

journal_title：Antimicrobial agents and chemotherapy

authors： Sirot DL,Goldstein FW,Soussy CJ,Courtieu AL,Husson MO,Lemozy J,Meyran M,Morel C,Perez R,Quentin-Noury C

更新日期：1992-08-01 00:00:00

abstract：:The prophylactic efficacy of 17C91, a carbamate prodrug of atovaquone (ATQ), was investigated in a severe combined immunodeficient mouse model of Pneumocystis carinii pneumonia (PCP). At an oral dosage equivalent to 100 mg of ATQ per kg of body weight per day, 17C91 protected 9 of 10 mice from PCP and had a prophylact...

journal_title：Antimicrobial agents and chemotherapy

authors： Comley JC,Yeates CL,Frend TJ

更新日期：1995-10-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans and Capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. They are resistant to many antibiotics of microbial origin but are sensitive to the n...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

更新日期：1993-12-01 00:00:00

abstract：:Two Klebsiella pneumoniae isolates of the same strain, identified in Poland, produced either TEM-47 or TEM-68, which differed by the Arg275Leu substitution. They harbored a few virulence factors, including an iron-chelating factor and capsule overproduction, suggesting that these factors were sufficient to enhance the...

journal_title：Antimicrobial agents and chemotherapy

authors： Robin F,Hennequin C,Gniadkowski M,Beyrouthy R,Empel J,Gibold L,Bonnet R

更新日期：2012-02-01 00:00:00

abstract：:Identifying and understanding potential drug-drug interactions (DDIs) are vital for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. This article discusses DDIs between doravirine, a nonnucleoside reverse transcriptase inhibitor (NNRTI), and cytochrome P450 3A (CYP3A) substrates and drugs that m...

journal_title：Antimicrobial agents and chemotherapy

authors： Khalilieh SG,Yee KL,Sanchez RI,Fan L,Anderson MS,Sura M,Laethem T,Rasmussen S,van Bortel L,van Lancker G,Iwamoto M

更新日期：2019-04-25 00:00:00

abstract：:Cryptic species of Aspergillus fumigatus, including the Aspergillus viridinutans species complex, are increasingly reported to be causes of invasive aspergillosis. Their identification is clinically relevant, as these species frequently have intrinsic resistance to common antifungals. We evaluated the susceptibilities...

journal_title：Antimicrobial agents and chemotherapy

authors： Lyskova P,Hubka V,Svobodova L,Barrs V,Dhand NK,Yaguchi T,Matsuzawa T,Horie Y,Kolarik M,Dobias R,Hamal P

更新日期：2018-03-27 00:00:00

abstract：:Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A(1), and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1,...

journal_title：Antimicrobial agents and chemotherapy

authors： Isaka M,Jaturapat A,Kramyu J,Tanticharoen M,Thebtaranonth Y

更新日期：2002-04-01 00:00:00

abstract：:The in vitro activities of four fluoroquinolone compounds were tested against 92 Escherichia coli strains of ovine and caprine origin under aerobic and anaerobic incubation conditions. The four fluoroquinolones proved to be highly effective against the E. coli isolates tested. When bacteria were cultured anaerobically...

journal_title：Antimicrobial agents and chemotherapy

authors： Cid D,Piriz S,Ruiz-Santa-Quiteria JA,Valle J,Garcia S,Vadillo S,de la Fuente R

更新日期：1994-10-01 00:00:00

abstract：:Metronidazole (MDZ) and related 5-nitroimidazoles are the recommended drugs for treatment of trichomoniasis, a sexually transmitted disease caused by the protozoan parasite Trichomonas vaginalis. However, novel treatment options are needed, as recent reports have claimed resistance to these drugs in T. vaginalis isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Mallo N,Lamas J,Leiro JM

更新日期：2013-06-01 00:00:00

abstract：:Among 730 Escherichia coli, 438 Klebsiella pneumoniae, and 141 Proteus mirabilis isolates obtained between September 2000 and September 2001 in seven hospitals in Ho Chi Minh City, Vietnam, 26.6% were resistant to ceftazidime, 30% were resistant to cefotaxime, 31.5% were resistant to ceftriaxone, 15.9% were resistant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao V,Lambert T,Nhu DQ,Loan HK,Hoang NK,Arlet G,Courvalin P

更新日期：2002-12-01 00:00:00

abstract：:Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma G,Khan SI,Jacob MR,Tekwani BL,Li Z,Pasco DS,Walker LA,Khan IA

更新日期：2004-11-01 00:00:00

abstract：:Whole and fractionated latex of Asclepias syriaca was tested for antimicrobial or growth-promoting activity with 16 genera and species of bacteria. Latex and extracted fractions (distilled water, acetic acid, sodium bicarbonate, sulfuric acid, and ethyl ether) possessed no detectable antimicrobial activity. Comparison...

journal_title：Antimicrobial agents and chemotherapy

authors： McCay S,Mahlberg P

更新日期：1973-02-01 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity of polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 h was conducted. The p...

journal_title：Antimicrobial agents and chemotherapy

authors： Crass RL,Rutter WC,Burgess DR,Martin CA,Burgess DS

更新日期：2017-03-24 00:00:00

abstract：:By the time-kill curve method, the combination of N-formimidoyl thienamycin and gentamicin showed synergism against 47 of 48 strains of enterococci, whereas the combination of N-formimidoyl thienamycin and tobramycin was synergistic against 46 strains. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanakunakorn C,Tisone JC

更新日期：1982-12-01 00:00:00

abstract：:The bactericidal activity of the novel beta-defensin hBD-3 against 28 species and 55 strains of gram-positive cocci and gram-negative fermentative and nonfermentative rods was tested. All strains proved to be highly or intermediately susceptible to hBD-3 (minimal bactericidal concentration [MBC],

journal_title：Antimicrobial agents and chemotherapy

authors： Sahly H,Schubert S,Harder J,Rautenberg P,Ullmann U,Schröder J,Podschun R

更新日期：2003-05-01 00:00:00

abstract：:Medicinal herbs may cause clinically relevant drug interactions with antiretroviral agents. Ginkgo biloba extract is a popular herbal product among HIV-infected patients because of its positive effects on cognitive function. Raltegravir, an HIV integrase inhibitor, is increasingly being used as part of combined antire...

journal_title：Antimicrobial agents and chemotherapy

authors： Blonk M,Colbers A,Poirters A,Schouwenberg B,Burger D

更新日期：2012-10-01 00:00:00

abstract：:The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared t...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Fothergill AW,McCarthy DI,Tavakkol A

更新日期：2014-06-01 00:00:00

abstract：:Pseudomonas aeruginosa AH, isolated in Ankara, Turkey, was highly resistant to ceftazidime (MIC, 128 microg/ml) and produced a beta-lactamase that gave a doublet of bands at pIs 8.7 and 8.9. beta-Lactamase production was transferable to P. aeruginosa PU21 by conjugation and was determined by a ca. 450-kb plasmid, pMLH...

journal_title：Antimicrobial agents and chemotherapy

authors： Danel F,Hall LM,Gur D,Livermore DM

更新日期：1997-04-01 00:00:00

abstract：:The in vitro susceptibilities of 22 penicillinase-producing and 32 non-penicillinase-producing strains of Neisseria gonorrhoeae to 13 antimicrobial agents, including the new semisynthetic penicillins and cephalosporins, are reported. Ceftriaxone, ceftazidime, and cefotaxime were the most active agents tested; none of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Coovadia YM,Ramsaroop U

更新日期：1984-11-01 00:00:00

abstract：:Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in Africa. We correlat...

journal_title：Antimicrobial agents and chemotherapy

authors： Karema C,Imwong M,Fanello CI,Stepniewska K,Uwimana A,Nakeesathit S,Dondorp A,Day NP,White NJ

更新日期：2010-01-01 00:00:00